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RECRUITING Phase 2 / Phase 3 ClinicalTrials.gov

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease

Sponsor: Pfizer • ClinicalTrials.gov ID: NCT07363694

Registry updated: 2026-10-22
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Description

The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.

Interventions

  • PF-07275315 dose 1 (Drug)
    SC injection dose 1
  • PF-07275315-dose 2 (Drug)
    SC injection dose 2
  • Placebo (Drug)
    SC injection matched
  • PF-07275315-dose 3 (Drug)
    SC injection dose 3

Eligibility criteria

Key Inclusion Criteria: * Diagnosis of chronic obstructive pulmonary disease (COPD) for at least 12 months (based on Global Initiative for Chronic Obstructive Lung Disease \[GOLD\] definition). * Spirometry values (post-bronchodilator forced expiratory volume in 1 second \[FEV1\]/forced vital capacity \[FVC\] less than \[\<\] 70 percent (%) and post-bronchodilator FEV1 % predicted \<70%, but greater than equal to 30%). * Continuous treatment with standard of care triple therapy of LABA + LAMA + ICS for ≥ 6 months prior to Screening Visit 1 and at a stable dose for ≥3 months * Documented history of at least 2 moderate or severe ECOPD within the last 12 months prior to Screening. Key Exclusion Criteria: * Significant pulmonary disease other than COPD. * Requirement for continuous chronic treatment with oxygen at \>4.0 liters / minute by nasal cannula or equivalent. * Hypoxemia with a resting SpO2 \<88% while breathing ambient air (or on the participant's usual level of oxygen supplementation). * Clinically significant cardiovascular disease, acute and/or severe left heart failure, or heart failure partial ejection fraction, and/or cor pulmonale.

Conditions

Moderate to Severe Chronic Obstructive Pulmonary Disease

Locations

  • University of Alabama at Birmingham Lung Health Center — Birmingham, Alabama, United States
  • SEC Clinical Research — Dothan, Alabama, United States
  • Pulmonary Associates of Mobile, P.C. — Mobile, Alabama, United States
  • Pulmonary Associates, PA — Phoenix, Arizona, United States
  • IMAX Clinical Trials — La Palma, California, United States
  • NewportNativeMD, Inc. — Newport Beach, California, United States
  • California Medical Research Associates — Northridge, California, United States
  • Institute of HealthCare Assessment d/b/a Apex Clinical Research — San Diego, California, United States
  • Finlay Medical Research — Greenacres City, Florida, United States
  • Clinical Research Specialists LLC — Kissimmee, Florida, United States
  • Advanced Pulmonary Research Institute — Loxahatchee Groves, Florida, United States
  • Reed Medical Research — Miami, Florida, United States
  • Renstar Medical Research — Ocala, Florida, United States
  • HCA Florida Ocala Imaging Center — Ocala, Florida, United States
  • Ocala Lung and Critical Care Associates — Ocala, Florida, United States
  • Renstar Medical Research — Ocala, Florida, United States
  • Coastal Medical Research Institute, LLC — St. Petersburg, Florida, United States
  • Coastal Pulmonary and Critical Care, P.L.C — St. Petersburg, Florida, United States
  • Clinical Research Trials of Florida, Inc. — Tampa, Florida, United States
  • Clinical Site Partners, LLC dba Flourish Research — Winter Park, Florida, United States
  • Cpcc-Research Llc — East Point, Georgia, United States
  • Centricity Research Rincon Pulmonology — Rincon, Georgia, United States
  • ASHA Clinical Research - Munster, LLC — Hammond, Indiana, United States
  • Methodist Hospital Southlake — Merrillville, Indiana, United States
  • University of Kansas Medical Center — Kansas City, Kansas, United States
  • Southern Clinical Research, LLC — Zachary, Louisiana, United States
  • Paul A. Shapero, MD, PA — Bangor, Maine, United States
  • Exordia Medical Research Inc. — Fall River, Massachusetts, United States
  • Infinity Medical Research — North Dartmouth, Massachusetts, United States
  • Revival Research Institute, LLC — Dearborn, Michigan, United States
  • AA Medical Research Center — Flint, Michigan, United States
  • Revive Research Institute, Inc. — Southfield, Michigan, United States
  • Oakland Medical Research — Troy, Michigan, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Barnes-Jewish Hospital Investigational Drug Service — St Louis, Missouri, United States
  • Barnes-Jewish Hospital — St Louis, Missouri, United States
  • Washington University School of Medicine — St Louis, Missouri, United States
  • Washington University School-Cardiovascular Imaging and Clinical Research Core Laboratory — St Louis, Missouri, United States
  • Henderson Clinical Trials — Henderson, Nevada, United States
  • Northwell Health Physician Partners at Chappaqua — Chappaqua, New York, United States
  • New York Presbyterian Queens — Flushing, New York, United States
  • Northern Westchester Hospital — Mount Kisco, New York, United States
  • Salem Chest Specialists — Winston-Salem, North Carolina, United States
  • Southeastern Research Center — Winston-Salem, North Carolina, United States
  • Toledo Institute of Clinical Research Inc. — Toledo, Ohio, United States
  • Layrek Clinical Research — Tulsa, Oklahoma, United States
  • Clinical Research Associates of Central PA, LLC — DuBois, Pennsylvania, United States
  • Temple University Hospital — Philadelphia, Pennsylvania, United States
  • Temple Health Oaks — Phoenixville, Pennsylvania, United States
  • Bogan Sleep Consultants, LLC — Columbia, South Carolina, United States
  • Velocity Clinical Research, Gaffney — Gaffney, South Carolina, United States
  • Clinical Research of Rock Hill — Rock Hill, South Carolina, United States
  • Velocity Clinical Research, Spartanburg — Spartanburg, South Carolina, United States
  • Health Concepts — Rapid City, South Dakota, United States
  • Clinical Trials Center of Middle Tennessee, LLC — Franklin, Tennessee, United States
  • Premier Research Center, LLC — Hendersonville, Tennessee, United States
  • South Texas Medical Research Institute, Inc., DBA TTS Research — Boerne, Texas, United States
  • Ten20 Clinical Research — Carrollton, Texas, United States
  • Horizon Clinical Research Group — Cypress, Texas, United States
  • Alina Clinical Trials, LLC. — Dallas, Texas, United States
  • Baylor Scott & White Advanced Lung Disease Specialists — Dallas, Texas, United States
  • Baylor University Medical Center (Research Office) — Dallas, Texas, United States
  • Baylor University Medical Center — Dallas, Texas, United States
  • Greater Heights & Memorial Pulmonary and Sleep — Houston, Texas, United States
  • Houston Pulmonary Sleep and Allergy Associates — Houston, Texas, United States
  • Sherman Clinical Research — Sherman, Texas, United States
  • IDIM - Instituto de Investigaciones Metabólicas — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
  • Centro Médico Dra. De Salvo - Fundación Respirar — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
  • Centro de Investigaciones Médicas Mar del Plata — Mar del Plata, Buenos Aires, Argentina
  • Instituto Médico DAMIC — Córdoba, Córdoba Province, Argentina
  • Instituto de Salud Respiratoria - (INSARES) — Mendoza, Mendoza Province, Argentina
  • Fundación Grupo Colaborativo Rosario Investigación y Prevención Médica — Rosario, Santa Fe Province, Argentina
  • Westmead Hospital — Westmead, New South Wales, Australia
  • Mater Misericordiae Limited — South Brisbane, Queensland, Australia
  • Monash Health — Clayton, Victoria, Australia
  • TrialsWest - Spearwood — Spearwood, Western Australia, Australia
  • Medical Center Pulmo - 2018 EOOD — Haskovo, Haskovo, Bulgaria
  • Specialized Hospital for Active Treatment of Lung Diseases - Sv. Panteleymon EOOD — Pernik, Pernik, Bulgaria
  • SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD — Rousse, Ruse, Bulgaria
  • MHAT Knyaginya Klementina - Sofia EAD — Sofia, Sofia, Bulgaria
  • Medical Center Hera EOOD — Sofia, Sofia (stolitsa), Bulgaria
  • Medical Center New Rehabilitation Center EOOD — Stara Zagora, Stara Zagora, Bulgaria
  • Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases Dr. Treiman — Veliko Tarnovo, Veliko Tarnovo, Bulgaria
  • MHAT "Sveta Ekaterina" Dimitrovgrad — Dimitrovgrad, Bulgaria
  • Medical Center Fama Medical — Plovdiv, Bulgaria
  • Fifth MHAT EAD — Sofia, Bulgaria
  • Synergy Respiratory Care — Sherwood Park, Alberta, Canada
  • Dr. Syed Anees Medicine Professional Corporation — Windsor, Ontario, Canada
  • Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval (IUCPQ-UL) — Québec, Quebec, Canada
  • C.I.C. Mauricie inc. — Trois-Rivières, Quebec, Canada
  • The People's Hospital of Chizhou — Chizhou, Anhui, China
  • Fuyang People's Hospital — Fuyang, Anhui, China
  • Anhui Chest Hospital — Hefei, Anhui, China
  • China-Japan Friendship Hospital — Beijing, Beijing Municipality, China
  • Chongqing Red Cross Hospital (Jiangbei District People's Hospital) — Chongqing, Chongqing Municipality, China
  • The Third Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
  • Huizhou Central People's Hospital — Huizhou, Guangdong, China
  • The First People's Hospital of Xinxiang — Xinxiang, Henan, China
  • The Central Hospital of Wuhan — Wuhan, Hubei, China
  • The First Hospital of Changsha — Changsha, Hunan, China
  • The Second Xiangya Hospital of Central South University — Changsha, Hunan, China
  • Inner Mongolia People's Hospital — Hohhot, Inner Mongolia, China
  • The Affiliated Hospital of Inner Mongolia Medical University — Hohhot, Inner Mongolia, China
  • Zhongda Hospital Southeast University — Nanjing, Jiangsu, China
  • The Affiliated Hospital of Xuzhou Medical College — Xuzhou, Jiangsu, China
  • Yangzhou University-Affiliated Hospital — Yangzhou, Jiangsu, China
  • Jiangxi Provincial People's Hospital — Nanchang, Jiangxi, China
  • Jinan Central Hospital — Jinan, Shandong, China
  • Ruijin Hospital Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China
  • Shanghai Tongji Hospital — Shanghai, Shanghai Municipality, China
  • Chengdu Fifth People's Hospital — Chengdu, Sichuan, China
  • Taizhou Hospital of Zhejiang Province — Linhai, Zhejiang, China
  • MUDr.I. Cierna Peterova s.r.o. — Brandýs nad Labem-Stará Boleslav, Czechia
  • MEDITRIAL s.r.o. — Jindřichův Hradec, Czechia
  • Oblastni nemocnice Mlada Boleslav, a.s., nemocnice Stredoceskeho kraje — Mladá Boleslav, Czechia
  • Ordinace chorob plicnich s.r.o. — Prague, Czechia
  • MEDICON a.s. — Prague, Czechia
  • Pneumologie Varnsdorf s.r.o. — Varnsdorf, Ústí nad Labem Region, Czechia
  • Hôpital Arnaud de Villeneuve - CHU Montpellier — Montpellier, HÉRAULT, France
  • Hopitaux Universitaires Paris Centre-Hopital Cochin — Paris, PARIS, France
  • Centre Hospitalier Annecy Genevois — Epagny Metz-Tessy, France
  • Hôpital de la Croix Rousse — Lyon, France
  • Medizentrum Essen Borbeck — Essen, North Rhine-Westphalia, Germany
  • KPPK Studienzentrum GmbH — Bendorf, Rhineland-Palatinate, Germany
  • Clinical Studies Pankow — Berlin, Germany
  • Klifeck GmbH — Delitzsch, Germany
  • IKF Pneumologie GmbH & Co KG; Institut für klinische Forschung — Frankfurt, Germany
  • Pneumologisch Onkologisch Internistisches Studienzentrum (POIS) Sachsen GmbH — Leipzig, Germany
  • Koch Róbert Kórház és Rendelőintézet — Edelény, Borsod-Abauj Zemplen county, Hungary
  • Omnimodus Elixír Kft. — Mosonmagyaróvár, Győr-Moson-Sopron, Hungary
  • Szalay János Rendelőintézet — Hajdúnánás, Hajdú-Bihar, Hungary
  • Erzsebet Gondozohaz — Gödöllő, Pest County, Hungary
  • Da Vinci Magánklinika — Pécs, Hungary
  • KLES Dr. Prabhakar Kore Hospital and Medical Research Centre — Belagavi, Karnataka, India
  • Bhaktivedanta Hospital and Research Institute — Thane, Maharashtra, India
  • All India Institute of Medical Sciences — New Delhi, National Capital Territory of Delhi, India
  • Sir Ganga Ram Hospital — New Delhi, National Capital Territory of Delhi, India
  • Maharaja Agrasen Superspeciality Hospital — Jaipur, Rajasthan, India
  • Hindusthan Hospital — Coimbatore, Tamil Nadu, India
  • Kamineni Hospitals Private Limited — Hyderabad, Telangana, India
  • Shri Guru Ram Rai Institute of Medical & Health Sciences & Shri Mahant lndiresh Hospital — Dehradun, Uttarakhand, India
  • Nil Ratan Sircar Medical College and Hospital — Kolkata, West Bengal, India
  • Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII — Bergamo, BERGAMO, Italy
  • Azienda Arcispedale Santa Maria Nuova _Usl Di Reggio Emilia/Irccs — Reggio Emilia, Emilia-Romagna, Italy
  • Azienda Ospedaliero Universitaria di Ferrara -Arcispedale Sant' Anna — Cona, FERRARA, Italy
  • San Paolo Hospital, ASST Santi Paolo e Carlo — Milan, Milan, Italy
  • Azienda Ospedaliero-Universitaria Policlinico Umberto I — Roma, ROME, Italy
  • Koujunkai Daido Clinic — Nagoya, Aichi-ken, Japan
  • Nishifukuoka Hospital — Fukuoka, Fukuoka, Japan
  • Aso Iizuka Hospital — Iizuka-shi, Fukuoka, Japan
  • Hiroshima Prefectural Hospital — Hiroshima, Hiroshima, Japan
  • Kure Kyosai Hospital — Kure, Hiroshima, Japan
  • National Hospital Organization Okinawa Hospital — Ginowan, Okinawa, Japan
  • NHO Kinki Chuo Chest Medical Center — Sakai, Osaka, Japan
  • Fujieda Municipal General Hospital — Fujieda, Shizuoka, Japan
  • Tokyo Medical University Hachioji Medical Center — Hachiōji, Tokyo, Japan
  • Yamaguchi University Hospital — Ube, Yamaguchi, Japan
  • Centrum Medyczne Pratia Katowice — Katowice, Poland
  • Pro Familia Altera Sp. z o.o. — Katowice, Poland
  • Diamond Clinic Sp. z o.o. — Krakow, Poland
  • Centermed Sp. z o.o. — Tarnów, Poland
  • ETG Warszawa — Warsaw, Poland
  • DOBROSTAN - Gabinety Lekarskie — Wroclaw, Poland
  • Ostrowieckie Centrum Medyczne spółka cywilna Anna Olech-Cudzik, Krzysztof Cudzik — Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, Poland
  • Jeonbuk National University Hospital — Jeonju, Jeonbuk-do, South Korea
  • Korea University Anam Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
  • The Catholic University of Korea, Eunpyeong St. Mary's Hospital — Seoul, South Korea
  • Konkuk University Medical Center — Seoul, South Korea
  • The Catholic Univ. of Korea Seoul St. Mary's Hospital — Seoul, South Korea
  • Hospital Universitario Virgen de las Nieves (HUVN) - Hospital Materno Infantil — Granada, Andalusia, Spain
  • Hospital Universitario Miguel Servet — Zaragoza, Aragon, Spain
  • Hospital de Merida — Mérida, BADAJOZ, Spain
  • Hospital Universitario Virgen de la Victoria — Málaga, MÁLAGA, Spain
  • Hospital Universitario Miguel Servet — Zaragoza, Spain
  • Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Kaohsiung, Taiwan
  • Taichung Veterans General Hospital — Taichung, TAICHUNG, Taiwan
  • Chang Gung Medical Foundation-Linkou Branch — Taoyuan, TAOYUAN, Taiwan
  • National Taiwan University Hospital - Hsinchu branch — Hsinchu, Taiwan
  • Far Eastern Memorial Hospital — New Taipei City, Taiwan
  • China Medical University Hospital — Taichung, Taiwan
  • National Taiwan University Hospital — Taipei, Taiwan
  • Bradford Royal Infirmary — Bradford, BRADFORD, United Kingdom
  • Glasgow Royal Infirmary — Glasgow, CITY of Glasgow, United Kingdom
  • The Glenfield Hospital — Leicester, LEICESTERSHIRE, United Kingdom
  • Guy's & St Thomas' NHS Foundation Trust — London, London, CITY of, United Kingdom
  • Wythenshawe Hospital — Manchester, MANCHESTER, United Kingdom
  • Ashford and St Peter's Hospital NHS Foundation Trust — Chertsey, United Kingdom
  • Queen Anne Street Medical Centre — London, United Kingdom
  • North Tyneside General Hospital — North Shields, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record