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RECRUITING Not applicable ClinicalTrials.gov

Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision

Sponsor: University of Maryland, Baltimore • ClinicalTrials.gov ID: NCT07463742

Registry updated: 2026-08-20
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Description

Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward. The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.

Interventions

  • Bronchoscopy, carbon dioxide (CO2) laser wedge resection (Procedure)
    CO2 laser wedge resection - removing scar tissue with laser, leading tissue bridges.
  • Radial incision with dilation (Procedure)
    Radial incision with dilation - making radial cuts at the circumferential scar site, followed by balloon dilation.

Eligibility criteria

Inclusion Criteria: * symptomatic tracheal stenosis * idiopathic subglottic stenosis * iatrogenic tracheal stenosis from intubation or tracheostomy Exclusion Criteria: * positive ANA or ANCA * tracheal stenosis from infection, i.e. TB * tracheal stenosis with cartilage fracture * tracheal stenosis with malacia * tracheal stenosis from malignancy * tracheal stenosis from benign tumor * presence of glottic or supraglottic stenosis

Conditions

Tracheal Stenosis

Locations

  • University of Maryland — Baltimore, Maryland, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record