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Exercise Intensity and Postprandial Effects of Breaking Sedentary Behavior in Overweight Adults

Sponsor: Hacettepe University • ClinicalTrials.gov ID: NCT07229963

Registry updated: 2026-09-24

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Description

The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk markers for cardiometabolic diseases; and (2) to assess substrate oxidation during this period in order to identify which exercise condition promotes the greatest increase in fat oxidation.

Interventions

Aerobic Exercise Intervention (Other)
In the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity (%50 Wattmax) continuous cycling.
Sprint Exercise Intervention (Other)
In the sprint condition, participants will complete a 10-second sprint at %200 Wattmax level, as determined during the preliminary test.
Sedentary Behaviour Intervention (Other)
Participants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes.

Eligibility criteria

Inclusion Criteria * Being physically inactive (not doing at least 150 minutes/week of structured exercise). * Being sedentary (having a daily sedentary time/day for \>7 hours). * Having a BMI between 25 and 29.9 kg/m2. * Having a history of regular menstrual cycles for female participants. * Having medical examination approval. Exclusion Criteria * Taking any acute or chronic medication or supplement that may affect metabolism. * Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.). * Consuming tobacco products. * Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).

Conditions

Cardiovascular Risk Markers Postprandial Metabolism Exercise Physiology Substrate Oxidation

Locations

Hacettepe Sports Science Faculty, Hacettepe Beytepe Clinic — Ankara, Beytepe, Turkey (Türkiye)

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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