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RECRUITING Not applicable ClinicalTrials.gov

K08 VR Fear Conditioning

Sponsor: University of California, Los Angeles • ClinicalTrials.gov ID: NCT07216222

Registry updated: 2026-10-13
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Description

The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implanted with a Responsive Neurostimulator (RNS) device for the treatment of epilepsy. This research may help improve our understanding of anxiety disorders and how to better treat them in the future. The main questions it aims to answer are: 1) How do people learn to associate certain cues in VR with feelings of fear or safety? 2) What brain and body responses happen during fear learning? Participants will: 1) Wear a virtual reality headset and experience different environments and sounds, 2) Have their brain activity, heart rate, and sweating measured, and 3) Receive safe, mild electrical pulses through the RNS device during the study to help study fear learning. Participants will attend one or more study sessions, each lasting about 3-4 hours.

Interventions

  • Deep Brain Stimulation (Device)
    Deep brain stimulation via the Responsive Neurostimulator (RNS) device.

Eligibility criteria

Inclusion Criteria: * Male * Female * Between 18 and 70 years of age * Adequate visual and auditory acuity to allow neuropsychological testing * Have undergone surgical placement of NeuroPace RNS System for the treatment of epilepsy or post-traumatic stress disorder Exclusion Criteria: \- History of traumatic brain injury

Conditions

Anxiety and Fear PTSD Veteran

Locations

  • UCLA Semel Institute for Neuroscience and Human Behavior — Los Angeles, California, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record