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RECRUITING Phase 4 ClinicalTrials.gov

Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease

Sponsor: The University of Texas Medical Branch, Galveston • ClinicalTrials.gov ID: NCT07203287

Registry updated: 2026-10-20
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Description

The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease. The main question it aims to answer is "The use of Cisatracurium with neostigmine leads to less post-operative pulmonary complications than Rocuronium with sugammadex."

Interventions

  • Rocuronium (Drug)
    Will be assessing neuromuscular blockade with rocuronium and reversal with sugammadex
  • Cisatracurium (Drug)
    Will be assessing neuromuscular blockade with neostigmine and reversal with neostigmine
  • Sugammadex (Drug)
    Will be assessing neuromuscular blockade with rocuronium and reversal with sugammadex
  • Neostigmine (Drug)
    Will be assessing neuromuscular blockade with neostigmine and reversal with neostigmine

Eligibility criteria

Inclusion Criteria: * The subject is able and willing to provide and sign informed consent * The subject must be between 18 and 80 years of age * The subject should have chronic kidney disease as defined by glomerular filtration rate * The surgery must require general anesthesia with endotracheal intubation and neuromuscular blockade Exclusion Criteria: * Any patient under the age of 18 * Any patient over the age of 80 * Any patient with end stage renal disease * Any patient requiring dialysis * Patients presenting for Renal Transplantation * Pregnant Female * Any patient in the correctional system * Urgent or Emergent procedure * The surgery requires intubation post-operatively * Documented allergy to Rocuronium, Sugammadex, Cisatracurium or Neostigmine

Conditions

Post Operative Pulmonary Complications Neuromuscular Blockade General Anesthesia

Locations

  • University of Texas Medical Branch — Galveston, Texas, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record