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RECRUITING Phase 3 ClinicalTrials.gov

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Sponsor: Eli Lilly and Company • ClinicalTrials.gov ID: NCT07353931

Registry updated: 2026-10-08
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Description

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Interventions

  • Eloralintide (Drug)
    Administered SC
  • Placebo (Drug)
    Placebo administered SC

Eligibility criteria

Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening * Have a stable body weight (less than 5% body weight change) for 90 days prior to screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have an active knee infection * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Conditions

Osteoarthritis Overweight or Obesity

Locations

  • AMR Clinical — Mobile, Alabama, United States
  • Care Access - 801 South Power Road, Mesa — Mesa, Arizona, United States
  • Elite Pain and Spine Institute - South Crimson Road — Mesa, Arizona, United States
  • Elite Clinical Studies, LLC — Phoenix, Arizona, United States
  • Tucson Orthopaedic Institute - North Wyatt Drive — Tucson, Arizona, United States
  • Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States
  • Wolverine Clinical Trials — Santa Ana, California, United States
  • Encompass Clinical Research — Spring Valley, California, United States
  • Diablo Clinical Research, Inc. — Walnut Creek, California, United States
  • Skylight Health Research - Colorado Springs — Colorado Springs, Colorado, United States
  • Westside Center for Clinical Research — Jacksonville, Florida, United States
  • Care Access - St. Petersburg — St. Petersburg, Florida, United States
  • Conquest Research — Winter Park, Florida, United States
  • Orita Clinical Research — Decatur, Georgia, United States
  • North Georgia Clinical Research — Woodstock, Georgia, United States
  • Medical Research Partners — Ammon, Idaho, United States
  • Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States
  • Qualmedica Research, LLC — Evansville, Indiana, United States
  • AMR Clinical — Newton, Kansas, United States
  • Monroe Biomedical Research - Louisville — Louisville, Kentucky, United States
  • Skylight Health Research - Burlington — Burlington, Massachusetts, United States
  • Care Access - Quincy — Quincy, Massachusetts, United States
  • Ellipsis Research Group - Brooklyn - 7th Street — Brooklyn, New York, United States
  • Rochester Clinical Research - Buffalo — Buffalo, New York, United States
  • NYC Research INC — Long Island City, New York, United States
  • Rochester Clinical Research, LLC — Rochester, New York, United States
  • Central States Research — Tulsa, Oklahoma, United States
  • Keystone Clinical Studies — Plymouth Meeting, Pennsylvania, United States
  • JCCT - Juno Bellaire Site — Bellaire, Texas, United States
  • Epic Medical Research - DeSoto — DeSoto, Texas, United States
  • Valley Institute of Research - Fort Worth — Fort Worth, Texas, United States
  • Care Access - Houston — Houston, Texas, United States
  • VIP Trials — San Antonio, Texas, United States
  • Endeavor Clinical Trials — San Antonio, Texas, United States
  • Consano Clinical Research, LLC — Shavano Park, Texas, United States
  • Texas Valley Clinical Research — Weslaco, Texas, United States
  • AMR Clinical — South Jordan, Utah, United States
  • Charlottesville Medical Research — Charlottesville, Virginia, United States
  • Paramount Clinical Research - Data Point Clinical Research — Kirkland, Washington, United States
  • Centro Privado de Medicina Familiar / Mindout Research — Buenos Aires, Argentina
  • CARDIAMET Investigaciones Médicas — Buenos Aires, Argentina
  • Organizacion Medica de Investigacion — Buenos Aires, Argentina
  • Stat Research S.A. — Buenos Aires, Argentina
  • Centro Médico Arsema — Buenos Aires, Argentina
  • Centro de Investigaciones Clínicas Baigorria — Granadero Baigorria, Argentina
  • INECO Neurociencias Oroño — Rosario, Argentina
  • Instituto Especialidades de la Salud Rosario — Rosario, Argentina
  • Medicina Reumatológica — San Fernando, Argentina
  • Instituto de Alta Complejidad San Isidro — San Isidro, Argentina
  • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan — San Juan, Argentina
  • Centro de Investigaciones Médicas Tucuman — SAN M. de Tucuman, Argentina
  • Centro de Investigaciones Reumatológicas — San Miguel de Tucumán, Argentina
  • Go Centro Medico San Nicolás — San Nicolás, Argentina
  • Antwerp University Hospital — Edegem, Belgium
  • Reuma Clinic, Locatie Jaarbeurslaan — Genk, Belgium
  • UZ Gent — Ghent, Belgium
  • Kormont — Kluisbergen, Belgium
  • UZ Leuven — Leuven, Belgium
  • Meclinas — Mechelen, Belgium
  • ZNA Jan Palfijn — Merksem, Belgium
  • Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location — Sint-Martens-Latem, Belgium
  • Centro de Pesquisa Sao Lucas — Campinas, Brazil
  • IBPClin - Instituto Brasil de Pesquisa Clínica — Rio de Janeiro, Brazil
  • CPHosp Medicina, Ensino e Pesquisa (CPQuali) — São Paulo, Brazil
  • INTEGRA - Pesquisa Clínica e Infusões — São Paulo, Brazil
  • CEPIC - Centro Paulista de Investigação Clínica — São Paulo, Brazil
  • Hospital das Clinicas FMUSP — São Paulo, Brazil
  • Apex Trials — Guelph, Canada
  • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc. — Québec, Canada
  • Diex Recherche Inc. Division Quebec — Québec, Canada
  • Stouffville Medical Research Institute Inc. — Stouffville, Canada
  • Maple Leaf Research — Toronto, Canada
  • Dr. Anil K. Gupta Medicine Professional Corporation — Toronto, Canada
  • Diex Recherche Inc. Division Victoriaville — Victoriaville, Canada
  • Beijing Ji Shui Tan Hospital — Beijing, China
  • The First Afflilated Hospital of Bengbu Medical College — Bengbu, China
  • Jilin Province People's Hospital — Changchun, China
  • The Second Hospital of Jilin University — Changchun, China
  • Xiangya Hospital Central South University — Changsha, China
  • 2nd Affiliated Hospital Chongqing Medical Universi — Chongqing, China
  • The Second Affiliated hospital of Zhejiang University school of medicine — Hangzhou, China
  • The Second People's Hospital of Hefei — Hefei, China
  • Jinan Central Hospital — Jinan, China
  • The First Affiliated Hospital of Henan University of Science &Technology — Luoyang, China
  • Nanjing First Hospital — Nanjing, China
  • Zhongda Hospital Southeast University — Nanjing, China
  • The Second Affiliated Hospital of Nanjing Medical University — Nanjing, China
  • Jiangsu Province Hospital — Nanjing, China
  • The first affiliated hospital of Ningbo university — Ningbo, China
  • Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, China
  • Zhongshan Hospital,Fudan University — Shanghai, China
  • Huashan Hospital, Fudan University — Shanghai, China
  • The Second Affiliated Hospital of Soochow University — Suzhou, China
  • Tianjin Hospital — Tianjin, China
  • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University — Wenzhou, China
  • Tongji Hospital Tongji Medical,Science & Technology — Wuhan, China
  • Xianyang Hospital of Yan'an University — Xianyang, China
  • Pratia Brno — Brno, Czechia
  • Revmatologie.s.r.o. — Brno, Czechia
  • INREA s.r.o. — Ostrava, Czechia
  • Pratia Pardubice a.s. — Pardubice, Czechia
  • Medical Plus Research — Uherské Hradiště, Czechia
  • Sanos Clinic - Nordjylland — Gandrup, Denmark
  • Sanos Clinic — Herlev, Denmark
  • Sanos Clinic - Syddanmark — Vejle, Denmark
  • Siteworks GmbH - Bochum — Bochum, Germany
  • Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann — Bünde, Germany
  • StudyPoint Duisburg — Duisburg, Germany
  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T — Hamburg, Germany
  • Siteworks GmbH - Zentrum für klinische Studien Karlsruhe — Karlsruhe, Germany
  • AmBeNet GmbH — Leipzig, Germany
  • CDG Studienambulanz Hartard — München, Germany
  • FutureMeds Offenbach — Offenbach, Germany
  • National Hospital Organization Chiba Medical Center — Chiba, Japan
  • Tokyo-Eki Center-building Clinic — Chūōku, Japan
  • Tokyo Asbo Clinic — Chūōku, Japan
  • Shin Komonji Hospital — Kitakyushu-Shi, Japan
  • Goto Orthopedic Surgery Clinic — Miyazaki, Japan
  • Komagidai Clinic — Nagareyama, Japan
  • Fujigaki Clinic — Ōita, Japan
  • Saitama City Hospital — Saitama, Japan
  • Ibaraki Seinan Medical Center Hospital — Sashima, Japan
  • Ogura Orthopedics Surgery — Sendai, Japan
  • Katsura Garden Orthopedics — Sendai, Japan
  • Ooimachi Orthopedic Surgery and surgery Clinic — Shinagawa-ku Tokyo, Japan
  • Masumoto Orthopedics Clinic — Suginami City, Japan
  • National Hospital Organization Toyohashi Medical Center — Toyohashi, Japan
  • Yamagata Tokushukai Hospital — Yamagata, Japan
  • Dorado Medical Complex — Dorado, Puerto Rico
  • GCM Medical Group, PSC - Hato Rey Site — San Juan, Puerto Rico
  • Keimyung University Dongsan Hospital — Daegu, South Korea
  • Boramae Medical Center — Dongjak-gu, South Korea
  • Seoul National University Hospital — Seoul, South Korea
  • Severance Hospital, Yonsei University Health System — Seoul, South Korea
  • Asan Medical Center — Seoul, South Korea
  • The Catholic Univ. of Korea Seoul St. Mary's Hospital — Seoul, South Korea
  • Hallym University Kangnam Sacred Heart Hospital — Seoul, South Korea
  • The Catholic University of Korea, Uijeongbu St. Mary's Hospital — Uijeongbu-si, South Korea
  • Changhua Christian Hospital — Changhua County, Taiwan
  • Chang Gung Memorial Hospital at Kaohsiung — Kaohsiung Niao Sung Dist, Taiwan
  • China Medical University Hospital — Taichung, Taiwan
  • National Cheng Kung University Hospital — Tainan, Taiwan
  • National Taiwan University Hospital — Taipei, Taiwan
  • Taipei Medical University Hospital — Taipei, Taiwan
  • Tri-Service General Hospital — Taipei, Taiwan
  • Velocity Clinical Research, Bristol — Bristol, United Kingdom
  • FutureMeds Glasgow - CPS Research — Glasgow, United Kingdom
  • FutureMeds - London — London, United Kingdom
  • Futuremeds-Newcastle — Newcastle, United Kingdom
  • Atlantic Medical — Penzance, United Kingdom
  • Woodstock Bower Surgery — Rotherham, United Kingdom
  • Panthera Biopartners - Sheffield — Sheffield, United Kingdom
  • Panthera Clinic - York — York, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record