N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Phase 3 ClinicalTrials.gov

REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

Sponsor: Regeneron Pharmaceuticals • ClinicalTrials.gov ID: NCT07213778

Registry updated: 2026-10-08
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Interventions

  • REGN7508 (Drug)
    Administered per the protocol
  • Acetylsalicylic Acid (ASA) (Drug)
    Administered per the protocol
  • Placebo (Drug)
    Administered per the protocol

Eligibility criteria

Key Inclusion Criteria: 1. Is undergoing a primary elective unilateral TKA 2. Is in good health based on laboratory safety testing as described in the protocol Key Exclusion Criteria: 1. Any condition that, as assessed by the investigator, may confound the results of the study or pose an additional risk to the participant by study participation 2. History of bleeding in the 6 months prior to randomization requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis (eg, hemophilia A or B, von Willebrand's Factor deficiency) 3. History of thromboembolic disease or thrombophilia 4. History of platelet dysfunction 5. Has received or plans to receive preoperative enoxaparin on the day prior to TKA surgery Note: Other protocol-defined Inclusion/ Exclusion criteria apply

Conditions

Symptomatic Venous Thromboembolism (VTE)

Locations

  • Horizon Clinical Research — La Mesa, California, United States
  • Eisenhower Medical Center — Rancho Mirage, California, United States
  • CARI Clinical Trials — Riverside, California, United States
  • Sky Ridge Medical Center — Lone Tree, Colorado, United States
  • South Florida Joint Replacement Center — Deerfield Beach, Florida, United States
  • Delray Physician Care Center — Delray Beach, Florida, United States
  • Medical Research of Westchester - MPLUS Research Network — Miami, Florida, United States
  • Larkin Community Hospital South Miami — South Miami, Florida, United States
  • Phoenix Clinical Research — Tamarac, Florida, United States
  • Endeavor Health — Skokie, Illinois, United States
  • The Orthopaedic Research Foundation, Inc. — Indianapolis, Indiana, United States
  • NextStage Clinical Research, St. Francis Medical Park — Wichita, Kansas, United States
  • Velocity Clinical Research, Annapolis — Annapolis, Maryland, United States
  • Sinai Hospital of Baltimore, Inc. — Baltimore, Maryland, United States
  • Tufts Medical Center — Boston, Massachusetts, United States
  • Boston Medical Center — Boston, Massachusetts, United States
  • Holy Name Medical Center — Teaneck, New Jersey, United States
  • Northwell Orthopaedic Institute — New York, New York, United States
  • University of Rochester Medical Center — Rochester, New York, United States
  • UBMD Orthopaedics and Sports Medicine — Williamsville, New York, United States
  • Atrium Health Musculoskeletal Institute and Sports Medicine — Charlotte, North Carolina, United States
  • Duke University Health System (Duke Health), Duke University Hospital — Durham, North Carolina, United States
  • Eximia Equihealth Research-Raleigh. LLC — Raleigh, North Carolina, United States
  • The Vein and Vascular Center at Raleigh Radiology — Raleigh, North Carolina, United States
  • Coastal Vascular Institute, PA — Wilmington, North Carolina, United States
  • University of Cincinnati — Cincinnati, Ohio, United States
  • The Ohio State University Wexner Medical Center — Columbus, Ohio, United States
  • Ohio Clinical Trials — Columbus, Ohio, United States
  • Penn State Health Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States
  • University of Pittsburgh — Pittsburgh, Pennsylvania, United States
  • HD Research - Memorial Hermann Village — Houston, Texas, United States
  • NextStage Clinical Research, All American Orthopedics and Sports Medicine — Houston, Texas, United States
  • Flourish Research - San Antonio (Formerly Clinical Trials of Texas) — San Antonio, Texas, United States
  • Endeavor Clinical Trials — San Antonio, Texas, United States
  • Carilion Clinic — Roanoke, Virginia, United States
  • Spokane Joint Replacement Center — Spokane, Washington, United States
  • Henry Dunant Hospital Center — Athens, Attica, Greece
  • National and Kapodistrian University of Athens, General Hospital of Nea Ionia Konstantopouleio Patision — Nea Ionia, Attica, Greece
  • Sultan Abdul Halim Hospital — Sungai Petani, Kedah, Malaysia
  • Hospital Pakar Universiti Sains Malaysia — Kota Bharu, Kelantan, Malaysia
  • Hospital Tengku Ampuan Afzan (HTTA) — Kuantan, Pahang, Malaysia
  • Hospital Queen Elizabeth II — Kota Kinabalu, Sabah, Malaysia
  • PMSI Emergency Medicine Institute — Chisinau, Moldova
  • Hospital Miks Ospitalea — Vitoria-Gasteiz, Araba/Alava, Spain
  • Hospital Universitario Costa del Sol — Marbella, Malaga, Spain
  • Clinica Universidad de Navarra — Pamplona, Navarre, Spain
  • Hospital Clinic Barcelona — Barcelona, Spain
  • Hospital Universitario Infanta Leonor — Madrid, Spain
  • Hospital Clinico Universitario de Valencia — Valencia, Spain
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record