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RECRUITING Not applicable ClinicalTrials.gov

Anderson-Fabry Disease Fitness Improvement Training

Sponsor: General University Hospital, Prague • ClinicalTrials.gov ID: NCT07495410

Registry updated: 2026-09-21
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Description

This study will evaluate physical function, cardiorespiratory fitness, muscle strength, and quality of life in patients with Fabry disease and assess the effects of a 12-week physiotherapy-led exercise programme. Participants will be non-randomly assigned to an exercise intervention group or a control group receiving no study-specific exercise intervention. The intervention group will be assessed at baseline, immediately after the 12-week intervention, and 12 months after baseline. The control group will be assessed at baseline and 12 months after baseline.

Interventions

  • Physiotherapy exercise programe (Behavioral)
    A 12-week physiotherapy-led exercise programme consisting of one supervised session and two home-based exercise sessions per week. Supervised sessions include a brief aerobic warm-up followed by strengthening exercises using body weight and resistance bands. The programme also includes a progressive increase in daily ambulatory physical activity, monitored primarily by daily step count. Adherence is monitored using exercise diaries and regular follow-up during supervised sessions.

Eligibility criteria

Inclusion Criteria: * Confirmed diagnosis of Fabry disease * Age 18 years or older * Followed at a participating clinical center * Able to understand the study procedures and provide informed consent * Clinically stable and medically suitable for exercise testing and participation in the exercise programme Exclusion Criteria: * Acute deterioration in health status at the time of enrollment * Medical contraindication to exercise testing or exercise training * Severe comorbidity preventing safe participation in the study procedures * Inability to comply with study procedures or complete follow-up assessments

Conditions

Fabry Disease

Locations

  • General University Hospital — Prague, Czechia
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record