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RECRUITING Not applicable ClinicalTrials.gov

A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke

Sponsor: Vanderbilt University Medical Center • ClinicalTrials.gov ID: NCT07231380

Registry updated: 2026-10-06
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Description

This prospective, randomized controlled trial will compare two manual aspiration techniques for treating acute ischemic stroke due to large vessel occlusion: cyclic aspiration (Plunger technique) and static aspiration. Both techniques use FDA-approved devices (Raptor Aspiration Catheters and VacLok syringes) and are standard of care. Approximately 500 participants across 20 sites will be randomized to one of the two techniques. The primary endpoint is First Pass Effect (TICI 2c/3 after first attempt), with secondary endpoints including overall recanalization and 90-day functional outcomes. Results will address a critical gap in optimizing aspiration thrombectomy techniques.

Interventions

  • Plunger Technique (Procedure)
    Rhythmic, cyclic application of suction using FDA-approved devices (Raptor Aspiration Catheter and VacLok Syringe) for clot removal in acute ischemic stroke.
  • Static Manual Aspiration Thrombectomy (Procedure)
    Continuous suction without modulation using FDA-approved devices (Raptor Aspiration Catheter and VacLok Syringe) for clot removal in acute ischemic stroke.

Eligibility criteria

Inclusion Criteria: \- Acute ischemic stroke due to occlusion of the terminal ICA or M1 segment of the MCA, Treatment can be initiated within 24 hours of symptom onset, Age 18 years or older Exclusion Criteria: * Evidence of acute intracranial hemorrhage prior to treatment, Failure to obtain informed consent

Conditions

Acute Ischemic Stroke Patients Large Vessel Occlusion

Locations

  • Vanderbilt University Medical Center — Nashville, Tennessee, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record