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RECRUITING Phase 2 / Phase 3 ClinicalTrials.gov

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Sponsor: EyeBiotech Ltd. • ClinicalTrials.gov ID: NCT07440225

Registry updated: 2026-10-02
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Description

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Interventions

  • Tiespectus (Drug)
    Administered by intravitreal (IVT) injection
  • Aflibercept (Drug)
    Administered by intravitreal injection (IVT)

Eligibility criteria

The main inclusion criteria include but are not limited to the following: * Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye) * The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment The main exclusion criteria include but are not limited to the following * Has uncontrolled blood pressure at screening * History of any prior macular laser photocoagulation in the study eye * History of uveitis in either eye * History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study * Has uncontrolled glaucoma in the study eye * Active retinal disease other than the condition under investigation in the study eye * Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

Conditions

Macular Degeneration Age-Related Macular Degeneration Choroidal Neovascularization Wet Macular Degeneration

Locations

  • Research Network Arizona / Retina Macula Institute of Arizona — Scottsdale, Arizona, United States
  • Retina Center of Arkansas — Fayetteville, Arkansas, United States
  • Retina Partners of Northwest Arkansas, PLLC — Springdale, Arkansas, United States
  • Global Research Management, Inc. — Glendale, California, United States
  • Retinal Consultants Medical Group (Site 024) — Modesto, California, United States
  • Azul Vision / California Eye Specialists Medical Group, Inc. — Pasadena, California, United States
  • Retina Consultants of Southern California (Site 043) — Redlands, California, United States
  • Retinal Consultants Medical Group (Site 020) — Sacramento, California, United States
  • Retinal Consultants Medical Group (Site 022) — Sacramento, California, United States
  • Florida Eye Clinic (Site 130) — Altamonte Springs, Florida, United States
  • Retina Group of Florida (Site 070) — Fort Lauderdale, Florida, United States
  • Vitreo Retinal Associates — Gainesville, Florida, United States
  • Florida Retina Institute — Jacksonville, Florida, United States
  • Florida Retina Consultants — Lakeland, Florida, United States
  • South Florida Retina Institute — Miami, Florida, United States
  • Retina Care Specialists — Palm Beach Gardens, Florida, United States
  • Fort Lauderdale Eye Institute (Site 042) — Plantation, Florida, United States
  • Retina Vitreous Associates of Florida (Site 049) — St. Petersburg, Florida, United States
  • Southern Vitreoretinal Associates — Tallahassee, Florida, United States
  • Retina Associates of Florida, LLC — Tampa, Florida, United States
  • Retina Vitreous Associates of Florida — Tampa, Florida, United States
  • Wildwood Clinical Research / Florida Retina Institute — Wildwood, Florida, United States
  • Illinois Retina Associates — Oak Park, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Associated Vitreoretinal and Uveitis Consultants — Carmel, Indiana, United States
  • Midwest Eye Institute — Carmel, Indiana, United States
  • Cumberland Valley Retina Consultants (Site 007) — Hagerstown, Maryland, United States
  • Foundation for Vision Research (Site 073) — Grand Rapids, Michigan, United States
  • Retina Consultants of Minnesota — Saint Louis Park, Minnesota, United States
  • Retina Specialists of Mississippi — Hattiesburg, Mississippi, United States
  • Mississippi Retina Associates (Site 084) — Madison, Mississippi, United States
  • Mid Atlantic Retina — Cherry Hill, New Jersey, United States
  • Vision Research Center Eye Associates of New Mexico — Albuquerque, New Mexico, United States
  • ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105) — Hauppauge, New York, United States
  • Retina Vitreous Surgeons of CNY, PC (Site 033) — Liverpool, New York, United States
  • Piedmont Retina Specialists - Greensboro — Greensboro, North Carolina, United States
  • North Carolina Retina Associates — Greenville, North Carolina, United States
  • Piedmont Retina Specialists - Winston-Salem — Winston-Salem, North Carolina, United States
  • Cincinnati Eye Institute (Site 133) — Cincinnati, Ohio, United States
  • Retina Vitreous Center — Edmond, Oklahoma, United States
  • Tulsa Retina Consultants — Tulsa, Oklahoma, United States
  • Retina Northwest, PC — Portland, Oregon, United States
  • EyeHealth Northwest — Portland, Oregon, United States
  • Mid Atlantic Retina (Site 050) — Bethlehem, Pennsylvania, United States
  • Palmetto Retina Center — Aiken, South Carolina, United States
  • Charleston Neuroscience Institute - Bluffton (Site 124) — Bluffton, South Carolina, United States
  • Charleston Neuroscience Institute (Site 104) — Charleston, South Carolina, United States
  • Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina — Mt. Pleasant, South Carolina, United States
  • Charles Retina Institute — Germantown, Tennessee, United States
  • Retina Research Institute of Texas (Site 010) — Abilene, Texas, United States
  • Southwest Retina Specialists — Amarillo, Texas, United States
  • Texas Retina Associates — Arlington, Texas, United States
  • Austin Research Center for Retina — Austin, Texas, United States
  • Austin Retina Associates (Site 012) — Austin, Texas, United States
  • Retina & Vitreous of Texas — Bellaire, Texas, United States
  • Texas Retina Associates — Dallas, Texas, United States
  • Texas Retina (Site 037) — Plano, Texas, United States
  • Retina Center of Texas — Southlake, Texas, United States
  • Retina Consultants of Texas (Site 014) — The Woodlands, Texas, United States
  • Tyler Retina Research Institute — Tyler, Texas, United States
  • Strategic Clinical Research Group — Weatherford, Texas, United States
  • Retina Associates of Utah — Salt Lake City, Utah, United States
  • Piedmont Eye Center (Site 054) — Lynchburg, Virginia, United States
  • Pacific Northwest Retina (Site 112) — Burlington, Washington, United States
  • Spokane Eye Clinical Research (Site 075) — Spokane, Washington, United States
  • Retina Consultants, PLLC — Charleston, West Virginia, United States
  • Eye Clinic of Wisconsin — Wausau, Wisconsin, United States
  • Grupo Laser Vision (Rosario Eximer Laser Vision SA) — Rosario, Santa Fe Province, Argentina
  • Oftalmología Global (Centro Médico Oftalmología Global) (Site 304) — Rosario, Santa Fe Province, Argentina
  • Microcirugia Ocular Rosario (Site 310) — Rosario, Santa Fe Province, Argentina
  • Centro de Ojos Quilmes — Buenos Aires, Argentina
  • Clinica Privada de Ojos — Buenos Aires, Argentina
  • Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302) — Buenos Aires, Argentina
  • RSresearch (Site 308) — Buenos Aires, Argentina
  • Instituto Oftalmologico de Buenos Aires SA (Site 306) — Buenos Aires, Argentina
  • Centro Oftalmologico Dr Charles y Asociados (Site 300) — Buenos Aires, Argentina
  • Centro de Ojos Loria SRL (Site 312) — Buenos Aires, Argentina
  • Centro Oftalmológico Dr. Zas — Buenos Aires, Argentina
  • Hospital Britanico- Microcentro — Cdad. Autónoma de Buenos Aires, Argentina
  • Instituto Donato — Cdad. Autónoma de Buenos Aires, Argentina
  • Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305) — Córdoba, Argentina
  • Centro Privado de Ojos Romagosa SA (Site 307) — Córdoba, Argentina
  • Centrovision Clinica Oftalmologica — Mendoza, Argentina
  • Oftar Centro De Oftalmología en Mendoza — Mendoza, Argentina
  • Centro de la Visión (Site 309) — Salta, Argentina
  • Centro de la Visión — Salta, Argentina
  • Instituto Zeman Bardeci (Site 311) — Salta, Argentina
  • Eye Clinic Albury Wodonga (Site 425) — Albury, Australia
  • Retina and Eye Consultants — Hurstville, Australia
  • Retina and Macula Specialists — Hurstville, Sydney, Australia
  • Launceston Eye Doctors — Launceston, Australia
  • Nexus Eyecare — Norwest, Australia
  • Marsden Eye Specialists (Site 420) — Parramatta, Australia
  • Marsden Eye Specialists (Site 423) — Strathfield, Australia
  • Sydney Eye Hospital (Site 426) — Sydney, Australia
  • Sydney Retina Clinic and Day Surgery (Site 424) — Sydney, Australia
  • Silmaarst Krista Turman OÜ — Tallinn, Estonia
  • East Tallinn Central Hospital — Tallinn, Estonia
  • Silmalaser OÜ — Tallinn, Estonia
  • Tartu University Hospital — Tartu, Estonia
  • Universitätsklinikum Hamburg Eppendorf Klinik und Poliklinik für Augenheilkunde — Hamburg, Germany
  • Augenzentrum am St. Franziskus Hospital Münster — Münster, Germany
  • Barzilai Medical Center — Ashkelon, Israel
  • Rambam Health Corporation (Site 706) — Haifa, Israel
  • Carmel Medical Center (Site 704) — Haifa, Israel
  • Hadassah Medical Center Opthalmology Department (Site 701) — Jerusalem, Israel
  • Rabin Medical Center (Site 700) — Petah Tikva, Israel
  • Sheba Medical Center (Site 707) — Ramat Gan, Israel
  • Kaplan Medical Center Ophthalmology Department (Site 705) — Rehovot, Israel
  • Shamir Medical Center (Site 703) — Ẕerifin, Israel
  • P.Stradins clinical university hospital — Riga, Latvia
  • Riga East University hospital, clinical centre Bikernieki — Riga, Latvia
  • Northern Kurzeme Regional Hospital — Ventspils, Latvia
  • Oculomedica Eye Hospital — Bydgoszcz, Poland
  • Oftalmika Sp. z o.o. — Bydgoszcz, Poland
  • Profesorskie Centrum Medyczne Sp. z o.o. — Gdansk, Poland
  • Gabinet Okulistyczny Edward Wylęgała — Katowice, Poland
  • Dietla Medical Center 19 Sp zoo — Krakow, Poland
  • Klinika okulistyczna w Olsztynie - Centrum Diagnostyki i Mikrochirurgii Oka Lens — Olsztyn, Poland
  • Caminomed Sp. zo.o — Tarnowskie Góry, Poland
  • Centro Oftalmologico Metropolitano — San Juan, Puerto Rico
  • Clinica de Oftalmologia Barraquer — Barcelona, Spain
  • Hospital Universitari Vall d'Hebron - despacho de coordinación de oftalmología. Planta 8, Edifici General — Barcelona, Spain
  • Hospital Universitario Puerta de Hierro - Majadahonda — Madrid, Spain
  • University Hospital Basel, Eye Clinic — Basel, Switzerland
  • Swiss Eye Institute and Berner Augenklinik — Bern, Switzerland
  • Vista Augenklinik Binningen — Binnigen, Switzerland
  • Fondation Asile des aveugles (Hôpital Ophtalmique Jules-Gonin) — Lausanne, Switzerland
  • Stadtspital Zurich Triemli Forschungszentrum Augenklinik — Zurich, Switzerland
  • University Hospitals of Leicester NHS Trust (Site 209) — Leicester, United Kingdom
  • South West Retina — Liverpool, United Kingdom
  • London North West University Healthcare NHS Trust (LNWH) (Site 201) — London, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record