N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Phase 2 / Phase 3 ClinicalTrials.gov

Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer

Sponsor: Pfizer • ClinicalTrials.gov ID: NCT07226999

Registry updated: 2026-10-08
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has spread widely in the body. To join the study, participants must meet the following conditions: * Be 18 years or older. * Have extensive-stage small cell lung cancer confirmed by lab tests. * Have not received chemotherapy or radiation for this type of lung cancer. * Be in good physical condition and have healthy organs based on medical tests. The study has two parts: * In the first part, researchers will check how safe the study medicine is and how well people tolerate it when given with chemotherapy. * In the second part, they will compare study medicine plus chemotherapy to another approved treatment (atezolizumab plus chemotherapy) to see which works better. Participants will receive the treatment through IV infusions (medicine given directly into a vein). The treatment will be given in repeated time periods called cycles. Some participants will continue receiving the study medicine alone after the initial treatment.

Interventions

  • PF-08634404 (Drug)
    Concentrate for solution for infusion
  • Atezolizumab (Biological)
    Injection for intravenous use
  • Chemotherapy (Drug)
    Injection for intravenous use

Eligibility criteria

Inclusion Criteria: * Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC). * Participants have not received systemic therapy (chemotherapy, radiotherapy, chemoradiation) for ES-SCLC. * Treatment-free for at least 6 months since last chemo/radiotherapy, among those treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC * Have at least one measurable lesion as the targeted lesion based on RECIST V1.1. * Eastern Cooperative Oncology Group performance status of 0 or 1. * Adequate organ function Exclusion Criteria: * known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression * Leptomeningeal disease * Clinically significant risk of hemorrhage or fistula * history of another malignancy within 3 years * active autoimmune diseases requiring systemic treatment within the past 2 years

Conditions

Small Cell Lung Cancer (SCLC)

Locations

  • Highlands Oncology Group — Fayetteville, Arkansas, United States
  • Highlands Oncology Group — Rogers, Arkansas, United States
  • Highlands Oncology Group — Springdale, Arkansas, United States
  • BRCR Coral Springs — Coral Springs, Florida, United States
  • Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
  • BRCR Global - Tamarac — Tamarac, Florida, United States
  • University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
  • Texas Oncology - Northeast Texas — Allen, Texas, United States
  • Texas Oncology - DFW — Arlington, Texas, United States
  • Texas Oncology - DFW — Arlington, Texas, United States
  • Texas Oncology - Gulf Coast — Beaumont, Texas, United States
  • Texas Oncology - DFW — Bedford, Texas, United States
  • Texas Oncology - DFW — Dallas, Texas, United States
  • Texas Oncology - DFW — Dallas, Texas, United States
  • Texas Oncology - DFW — Dallas, Texas, United States
  • Texas Oncology - DFW — Dallas, Texas, United States
  • Texas Oncology - DFW — Dallas, Texas, United States
  • Texas Oncology - Northeast Texas — Denison, Texas, United States
  • Texas Oncology - Northeast Texas — Denton, Texas, United States
  • Texas Oncology - Northeast Texas — Flower Mound, Texas, United States
  • Texas Oncology - DFW — Fort Worth, Texas, United States
  • Texas Oncology - San Antonio — Fredericksburg, Texas, United States
  • Texas Oncology - DFW — Grapevine, Texas, United States
  • Texas Oncology - Gulf Coast — Houston, Texas, United States
  • Texas Oncology - Gulf Coast — Houston, Texas, United States
  • US Oncology Investigational Product Center (IPC) — Irving, Texas, United States
  • US Oncology Investigational Products Center (IPC) — Irving, Texas, United States
  • Texas Oncology - Northeast Texas — Lewisville, Texas, United States
  • Texas Oncology - Northeast Texas — Longview, Texas, United States
  • Texas Oncology - Northeast Texas — McKinney, Texas, United States
  • Texas Oncology - San Antonio — New Braunfels, Texas, United States
  • Texas Oncology - Northeast Texas — Palestine, Texas, United States
  • Texas Oncology - Northeast Texas — Paris, Texas, United States
  • Texas Oncology - Gulf Coast — Pearland, Texas, United States
  • Texas Oncology - DFW — Plano, Texas, United States
  • Texas Oncology - DFW — Plano, Texas, United States
  • Texas Oncology - San Antonio — San Antonio, Texas, United States
  • Texas Oncology - San Antonio — San Antonio, Texas, United States
  • Texas Oncology - San Antonio — San Antonio, Texas, United States
  • Texas Oncology - Gulf Coast — Sugar Land, Texas, United States
  • Texas Oncology - Gulf Coast — The Woodlands, Texas, United States
  • Texas Oncology - Northeast Texas — Tyler, Texas, United States
  • Texas Oncology - Gulf Coast — Webster, Texas, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care — Blacksburg, Virginia, United States
  • Virginia Oncology Associates — Chesapeake, Virginia, United States
  • Virginia Oncology Associates — Hampton, Virginia, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care — Low Moor, Virginia, United States
  • Virginia Oncology Associates — Newport News, Virginia, United States
  • Virginia Oncology Associates — Norfolk, Virginia, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care — Roanoke, Virginia, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care — Salem, Virginia, United States
  • Virginia Oncology Associates — Virginia Beach, Virginia, United States
  • Virginia Oncology Associates — Williamsburg, Virginia, United States
  • Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care — Wytheville, Virginia, United States
  • Westmead Hospital — Westmead, New South Wales, Australia
  • Sunshine Coast University Hospital — Birtinya, Queensland, Australia
  • Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
  • Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
  • Gustave Roussy — Villejuif, France
  • Hôpital Ambroise Paré — Boulogne-Billancourt, Île-de-France Region, France
  • Marien Hospital Düsseldorf — Düsseldorf, Germany
  • Krankenhaus Nordwest GmbH — Frankfurt am Main, Germany
  • Centro di Riferimento Oncologico (CRO) IRCCS — Aviano, Pordenone, Italy
  • IRCCS Istituto Nazionale dei Tumori Regina Elena — Roma, ROME, Italy
  • Azienda Ospedaliero-Universitaria San Luigi Gonzaga — Orbassano, Turin, Italy
  • Kansai Medical University Hospital — Hirakata, Osaka, Japan
  • Shizuoka Cancer Center — Nagaizumi-cho, Shizuoka, Japan
  • Japanese Foundation for Cancer Research — Kotoku, Tokyo, Japan
  • Doctor's Center Hematology & Oncology Group — Manati, Puerto Rico
  • Pan American Center for Oncology Trials, LLC - Mayaguez Office Mayaguez Medical Center — Mayagüez, Puerto Rico
  • Pan American Center for Oncology Trials LLC — San Juan, Puerto Rico
  • Hospital Oncologico Dr. Isaac Gonzalez-Martinez — San Juan, Puerto Rico
  • HT Médica Jaen LAs Nieves — Jaén, Andalusia, Spain
  • Hospital Jerez de la Frontera — Jerez de la Frontera, Cádiz, Spain
  • Hospital Universitario 12 de Octubre — Madrid, Madrid, Comunidad de, Spain
  • Parc de Salut Mar - Hospital del Mar — Barcelona, Spain
  • CETIR — Barcelona, Spain
  • Hospital Universitari Vall d'Hebron — Barcelona, Spain
  • Hospital Universitario de Jaen — Jaén, Spain
  • National Cheng Kung University Hospital — Tainan, Taiwan
  • National Taiwan University Hospital — Taipei, Taiwan
  • Taipei Medical University Hospital — Taipei, Taiwan
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record