RECRUITING Phase 3 ClinicalTrials.gov

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Sponsor: Eli Lilly and Company • ClinicalTrials.gov ID: NCT07174336

Registry updated: 2026-10-08

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Description

The purpose of the study is to assess the efficacy and safety of the addition of Tersolisib (LY4064809/STX-478) to other anti-cancer drugs as first treatment for advanced hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Participants can remain in the study as long as the drug is helping the cancer without unbearable side effects.

Interventions

LY4064809 (Drug)
Administered orally
Placebo (Drug)
Administered orally
Ribociclib (Drug)
Administered orally
Palbociclib (Drug)
Administered orally
Abemaciclib (Drug)
Administered orally
Anastrozole (Drug)
Administered orally
Letrozole (Drug)
Administered orally
Exemestane (Drug)
Administered orally
Fulvestrant (Drug)
Administered intramuscular

Eligibility criteria

Inclusion Criteria: * Are willing to follow contraception requirements. Contraceptive use by participants should be consistent with local regulations regarding the methods of contraception for those participating in clinical trials. * If assigned female at birth, pre-/peri- and postmenopausal status is allowed. Those with pre- or peri-menopausal status at study entry must agree to use ovarian function suppression with any locally approved gonadotropin-releasing hormone (GnRH) agonist. * If assigned male at birth with an estrogen receptor positive (ER+) breast cancer diagnosis, they must agree to use hormone suppression with a GnRH agonist. * Have histologically or cytologically confirmed breast cancer, defined as individuals with * locally advanced breast cancer not amenable to curative therapy (for example, surgery) or metastatic disease, and * hormone receptors (HR)+/human epidermal growth factor receptor 2 (HER2)- or HR+/HER low defined by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Guidelines * HR status: Documented ER+ and/or progesterone receptor-positive (PR+) tumor according to ASCO/CAP Guidelines, defined as greater than or equal to (≥)1 percent (%) of tumor cells stained positive based on the most recent tumor biopsy and assessed locally * HER status: immunohistochemistry score of 1+ or score of 2+ with a negative Fluorescence In Situ Hybridization (FISH) based on local results as defined in the ASCO/CAP Guidelines * Have evidence of an activating PIK3CA mutation, detected in tumor or blood samples using an appropriate assay. * Have measurable disease or non-measurable, evaluable bone disease * Part 1: * Received 0-2 prior systemic treatments for advanced breast cancer not amenable to curative therapy (for example, surgery) or metastatic disease. * Up to 1 of these prior systemic treatments may contain chemotherapy * Part 2: * Received 0 prior systemic treatment for advanced breast cancer not amenable to curative therapy (for example, surgery) or metastatic disease. * Individuals who are eligible are either * Population 1 (P1): Endocrine sensitive * newly diagnosed with advanced breast cancer (de novo) * participants with a history of HR+, HER2- EBC and did not receive SOC adjuvant ET * relapsed with documented evidence of progression greater than (\>)12 months from completion of (neo)adjuvant ET ± cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor, or * Population 2 (P2): Endocrine resistant * relapsed with documented evidence of progression less than or equal to (≤)12 months of completing (neo)adjuvant ET ± CDK4/6 inhibitor. * if a CDK4/6 inhibitor was included as part of neoadjuvant or adjuvant therapy, progression event must be \>12 months since completion of CDK4/6 inhibitor portion of neoadjuvant or adjuvant therapy. Exclusion Criteria: * Have an established diagnosis of Type 1 diabetes mellitus or Type 2 diabetes mellitus with hemoglobin A1c (HbA1c) ≥8%, fasting blood glucose (FBG) ≥140 milligrams per deciliter (mg/dL) (7.7 millimoles per liter \[mmol/L\]), or requiring insulin. * Have inflammatory or metaplastic breast cancer. * History of leptomeningeal disease or carcinomatous meningitis. * Have known and untreated or active central nervous system (CNS) metastases. Exception: Asymptomatic brain or spinal metastases if treated by surgery, surgery plus radiotherapy, or radiotherapy alone with no evidence of radiographic progression or hemorrhage within at least 28 days before randomization and no requirement for anticonvulsants or systemic corticosteroids for at least 28 days before randomization. * Have received treatment with any local or systemic antineoplastic therapy or investigational anticancer agent within 14 days or 4 half-lives, whichever is longer, prior to randomization up to a maximum washout period of 28 days. * Have a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (dose more than 10 milligrams \[mg\] daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to randomization. * Are pregnant, breastfeeding, or intend to become pregnant during the study or within 6 months of the last dose of study intervention and at least 2 years after the last dose of fulvestrant and/or CDK4/6 inhibitor after the final administration of study treatment. * Have active bacterial or fungal infection that is not recovered at randomization.

Conditions

Breast Neoplasms Neoplasm Metastasis

Locations

Alaska Oncology and Hematology — Anchorage, Alaska, United States
Ironwood Cancer & Research Centers — Chandler, Arizona, United States
St. Joseph's Hospital and Medical Center — Phoenix, Arizona, United States
Mayo Clinic in Arizona - Phoenix — Phoenix, Arizona, United States
The University of Arizona Cancer Center - North Campus — Tucson, Arizona, United States
Genesis Cancer and Blood Institute — Hot Springs, Arkansas, United States
Highlands Oncology Group — Springdale, Arkansas, United States
Community Cancer Institute — Clovis, California, United States
City of Hope — Duarte, California, United States
Epic Care - Emeryville — Emeryville, California, United States
Marin Cancer Care — Greenbrae, California, United States
Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine — Irvine, California, United States
City of Hope Orange County Lennar Foundation Cancer Center — Irvine, California, United States
Moores Cancer Center — La Jolla, California, United States
USC/Norris Comprehensive Cancer Center — Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
Kaiser Permanente Oakland — Oakland, California, United States
Profound Research LLC — Oceanside, California, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center — Orange, California, United States
Desert Regional Medical Center — Palm Springs, California, United States
Stanford Cancer Center — Palo Alto, California, United States
Kaiser Permanente — Roseville, California, United States
Kaiser Permanente — San Francisco, California, United States
Kaiser Permanente — Santa Clara, California, United States
UCLA Hematology/Oncology - Parkside — Santa Monica, California, United States
Providence Medical Foundation — Santa Rosa, California, United States
Kaiser Permanente — Vallejo, California, United States
Kaiser Permanente Walnut Creek — Walnut Creek, California, United States
UCHealth Harmony — Fort Collins, Colorado, United States
Cancer Centers of Colorado St. Mary's Regional Hospital — Grand Junction, Colorado, United States
Banner MD Anderson Cancer Center at North Colorado Medical Center — Greeley, Colorado, United States
Banner MD Anderson Cancer Center at McKee Medical Center — Loveland, Colorado, United States
UConn Health — Farmington, Connecticut, United States
MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
AdventHealth Altamonte Springs — Altamonte Springs, Florida, United States
Clermont Oncology Center — Clermont, Florida, United States
Florida Oncology & Hematology — Fort Myers, Florida, United States
Mayo Clinic in Florida — Jacksonville, Florida, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center — Miami, Florida, United States
Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center — Tampa, Florida, United States
Piedmont Columbus Regional - John B. Amos Cancer Center — Columbus, Georgia, United States
Central Georgia Cancer Care — Macon, Georgia, United States
City of Hope National Medical Center, Atlanta Cancer Center — Newnan, Georgia, United States
Low Country Cancer Care — Savannah, Georgia, United States
Summit Cancer Care, PC — Savannah, Georgia, United States
Kaiser Permanente Moanalua Medical Center — Honolulu, Hawaii, United States
City of Hope, Chicago — Chicago, Illinois, United States
Northwestern Memorial Hospital — Chicago, Illinois, United States
University of Illinois at Chicago — Chicago, Illinois, United States
Endeavor Health — Evanston, Illinois, United States
Accellacare of Duly — Lisle, Illinois, United States
Simmons Cancer Institute at SIU — Springfield, Illinois, United States
Indiana University Health University Hospital — Indianapolis, Indiana, United States
Hematology Oncology of Indiana — Indianapolis, Indiana, United States
Deaconess GI Specialty Center — Newburgh, Indiana, United States
University of Iowa — Iowa City, Iowa, United States
Saint Elizabeth Medical Center Edgewood — Edgewood, Kentucky, United States
Our Lady of the Lake RMC — Baton Rouge, Louisiana, United States
New England Cancer Specialists — Westbrook, Maine, United States
American Oncology Partners, PA — Bethesda, Maryland, United States
James M Stockman Cancer Institute — Frederick, Maryland, United States
Mass General Cancer Center — Boston, Massachusetts, United States
Dana-Farber Cancer Institute — Boston, Massachusetts, United States
University of Massachusetts Medical School — Worcester, Massachusetts, United States
Profound Research LLC — Sterling Heights, Michigan, United States
Allina Health Cancer Institute - Abbott Northwestern Hospital — Minneapolis, Minnesota, United States
Mayo Clinic in Rochester, Minnesota — Rochester, Minnesota, United States
Metro-Minnesota Community Clinical Oncology — Saint Louis Park, Minnesota, United States
North Mississippi Hematology and Oncology Associates — Tupelo, Mississippi, United States
Saint Luke's Cancer Institute — Kansas City, Missouri, United States
Oncology Hematology Associates — Springfield, Missouri, United States
Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
Jefferson Health - Cherry Hill — Cherry Hill, New Jersey, United States
Sidney Kimmel Cancer Center - Washington Township — Sewell, New Jersey, United States
Atlantic Health System Overlook Medical Center — Summit, New Jersey, United States
NYOH Albany Cancer Center — Albany, New York, United States
New York University (NYU) Brooklyn — Brooklyn, New York, United States
Memorial Sloan Kettering Cancer Center — New York, New York, United States
NYC Health + Hospitals / Bellevue — New York, New York, United States
Messino Cancer Centers — Asheville, North Carolina, United States
WakeMed Cancer Care - Waverly Hematology & Medical Oncology — Cary, North Carolina, United States
University of North Carolina Medical Center — Chapel Hill, North Carolina, United States
Carolina Cancer Research Center — Wilson, North Carolina, United States
Sanford Fargo Medical Center — Fargo, North Dakota, United States
Cleveland Clinic Akron General — Akron, Ohio, United States
Gabrail Cancer Center — Canton, Ohio, United States
University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
Fairview Hospital — Cleveland, Ohio, United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T — Columbus, Ohio, United States
Cleveland Clinic - Hillcrest Hospital — Mayfield Heights, Ohio, United States
Good Samaritan Regional Medical Center — Corvallis, Oregon, United States
Oncology Associates of Oregon — Eugene, Oregon, United States
Oregon Health and Science University — Portland, Oregon, United States
St. Luke's University Health Network — Bethlehem, Pennsylvania, United States
Lancaster General Hospital - Ann B Barshinger Cancer Institute — Lancaster, Pennsylvania, United States
University of Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
Thomas Jefferson University - Clinical Research Institute — Philadelphia, Pennsylvania, United States
Jefferson Hospital Northeast — Philadelphia, Pennsylvania, United States
Asplundh Cancer Pavilion — Willow Grove, Pennsylvania, United States
Medical University of South Carolina — Charleston, South Carolina, United States
Sanford Cancer Center — Sioux Falls, South Dakota, United States
Sarah Cannon Research Institute SCRI — Nashville, Tennessee, United States
Nashville General Hospital — Nashville, Tennessee, United States
Hendrick Medical Center — Abilene, Texas, United States
World Research Link — Baytown, Texas, United States
Parkland Health and Hospital System — Dallas, Texas, United States
USO - Texas Oncology — Dallas, Texas, United States
UT Southwestern Medical Center — Dallas, Texas, United States
Texas Oncology - West Texas — El Paso, Texas, United States
The University of Texas MD Anderson Cancer Center — Houston, Texas, United States
Houston Methodist Hospital — Houston, Texas, United States
Oncology Consultants P.A. — Houston, Texas, United States
Nova Oncology — McAllen, Texas, United States
Texas Oncology - San Antonio Medical Center — San Antonio, Texas, United States
US Oncology Research Network — The Woodlands, Texas, United States
Tranquility Research — Webster, Texas, United States
Utah Cancer Specialists — Salt Lake City, Utah, United States
The University of Vermont Medical Center Inc. — Burlington, Vermont, United States
Virginia Cancer Specialists — Fairfax, Virginia, United States
Swedish Cancer Institute - Edmonds — Edmonds, Washington, United States
Providence Regional Cancer Partnership — Everett, Washington, United States
UW Medicine Valley Medical Center — Renton, Washington, United States
Swedish Medical Center — Seattle, Washington, United States
Deaconess Hospital — Spokane, Washington, United States
Cancer Care Northwest - Vercler — Spokane Valley, Washington, United States
MultiCare Health System — Tacoma, Washington, United States
North Star Lodge — Yakima, Washington, United States
ThedaCare Physicians - Appleton North — Appleton, Wisconsin, United States
CIPREC — Buenos Aires, Argentina
Centro de Investigaciones Medicas y Desarrollo LC — Buenos Aires, Argentina
Investigaciones Clinicas Moleculares (ICM) — Buenos Aires, Argentina
Centro Oncologico Korben — Buenos Aires, Argentina
Organizacion Medica de Investigacion — Buenos Aires, Argentina
Focus CECIC — Buenos Aires, Argentina
Fundación Respirar — Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Córdoba — Córdoba, Argentina
Fundación Innovaciencia — Rosario, Argentina
Hospital Provincial del Centenario — Rosario, Argentina
COE (Centro Oncológico de Excelencia) — San Juan, Argentina
Instituto San Marcos — San Juan, Argentina
Go Centro Medico San Nicolás — San Nicolás, Argentina
Ballarat Health Services — Ballarat Central, Australia
The Prince Charles Hospital — Brisbane, Australia
St Vincent's Hospital — Darlinghurst, Australia
Royal Hobart Hospital — Hobart, Australia
Peter MacCallum Cancer Centre — Melbourne, Australia
Lake Macquarie Private Hospital — Newcastle, Australia
Macquarie University — North Ryde, Australia
Goulburn Valley Health — Shepparton, Australia
St. John of God Subiaco Hospital — Subiaco, Australia
The Townsville Hospital — Townsville, Australia
Institut Jules Bordet — Anderlecht, Belgium
Jessa Ziekenhuis — Hasselt, Belgium
AZ Groeninge Campus Kennedylaan — Kortrijk, Belgium
UZ Leuven — Leuven, Belgium
CHU UCL Namur/Site Sainte Elisabeth — Namur, Belgium
Clinique Saint Pierre — Ottignies, Belgium
AZ Nikolaas — Sint-Niklaas, Belgium
Fundação Pio XII - Hospital de Câncer de Barretos — Barretos, Brazil
Hospital São Domingos — Bequimão, Brazil
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará — Fortaleza, Brazil
Hospital Araújo Jorge — Goiânia, Brazil
Hospital Brasilia — Lago Sul, Brazil
Hospital de Cancer de Londrina — Londrina, Brazil
Instituto Atena de Pesquisa Clinica - Mossoró — Mossoró, Brazil
Liga Norte Riograndense Contra o Câncer — Natal, Brazil
Futtura Oncology - Clinical Research Hub — Porto Alegre, Brazil
Hospital São Lucas da PUCRS — Porto Alegre, Brazil
Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA — Rio de Janeiro, Brazil
Instituto do Cancer Arnaldo Vieira de Carvalho — São Paulo, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo — São Paulo, Brazil
Hospital Santa Catarina - Paulista — São Paulo, Brazil
Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda — São Paulo, Brazil
IBCC - Núcleo de Pesquisa e Ensino — São Paulo, Brazil
Hamilton Health Sciences-Juravinski Cancer Centre — Hamilton, Canada
CHU de Québec-Université Laval, Hôpital du Saint-Sacrement — Québec, Canada
Princess Margaret Cancer Centre — Toronto, Canada
BC Cancer Vancouver — Vancouver, Canada
Anyang Cancer Hospital — Anyang, China
Beijing Cancer hospital — Beijing, China
The First Hospital of Jilin University — Changchun, China
The First People's Hospital of Changde City — Changde, China
Xiangya Hospital Central South University — Changsha, China
Sichuan Provincial People's Hospital — Chengdu, China
Deyang City People's Hospital — Deyang, China
Fujian Cancer Hospital — Fuzhou, China
Fujian Medical University Union Hospital — Fuzhou Fujian, China
Sun Yat-sen University Cancer Center — Guangzhou, China
Guangdong Provincial People's Hospital — Guangzhou, China
Harbin Medical University Cancer Hospital — Harbin, China
Jiangmen Center Hospital — Jiangmen, China
The first affiliated hospital of Ningbo university — Ningbo, China
Fudan University Shanghai Cancer Center — Shanghai, China
Cancer Hospital of Shantou University Medical College — Shantou, China
Tianjin Medical University Cancer Institute & Hospital — Tianjin, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan, China
Tongji Hospital Tongji Medical,Science & Technology — Wuhan, China
Central Hospital of Guangdong Provincial Agricutural Reclamation — Zhanjiang, China
Sainte Catherine Institut du Cancer Avignon Provence — Avignon, France
CHU Besançon — Besançon, France
CHRU de Brest — Brest, France
Pole Santé République — Clermont-Ferrand, France
Centre Georges François Leclerc — Dijon, France
Clinique Victor Hugo Le Mans — Le Mans, France
Hopital Prive Jean Mermoz — Lyon, France
Centre de Cancérologie du Grand Montpellier — Montpellier, France
Institut Curie — Paris, France
Hôpital Privé Des Côtes d'Armor — Plérin, France
Institut Jean Godinot — Reims, France
Institut Curie - site Saint-Cloud — Saint-Cloud, France
Institut de Cancérologie de l'Ouest — Saint-Herblain, France
Oncopole Claudius Regaud — Toulouse, France
Institut de Cancérologie de Lorraine Alexis Vautrin — Vandœuvre-lès-Nancy, France
Gustave Roussy — Villejuif, France
Charité Universitaetsmedizin Berlin - Campus Mitte — Berlin, Germany
Marienhospital Bottrop — Bottrop, Germany
Universitaetsklinikum Koeln — Cologne, Germany
Städtisches Klinikum Dessau — Dessau, Germany
Onkologiezentrum Donauwörth — Donauwörth, Germany
Universitaetsklinikum Carl Gustav Carus Dresden — Dresden, Germany
Kostara Gyn. Oncology Clinic Research UG — Düsseldorf, Germany
Universitaetsklinikum Erlangen — Erlangen, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung — Essen, Germany
Agaplesion Markus Krankenhaus — Frankfurt, Germany
Universitaetsklinikum Freiburg — Freiburg im Breisgau, Germany
Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer — Friedrichshafen, Germany
OSP Göttingen — Göttingen, Germany
Mammazentrum HH - Krankenhaus Jerusalem — Hamburg, Germany
Universitaetsklinikum des Saarlandes — Homburg, Germany
Universitätsklinikum Leipzig — Leipzig, Germany
Klinikum Ludwigsburg — Ludwigsburg, Germany
Universitätsmedizin Johannes Gutenberg Universität Mainz — Mainz, Germany
Klinikum der Ludwig-Maximilians-Universitaet Muenchen — München, Germany
Klinikum Ernst von Bergmann — Potsdam, Germany
SRH Zentralklinikum Suhl — Suhl, Germany
Helios HSK Wiesbaden — Wiesbaden, Germany
Marien Hospital Witten — Witten, Germany
HELIOS Klinikum Wuppertal — Wuppertal, Germany
Agios Savvas Regional Cancer Hospital — Athens, Greece
Aretaieio Hospital — Athens, Greece
Alexandra General Hospital of Athens — Athens, Greece
IASO Obstetrics - Gynecology Clinic — Athens, Greece
Iaso Private General Obstetrics Gynecological & Pediatric Clinic Diagnostic Therapeutic & Research Center -T — Athens, Greece
Attikon General University Hospital — Chaïdári, Greece
University General Hospital of Heraklion — Heraklion, Greece
University Hospital of Ioannina — Ioannina, Greece
University General Hospital of Larissa — Larissa, Greece
Hygeia Hospital — Marousi, Greece
University Hospital of Patras — Pátrai, Greece
European Interbalkan Medical Center — Thessaloniki, Greece
European Interbalkan Medical Center — Thessaloniki, Greece
European Interbalkan Medical Center — Thessaloniki, Greece
Bon Secours Cork Hospital — Cork, Ireland
St. Vincent's University Hospital — Dublin, Ireland
Mater Misericordiae University Hospital — Dublin, Ireland
St. James's Hospital — Dublin, Ireland
Beaumont Hospital, Dublin — Dublin, Ireland
Galway University Hospital — Galway, Ireland
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII — Bergamo, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola — Bologna, Italy
Azienda Ospedaliera Universitaria Careggi — Florence, Italy
Ospedale San Martino — Genova, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori — Meldola, Italy
Istituto Europeo di Oncologia IRCCS — Milan, Italy
Humanitas Istituto Clinico Catanese — Misterbianco, Italy
Fondazione IRCCS San Gerardo dei Tintori — Monza, Italy
Azienda Ospedaliera Universitaria Federico II — Naples, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale — Naples, Italy
Istituto Oncologico Veneto IRCCS — Padova, Italy
Fondazione Policlinico Universitario Agostino Gemelli — Roma, Italy
Juntendo University Hospital — Bunkyō City, Japan
Chiba cancer center — Chiba, Japan
National Hospital Organization Kyushu Cancer Center — Fukuoka, Japan
Kyushu University Hospital — Fukuoka, Japan
Fukushima Medical University — Fukushima, Japan
Saitama Medical University International Medical Center — Hidaka, Japan
Kansai Medical University Hospital — Hirakata, Japan
Hiroshima City Hospital — Hiroshima, Japan
Hiroshima University Hospital — Hiroshima, Japan
Sagara Hospital — Kagoshima, Japan
Kanazawa Medical University Hospital — Kahoku-gun, Japan
The Cancer Institute Hospital of JFCR — Kōtoku, Japan
Kyoto University Hospital — Kyoto, Japan
Aichi Cancer Center Hospital — Nagoya, Japan
Nagoya City University Hospital — Nagoya, Japan
Nakagami Hospital — Okinawa, Japan
Gunma Prefectural Cancer Center — Otashi, Japan
Saitama Red Cross Hospital — Saitama, Japan
Hokkaido University Hospital — Sapporo, Japan
Tohoku University Hospital — Sendai, Japan
Showa Medical University Hospital — Shinagawa City, Japan
Shizuoka General Hospital — Shizuoka, Japan
The University of Osaka Hospital — Suita, Japan
Tsukuba University Hospital — Tsukuba, Japan
Kanagawa cancer center — Yokohama, Japan
National University Hospital — Singapore, Singapore
National Cancer Centre Singapore — Singapore, Singapore
Tan Tock Seng Hospital — Singapore, Singapore
Soon Chun Hyang University Cheonan Hospital — Cheonan-si, South Korea
Kyungpook National University Chilgok Hospital — Deagu, South Korea
Gangnam Severance Hospital, Yonsei University Health System — Gangnam-gu, South Korea
Yeungnam Univeristy Medical Center — Gyeongsan-si, South Korea
Inha University Hospital — Incheon, South Korea
Korea University Anam Hospital — Seoul, South Korea
Seoul National University Hospital — Seoul, South Korea
Severance Hospital, Yonsei University Health System — Seoul, South Korea
Asan Medical Center — Seoul, South Korea
Samsung Medical Center — Seoul, South Korea
Hospital Infanta Cristina — Badajoz, Spain
Hospital Universitari Dexeus — Barcelona, Spain
Hospital Universitari Vall d'Hebron — Barcelona, Spain
Hospital Clínic de Barcelona — Barcelona, Spain
Hospital San Pedro de Alcántara — Cáceres, Spain
Hospital Universitario Donostia — Donostia / San Sebastian, Spain
Hospital Universitario San Cecilio — Granada, Spain
Instituto Catalan de Oncologia - Hospital Duran i Reynals — Hospitalet, Spain
Complejo Hospitalario de Jaén — Jaén, Spain
Hospital Insular de Gran Canaria — Las Palmas de Gran Canaria, Spain
Hospital Universitario Arnau de Vilanova de Lleida — Lleida, Spain
Hospital Beata María Ana — Madrid, Spain
Hospital General Universitario Gregorio Marañon — Madrid, Spain
Hospital Universitario Ramón y Cajal — Madrid, Spain
Hospital Clinico San Carlos — Madrid, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain
Hospital Universitario HM Sanchinarro — Madrid, Spain
Hospital Universitario Virgen de la Victoria — Málaga, Spain
Hospital Universitari Son Espases — Palma, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca — Salamanca, Spain
Hospital Universitario de Canarias — San Cristóbal de La Laguna, Spain
CHUS - Hospital Clinico Universitario — Santiago de Compostela, Spain
Hospital Universitario Virgen Macarena — Seville, Spain
Hospital Universitario Virgen Del Rocio — Seville, Spain
Fundación Instituto Valenciano de Oncología — Valencia, Spain
Hospital Clinico de Valencia — Valencia, Spain
Hospital Arnau de Vilanova — Valencia, Spain
Hospital Clínico Universitario Lozano Blesa — Zaragoza, Spain
Taichung Veterans General Hospital — Taichung, Taiwan
National Cheng Kung University Hospital — Tainan, Taiwan
Chi Mei Medical Center — Tainan, Taiwan
National Taiwan University Hospital — Taipei, Taiwan
Taipei Veterans General Hospital — Taipei, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center — Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch — Taoyuan, Taiwan
Baskent University Dr. Turgut Noyan Research and Training Center — Adana, Turkey (Türkiye)
Adana City Hospital — Adana, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi — Ankara, Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals — Ankara, Turkey (Türkiye)
Aydın Adnan Menderes Universitesi Hastanesi — Aydin, Turkey (Türkiye)
Trakya University — Edirne, Turkey (Türkiye)
Koç Üniversitesi Hastanesi — Istanbul, Turkey (Türkiye)
Yeditepe Üniversitesi Koşuyolu Hastanesi — Istanbul, Turkey (Türkiye)
Acibadem Atasehir Hospital — Istanbul, Turkey (Türkiye)
Ege Universitesi Hastanesi — Izmir, Turkey (Türkiye)
Mersin Sehir Eğitim ve Araştırma Hastanesi — Mersin, Turkey (Türkiye)
Western General Hospital — Edinburgh, United Kingdom
Huddersfield Royal Infirmary — Huddersfield, United Kingdom
St Bartholomew's Hospital — London, United Kingdom
Royal Marsden Hospital (Sutton) — London, United Kingdom
Royal Marsden Hospital (Chelsea) — London, United Kingdom
The Christie NHS Foundation Trust — Manchester, United Kingdom
Derriford Hospital — Plymouth, United Kingdom
Worcestershire Royal Hospital — Worcester, United Kingdom

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