RECRUITING Phase 3 ClinicalTrials.gov

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

Sponsor: Sanofi • ClinicalTrials.gov ID: NCT07184931

Registry updated: 2026-10-21

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Description

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active CD. Study details include: The study duration may be up to 35 weeks with: * Up to 5-week Screening Period. * 12-week Sub-Study 1 (Single Arm Open-Label Feeder Induction) or Sub-Study 2 (Pivotal Induction). * 12-week Sub-Study 3 (Extended Induction for non-responders). * 6 weeks (45 days) follow-up period for participants who do not enroll into the Pivotal Maintenance Study (EFC18327). The treatment duration will be up to 12 weeks in each sub-study. The number of scheduled study visits for participants who continue to the Pivotal Maintenance Study (EFC18327) will be up to 8 (Sub-Study 1 and Sub-Study 2) and up to 15 for participants who enroll in Sub-Study 3.

Interventions

Duvakitug (Drug)
Pharmaceutical form:Injection solution Route of administration:SC injection
Placebo (Drug)
Pharmaceutical form:Injection solution Route of administration:SC injection

Eligibility criteria

Inclusion Criteria: * Participants aged ≥18 and ≤80 years of age at Screening. Where permitted locally, participants 16 to \<18 years of age who meet the definition of Tanner Stage 5 for development * Confirmed diagnosis of moderately to severely active Crohn's Disease (CD) for at least 3 months prior to baseline * Demonstrated inadequate response, have shown loss of response or intolerance to conventional therapies or advanced therapies (ATs) Exclusion Criteria: * Participants with Ulcerative Colitis (UC) or indeterminate colitis * Participants with two entire missing segments of the: terminal ileum, right colon transverse colon, sigmoid and left colon, and rectum * Prior or current high-grade gastrointestinal (GI) dysplasia * Participants on treatment with but not on stable doses of conventional therapy prior to baseline * Participants receiving prohibited medications or therapies * Participants with previous exposure to anti-TL1A investigational therapy The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

Conditions

Crohn's Disease

Locations

Onyx Clinical Research - Site Number:8400021 — Peoria, Arizona, United States
One of a Kind Clinical Research Center AZ, LLC-Site Number: 8400061 — Scottsdale, Arizona, United States
Scottsdale Clinical Trials-Site Number: 8400145 — Scottsdale, Arizona, United States
Del Sol Research Management, LLC-Site Number: 8400012 — Tucson, Arizona, United States
Preferred Research Partners-Site Number: 8400018 — Little Rock, Arkansas, United States
Alliance Research Institute-Site Number: 8400008 — Canoga Park, California, United States
Southern California GI & Liver Centers-Site Number: 8400062 — Coronado, California, United States
Gastroenterology and Liver Institute - Escondido-Site Number: 8400146 — Escondido, California, United States
GMC Clinical Research, LLC-Site Number: 8400113 — Folsom, California, United States
Om Research, LLC - Lancaster-Site Number: 8400148 — Lancaster, California, United States
TLC Clinical Research Inc.-Site Number: 8400030 — Los Angeles, California, United States
GastroIntestinal Bioscience - Los Angeles-Site Number: 8400019 — Los Angeles, California, United States
United Medical Doctors CA-Site Number: 8400044 — Murrieta, California, United States
Om Research, LLC - Oxnard-Site Number: 8400150 — Oxnard, California, United States
Prospective Research Innovations Inc.-Site Number: 8400017 — Rancho Cucamonga, California, United States
UC Davis Health System-Site Number: 8400071 — Sacramento, California, United States
Clinical Applications Laboratories Inc-Site Number: 8400056 — San Diego, California, United States
Medical Associates Research Group-Site Number:8400063 — San Diego, California, United States
Valiance Clinical Research - Tarzana-Site Number: 8400023 — Tarzana, California, United States
Clinical Trials Management Services-Site Number: 8400047 — Thousand Oaks, California, United States
Amicis Research Center - Valencia-Site Number: 8400064 — Valencia, California, United States
Om Research, LLC - Victorville-Site Number: 8400022 — Victorville, California, United States
UCHealth Digestive Health Center - Anschutz Medical Campus-Site Number: 8400085 — Aurora, Colorado, United States
Peak Gastroenterology Associates - Colorado Springs-Site Number: 8400039 — Colorado Springs, Colorado, United States
Gastroenterology of the Rockies - Denver-Site Number: 8400122 — Denver, Colorado, United States
Yale University Digestive Disease-Site Number: 8400108 — New Haven, Connecticut, United States
Novum Research, LLC-Site Number: 8400003 — Clermont, Florida, United States
Sarkis Clinical Trials - Gainesville-Site Number: 8400048 — Gainesville, Florida, United States
Clinical Research of Osceola-Site Number: 8400013 — Kissimmee, Florida, United States
Columbus Clinical Services LLc-Site Number: 8400038 — Miami, Florida, United States
Regis Clinical Research, LLC-Site Number: 8400041 — Miami, Florida, United States
Sylvester Comprehensive Cancer Center - A University of Miami Hospital and Clinics Facility - Miami-Site Number: 8400111 — Miami, Florida, United States
Medical Professional Clinical Research Center-Site Number: 8400119 — Miami, Florida, United States
Bioresearch Partner-Kendale Lakes-Site Number: 8400053 — Miami, Florida, United States
Paradisus Med Research-Site Number: 8400036 — Miami, Florida, United States
Correa Research Center-Site Number: 8400010 — Miami, Florida, United States
AdventHealth Orlando-Site Number: 8400070 — Orlando, Florida, United States
Orlando Health, Inc.-Site Number: 8400084 — Orlando, Florida, United States
Tropical Clinical Trials-Site Number: 8400082 — Palmetto Bay, Florida, United States
Precision Clinical Research - Sunrise-Site Number: 8400059 — Sunrise, Florida, United States
NMC Research LLC-Site Number: 8400033 — Tampa, Florida, United States
Atlanta Gastroenterology Associates-Site Number: 8400109 — Atlanta, Georgia, United States
M3 Wake Research - Atlanta-Site Number: 8400028 — Sandy Springs, Georgia, United States
EBGS Clinical Research Center, LLC-Site Number: 8400037 — Snellville, Georgia, United States
Atlanta Gastroenterology Specialists-Site Number: 8400149 — Suwanee, Georgia, United States
Grand Teton Research Group, PLLC-Site Number: 8400127 — Idaho Falls, Idaho, United States
Rush University Medical Center-Site Number: 8400015 — Chicago, Illinois, United States
Midwest Digestive Health and Nutrition-Site Number: 8400136 — Des Plaines, Illinois, United States
GI Alliance - Glenview-Site Number: 8400068 — Glenview, Illinois, United States
GI Alliance - Gurnee-Site Number: 8400049 — Gurnee, Illinois, United States
Gastroenterology Health Partners, PLLC - New Albany-Site Number: 8400100 — New Albany, Indiana, United States
Heartland Medical Research, Inc.-Site Number: 8400134 — Clive, Iowa, United States
Digestive Health Research Center-Site Number: 8400096 — Waterloo, Iowa, United States
University of Kansas Medical Center-Site Number: 8400110 — Kansas City, Kansas, United States
University of Kentucky Hospital/UK Albert B. Chandler Hospital-Site Number: 8400058 — Lexington, Kentucky, United States
GI Alliance - Baton Rouge-Site Number: 8400129 — Baton Rouge, Louisiana, United States
Tandem Intermediate, LLC - Houma-Site Number: 8400034 — Houma, Louisiana, United States
Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance - Mandeville-Site Number: 8400128 — Mandeville, Louisiana, United States
Tandem Clinical Research - Marrero-Site Number: 8400002 — Marrero, Louisiana, United States
GI Alliance - Metairie-Site Number: 8400124 — Metairie, Louisiana, United States
Delta Research Partners-Site Number: 8400087 — Monroe, Louisiana, United States
Care Access - New Iberia-Site Number: 8400031 — New Iberia, Louisiana, United States
Mercy Medical Center, Baltimore-Site Number: 8400117 — Baltimore, Maryland, United States
Mid-Atlantic GI Research, LLC-Site Number: 8400106 — Laurel, Maryland, United States
Tufts Medical Center-Site Number: 8400126 — Boston, Massachusetts, United States
UMass Memorial Medical Center-Site Number: 8400121 — Worcester, Massachusetts, United States
Henry Ford Medical Center - Columbus-Site Number: 8400118 — Novi, Michigan, United States
Gastroenterology Associates of Western Michigan-Site Number: 8400060 — Wyoming, Michigan, United States
Allied Health Clinical Research Organization, LLC - Jackson-Site Number:8400007 — Jackson, Mississippi, United States
BVL Clinical Research-Site Number: 8400005 — Liberty, Missouri, United States
Washington University School of Medicine-Site Number: 8400075 — St Louis, Missouri, United States
Gateway Gastroenterology-Site Number: 8400097 — St Louis, Missouri, United States
Las Vegas Clinical Trials-Site Number: 8400079 — Las Vegas, Nevada, United States
Sanmora Bespoke Clinical Research Solutions LLC-Site Number: 8400123 — East Orange, New Jersey, United States
Allied Health Clinical Research Organization, LLC - Freehold-Site Number: 8400014 — Freehold, New Jersey, United States
Atlantic Health System, Morristown Medical Center-Site Number: 8400137 — Morristown, New Jersey, United States
Tandem-Allied Clinical Research - Somers Point-Site Number: 8400050 — Somers Point, New Jersey, United States
Premier Health Research, LLC-Site Number: 8400114 — Sparta, New Jersey, United States
MedTraits NY-Site Number: 8400045 — Maspeth, New York, United States
Manhattan Clinical Research, LLC-Site Number: 8400069 — New York, New York, United States
NYU Langone Health-Site Number: 8400091 — New York, New York, United States
Columbia University Medical Center-Site Number: 8400138 — New York, New York, United States
Weill Cornell Medicine - NewYork-Presbyterian Hospital-Site Number: 8400040 — New York, New York, United States
New York Gastroenterology Associates-Site Number: 8400009 — New York, New York, United States
Montefiore Medical Center - Bronx-Site Number: 8400142 — The Bronx, New York, United States
UNC Hospitals, The University of North Carolina at Chapel Hill-Site Number: 8400074 — Chapel Hill, North Carolina, United States
OnSite Clinical Solutions-Site Number: 8400051 — Charlotte, North Carolina, United States
Duke University Medical Center-Site Number: 8400093 — Durham, North Carolina, United States
Cross Creek Medical Clinic-Site Number: 8400057 — Fayetteville, North Carolina, United States
Monroe Biomedical Research-Site Number: 8400046 — Monroe, North Carolina, United States
ClinTrial Research, LLC-Site Number: 8400043 — Raleigh, North Carolina, United States
Plains Clinical Research Center-Site Number: 8400078 — Fargo, North Dakota, United States
Gastroenterology & Hepatology Specialists, Inc.-Site nUmber: 8400139 — Canton, Ohio, United States
University Hospitals Cleveland Medical Center-Site Number: 8400073 — Cleveland, Ohio, United States
Ohio Gastroenterology Group Inc.-8400006 — Columbus, Ohio, United States
OSU Wexner Medical Center-Site Number: 8400077 — Columbus, Ohio, United States
DSI Research Northridge - Dayton-Site Number: 8400115 — Dayton, Ohio, United States
DSI Research - Springboro-Site Number: 8400105 — Springboro, Ohio, United States
University of Toledo Medical Center-Site Number: 8400042 — Toledo, Ohio, United States
North Shore Gastroenterology Research-Site Number: 8400130 — Westlake, Ohio, United States
Central Sooner Research-Site Number: 8400094 — Norman, Oklahoma, United States
Oregon Health & Science University-Site Number: 8400131 — Portland, Oregon, United States
Penn State Milton S. Hershey Medical Center-Site Number: 8400066 — Hershey, Pennsylvania, United States
University of Pennsylvania School of Medicine-Site Number: 8400072 — Philadelphia, Pennsylvania, United States
The Allegheny Health Network (AHN) Center for Digestive Health-Site Number: 8400107 — Pittsburgh, Pennsylvania, United States
University Gastroenterology-Site Number: 8400103 — Providence, Rhode Island, United States
Johns Hopkins University Gastroenterology and Hepatology-Site Number: 8400116 — Columbia, South Carolina, United States
Biocentric Health Research Center-Site Number: 8400089 — Columbia, South Carolina, United States
Gastro One - Cordova-Site Number: 8400158 — Cordova, Tennessee, United States
Tri-Cities Gastroenterology-Site Number: 8400076 — Kingsport, Tennessee, United States
Inquest Clinical Research-Site Number: 8400144 — Baytown, Texas, United States
The University of Texas Southwestern Medical Center-Site Number: 8400098 — Dallas, Texas, United States
Valley Institute of Research-Site Number: 8400004 — Harlingen, Texas, United States
One of a Kind Clinical Research Center TX, LLC-Site Number; 8400125 — Kingwood, Texas, United States
Innovare Research Group-Site number: 8400067 — Lake Jackson, Texas, United States
GI Alliance - Lubbock-Site Number: 8400092 — Lubbock, Texas, United States
SMS Clinical Research-Site Number: 8400035 — Mesquite, Texas, United States
Gastroenterology Research of San Antonio LLC-Site Number: 8400054 — San Antonio, Texas, United States
Texas Digestive Disease Consultants, PLLC. dba GI Alliance - Southlake - Corporate Office-Site Number: 8400101 — Southlake, Texas, United States
Texas Gastro Consultants-Site Number: 8400029 — Tomball, Texas, United States
Tyler Research Institute, LLC-Site Number: 8400095 — Tyler, Texas, United States
Velocity Clinical Research, Salt Lake City-Site Number: 8400147 — West Jordan, Utah, United States
Blue Ridge Medical Research-Site Number: 8400020 — Lynchburg, Virginia, United States
Clinical Research Partners-Site Number: 8400080 — Richmond, Virginia, United States
GI Alliance - Bellevue-Site Number: 8400143 — Bellevue, Washington, United States
The Vancouver Clinic Inc. P.S.-Site Number: 8400090 — Vancouver, Washington, United States
Froedtert Hospital and the Medical College of Wisconsin-Site Number: 8400081 — Milwaukee, Wisconsin, United States
Investigational Site Number : 0320002 — La Plata, Buenos Aires, Argentina
Investigational Site Number : 0320001 — Buenos Aires, City of Buenos Aires, Argentina
Investigational Site Number : 0320006 — Rosario, Santa Fe Province, Argentina
Investigational Site Number : 0320007 — Rosario, Santa Fe Province, Argentina
Investigational Site Number : 0320005 — Buenos Aires, Argentina
Investigational Site Number : 0320003 — Buenos Aires, Argentina
Investigational Site Number : 0320004 — Córdoba, Argentina
Investigational Site Number : 0360005 — Birtinya, Australia
Investigational Site Number : 0360003 — Clayton, Australia
Investigational Site Number : 0360004 — Liverpool, Australia
Investigational Site Number : 0360006 — Nedlands, Australia
Investigational Site Number : 0360001 — South Brisbane, Australia
Investigational Site Number : 0360002 — Southport, Australia
Investigational Site Number : 0360007 — Wollongong, Australia
Investigational Site Number : 0400006 — Sankt Veit an der Glan, Carinthia, Austria
Investigational Site Number : 0400003 — Krems, Lower Austria, Austria
Investigational Site Number : 0400004 — Graz, Styria, Austria
Investigational Site Number : 0400005 — Linz, Upper Austria, Austria
Investigational Site Number : 0400002 — Salzburg, Austria
Investigational Site Number : 0400001 — Vienna, Austria
Investigational Site Number : 0400008 — Vienna, Austria
Investigational Site Number : 0400007 — Vienna, Austria
Investigational Site Number : 0560001 — Genk, Belgium
Investigational Site Number : 0560004 — Liège, Belgium
Investigational Site Number : 0560002 — Sint-Niklaas, Belgium
Investigational Site Number : 0560003 — Yvoir, Belgium
Investigational Site Number: 0760005 — Juiz de Fora, Minas Gerais, Brazil
Investigational Site Number: 0760003 — Caxias do Sul, Rio Grande do Sul, Brazil
Investigational Site Number : 0760009 — Porto Alegre, Rio Grande do Sul, Brazil
Investigational Site Number : 0760006 — São José do Rio Preto, Sao Jose Do Rio Preto, Sao Paulo, Brazil
Investigational Site Number: 0760002 — Barretos, São Paulo, Brazil
Investigational Site Number : 0760012 — Campinas, São Paulo, Brazil
Investigational Site Number : 0760008 — Aracaju, Brazil
Investigational Site Number : 0760010 — Brasília, Brazil
Investigational Site Number : 0760001 — Goiânia, Brazil
Investigational Site Number : 0760007 — Porto Alegre, Brazil
Investigational Site Number : 0760013 — Salvador, Brazil
Investigational Site Number : 0760014 — São Paulo, Brazil
Investigational Site Number : 0760011 — Teresina, Brazil
Investigational Site Number : 1000003 — Gorna Oryahovitsa, Oblast Veliko Tirnovo, Bulgaria
Investigational Site Number : 1000007 — Rousse, Bulgaria
Investigational Site Number : 1000008 — Sofia, Bulgaria
Investigational Site Number : 1000005 — Sofia, Bulgaria
Investigational Site Number : 1000006 — Sofia, Bulgaria
Investigational Site Number : 1000004 — Sofia, Bulgaria
Investigational Site Number : 1000001 — Sofia, Bulgaria
Investigational Site Number : 1000002 — Sofia, Bulgaria
Investigational Site Number : 1240010 — Oakville, Ontario, Canada
Investigational Site Number : 1240014 — Brampton, Canada
Investigational Site Number : 1240004 — Edmonton, Canada
Investigational Site Number : 1240005 — Greater Sudbury, Canada
Investigational Site Number : 1240009 — Hamilton, Canada
Investigational Site Number : 1240011 — London, Canada
Investigational Site Number : 1240013 — London, Canada
Investigational Site Number : 1240002 — Montreal, Canada
Investigational Site Number : 1240007 — Montreal, Canada
Investigational Site Number : 1240006 — New Westminster, Canada
Investigational Site Number : 1240003 — Toronto, Canada
Investigational Site Number : 1520004 — Santiago, Chile
Investigational Site Number : 1520003 — Santiago, Chile
Investigational Site Number : 1520002 — Santiago, Chile
Investigational Site Number : 1520001 — Viña del Mar, Chile
Investigational Site Number : 1560006 — Xiamen, Fujian, China
Investigational Site Number : 1560034 — Guangzhou, Guangdong, China
Investigational Site Number : 1560049 — Guangzhou, Guangdong, China
Investigational Site Number : 1560002 — Guangzhou, Guangdong, China
Investigational Site Number : 1560026 — Huizhou, Guangdong, China
Investigational Site Number : 1560043 — Shenzhen, Guangdong, China
Investigational Site Number : 1560010 — Wuhan, Hubei, China
Investigational Site Number : 1560003 — Wuhan, Hubei, China
Investigational Site Number : 1560037 — Changsha, Hunan, China
Investigational Site Number : 1560025 — Nanjing, Jiangsu, China
Investigational Site Number : 1560004 — Nanjing, Jiangsu, China
Investigational Site Number : 1560018 — Wuxi, Jiangsu, China
Investigational Site Number : 1560001 — Chengdu, Sichuan, China
Investigational Site Number : 1560013 — Hangzhou, Zhejiang, China
Investigational Site Number : 1560029 — Taizhou, Zhejiang, China
Investigational Site Number : 1560016 — Beijing, China
Investigational Site Number : 1560027 — Beijing, China
Investigational Site Number : 1560017 — Changshu, China
Investigational Site Number : 1560011 — Changzhou, China
Investigational Site Number : 1560061 — Chengdu, China
Investigational Site Number : 1560036 — Fuzhou, China
Investigational Site Number : 1560009 — Guangzhou, China
Investigational Site Number : 1560005 — Hangzhou, China
Investigational Site Number : 1560060 — Hefei, China
Investigational Site Number : 1560008 — Jinan, China
Investigational Site Number : 1560022 — Jingzhou, China
Investigational Site Number : 1560056 — Jinhua, China
Investigational Site Number : 1560039 — Luzhou, China
Investigational Site Number : 1560030 — Mianyang, China
Investigational Site Number : 1560019 — Nanjing, China
Investigational Site Number : 1560024 — Nanjing, China
Investigational Site Number : 1560057 — Qingdao, China
Investigational Site Number : 1560059 — Qingyuan, China
Investigational Site Number : 1560020 — Shanghai, China
Investigational Site Number : 1560058 — Shanghai, China
Investigational Site Number : 1560042 — Suzhou, China
Investigational Site Number : 1560007 — Wenzhou, China
Investigational Site Number : 1560050 — Yangzhou, China
Investigational Site Number : 1700005 — Medellín, Antioquia, Colombia
Investigational Site Number : 1700006 — Medellín, Antioquia, Colombia
Investigational Site Number : 1700002 — Medellín, Antioquia, Colombia
Investigational Site Number : 1700003 — Barranquilla, Atlántico, Colombia
Investigational Site Number : 1700001 — Armenia, Quindío Department, Colombia
Investigational Site Number : 1700004 — Floridablanca, Santander Department, Colombia
Investigational Site Number : 2030001 — Brno, Czechia
Investigational Site Number : 2030008 — Brno, Czechia
Investigational Site Number : 2030003 — Brno, Czechia
Investigational Site Number : 2030011 — Hradec Králové, Czechia
Investigational Site Number : 2030013 — Prague, Czechia
Investigational Site Number : 2030006 — Prague, Czechia
Investigational Site Number : 2500009 — Amiens, Cedex 1, France
Investigational Site Number : 2500002 — Saint-Etienne, Cedex 2, France
Investigational Site Number : 2500008 — Besançon, France
Investigational Site Number : 2500003 — Créteil, France
Investigational Site Number : 2500004 — La Tronche, France
Investigational Site Number : 2500010 — Lille, France
Investigational Site Number : 2500012 — Marseille, France
Investigational Site Number : 2500007 — Nantes, France
Investigational Site Number : 2500005 — Nantes, France
Investigational Site Number : 2500013 — Nice, France
Investigational Site Number : 2500001 — Paris, France
Investigational Site Number : 2500011 — Toulouse, France
Investigational Site Number : 2500006 — Vandœuvre-lès-Nancy, France
Investigational Site Number : 2680007 — Kutaisi, Georgia
Investigational Site Number : 2680006 — Tbilisi, Georgia
Investigational Site Number : 2680001 — Tbilisi, Georgia
Investigational Site Number : 2680008 — Tbilisi, Georgia
Investigational Site Number : 2680003 — Tbilisi, Georgia
Investigational Site Number : 2680005 — Tbilisi, Georgia
Investigational Site Number : 2680009 — Tbilisi, Georgia
Investigational Site Number : 2680002 — Tbilisi, Georgia
Investigational Site Number : 2680004 — Tbilisi, Georgia
Investigational Site Number : 2760009 — Tübingen, Baden-Wurttemberg, Germany
Investigational Site Number : 2760005 — Ulm, Baden-Wurttemberg, Germany
Investigational Site Number : 2760023 — Würzburg, Bavaria, Germany
Investigational Site Number : 2760013 — Remscheid, North Rhine-Westphalia, Germany
Investigational Site Number : 2760014 — Ludwigshafen am Rhein, Rhineland-Palatinate, Germany
Investigational Site Number : 2760008 — Dresden, Saxony, Germany
Investigational Site Number : 2760015 — Leipzig, Saxony, Germany
Investigational Site Number : 2760020 — Leipzig, Saxony, Germany
Investigational Site Number : 2760021 — Halle, Saxony-Anhalt, Germany
Investigational Site Number : 2760016 — Jerichow, Saxony-Anhalt, Germany
Investigational Site Number : 2760001 — Kiel, Schleswig-Holstein, Germany
Investigational Site Number : 2760017 — Berlin, Germany
Investigational Site Number : 2760006 — Berlin, Germany
Investigational Site Number : 2760003 — Berlin, Germany
Investigational Site Number : 2760019 — Dachau, Germany
Investigational Site Number : 2760007 — Duisburg, Germany
Investigational Site Number : 2760004 — Hamburg, Germany
Investigational Site Number : 2760026 — Herne, Germany
Investigational Site Number : 2760029 — Lüneburg, Germany
Investigational Site Number : 2760010 — Minden, Germany
Investigational Site Number : 3000001 — Heraklion, Crete, Greece
Investigational Site Number : 3000003 — Larissa, Thessaly, Greece
Investigational Site Number : 3000002 — Athens, Greece
Investigational Site Number : 3480004 — Budapest, Hungary
Investigational Site Number : 3480002 — Budapest, Hungary
Investigational Site Number : 3480005 — Eger, Hungary
Investigational Site Number : 3480003 — Tatabánya, Hungary
Investigational Site Number : 3480001 — Veszprém, Hungary
Investigational Site Number : 3760004 — Afula, Israel
Investigational Site Number : 3760006 — Ashkelon, Israel
Investigational Site Number : 3760003 — Beersheba, Israel
Investigational Site Number : 3760001 — Jerusalem, Israel
Investigational Site Number : 3760005 — Nahariya, Israel
Investigational Site Number : 3760007 — Petah Tikva, Israel
Investigational Site Number : 3760002 — Tel Aviv, Israel
Investigational Site Number : 3800007 — Legnano, Italy
Investigational Site Number : 3800002 — Milan, Italy
Investigational Site Number : 3800009 — Rome, Italy
Investigational Site Number : 3800003 — Rozzano, Italy
Investigational Site Number : 3800006 — San Donato Milanese, Italy
Investigational Site Number : 3800005 — Turin, Italy
Investigational Site Number : 3920046 — Shizuoka, Hamamatsu, Japan
Investigational Site Number : 3920005 — Asahikawa, Japan
Investigational Site Number : 3920012 — Bunkyō City, Japan
Investigational Site Number : 3920059 — Bunkyō City, Japan
Investigational Site Number : 3920039 — Chikushino-shi, Japan
Investigational Site Number : 3920045 — Fukuoka, Japan
Investigational Site Number : 3920063 — Fukuoka, Japan
Investigational Site Number : 3920027 — Fukuoka, Japan
Investigational Site Number : 3920031 — Hachiōji, Japan
Investigational Site Number : 3920065 — Isehara, Japan
Investigational Site Number : 3920028 — Isesaki, Japan
Investigational Site Number : 3920049 — Kagoshima, Japan
Investigational Site Number : 3920030 — Kamakura, Japan
Investigational Site Number : 3920018 — Kashiwa, Japan
Investigational Site Number : 3920054 — Kitakyushu, Japan
Investigational Site Number : 3920019 — Kobe, Japan
Investigational Site Number : 3920060 — Kobe, Japan
Investigational Site Number : 3920033 — Kōriyama, Japan
Investigational Site Number : 3920036 — Kumamoto, Japan
Investigational Site Number : 3920061 — Kurume, Japan
Investigational Site Number : 3920052 — Maebashi, Japan
Investigational Site Number : 3920058 — Minato, Japan
Investigational Site Number : 3920024 — Mitaka, Japan
Investigational Site Number : 3920062 — Nagakute, Japan
Investigational Site Number : 3920026 — Nagoya, Japan
Investigational Site Number : 3920057 — Nagoya, Japan
Investigational Site Number : 3920013 — Nishinomiya, Japan
Investigational Site Number : 3920025 — Okayama, Japan
Investigational Site Number : 3920050 — Osaka, Japan
Investigational Site Number : 3920002 — Osaka, Japan
Investigational Site Number : 3920022 — Osaka, Japan
Investigational Site Number : 3920001 — Saga, Japan
Investigational Site Number : 3920014 — Saga, Japan
Investigational Site Number : 3920064 — Sagamihara, Japan
Investigational Site Number : 3920023 — Sakura, Japan
Investigational Site Number : 3920029 — Sapporo, Japan
Investigational Site Number : 3920042 — Sapporo, Japan
Investigational Site Number : 3920048 — Sendai, Japan
Investigational Site Number : 3920004 — Sendai, Japan
Investigational Site Number : 3920003 — Sendai, Japan
Investigational Site Number : 3920047 — Shimotsuga-gun, Japan
Investigational Site Number : 3920034 — Shinjuku, Japan
Investigational Site Number : 3920006 — Shinjuku, Japan
Investigational Site Number : 3920020 — Shiwa-gun, Japan
Investigational Site Number : 3920032 — Toyama, Japan
Investigational Site Number : 3920037 — Toyama, Japan
Investigational Site Number : 3920015 — Toyohashi, Japan
Investigational Site Number : 3920009 — Tsu, Japan
Investigational Site Number : 3920035 — Yokohama, Japan
Investigational Site Number : 4400001 — Kaunas, Lithuania
Investigational Site Number : 4400002 — Panevezys, Lithuania
Investigational Site Number : 4840006 — Monterrey, Nuevo León, Mexico
Investigational Site Number : 4840001 — Jalisco, Mexico
Investigational Site Number : 4840004 — Veracruz, Mexico
Investigational Site Number : 4980001 — Chisinau, Moldova
Investigational Site Number : 4980002 — Chisinau, Moldova
Investigational Site Number : 4980003 — Chisinau, Moldova
Investigational Site Number : 4980004 — Chisinau, Moldova
Investigational Site Number : 5280002 — Amsterdam, Netherlands
Investigational Site Number : 5540001 — Christchurch, Netherlands
Investigational Site Number : 5540003 — Lower Hutt, Netherlands
Investigational Site Number : 5280001 — Nijmegen, Netherlands
Investigational Site Number : 5540002 — Tauranga, Netherlands
Investigational Site Number : 5280003 — Tilburg, Netherlands
Investigational Site Number : 5540005 — Wellington, Netherlands
Investigational Site Number : 5780001 — Lorenskog, Norway
Investigational Site Number : 5780002 — Tromsø, Norway
Investigational Site Number : 6160026 — Bydgoszcz, Poland
Investigational Site Number : 6160019 — Bydgoszcz, Poland
Investigational Site Number : 6160013 — Elblag, Poland
Investigational Site Number : 6160035 — Katowice, Poland
Investigational Site Number : 6160014 — Katowice, Poland
Investigational Site Number : 6160022 — Krakow, Poland
Investigational Site Number : 6160030 — Kłodzko, Poland
Investigational Site Number : 6160016 — Lodz, Poland
Investigational Site Number : 6160011 — Lodz, Poland
Investigational Site Number : 6160034 — Lublin, Poland
Investigational Site Number : 6160027 — Nowy Targ, Poland
Investigational Site Number : 6160032 — Olsztyn, Poland
Investigational Site Number : 6160010 — Opole, Poland
Investigational Site Number : 6160018 — Poznan, Poland
Investigational Site Number : 6160001 — Poznan, Poland
Investigational Site Number : 6160025 — Rzeszów, Poland
Investigational Site Number : 6160029 — Siedlce, Poland
Investigational Site Number : 6160004 — Sopot, Poland
Investigational Site Number : 6160007 — Staszów, Poland
Investigational Site Number : 6160002 — Szczecin, Poland
Investigational Site Number : 6160020 — Szczecin, Poland
Investigational Site Number : 6160023 — Torun, Poland
Investigational Site Number : 6160015 — Tychy, Poland
Investigational Site Number : 6160012 — Wadowice, Poland
Investigational Site Number : 6160005 — Warsaw, Poland
Investigational Site Number : 6160031 — Warsaw, Poland
Investigational Site Number : 6160009 — Warsaw, Poland
Investigational Site Number : 6160003 — Warsaw, Poland
Investigational Site Number : 6160008 — Warsaw, Poland
Investigational Site Number : 6160006 — Wroclaw, Poland
Investigational Site Number : 6160028 — Wroclaw, Poland
Investigational Site Number : 6160017 — Wroclaw, Poland
Puerto Rico Health and Wellness Institute-Site Number: 8400104 — Dorado, Puerto Rico
Wellness Clinical Research - Vega Baja-Site Number: 8400099 — Vega Baja, Puerto Rico
Investigational Site Number : 6880001 — Belgrade, Serbia
Investigational Site Number : 6880002 — Belgrade, Serbia
Investigational Site Number : 6880006 — Belgrade, Serbia
Investigational Site Number : 6880007 — Belgrade, Serbia
Investigational Site Number : 6880003 — Belgrade, Serbia
Investigational Site Number : 6880004 — Niš, Serbia
Investigational Site Number : 7030001 — Bratislava, Slovakia
Investigational Site Number : 7030003 — Košice, Slovakia
Investigational Site Number : 7030002 — Prešov, Slovakia
Investigational Site Number : 7030004 — Prešov, Slovakia
Investigational Site Number : 7100002 — Cape Town, South Africa
Investigational Site Number : 7100005 — Claremont, South Africa
Investigational Site Number : 7100004 — Durban, South Africa
Investigational Site Number : 7100003 — East London, South Africa
Investigational Site Number : 7100001 — Kempton Park, South Africa
Investigational Site Number : 7100006 — KwaZulu-Natal, South Africa
Investigational Site Number : 4100010 — Ansan-si, South Korea
Investigational Site Number : 4100008 — Busan, South Korea
Investigational Site Number : 4100009 — Busan, South Korea
Investigational Site Number : 4100004 — Daegu, South Korea
Investigational Site Number : 4100003 — Daejeon, South Korea
Investigational Site Number : 4100007 — Gwangju, South Korea
Investigational Site Number : 4100006 — Seoul, South Korea
Investigational Site Number : 4100001 — Seoul, South Korea
Investigational Site Number : 4100002 — Seoul, South Korea
Investigational Site Number : 4100005 — Suwon, South Korea
Investigational Site Number : 7240006 — Ourense, Galicia, Spain
Investigational Site Number : 7240005 — Gijón, Spain
Investigational Site Number : 7240002 — Huelva, Spain
Investigational Site Number : 7240004 — Madrid, Spain
Investigational Site Number : 7560002 — Basel, Switzerland
Investigational Site Number : 7560001 — Bern, Switzerland
Investigational Site Number : 1580005 — Changhua County, Taiwan
Investigational Site Number : 1580003 — Chiayi City, Taiwan
Investigational Site Number : 1580010 — Kaohsiung City, Taiwan
Investigational Site Number : 1580006 — Kaohsiung City, Taiwan
Investigational Site Number : 1580009 — New Taipei City, Taiwan
Investigational Site Number : 1580008 — Tainan, Taiwan
Investigational Site Number : 1580007 — Tainan, Taiwan
Investigational Site Number : 1580002 — Taipei, Taiwan
Investigational Site Number : 1580001 — Taoyuan City, Taiwan
Investigational Site Number : 8040003 — Chernivtsi, Ukraine
Investigational Site Number : 8040001 — Kyiv, Ukraine
Investigational Site Number : 8040013 — Kyiv, Ukraine
Investigational Site Number : 8040002 — Kyiv, Ukraine
Investigational Site Number : 8040004 — Lviv, Ukraine
Investigational Site Number : 8040011 — Lviv, Ukraine
Investigational Site Number : 8040005 — Lviv, Ukraine
Investigational Site Number : 8040006 — Uzhhorod, Ukraine
Investigational Site Number : 8040010 — Vinnytsia, Ukraine
Investigational Site Number : 8040009 — Vinnytsia, Ukraine
Investigational Site Number : 8040008 — Vinnytsia, Ukraine
Investigational Site Number : 8260008 — Cottingham, Hull, United Kingdom
Investigational Site Number : 8260005 — Cambridge, United Kingdom
Investigational Site Number : 8260007 — London, United Kingdom
Investigational Site Number : 8260001 — London, United Kingdom
Investigational Site Number : 8260004 — Norwich, United Kingdom
Investigational Site Number : 8260003 — Rochdale, United Kingdom

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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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