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Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair

Sponsor: Swissmed Hospital • ClinicalTrials.gov ID: NCT07422441

Registry updated: 2026-10-07

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Description

People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed. During closure, pressure inside the abdomen may increase and lung mechanics can worsen. This study will evaluate a structured intraoperative decision approach that uses standard anesthesia measurements of static respiratory system compliance at predefined timepoints to support the choice of abdominal wall closure technique. The main goal is to assess the rate of early postoperative respiratory failure within 72 hours after surgery.

Interventions

Compliance-Guided Abdominal Wall Closure Decision Strategy (Other)
A predefined intraoperative decision strategy that uses standardized measurements of static respiratory system compliance (Cstat) during abdominal wall closure to support selection of closure technique, with a predefined physiological tolerance threshold based on the baseline measurement.

Eligibility criteria

Inclusion Criteria: * Age 18 years or older * Elective repair of a large ventral abdominal wall hernia (including incisional hernia) * Preoperative botulinum toxin A preparation performed as part of the local prehabilitation pathway * Preoperative abdominal CT available * General anesthesia with mechanical ventilation and feasibility of standardized intraoperative respiratory mechanics measurements Exclusion Criteria: * Severe preoperative respiratory failure judged to preclude standardized intraoperative respiratory mechanics assessment * Inability to obtain reliable static respiratory system compliance measurements at predefined timepoints * Hemodynamic instability preventing protocolized measurements (as judged by the anesthesiologist)

Conditions

Hernia, Ventral Hernia Incisional Postoperative Complications Respiratory Insufficiency

Locations

LUX MED Hospital, Gdańsk — Gdansk, Poland

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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