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RECRUITING Not applicable ClinicalTrials.gov

Mind After Midnight

Sponsor: University of Arizona • ClinicalTrials.gov ID: NCT07438912

Registry updated: 2026-10-01
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Description

This study examines whether wakefulness during the biological night (2:00-4:00 AM) is associated with increased negative mood, impaired decision-making, and suicidal thoughts. Adults with a history of suicidal ideation in the past six months will complete laboratory and home-based assessments under varying levels of sleep pressure. Participants will be evaluated during late-night wakefulness and under conditions of both higher and lower sleep pressure. The goal of the study is to better understand the biological and behavioral mechanisms that may contribute to elevated suicide risk during nocturnal wakefulness.

Interventions

  • Sleep Pressure Manipulation (Behavioral)
    Participants undergo an experimental manipulation of homeostatic sleep pressure involving controlled wakefulness or scheduled awakening during the biological night. Mood, suicidal ideation, impulsivity, and decision-making are assessed during overnight laboratory sessions.

Eligibility criteria

Inclusion Criteria * Age 18-55 years * History of suicidal ideation within the past 6 months * Habitual bedtime between 9:00 PM and 1:00 AM * Habitual wake time between 6:00 AM and 9:00 AM * Ability to provide informed consent Exclusion Criteria: * Current suicidal intent requiring immediate clinical intervention * Diagnosis of a primary sleep disorder (e.g., untreated obstructive sleep apnea, narcolepsy) * Bipolar disorder or psychotic disorder * Substance use disorder within the past 3 months * Use of medications that significantly affect sleep or circadian rhythms * Night shift work or transmeridian travel within the past month * Medical or neurological condition that would interfere with participation * Pregnancy

Conditions

Suicidal Ideation Circadian Rhythm Disorders Sleep Deprivation Sleep Wake Disorders

Locations

  • University of Arizona - Center for Sleep, Circadian, and Neuroscience Research — Tucson, Arizona, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record