RECRUITING Not applicable ClinicalTrials.gov

Efficacy of CAD in Screening Colonoscopy to Reduce the Risk of Advanced Adenoma at 3 Years.

Sponsor: University Hospital, Bordeaux • ClinicalTrials.gov ID: NCT07299071

Registry updated: 2026-09-24

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Description

The occurrence of interval cancers after colonoscopy raises the possibility of missed lesions. High- performance computer aided diagnosis (CAD) systems have been specially designed for the detection of colorectal lesions (CAD for detection is named CADe). The use of CADe improves adenoma detection in screening colonoscopy. The potential of CADe system in reducing the rate of progression to advanced polyps or interval cancer between two colonoscopies remains still uncertain.

Interventions

Standard colonoscopy (Procedure)
Colonoscopy standard (without CADe)
Colonoscopy CADe (Procedure)
colonoscopy with CADe

Eligibility criteria

Inclusion Criteria: * Patients over 18 years of age with indication for colonoscopy as part of a screening program, after a positive immunological (FIT) test, and/or for personal or family history of colorectal cancer and/or personal history of colonic adenomas and/or sessile serrated polyp, * Written informed consent signed * Patients covered by a health-care insurance. Exclusion Criteria: * Failed complete colonoscopy, defined by the absence of cecal intubation or identification of the terminal ileum. * Inadequate bowel preparation (Boston bowel preparation score \< 6, and/or least at one part of colon with score ≤ 1) * An infiltrative tumor was diagnosed during colonoscope insertion time, not accessible to endoscopic resection and likely to require surgical management (a procedure where part of the colon may need to be removed). * Patient under guardianship or protection * Pregnant women * Not fluent in French or illiterate * Personal history of inflammatory bowel disease * Personal history of genetic predisposition of CRC * Personal history of major colorectal surgery involving total or subtotal colectomy

Conditions

Colonoscopy Colorectal Neoplasms Intestinal Polyps

Locations

CH de la Côte Basque — Bayonne, France
CHU Brest la Cavale Blanche — Brest, France
Hôpital de Carhaix — Carhaix-Plouguer, France
Clinique Paris Bercy — Charenton-le-Pont, France
CHU de Limoges — Limoges, France
Institut Paoli Calmettes — Marseille, France
Clinique Jules Verne — Nantes, France
CHU Nîmes — Nîmes, France
APHP - Hôpital Saint Antoine — Paris, France
Aphp-Hegp — Paris, France
APHP - Hôpital Tenon — Paris, France
CHU Bordeaux - Hôpital Haut Lévêque — Pessac, France
CHU de Rennes — Rennes, France
Clinique Pasteur — Toulouse, France
CHRU de Nancy - Hôpital Brabois Adultes — Vandœuvre-lès-Nancy, France

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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