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RECRUITING Not applicable ClinicalTrials.gov

Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA)

Sponsor: Changi General Hospital • ClinicalTrials.gov ID: NCT07297745

Registry updated: 2026-10-02
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Description

The goal of this project is to improve the diagnostic pathway for patients with primary aldosteronism, by validating non-invasive biomarkers coupled with routine computed tomography imaging. The aim is to reduce reliance on invasive procedures, shorten diagnostic timelines, and enhance accessibility to definitive diagnosis and treatment globally.

Interventions

  • Hybrid hormones (Diagnostic test)
    Participants will have a baseline blood sample taken so the investigators can measure the adrenal steroid biomarkers 18-oxocortisol, 18-hydroxylcortisol and other steroids. The collected plasma or serum will then be analyzed in the laboratory using validated methods, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), to determine the levels of these biomarkers.

Eligibility criteria

Inclusion Criteria: * Confirmed diagnosis of primary aldosteronism according to the Endocrine Society guideline 2025. * Willing to undergo subtype testing with adrenal vein sampling and/or molecular imaging (Positron Emission Tomography/Computed Tomography, PET/CT). * Keen for surgical treatment if shown to have unilateral primary aldosteronism. Exclusion Criteria: * Inability to provide written informed consent.

Conditions

Hyperaldosteronism; Primary Primary Aldosteronism Due to Aldosterone Producing Adenoma

Locations

  • Changi General Hospital — Singapore, Singapore, Singapore
  • National University Hospital — Singapore, Singapore
  • Sengkang General Hospital — Singapore, Singapore
  • Singapore General Hospital — Singapore, Singapore
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record