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RECRUITING Phase 1 / Phase 2 ClinicalTrials.gov

Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration

Sponsor: Eyconis INC. • ClinicalTrials.gov ID: NCT07587515

Registry updated: 2026-10-09
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Description

This Phase 1b/2a study will primarily investigate the safety and tolerability of EYC-0305 delivered by intravitreal (IVT) injection every 24 weeks in patients with neovascular (wet) age-related macular degeneration (AMD). The pharmacokinetics (PK) and immunogenicity of EYC-0305, and the effect on disease activity and vision will also be evaluated.

Interventions

  • EYC-0305 (Biological)
    Extended-delivery anti-VEGF

Eligibility criteria

Inclusion Criteria: * Men or women 50 years and older with neovascular (wet) AMD meeting all study-specified eligibility criteria * Willing and able to comply with clinic visits and study-related procedures * Provide signed informed consent Exclusion Criteria: * Known hypersensitivity or known allergy that would preclude study drug administration * Inability to obtain ophthalmic imaging, eg, due to media opacity, inadequate pupillary dilation, allergy to fluorescein dye or lack of venous access * Uncontrolled diabetes mellitus * History of cerebrovascular accident (CVA) or myocardial infarction within 180 days of the Day 1 visit * Renal failure, dialysis, or history of renal transplant * Concurrent psychiatric or medical condition that in the opinion of the Investigator will interfere with study participation or completion * Pregnant or breastfeeding women

Conditions

Neovascular (Wet) Age-Related Macular Degeneration

Locations

  • Beverly Hills, CA — Beverly Hills, California, United States
  • Modesto, CA — Modesto, California, United States
  • Wake Forest, NC — Wake Forest, North Carolina, United States
  • Erie, PA — Erie, Pennsylvania, United States
  • Bellaire, TX — Bellaire, Texas, United States
  • McAllen, TX — McAllen, Texas, United States
  • The Woodlands, TX — The Woodlands, Texas, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record