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RECRUITING Early Phase 1 ClinicalTrials.gov

Orthobiological Therapies in Musculoskeletal Disorders

Sponsor: PROREGEN • ClinicalTrials.gov ID: NCT07434115

Registry updated: 2026-09-17
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Description

To evaluate the clinical and functional effects of using orthobiological therapies (hyaluronic acid, platelet-rich plasma, bone marrow aspirate, nanofat, among others) in the treatment of various musculoskeletal diseases in patients routinely treated at the Proregen Medical Clinic and its affiliates. The sample will consist of adult patients (≥18 years), of both sexes, with different musculoskeletal diagnoses involving joints, tendons, ligaments, cartilage or bone, among others.

Interventions

  • PRP injection (Biological)
    Obtained by centrifuging blood, it concentrates platelets and growth factors for regeneration.
  • Bone Marrow Concentrate (BMAC) (Biological)
    Bone marrow aspirate, rich in mesenchymal stem cells and progenitor cells for tissue repair.
  • Hyaluronic Acid (Viscosupplementation) (Biological)
    Used for joint lubrication and cartilage protection, very common in osteoarthritis.
  • Nanofat (Biological)
    It is an even more refined and liquefied form of processed fat, used primarily for high-precision tissue repair.

Eligibility criteria

Inclusion Criteria: * Age 18 or older; * Clinical and/or radiological diagnosis of an eligible musculoskeletal condition; * Formal clinical indication for treatment with orthobiological agents, according to routine care; * Regular access to the WhatsApp application, ensuring the necessary communication for sending and receiving digital questionnaires and other study instructions; * Ability to understand the study and sign the Informed Consent Form. Exclusion Criteria: * Medical contraindication to the use of orthobiologics (e.g., active infection, severe hematological diseases, active cancer); * Recent use (≤3 months) of orthobiologic therapies in the same area to be treated; * Pregnant or breastfeeding women; * Cognitive or psychiatric diseases that prevent adequate clinical follow-up; * Simultaneous participation in another interventional clinical study with the same therapeutic purpose.

Conditions

Musculoskeletal Diseases or Conditions

Locations

  • Clínica Proregen | Clínica Ortopédica em Bento | Dr. André Kruel — Bento Gonçalves, Rio Grande do Sul, Brazil
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record