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RECRUITING Phase 3 ClinicalTrials.gov

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Sponsor: Eli Lilly and Company • ClinicalTrials.gov ID: NCT07321886

Registry updated: 2026-09-22
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Description

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Interventions

  • Eloralintide (Drug)
    Administered SC
  • Placebo (Drug)
    Administered SC

Eligibility criteria

Inclusion Criteria: * Have Body Mass Index (BMI) at screening of the following: * 30 kilogram per square meter (kg/m2) OR * 27 kg/m2 with at least one of the following weight-related health conditions at screening: * high blood pressure * dyslipidemia * obstructive sleep apnea, or * heart disease * Have a stable body weight (\<5% body weight change) for 90 days prior to screening. * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes or type 2 diabetes * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Conditions

Obesity Overweight

Locations

  • MFA Clinical Research — Tuscaloosa, Alabama, United States
  • Headlands Research - Scottsdale — Scottsdale, Arizona, United States
  • Neighborhood Healthcare Institute of Health — Escondido, California, United States
  • Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States
  • Desert Oasis Healthcare Medical Group — Palm Springs, California, United States
  • Peninsula Research Associates — Rolling Hills Estates, California, United States
  • Care Access - Sacramento — Sacramento, California, United States
  • Southern California Clinical Research — Santa Ana, California, United States
  • University Clinical Investigators, Inc. — Tustin, California, United States
  • Chase Medical Research, LLC — Waterbury, Connecticut, United States
  • JEM Research Institute — Atlantis, Florida, United States
  • BioMed Research & Medical Center — Miami, Florida, United States
  • Adult Medicine of Lake County, Inc. — Mt. Dora, Florida, United States
  • American Research Centers of Florida — Pembroke Pines, Florida, United States
  • AHF Pensacola — Pensacola, Florida, United States
  • IMA Clinical Research St. Petersburg — St. Petersburg, Florida, United States
  • Teak Research Consults - Dunwoody — Dunwoody, Georgia, United States
  • Teak Research Consults — Lawrenceville, Georgia, United States
  • Clinical Research Atlanta — Stockbridge, Georgia, United States
  • East-West Medical Research Institute — Honolulu, Hawaii, United States
  • Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
  • Cotton O'Neil Clinical Research Center — Topeka, Kansas, United States
  • Care Access - Lake Charles (Bayou Pines) — Lake Charles, Louisiana, United States
  • MedStar Good Samaritan Hospital — Baltimore, Maryland, United States
  • MedStar Health Research Institute (MedStar Physician Based Research Network) — Hyattsville, Maryland, United States
  • Care Access - Quincy — Quincy, Massachusetts, United States
  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
  • AMR Clinical — Las Vegas, Nevada, United States
  • IMA Clinical Research Warren — Warren Township, New Jersey, United States
  • Albuquerque Clinical Trials, Inc. — Albuquerque, New Mexico, United States
  • Rochester Clinical Research, LLC — Rochester, New York, United States
  • Monroe Biomedical Research — Monroe, North Carolina, United States
  • Preferred Primary Care Physicians — Uniontown, Pennsylvania, United States
  • Tribe Clinical Research, LLC — Greenville, South Carolina, United States
  • Accellacare - Mt Pleasant — Mt. Pleasant, South Carolina, United States
  • AMR Clinical — Nashville, Tennessee, United States
  • The University of Texas Health Science Center at Houston — Bellaire, Texas, United States
  • Velocity Clinical Research, Dallas — Dallas, Texas, United States
  • UT Southwestern Medical Center — Dallas, Texas, United States
  • IMA Clinical Research San Antonio — San Antonio, Texas, United States
  • AMR Clinical — Norfolk, Virginia, United States
  • CONEXA Investigacion Clinica S.A. — Buenos Aires, Argentina
  • Cicemo Srl — Buenos Aires, Argentina
  • Cardiología Palermo — Buenos Aires, Argentina
  • Glenny Corp. S.A. — Buenos Aires, Argentina
  • CARDIAMET Investigaciones Médicas — Buenos Aires, Argentina
  • Centro Médico Viamonte — Buenos Aires, Argentina
  • Fundación Respirar — Buenos Aires, Argentina
  • Instituto de Investigaciones Clínicas Córdoba — Córdoba, Argentina
  • INECO Neurociencias Oroño — Rosario, Argentina
  • Centro Modelo de Cardiología — San Miguel de Tucumán, Argentina
  • Emeritus Research — Botany, Australia
  • Core Research Group — Brisbane, Australia
  • Emeritus Research — Camberwell, Australia
  • Life Clinical Research — Ipswich, Australia
  • Paratus Clinical Research Central Coast — Kanwal, Australia
  • University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook — Meadowbrook, Australia
  • Momentum Sunshine — Melbourne, Australia
  • Paratus Clinical Research - Melbourne — Melbourne, Australia
  • AIM Research — Merewether, Australia
  • Fusion Clinical Research — Norwood, Australia
  • USC Clinical Trials Sunshine Coast — Sippy Downs, Australia
  • ANIMA Research — Diepenbeek, Belgium
  • Jessa Ziekenhuis — Hasselt, Belgium
  • Kormont — Kluisbergen, Belgium
  • Gezondheidshuis De Gloed — Machelen, Belgium
  • Chronos Pesquisa Clínica — Brasília, Brazil
  • Instituto de Pesquisa clinica de Campinas — Campinas, Brazil
  • Private Practice - Dr.Miguel N. Hissa — Fortaleza, Brazil
  • Centro de Pesquisa Clínica de Marília - CPCLIM — Marília, Brazil
  • Núcleo de Pesquisa Clínica do Rio Grande do Sul — Porto Alegre, Brazil
  • IBPClin - Instituto Brasil de Pesquisa Clínica — Rio de Janeiro, Brazil
  • Ruschel Medicina e Pesquisa Clínica — Rio de Janeiro, Brazil
  • CEPIC - Centro Paulista de Investigação Clínica — São Paulo, Brazil
  • Aggarwal and Associates Limited — Brampton, Canada
  • Med Trust Research — Courtice, Canada
  • Dawson Clinical Research Inc. — Guelph, Canada
  • The Wharton Medical Clinic Clinical Trials Inc — Hamilton, Canada
  • Alpha Recherche Clinique — Québec, Canada
  • ALPHA Recherche Clinique — Québec, Canada
  • Bluewater Clinical Research Group Inc. — Sarnia, Canada
  • Winterberry Research Inc. — Stoney Creek, Canada
  • Diex Recherche Inc. Division Trois-Rivieres — Trois-Rivières, Canada
  • Luhe Hospital — Beijing, China
  • Beijing Pinggu District Hospital — Beijing, China
  • Sichuan Provincial People's Hospital — Chengdu, China
  • West China Hospital Sichuan University — Chengdu, China
  • Zhujiang Hospital — Guangzhou, China
  • The Second People's Hospital of Hefei — Hefei, China
  • Jinan Central Hospital — Jinan, China
  • The First Affiliated Hospital of Henan University of Science &Technology — Luoyang Shi, China
  • Jiangxi Provincial People's Hospital — Nanchang, China
  • Nanjing First Hospital — Nanjing, China
  • Jiangsu Province Official Hospital — Nanjing, China
  • Zhongda Hospital Southeast University — Nanjing, China
  • The Second Affiliated Hospital of Nanjing Medical University — Nanjing, China
  • Shanghai Sixth People's Hospital — Shanghai, China
  • Zentrum fur klinische Forschung - Köln — Cologne, Germany
  • Universitaetsklinikum Carl Gustav Carus Dresden — Dresden, Germany
  • StudyPoint Duisburg — Duisburg, Germany
  • InnoDiab Forschung Gmbh — Essen, Germany
  • Medizentrum Essen Borbeck — Essen, Germany
  • Diabetes Zentrum Wilhelmsburg — Hamburg, Germany
  • AmBeNet GmbH — Leipzig, Germany
  • Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz — Lingen, Germany
  • BAG Drs. Med. Quist PartG — Mainz, Germany
  • CRS Clinical Research Services Mannheim — Mannheim, Germany
  • RED-Institut GmbH — Oldenburg, Germany
  • Praxis Sauter & Sauter & Vorbach — Wangen, Germany
  • Endolife Speciality Hospitals — Guntur, India
  • Gauhati Medical College and Hospital — Guwahati, India
  • Care Hospitals Hyderabad- Banjara Hills — Hyderabad, India
  • Mandya Institute Of Medical Sciences — Mandya, India
  • Topiwala National Medical College & B. Y. L. Nair Charitable Hospital — Mumbai, India
  • Mysore Medical College — Mysore, India
  • All India Institute of Medical Sciences (AIIMS) - Nagpur — Nagpur, India
  • Supe Heart & Diabetes Hospital and Research Centre — Nashik, India
  • Lifepoint Multispeciality Hospital — Pune, India
  • Prabhu Diabetes Multi-Speciality Centre — Trichy, India
  • Adachi Kyosai Hospital — Adachi-ku, Japan
  • Nihonbashi Sakura Clinic — Chūōku, Japan
  • Medical Corporation Chiseikai Tokyo Center Clinic — Chūōku, Japan
  • Tokyo-Eki Center-building Clinic — Chūōku, Japan
  • Boocs Clinic Fukuoka — Fukuoka, Japan
  • Patient First Clinic Ginza-Shimbashi — Minato, Japan
  • Kanno Naika — Mitaka, Japan
  • Medical Corporation Heishinkai OCROM Clinic — Suita-shi, Japan
  • Higashi Shinjuku Clinic — Tokyo, Japan
  • Zdrowie Osteo-Medic — Bialystok, Poland
  • Legeartis - Poradnie Specjalistyczne — Bialystok, Poland
  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET — Krakow, Poland
  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna — Lodz, Poland
  • Gabinety TERPA — Lublin, Poland
  • Ekamed — Lublin, Poland
  • Centrum Zdrowia Metabolicznego Pawel Bogdanski — Poznan, Poland
  • Pracownia Badań Klinicznych Salus — Wroclaw, Poland
  • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM — Zabrze, Poland
  • Puerto Rico Health and Wellness Institute — Dorado, Puerto Rico
  • Wellness clinical Research Vega Baja — Vega Baja, Puerto Rico
  • Gachon University Gil Medical Center — Namdong-gu, South Korea
  • Konyang University Hospital — Seogu, South Korea
  • Seoul National University Bundang Hospital — Seongnam, South Korea
  • Seoul National University Hospital — Seoul, South Korea
  • Pusan National University Yangsan Hospital — Yangsan, South Korea
  • Chiayi Christian Hospital — Chiayi City, Taiwan
  • Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
  • Chang Gung Memorial Hospital at Kaohsiung — Kaohsiung Niao Sung Dist, Taiwan
  • National Taiwan University Hospital — Taipei, Taiwan
  • Taipei Veterans General Hospital — Taipei, Taiwan
  • Layton Medical Centre — Blackpool, United Kingdom
  • Bradford on Avon Health Centre — Bradford on Avon, United Kingdom
  • Ashton Medical Group - Chapel House — Lancashire, United Kingdom
  • Royal Lancaster Infirmary — Lancaster, United Kingdom
  • Altnagelvin Area Hospital — Londonderry, United Kingdom
  • Bodyline Clinic - Openshaw — Manchester, United Kingdom
  • Wansford Research Limited — Peterborough, United Kingdom
  • Abbeywell Surgery — Romsey, United Kingdom
  • Rame Group Practice — Torpoint, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record