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RECRUITING Not applicable ClinicalTrials.gov

Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

Sponsor: University of Minnesota • ClinicalTrials.gov ID: NCT07246993

Registry updated: 2026-09-01
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Description

This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mild traumatic brain injury (mTBI).

Interventions

  • Active tDCS (Device)
    All participants will receive 10 sessions of cognitive training focused on executive functions, delivered over approximately 3 weeks. Cognitive training will be completed on a lab provided computer using PositScience BrainHQ or TaskFlow software. Concurrently, during each training session, participants will receive either active or sham tDCS. Stimulation will be delivered via saline-soaked sponge electrodes using the Soterix 1x1 miniCT TES device. The anode (active electrode) will be placed over the L-DLPFC (approximated by EEG coordinate F3) and the cathode (reference electrode) over the contralateral supraorbital area (Fp2). The active tDCS group will receive 2mA constant current for 20 minutes.
  • Sham tDCS (Device)
    All participants will receive 10 sessions of cognitive training focused on executive functions, delivered over approximately 3 weeks. Cognitive training will be completed on a lab provided computer using PositScience BrainHQ or TaskFlow software. Concurrently, during each training session, participants will receive either active or sham tDCS. Stimulation will be delivered via saline-soaked sponge electrodes using the Soterix 1x1 miniCT TES device. The anode (active electrode) will be placed over the L-DLPFC (approximated by EEG coordinate F3) and the cathode (reference electrode) over the contralateral supraorbital area (Fp2). The sham tDCS group will receive a brief ramp up and ramp down of current at the beginning and end of the 20 minutes to mimic the sensation of active stimulation.

Eligibility criteria

Inclusion Criteria: * Age 18-65 * Has sustained a single mTBI 3-12 months prior to enrollment * Meets criteria for PPCS (assessed using the CP Screen) * Has reliable access to a smartphone Exclusion Criteria: * Inability to provide informed consent or complete study procedures * History of moderate/severe TBI * Significant neurological or psychiatric disorders (other than PPCS-related symptoms like mild depression/anxiety) * Substance dependence within the last six months * Contraindications to tDCS (e.g., implanted metal, skin lesions on scalp)

Conditions

Persistent Post Concussion Syndrome Mild Traumatic Brain Injury

Locations

  • University of Minnesota — Minneapolis, Minnesota, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record