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RECRUITING Not applicable ClinicalTrials.gov

Perioperative Multimodal Analgesia for Supratentorial Craniotomy

Sponsor: Beijing Tiantan Hospital • ClinicalTrials.gov ID: NCT07441421

Registry updated: 2026-10-15
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Description

This randomized clinical trial aims to evaluate the effectiveness of scalp nerve blocks and dexmedetomidine in reducing opioid use and preventing postoperative delirium in patients undergoing supratentorial brain tumor surgery. A total of 2000 patients will be randomly assigned to one of four groups, receiving either active treatments, placebos, or their combinations.

Interventions

  • Dexmedetomidine (Drug)
    The 200ug dexmedetomidine will be diluted into a 50ml syringe and administered with 0.4ug/kg/h intraoperatively and 0.05 μg/kg/h for 48 hours after surgery.
  • Scalp-Nerve Block (Procedure)
    The 10ml 1.33% liposomal bupivacaine will be diluted into a 20ml syringe. As for scalp nerve block, each nerve will be blocked separately with 1-2 mL 0.67% liposomal bupivacaine.

Eligibility criteria

Inclusion Criteria: * Aged from 18 to 65 years * American Society of Anesthesiologists physical status I to III * Scheduled to undergo elective supratentorial tumor resection Exclusion Criteria: * Incision-area skin infection * A history of previous craniotomy * Allergy to study medications * A history of preoperative change in consciousness or cognitive function * Inability to communicate, * Preoperative pain in the surgical region * Severe hepatic or renal dysfunction * Severe bradycardia (heart rate\<40 beats/min) * Sick sinus syndrome or second- to-third degree atrioventricular block

Conditions

Postoperative Pain Analgesia Supratentorial Brain Tumor

Locations

  • Beijing Tian Tan Hospital, Capital Medical University — Beijing, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record