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RECRUITING Not applicable ClinicalTrials.gov

Transoral Ultrasound Versus no Transoral Ultrasound in Diagnostic Workup of Peritonsillar Abscess

Sponsor: Copenhagen University Hospital, Rigshospitalet • ClinicalTrials.gov ID: NCT07577232

Registry updated: 2026-09-08
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Description

Peritonsillar abscess (PTA) is a collection of pus between the palatine tonsil and the constrictor muscle. PTA is detected by recognizing characteristics during clinical examination: redness, pain, malaise, trismus, and unilateral peritonsillar swelling. Clinical assessment, including inspection and palpation, is the traditional diagnostic method for patients suspected of having PTA. If PTA is suspected, aspiration with a large-gauge needle or incision is performed to drain the abscess . It can be challenging to distinguish PTA and peritonsillar cellulitis (PTC) based on clinical examination alone. Due to the increased availability of point-of-care ultrasound, it is a part of the diagnostic workup of PTA. Several studies have shown that transoral US can improve the diagnostic accuracy of patients with a suspected PTA. However, no large multicenter study has evaluated whether one of these methods is superior to the other. It is therefore very clinician-dependent whether the patient will have a transoral US performed or not. The investigators hypothesize that transoral US will increase the diagnostic accuracy of PTA compared to solely clinical examination, which is a visual and palpatory assessment. This will result in fewer unnecessary aspiration attempts and overlooked PTAs. Additionally, the investigators wish to investigate the number of aspirations of transoral US-guided needle aspirations compared to aspirations without ultrasound. Methods This is a cluster randomized study. Patients with suspected PTA will be randomized 1:1 to groups A and B. The cluster randomization will happen weekly using an online randomization tool. Participants are patients refeered to the outpatient clinic on suspicion of a peritonsillar absces. The primary outcome is the diagnostic accuracy The investigators aim to determine whether transoral US is a standard part of the clinical examination by comparing clinical examinations with and without US.

Interventions

  • Transoral Ultrasound (Device)
    A small hockey stick ultrasound to scan the oropharynx through the mouth

Eligibility criteria

Inclusion Criteria: * Patients referred to the ENT outpatient clinic with a suspected PTA. * 18 years of age or older. Exclusion Criteria: * Unable to understand the verbal information, participating in research. * Prior surgical interventions (needle aspiration, surgery, incision) during the course of the disease. * Compromised airways, needing acute airway management.

Conditions

Peritonsillar Abscess Peritonsillar Cellulitis Tonsillitis

Locations

  • Department of Otorhinolaryngology, Head and Neck Surgery & Audiolog — Copenhagen, Denmark
  • Department of Otorhinolaryngology, Head and Neck Surgery & Audiology, North Zealand Hospital — Hillerød, Denmark
  • Department of ORL - Head & Neck Surgery and Audiology, Zealand University Hospital, — Køge, Denmark
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record