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RECRUITING Not applicable ClinicalTrials.gov

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

Sponsor: University of California, San Francisco • ClinicalTrials.gov ID: NCT07220525

Registry updated: 2026-10-02
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Description

Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.

Interventions

  • HGNS Use Randomized Instructions (Device)
    In this intervention assignment, participants will be instructed to turn off/not use their HGNS device during that night of sleep. HGNS 'on': In this intervention assignment, participants will be instructed to turn on/use their HGNS device during that night of sleep.

Eligibility criteria

Inclusion Criteria: * Are age 21 years or older * Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health * Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period * Able and willing to provide written informed consent Exclusion Criteria: * Currently pregnant or trying to get pregnant * Are currently taking class 1 or 3 anti-arrhythmic medications * Have a history of permanent AF or expected to have continuous AF throughout the study period * Have congenital heart disease * Ventricular pacing \>40% * Are unable to read or sign to provide informed consent

Conditions

Obstructive Sleep Apnea Premature Ventricular Contraction (PVC) Atrial Fibrillation (AF) Premature Atrial Contraction

Locations

  • UCSF Medical Center at Parnassus — San Francisco, California, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record