RECRUITING Not applicable ClinicalTrials.gov

Routine Probe Compression After Transrectal Prostate Biopsy(RPCAB) to Reduce Bleeding and Infectious Complications

Sponsor: Veterans Health Service Medical Center, Seoul, Korea • ClinicalTrials.gov ID: NCT07550985

Registry updated: 2026-08-27

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Description

Hematuria (up to 50%) and rectal bleeding (up to 30%) are common complications following transrectal ultrasound-guided prostate biopsy. Although most cases are mild, some require additional intervention. Short-duration compression has been shown to achieve hemostasis in cases of post-biopsy bleeding, suggesting that routine probe compression may reduce bleeding complications. Post-biopsy bleeding may also be associated with an increased risk of subsequent infection. This randomized controlled trial aims to evaluate the effect of routine probe compression and compression duration after transrectal prostate biopsy on bleeding and infectious complications.

Interventions

Probe compression (Behavioral)
Probe compression using the transrectal ultrasound probe applied immediately after biopsy, with duration of 0, 1, or 3 minutes according to randomization.

Eligibility criteria

Inclusion Criteria: * Male patients aged ≥18 years * Scheduled to undergo transrectal ultrasound-guided prostate biopsy * Biopsy-naïve patients (first-time prostate biopsy) * Able to provide written informed consent Exclusion Criteria: * Uncorrectable coagulopathy or bleeding disorder * Active urinary tract infection at the time of biopsy * Acute anorectal conditions (e.g., hemorrhoidal bleeding, anal fissure, proctitis) * Inability to discontinue or appropriately manage anticoagulant or antiplatelet therapy * History of severe drug allergy or hypersensitivity to medications used in the study * Individuals unable to provide informed consent (e.g., cognitive impairment, medically incapacitated) or other vulnerable populations * Participation in another interventional study related to prostate disease that may interfere with the outcomes of this study * Severe comorbid conditions limiting study participation * Inability to comply with follow-up procedures

Conditions

Prostate Biopsy Post Biopsy Bleeding Transrectal Ultrasound-guided Prostate Biopsy

Locations

VHS medical center — Seoul, Seoul, South Korea

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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