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RECRUITING Not applicable ClinicalTrials.gov

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

Sponsor: Children's Hospital Medical Center, Cincinnati • ClinicalTrials.gov ID: NCT07325175

Registry updated: 2026-10-20
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Description

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are: How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)? Participants will: * Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task. * Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.

Interventions

  • DBS (Device)
    Subjects with DBS will complete protocol with and without active stimulation

Eligibility criteria

Inclusion Criteria: * For dystonia subjects: * Dx of dystonia (with and without DBS) * willingness and ability to complete study protocols. * For Typically Developing Controls: * normal developmental milestones * absence of any neuropsychiatric disorder * no significant medical condition. Exclusion Criteria: * history of epilepsy * presence of implanted medical devices (except DBS in dystonia subjects) * lack of cognitive or physical ability to complete study protocol.

Conditions

Dystonia Pediatric Deep Brain Stimulation Motor Development

Locations

  • Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record