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RECRUITING Not applicable ClinicalTrials.gov

The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension

Sponsor: Johns Hopkins University • ClinicalTrials.gov ID: NCT07460882

Registry updated: 2026-08-21
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Description

The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are: Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population? Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels? Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.

Interventions

  • Low-sodium salt substitute (Dietary supplement)
    The low sodium salt substitute contains 25% potassium chloride (KCl range; 20%-35%)

Eligibility criteria

Inclusion Criteria: * Adults ≥18 years with clinically diagnosed hypertension treated with medication \[on a stable dose at least for 2 months\] * Have a phone for contact Exclusion Criteria: * Those with baseline K ≥5.0 or K \<3.0 mmol/L * Advanced kidney disease (eGFR \<45 ml/min/1.73m2). * Those on potassium sparing diuretics (e.g., spironolactone) * Other medical conditions determined by physicians (e.g., heart failure treated with medication; life expectancy less than 12 months) * Dine out for dinner more than 3 times a week

Conditions

Hypertension

Locations

  • The National Heart Foundation of Bangladesh — Dhaka, Bangladesh
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record