N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Phase 3 ClinicalTrials.gov

PREcision MEDicine In Achalasia (PREMEDIA)

Sponsor: Northwestern University • ClinicalTrials.gov ID: NCT07293650

Registry updated: 2026-10-13
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.

Interventions

  • Standard Myotomy (Procedure)
    Myotomy during POEM of 8-10 cm in length, extending 2-3 cm into the gastric cardia; intention to perform selective circular myotomy, but allowing full thickness myotomy. FLIP is used to confirm adequate myotomy.
  • Tailored Short Myotomy (Procedure)
    Myotomy during POEM of 4-5 cm in length, extending 1-2 cm into the gastric cardia; intend to perform selective circular myotomy, but allowing full thickness myotomy. FLIP is used to confirm adequate myotomy.

Eligibility criteria

Inclusion Criteria 1. Age ≥ 18 2. Type I achalasia or type II achalasia or cEGJOO 3. Eckardt score \> 3 Exclusion Criteria The following exclusion criteria are for the RCT, but 1-13 below also pertain to the observational study: 1. Prior POEM 2. Prior surgical treatment for achalasia 3. Endoscopic pneumatic dilation or lower esophageal sphincter botulinum toxin (botox) injection within 6 months 4. Prior unrelated esophageal or upper gastric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy 5. Prior endoscopic gastroesophageal intervention for obesity or GERD, such endoscopic sleeve gastroplasty or transoral incisionless fundoplication 6. Known secondary achalasia related to malignancy (pseudoachalasia) 7. Known eosinophilic esophagitis 8. Diverticulum (\> 2 cm) in distal esophagus 9. Megaesophagus 10. Fibroinflammatory stricture of the esophagus due to any etiology (e.g., peptic, radiation, eosinophilic) 11. Pregnancy 12. Standard contraindications to general anesthesia 13. Standard contraindications to endoscopic myotomy in the esophagus (e.g. untreated varices) 14. Unwillingness or inability to consent for the study 15. Anticipated inability to follow protocol 16. Weekly (or more frequent) opioid medication use in the last 2 years

Conditions

Type I Achalasia Type II Achalasia EGJ Outflow Obstruction Without Spastic/Hypercontractile Features

Locations

  • Mayo Clinic Arizona — Scottsdale, Arizona, United States
  • University of California San Diego — La Jolla, California, United States
  • University of Colorado Denver — Denver, Colorado, United States
  • University of Florida — Gainesville, Florida, United States
  • Adventist Health System/Sunbelt, Inc — Orlando, Florida, United States
  • Emory University — Atlanta, Georgia, United States
  • Northwestern University — Chicago, Illinois, United States
  • Johns Hopkins University — Baltimore, Maryland, United States
  • Massachusetts General Hospital — Boston, Massachusetts, United States
  • Washington University — St Louis, Missouri, United States
  • Weill Cornell Medical College — New York, New York, United States
  • Atrium Health/Wake Forest — Charlotte, North Carolina, United States
  • Case Western Reserve University — Cleveland, Ohio, United States
  • MetroHealth Medical Center — Cleveland, Ohio, United States
  • Vanderbilt University Medical Center — Nashville, Tennessee, United States
  • Baylor Scott & White Health — Dallas, Texas, United States
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record