A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

Description

The main purpose of the SYNERGY-OUTCOMES study is to find out whether retatrutide and tirzepatide can prevent major adverse liver outcomes (MALO) in people with high-risk metabolic dysfunction-associated steatotic liver disease (MASLD). The study will enroll adults who have MASLD based on non-invasive tests (NITs), which indicate they are more likely to develop MALO. Participants will be randomly assigned within a Master Protocol to receive either retatrutide (N1T-MC-RT01), tirzepatide (N1T-MC-TZ01) or placebo. The trial plans to enroll about 4,500 adults and will run for approximately 224 weeks. Participants may have up to approximately 25 to 30 clinic visits throughout the study to monitor their health, complete study procedures, and assess liver function and disease progression. Once the study is complete, eligible participants may participate in an optional 2-year extension study, in which all participants will receive either retatrutide or tirzepatide, even if they received placebo in the main study.

Interventions

• Tirzepatide (Drug)
  Administered SC
• Retatrutide (Drug)
  Administered SC
• Placebo (Drug)
  Administered SC

Eligibility criteria

Conditions

Locations

• MFA Clinical Research — Tuscaloosa, Alabama, United States
• The Institute for Liver Health II dba Arizona Clinical Trials - Chandler — Chandler, Arizona, United States
• Spectrum Research Institute — Gilbert, Arizona, United States
• The Institute for Liver Health II dba Arizona Liver Health - Peoria — Peoria, Arizona, United States
• Epic Medical Research-Sun City — Sun City, Arizona, United States
• The Institute for Liver Health II dba Arizona Clinical Trials - Tucson — Tucson, Arizona, United States
• Del Sol Research Management, LLC — Tucson, Arizona, United States
• Arkansas Gastroenterology - North Little Rock — North Little Rock, Arkansas, United States
• San Fernando Valley Health Institute — Canoga Park, California, United States
• Ark Clinical Research - Fountain Valley — Fountain Valley, California, United States
• Fresno Clinical Research Center — Fresno, California, United States
• UCSD - Altman Clinical and Translational Research Institute (ACTRI) — La Jolla, California, United States
• Orange County Research Center — Lake Forest, California, United States
• Om Research LLC — Lancaster, California, United States
• Ark Clinical Research — Long Beach, California, United States
• Los Angeles Institute for Metabolic Research — Los Angeles, California, United States
• United Medical Doctors - Murrieta — Murrieta, California, United States
• Knowledge Research Center — Orange, California, United States
• California Liver Research Center — Pasadena, California, United States
• Artemis Institute for Clinical Research — Riverside, California, United States
• Medical Associates Research Group — San Diego, California, United States
• Quest Clinical Research — San Francisco, California, United States
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
• South Denver Gastroenterology — Englewood, Colorado, United States
• Medical Research Center of Connecticut — Hamden, Connecticut, United States
• K2 Medical Research WINTER GARDEN — Clermont, Florida, United States
• K2 Medical Research - Daytona Beach — Daytona Beach, Florida, United States
• Care Access - Delray Beach — Delray Beach, Florida, United States
• AMR Clinical — Doral, Florida, United States
• Southwest General Healthcare Center — Fort Myers, Florida, United States
• University of Florida College of Medicine — Gainesville, Florida, United States
• Encore Medical Research — Hollywood, Florida, United States
• Nature Coast Clinical Research - Inverness — Inverness, Florida, United States
• Encore Borland-Groover Clinical Research — Jacksonville, Florida, United States
• Health Awareness — Jupiter, Florida, United States
• K2 MEDICAL Research THE VILLAGES — Lady Lake, Florida, United States
• Florida Research Institute — Lakewood Rch, Florida, United States
• Tampa Bay Medical Research - Largo — Largo, Florida, United States
• Evolution Clinical Trials — Miami, Florida, United States
• Floridian Clinical Research, LLC — Miami Lakes, Florida, United States
• GI PROS Research — Naples, Florida, United States
• Charter Research - Orlando — Orlando, Florida, United States
• Headlands Research Orlando — Orlando, Florida, United States
• Progressive Medical Research — Port Orange, Florida, United States
• Covenant Metabolic Specialists - Riverview — Riverview, Florida, United States
• Care Access - St. Petersburg — St. Petersburg, Florida, United States
• Care Access - Tamarac — Tamarac, Florida, United States
• Covenant Metabolic Specialists, LLC — University Park, Florida, United States
• Southeast Clinical Research Center — Dalton, Georgia, United States
• Gastrointestinal Specialists of Georgia — Marietta, Georgia, United States
• Rophe Adult and Pediatric Medicine/SKYCRNG — Union City, Georgia, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Indiana University Health University Hospital — Indianapolis, Indiana, United States
• Gastroenterology Health Partners — New Albany, Indiana, United States
• Deaconess Clinic- Gateway — Newburgh, Indiana, United States
• Digestive Research Alliance of Michiana — South Bend, Indiana, United States
• Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa, United States
• AMR Clinical — El Dorado, Kansas, United States
• Johnson County Clinical Trials — Lenexa, Kansas, United States
• Cotton O'Neil Digestive Health Center — Topeka, Kansas, United States
• AMR Clinical — Lexington, Kentucky, United States
• Delta Research Partners of Bastrop, LLC — Bastrop, Louisiana, United States
• Tandem Clinical Research — Marrero, Louisiana, United States
• Care Access - New Iberia — New Iberia, Louisiana, United States
• Louisiana Research Center — Shreveport, Louisiana, United States
• Delta Research Partners of West Monroe — West Monroe, Louisiana, United States
• Mercy Medical Center - Baltimore — Baltimore, Maryland, United States
• Capital Digestive Care - Chevy Chase — Chevy Chase, Maryland, United States
• Lucida Clinical Trials — New Bedford, Massachusetts, United States
• Clinical Research Institute of Michigan, LLC — Clinton Township, Michigan, United States
• Great Lakes Research Institute — Southfield, Michigan, United States
• Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
• MNGI Digestive Health — Minneapolis, Minnesota, United States
• GI Associates - GIA and Endoscopy Center - Flowood — Flowood, Mississippi, United States
• AMR Clinical — Kansas City, Missouri, United States
• Jubilee Clinical Research NV. LLC — Las Vegas, Nevada, United States
• Excel Clinical Research, LLC — Las Vegas, Nevada, United States
• Tandem Clinical Research - Freehold — Freehold, New Jersey, United States
• Atlantic Health System Morristown Medical Center — Morristown, New Jersey, United States
• Clinical Research of Philadelphia — Pennington, New Jersey, United States
• The Cognitive and Research Center of New Jersey - Ridgewood — Ridgewood, New Jersey, United States
• IMA Clinical Research Warren — Warren Township, New Jersey, United States
• Southwest Gastroenterology Associates — Albuquerque, New Mexico, United States
• Research Foundation of SUNY - University of Buffalo — Buffalo, New York, United States
• NYU Langone Health — New York, New York, United States
• IMA Clinical Research Manhattan — New York, New York, United States
• New York Gastroenterology Associates — New York, New York, United States
• Care Access - Yonkers — Yonkers, New York, United States
• Duke University - Main Hospital and Clinics — Durham, North Carolina, United States
• Monroe Biomedical Research — Monroe, North Carolina, United States
• Carteret Medical Group — Morehead City, North Carolina, United States
• Akron Gastro Research — Akron, Ohio, United States
• Dayton Gastroenterology - Beavercreek — Beavercreek, Ohio, United States
• Clinical Research Institute of Ohio - Brooklyn — Brooklyn, Ohio, United States
• CRIOH — Westlake, Ohio, United States
• US Digestive Health - Flourtown — Flourtown, Pennsylvania, United States
• Penn Medicine: University of Pennsylvania Health System — Philadelphia, Pennsylvania, United States
• US Digestive Health - Wyomissing — Wyomissing, Pennsylvania, United States
• University Gastroenterology — Providence, Rhode Island, United States
• Columbia Digestive Health Research — Columbia, South Carolina, United States
• Galen Medical Group - Galen Hepatology — Chattanooga, Tennessee, United States
• Gastro One (Walnut Run Road) — Cordova, Tennessee, United States
• IMA Clinical Research Austin — Austin, Texas, United States
• American Research Corporation — Austin, Texas, United States
• Pinnacle Clinical Research — Austin, Texas, United States
• Bellaire Clinical Research — Bellaire, Texas, United States
• South Texas Research Institute - Brownsville — Brownsville, Texas, United States
• Headlands Horizons, LLC dba Headlands Research-Brownsville — Brownsville, Texas, United States
• Soma Clinical Trials — Denison, Texas, United States
• Epic Medical Research - DeSoto — DeSoto, Texas, United States
• South Texas Research Institute — Edinburg, Texas, United States
• Dallas Research Institute — Farmers Branch, Texas, United States
• Care United Research, LLC — Forney, Texas, United States
• GI Alliance - Fort Worth — Fort Worth, Texas, United States
• HRI- Medical Center — Houston, Texas, United States
• Care Access - Houston — Houston, Texas, United States
• Houston Research Institute — Houston, Texas, United States
• Biopharma Informatic, LLC — Houston, Texas, United States
• Research Physicians Network, LLC — Houston, Texas, United States
• Biopharma Informatic, LLC — McAllen, Texas, United States
• DHR Health Institute for Research and Development (Administrative Office & Laboratory) — McAllen, Texas, United States
• Southern Endocrinology Associates — Mesquite, Texas, United States
• HRI Pasadena — Pasadena, Texas, United States
• American Research Corporation at Texas Liver Institute — San Antonio, Texas, United States
• Clinical Trials of Texas, LLC dba Flourish Research — San Antonio, Texas, United States
• IMA Clinical Research San Antonio — San Antonio, Texas, United States
• Consano Clinical Research, LLC — Shavano Park, Texas, United States
• GI Alliance - Southlake — Southlake, Texas, United States
• Houston Research Institute (HRI) - Sugar Land — Sugar Land, Texas, United States
• Texas Valley Clinical Research — Weslaco, Texas, United States
• Medrasa Clinical Research — Wylie, Texas, United States
• Care Access - Ogden — Ogden, Utah, United States
• Advanced Research Institute - Sandy — Sandy City, Utah, United States
• Eximia Research - Norfolk — Norfolk, Virginia, United States
• Richmond Veterans Affairs Medical Center (Richmond VA Medical Center) — Richmond, Virginia, United States
• Virginia Commonwealth University (VCU) Medical Center — Richmond, Virginia, United States
• Gastroenterology Consultants of Southwest Virginia — Roanoke, Virginia, United States
• Washington Gastroenterology - Bellevue — Bellevue, Washington, United States
• UW Medicine Diabetes Institute — Seattle, Washington, United States
• Washington Gastroenterology - Tacoma — Tacoma, Washington, United States
• CAMC Health Education and Research Institute Inc — Charleston, West Virginia, United States
• Hospital Italiano de Buenos Aires — ABB, Argentina
• CIPREC — Buenos Aires, Argentina
• DOM Centro de Reumatología — Buenos Aires, Argentina
• Cicemo Srl — Buenos Aires, Argentina
• Glenny Corp. S.A. — Buenos Aires, Argentina
• Centro de Investigaciones Metabólicas (CINME) — Buenos Aires, Argentina
• Centro Médico Viamonte — Buenos Aires, Argentina
• Mautalen Salud e Investigación — Buenos Aires, Argentina
• Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada — Buenos Aires, Argentina
• Fundación Respirar — Buenos Aires, Argentina
• Instituto de Investigaciones Clínicas Córdoba — Córdoba, Argentina
• Centro de Investigaciones Clínicas Baigorria — Granadero Baigorria, Argentina
• Instituto de Investigaciones Clínicas Mar del Plata — Mar del Plata, Argentina
• DIM Clínica Privada — Ramos Mejía, Argentina
• INECO Neurociencias Oroño — Rosario, Argentina
• Instituto de Investigaciones Clinicas Rosario — Rosario, Argentina
• Centro de Diagnóstico y Rehabilitación (CEDIR) — Santa Fe, Argentina
• Nightingale Research — Adelaide, Australia
• Flinders Medical Centre — Adelaide, Australia
• Box Hill Hospital — Box Hill, Australia
• Royal Brisbane and Women's Hospital — Brisbane, Australia
• Core Research Group — Brisbane, Australia
• Mater Misericordiae Limited — Brisbane, Australia
• Gallipoli Medical Research Ltd — Brisbane, Australia
• Genesis Research Services — Broadmeadow, Australia
• Barwon Health — Geelong, Australia
• Austin Health — Heidelberg, Australia
• Ipswich Hospital — Ipswich, Australia
• Fiona Stanley Hospital — Murdoch, Australia
• TrialsWest - Osborne Park — Osborne Park, Australia
• The Royal Melbourne Hospital — Parkville, Australia
• Gold Coast University Hospital — Southport, Australia
• Westmead Hospital — Westmead, Australia
• Medizinische Universität Graz — Graz, Austria
• Uniklinikum Salzburg — Salzburg, Austria
• Klinik Landstraße — Vienna, Austria
• Medizinische Universität Wien — Vienna, Austria
• Landesklinikum Wiener Neustadt — Wiener Neustadt, Austria
• Centre Hospitalier Universitaire Brugmann — Brussels, Belgium
• Université Libre de Bruxelles - Hôpital Erasme — Brussels, Belgium
• UZ Brussel — Brussels, Belgium
• Cliniques universitaires Saint-Luc — Brussels, Belgium
• Antwerp University Hospital — Edegem, Belgium
• AZ Maria Middelares — Ghent, Belgium
• UZ Gent — Ghent, Belgium
• AZ Groeninge Campus Kennedylaan — Kortrijk, Belgium
• AZ Oostende vzw — Ostend, Belgium
• AZ Delta vzw — Roeselare, Belgium
• VITAZ — Sint-Niklaas, Belgium
• NewData Clinical Research - Aracaju — Aracaju, Brazil
• Fundação Pio XII - Hospital de Câncer de Barretos — Barretos, Brazil
• Hospital Universitário João de Barros Barreto — Belém, Brazil
• NUPEC - Cardio — Belo Horizonte, Brazil
• Faculdade de Medicina da UNESP — Botucatu, Brazil
• Centro de Pesquisa Clinica do Brasil — Brasília, Brazil
• Chronos Pesquisa Clínica — Brasília, Brazil
• Instituto de Pesquisa clinica de Campinas — Campinas, Brazil
• Cline Research Center — Curitiba, Brazil
• Hospital Universitario Walter Cantidio — Fortaleza, Brazil
• Universidade Federal de Goias — Goiânia, Brazil
• Hospital Brasilia — Lago Sul, Brazil
• CHN - Complexo Hospitalar de Niterói — Niterói, Brazil
• Hospital de Clinicas de Porto Alegre — Porto Alegre, Brazil
• Hospital Moinhos de Vento — Porto Alegre, Brazil
• IMV Pesquisa Cardiologica - Porto Alegre - Rua Orfanotrofio — Porto Alegre, Brazil
• Instituto do Fígado e Tranplantes de Pernambuco — Recife, Brazil
• IBPClin - Instituto Brasil de Pesquisa Clínica — Rio de Janeiro, Brazil
• Universidade Federal do Rio de Janeiro — Rio de Janeiro, Brazil
• Ruschel Medicina e Pesquisa Clínica — Rio de Janeiro, Brazil
• Inovace Pesquisa Clínica — Salvador, Brazil
• Centro Multidisciplinar de Estudos Clinicos — São Bernardo do Campo, Brazil
• CPHosp Medicina, Ensino e Pesquisa (CPQuali) — São Paulo, Brazil
• Clínica Hepatogastro JK — São Paulo, Brazil
• Hospital das Clinicas FMUSP — São Paulo, Brazil
• CEDOES — Vitória, Brazil
• Saint Marina Hospital — Pleven, Bulgaria
• UMHATEM 'N.I. Pirogov' — Sofia, Bulgaria
• Medical Center - Arcus Medical — Veliko Tarnovo, Bulgaria
• Heritage Medical Research Clinic — Calgary, Canada
• Ecogene-21 — Chicoutimi, Canada
• Wells Research Group — Edmonton, Canada
• University Of Alberta Hospital — Edmonton, Canada
• QEII Health Sciences Centre - Victoria General Site — Halifax, Canada
• University Hospital - London Health Sciences Centre — London, Canada
• Private Practice - Dr. Stephane M. Gauthier — North Bay, Canada
• Diex Recherche Quebec — Québec, Canada
• Clinical Research of Ontario — Toronto, Canada
• Toronto General Hospital — Toronto, Canada
• St. Joseph's Health Centre — Toronto, Canada
• Diex Recherche Inc. Division Trois-Rivieres — Trois-Rivières, Canada
• Vancouver General Hospital — Vancouver, Canada
• (G.I.R.I.) GI Research Institute Foundation — Vancouver, Canada
• Health Sciences Centre Winnipeg — Winnipeg, Canada
• Beijing Ditan Hospital — Beijing, China
• Peking University People's Hospital — Beijing, China
• Beijing Friendship Hospital Affiliate of Capital University — Beijing, China
• Beijing Youan Hospital — Beijing, China
• Hunan Provincial People's Hospital — Changsha, China
• Xiangya Hospital Central South University — Changsha, China
• The Second Xiangya Hospital of Central South University — Changsha, China
• Sichuan Provincial People's Hospital — Chengdu, China
• 2nd Affiliated Hospital Chongqing Medical Universi — Chongqing, China
• The First People's Hospital of Foshan — Foshan, China
• Fujian Medical University Mengchao Hepatobiliary Hospital (Fuzhou Infectious Disease Hospital) — Fuzhou, China
• The First Affiliated Hospital Of Fujian Medical University — Fuzhou, China
• Guangzhou 8th People's Hospital — Guangzhou, China
• Southern Medical University Nanfang Hospital — Guangzhou, China
• Guizhou Provincial People's Hospital — Guiyang, China
• The Affiliated Hospital of Guizhou Medical University — Guiyang, China
• Affiliated Hospital of Hangzhou Normal University — Hangzhou, China
• Jinhua Central Hospital — Jinhua, China
• Liaocheng People's Hospital — Liaocheng, China
• The First Affiliated Hospital of Henan University of Science &Technology — Luoyang, China
• The Affiliated Hospital of Southwest Medical University — Luzhou, China
• The Second Affiliated Hospital of Nanchang University — Nanchang, China
• The First affiliated hospital of Nanchang University (Xianghu campus) — Nanchang, China
• Jiangsu Province Hospital — Nanjing, China
• The First Affiliated Hospital of Nanyang Medical College — Nanyang, China
• Ningbo 2nd Hospital — Ningbo, China
• The first affiliated hospital of Ningbo university — Ningbo, China
• Ningbo Medical Center — Ningbo, China
• Pingxiang People's Hospital — Pingxiang, China
• Ruijin Hospital Shanghai Jiaotong University School of Medicine — Shanghai, China
• Zhongshan Hospital,Fudan University — Shanghai, China
• Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine — Shanghai, China
• Shengjing Hospital of China Medical University — Shenyang, China
• Peking University Shenzhen Hospital — Shenzhen, China
• The Third Hospital of Hebei Medical University — Shijiazhuang, China
• Tianjin People' s Hospital — Tianjin, China
• The First Affiliated Hospital of Wenzhou Medical University — Wenzhou, China
• The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, China
• General Hospital of Ningxia Medical University — Yinchuan, China
• Zhoukou Central Hospital — Zhoukou, China
• Krajská nemocnice Liberec — Liberec, Czechia
• Fakultni nemocnice Ostrava — Ostrava, Czechia
• Mestska nemocnice Ostrava — Ostrava, Czechia
• Vseobecna fakultni nemocnice v Praze — Prague, Czechia
• CHU d'Amiens-Picardie - Hôpital Sud — Amiens, France
• Centre Hospitalier Universitaire d'Angers — Angers, France
• CHU Besançon — Besançon, France
• Hôpital Beaujon — Clichy, France
• Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand — Dijon, France
• CHD Vendee — La Roche-sur-Yon, France
• Hopital Claude Huriez - CHU de Lille — Lille, France
• Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren — Limoges, France
• Centre Hospitalier Universitaire de Nice - Hôpital l'Archet — Nice, France
• Pitie Salpetriere University Hospital — Paris, France
• Hôpital Saint Antoine — Paris, France
• CHU Bordeaux Haut-Leveque — Pessac, France
• Centre Hospitalier Lyon Sud — Pierre-Bénite, France
• Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou — Rennes, France
• Nouvel Hôpital Civil (NHC) — Strasbourg, France
• CHU Rangueil — Toulouse, France
• Herz - und Diabeteszentrum Nordrhein - Westfalen, Bad Oeynhausen — Bad Oeynhausen, Germany
• Charité Campus Virchow-Klinikum — Berlin, Germany
• Universitätsklinikum Brandenburg an der Havel — Brandenburg, Germany
• Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden — Dresden, Germany
• Deutsches Diabetes-Zentrum (DDZ) — Düsseldorf, Germany
• Universitätsklinikum Frankfurt Goethe-Universität — Frankfurt, Germany
• Medizinische Hochschule Hannover — Hanover, Germany
• Universitaetsklinikum Heidelberg — Heidelberg, Germany
• Universitaetsklinikum des Saarlandes — Homburg, Germany
• Eugastro GmbH — Leipzig, Germany
• Universitätsklinikum Leipzig — Leipzig, Germany
• Universitätsmedizin Johannes Gutenberg Universität Mainz — Mainz, Germany
• Ruppiner Kliniken — Neuruppin, Germany
• Queen Mary Hospital — Hksar, Hong Kong
• Prince of Wales Hospital — Shatin, Hong Kong
• Tuen Mun Hospital — Tuenmen, Hong Kong
• Óbudai Egészségügyi Centrum — Budapest, Hungary
• Debreceni Egyetem Klinikai Kozpont — Debrecen, Hungary
• Szabolcs Szatmár Bereg Vármegyei Oktatókórház — Nyíregyháza, Hungary
• Avron Hospitals — Ahmedabad, India
• All India Institute of Medical Sciences — Bhubaneswar, India
• Postgraduate Institute of Medical Education & Research — Chandigarh, India
• Amrita Institute of Medical Sciences and Research Center — Ernākulam, India
• Endolife Speciality Hospitals — Guntur, India
• Asian Institute of Gastroenterology — Hyderabad, India
• SR Kalla Memorial Gastro & General Hospital — Jaipur, India
• Lisie Hospital — Kochi, India
• John C. Martin Centre for Liver Research & Innovations (JCMLRI) — Kolkata, India
• Sanjay Gandhi Post Graduate Institute of Medical Sciences — Lucknow, India
• Dayanand Medical College and Hospital — Ludhiana, India
• Fortis Hospital - Mohali — Mohali, India
• Topiwala National Medical College & B. Y. L. Nair Charitable Hospital — Mumbai, India
• Mysore Medical College — Mysore, India
• Midas Multispeciality Hospital Pvt.Ltd. — Nagpur, India
• All India Institute of Medical Sciences (AIIMS) - Nagpur — Nagpur, India
• All India Institute of Medical Sciences — New Delhi, India
• Sir Ganga Ram Hospital — New Delhi, India
• All India Institute of Medical Sciences - Rishikesh — Rishikesh, India
• Surat Institute of Digestive Sciences Hospitals — Surat, India
• Acharya Vinoba Bhave Rural Hospital — Wardha, India
• Barzilai Medical Center — Ashkelon, Israel
• Soroka Medical Center — Beersheba, Israel
• Rambam Health Care Campus — Haifa, Israel
• Carmel Hospital — Haifa, Israel
• Hadassah Medical Center — Jerusalem, Israel
• Shaare Zedek Medical Center — Jerusalem, Israel
• Maccabi Health Services - Petah Tikva — Petah Tikva, Israel
• Rabin Medical Center — Petah Tikva, Israel
• Sheba Medical Center — Ramat Gan, Israel
• Sourasky Medical Center — Tel Aviv, Israel
• Assuta Medical Center — Tel Aviv, Israel
• Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII — Bergamo, Italy
• IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola — Bologna, Italy
• Azienda Ospedaliera Universitaria Careggi — Florence, Italy
• Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico — Milan, Italy
• Azienda Ospedaliera Universitaria Federico II — Naples, Italy
• Azienda Ospedale - Università Padova — Padova, Italy
• A.O.U. Policlinico Paolo Giaccone — Palermo, Italy
• Fondazione Policlinico Universitario Agostino Gemelli — Roma, Italy
• Fondazione Policlinico Universitario Campus Bio-Medico — Rome, Italy
• IRCCS Istituto Clinico Humanitas — Rozzano, Italy
• Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino — Torino, Italy
• Policlinico GB Rossi Borgo Roma — Verona, Italy
• Kansai Rosai Hospital — Amagasaki, Japan
• Hyogo Prefectural Amagasaki General Medical Center — Amagasaki, Japan
• Asahikawa Medical University Hospital — Asahikawa, Japan
• Institute of Science Tokyo Hospital — Bunkyō, Japan
• Juntendo University Hospital — Bunkyō City, Japan
• The University of Tokyo Hospital — Bunkyō City, Japan
• Tokyo Metropolitan Komagome Hospital — Bunkyō City, Japan
• Fukuoka University Chikushi Hospital — Chikushino-shi, Japan
• Hamanomachi Hospital — Fukuoka, Japan
• Fukuoka University Hospital — Fukuoka, Japan
• Gifu Municipal Hospital — Gifu, Japan
• University of the Ryukyus Hospital — Ginowan, Japan
• Hamamatsu University Hospital — Hamamatsu, Japan
• Hiroshima University Hospital — Hiroshima, Japan
• National Kohnodai Medical Center — Ichikawa, Japan
• Nihon University Itabashi Hospital — Itabashiku, Japan
• Shimane University Hospital — Izumo, Japan
• Juntendo University Shizuoka Hospital — Izunokuni, Japan
• Kagoshima University Hospital — Kagoshima, Japan
• Nara Medical University Hospital — Kashihara, Japan
• St. Marianna University Hospital — Kawasaki, Japan
• Kagawa University Hospital — Kita-ku, Japan
• Yamanashi Prefectural Central Hospital — Kofu, Japan
• Kumamoto University Hospital — Kumamoto, Japan
• Kumamoto Shinto General Hospital — Kumamoto, Japan
• Kurume University Hospital — Kurume, Japan
• University Hospital,Kyoto Prefectural University of Medicine — Kyoto, Japan
• Saiseikai Maebashi Hospital — Maebashi, Japan
• Toranomon Hospital — Minatoku, Japan
• Tokyo Saiseikai Central Hospital — Minatoku, Japan
• Japanese Red Cross Musashino Hospital — Musashino-shi, Japan
• Nagasaki University Hospital — Nagasaki, Japan
• Meitetsu Hospital — Nagoya, Japan
• Nagoya City University Hospital — Nagoya, Japan
• International University of Health and Welfare Narita Hospital — Narita, Japan
• Hyogo Medical University Hospital — Nishinomiya, Japan
• Okayama University Hospital — Okayama, Japan
• National Hospital Organization Osaka National Hospital — Osaka, Japan
• Osaka Keisatsu Hospital — Osaka, Japan
• Osaka Metropolitan University Hospital — Osaka, Japan
• Osaka General Medical Center — Osaka, Japan
• Ogaki Municipal Hospital — Ōgaki, Japan
• Abe Clinic — Ōita, Japan
• Oita Cardiovascular Hospital — Ōita, Japan
• National Hospital Organization Nagasaki Medical Center — Ōmura, Japan
• Saga University Hospital — Saga, Japan
• Osaka Rosai Hospital — Sakai, Japan
• Bell Land General Hospital — Sakai, Japan
• Hokkaido University Hospital — Sapporo, Japan
• Jichi Medical University Hospital — Shimotsuke, Japan
• Tokyo Medical University Hospital — Shinjuku-ku, Japan
• National Center for Global Health and Medicine — Shinjyuku-ku, Japan
• Iwate Medical University Hospital — Shiwa-gun Yahaba-cho, Japan
• Osaka Saiseikai Suita hospital — Suita, Japan
• The University of Osaka Hospital — Suita, Japan
• Kagawa Prefectural Central Hospital — Takamatsu, Japan
• National Hospital Organization Takasaki General Medical Center — Takasaki, Japan
• Tokyo Women's Medical University — Tokyo, Japan
• Nagano Municipal Hospital — Tomitake, Japan
• Sekino Hospital — Toshimaku, Japan
• Ehime University Hospital — Tōon, Japan
• Mie University Hospital — Tsu, Japan
• National Hospital Organization Ureshino Medical Center — Ureshino, Japan
• Yamagata University Hospital — Yamagata, Japan
• Yokohama City University Hospital — Yokohama, Japan
• Medical Center Metas — Chihuahua City, Mexico
• Centro de Investigación y Gastroenterología — Cuauhtémoc, Mexico
• Instituto de Diabetes, Obesidad y Nutricion — Cuernavaca, Mexico
• Centro de Investigación Clínica y Medicina Traslacional (CIMeT) — Guadalajara, Mexico
• Private Practice - Dr. Arechavaleta Granell Maria del Rosario — Guadalajara, Mexico
• Unidad de Investigación Clínica y Atención Médica HEPA S.C. — Guadalajara, Mexico
• Centro Médico Lic. Arturo Montiel Rojas ISSEMYM — Metepec, Mexico
• Grupo Medico Camino Sc — Mexico City, Mexico
• Centro de Investigación y Gastroenterología - S.C. — Mexico City, Mexico
• Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares — Mexico City, Mexico
• Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran — Mexico City, Mexico
• Kohler & Milstein Research S.A. De C.V. — Mérida, Mexico
• CEINV Salud — Monterrey, Mexico
• Clinica de Enfermedades Cronicas y Procedimientos Especiales, SC — Morelia, Mexico
• Oncare Vasconcelos — San Pedro Garza García, Mexico
• Avant Sante Research Center — San Pedro Garza García, Mexico
• Fundación Santos y de la Garza Evía I.B.P — San Pedro Garza García, Mexico
• Instituto Veracruzano en Investigación Clínica S.C. — Veracruz, Mexico
• Hospital General de Occidente — Zapopan, Mexico
• Progress Clinical Research - Den Bosch — 's-Hertogenbosch, Netherlands
• Amsterdam UMC, locatie AMC — Amsterdam, Netherlands
• Radboudumc — Nijmegen, Netherlands
• Erasmus Medisch Centrum — Rotterdam, Netherlands
• Universitair Medisch Centrum Utrecht — Utrecht, Netherlands
• Progress Clinical Research - Zwolle — Zwolle, Netherlands
• New Zealand Clinical Research (Auckland) — Auckland, New Zealand
• Aotearoa Clinical Trials — Auckland, New Zealand
• Aotearoa Clinical Trials - Whangarei — Whangarei, New Zealand
• Oslo Universitetssykehus Ullevål — Oslo, Norway
• Universitetssykehuset Nord-Norge HF — Tromsø, Norway
• KRESMED Sp. z o.o. — Bialystok, Poland
• Centrum Badan Klinicznych PI-House sp. z o.o. — Gdansk, Poland
• Centrum Medyczne Pratia Katowice — Katowice, Poland
• Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero — Katowice, Poland
• Santa Familia PTG Lodz — Lodz, Poland
• ID Clinic — Mysłowice, Poland
• Uniwersyteckie Centrum Stomatologii i Medycyny Specjalistycznej — Poznan, Poland
• Private Practice - Dr. Lukasz Krupa — Rzeszów, Poland
• NZOZ GynCentrum - Oddział Warszawa — Warsaw, Poland
• Przychodnie Care Access — Warsaw, Poland
• Szpital Czerniakowski — Warsaw, Poland
• MTZ Clinical Research Powered by Pratia — Warsaw, Poland
• Państwowy Instytut Medyczny MSWiA — Warsaw, Poland
• Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś — Warsaw, Poland
• ETG Zamość — Zamość, Poland
• Associação Protectora dos Diabéticos de Portugal — Lisbon, Portugal
• Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria — Lisbon, Portugal
• Isis Clinical Research Center — Guaynabo, Puerto Rico
• Klinical Investigations Group — San Juan, Puerto Rico
• Delta Health Care — Bucharest, Romania
• Spitalul Clinic Colentina — Bucharest, Romania
• Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian Fodor — Cluj-Napoca, Romania
• Constanta County Emergency Clinical Hospital Sf.Ap.Andrei — Constanța, Romania
• Spital Judetean de Urgenta — Satu Mare, Romania
• Korea University Ansan Hospital — Ansan-si, South Korea
• Soon Chun Hyang University Bucheon Hospital — Bucheon-si, South Korea
• Pusan National University Yangsan Hospital — Busan, South Korea
• Yeungnam Univeristy Medical Center — Daegu, South Korea
• Keimyung University Dongsan Hospital — Daegu, South Korea
• Chung-Ang University Hospital — Dongjak-gu, South Korea
• Boramae Medical Center — Dongjak-gu, South Korea
• Hanyang University Guri Hospital — Guri-si, South Korea
• Inha University Hospital — Incheon, South Korea
• Gyeongsang National University Hospital — Jinju, South Korea
• Kyungpook National University Hospital — Junggu, South Korea
• Seoul National University Hospital — Seoul, South Korea
• The Catholic University of Korea, Eunpyeong St. Mary's Hospital — Seoul, South Korea
• Severance Hospital, Yonsei University Health System — Seoul, South Korea
• Severance Hospital, Yonsei University Health System — Seoul, South Korea
• Hanyang University Seoul Hospital — Seoul, South Korea
• Asan Medical Center — Seoul, South Korea
• Samsung Medical Center — Seoul, South Korea
• The Catholic Univ. of Korea Seoul St. Mary's Hospital — Seoul, South Korea
• Wonju Severance Christian Hospital — Wŏnju, South Korea
• CHUAC-Complejo Hospitalario Universitario A Coruña — A Coruña, Spain
• Hospital Germans Trias i Pujol — Badalona, Spain
• Hospital Universitari Vall d'Hebron — Barcelona, Spain
• Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval — Ferrol, Spain
• Hospital Infanta Elena — Huelva, Spain
• Hospital General Universitario Gregorio Marañon — Madrid, Spain
• Hospital Universitario La Paz — Madrid, Spain
• Hospital Universitari Son Espases — Palma, Spain
• CHOP - Hospital Universitario Montecelo — Pontevedra, Spain
• Hospital Universitario Marqués de Valdecilla — Santander, Spain
• Hospital Universitario Virgen Del Rocio — Seville, Spain
• Hospital Clinico de Valencia — Valencia, Spain
• Hospital Universitari i Politecnic La Fe — Valencia, Spain
• Universitetssjukhuset i Linköping — Linköping, Sweden
• University Hospital Basel — Basel, Switzerland
• Kantonsspital Olten — Olten, Switzerland
• Chiayi Christian Hospital — Chiayi City, Taiwan
• Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
• E-Da hospital — Kaohsiung City, Taiwan
• Chang Gung Memorial Hospital at Kaohsiung — Kaohsiung Niao Sung Dist, Taiwan
• Taipei Tzu Chi General Hospital — New Taipei City, Taiwan
• Fu Jen Catholic University Hospital — New Taipei City, Taiwan
• China Medical University Hospital — Taichung, Taiwan
• Taichung Veterans General Hospital — Taichung, Taiwan
• National Cheng Kung University Hospital — Tainan, Taiwan
• Chi Mei Medical Center — Tainan, Taiwan
• National Taiwan University Hospital — Taipei, Taiwan
• Cathay General Hospital — Taipei, Taiwan
• Taipei Medical University Hospital — Taipei, Taiwan
• Taipei Veterans General Hospital — Taipei, Taiwan
• Chang Gung Medical Foundation-Linkou Branch — Taoyuan, Taiwan
• Adana Sehir Egitim ve Arastirma Hastanesi — Adana, Turkey (Türkiye)
• Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi — Adana, Turkey (Türkiye)
• Hacettepe Universitesi — Ankara, Turkey (Türkiye)
• Ankara Bilkent Şehir Hastanesi — Ankara, Turkey (Türkiye)
• Bursa Şehir Hastanesi — Bursa, Turkey (Türkiye)
• T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik Eğitim Ve Araştirma Hastanesi — Pendik, Turkey (Türkiye)
• Recep Tayyip Erdogan University Training and Research Hospital — Rize, Turkey (Türkiye)
• Karadeniz Teknik Universitesi Tip Fakultesi — Trabzon, Turkey (Türkiye)
• Clinical Diagnostic Center — Ivano-Frankivsk, Ukraine
• Medical Center of Limited Liability Company "Medical Center "Consilium Medical" — Kiev, Ukraine
• Edelweiss Medics — Kyiv, Ukraine
• Medical Center Ok!Clinic+ — Kyiv, Ukraine
• Medbud Clinic — Kyiv, Ukraine
• Center of Family Medicine Plus — Kyiv, Ukraine
• Progastro Clinic — Lviv, Ukraine
• Medical Center Salutem — Vinnytsia, Ukraine
• Limited liability company "Medical center Health Clinic" — Vinnytsia, Ukraine
• Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia Regio -T — Vinnytsia, Ukraine
• CRZ Vidnovlennya — Zhytomyr, Ukraine
• Aberdeen Royal Infirmary — Aberdeen, United Kingdom
• 4 Medical Solutions, Ltd - Manchester — Clifton, United Kingdom
• Panthera Biopartners - North London — Enfield, United Kingdom
• Panthera Biopartners - Glasgow — Glasgow, United Kingdom
• Ipswich Hospital — Ipswich, United Kingdom
• Liverpool University Hospitals NHS Foundation Trust — Liverpool, United Kingdom
• Royal London Hospital — London, United Kingdom
• 4 Medical Solutions, Ltd - London — London, United Kingdom
• Royal Free Hospital — London, United Kingdom
• King's College Hospital — London, United Kingdom
• Freeman Hospital — Newcastle upon Tyne, United Kingdom
• The John Radcliffe Hospital — Oxford, United Kingdom
• Atlantic Medical — Penzance, United Kingdom
• Panthera Biopartners - Preston — Preston, United Kingdom
• Panthera Biopartners - Manchester — Rochdale, United Kingdom
• Panthera Biopartners - Sheffield — Sheffield, United Kingdom
• Panthera Clinic - York — York, United Kingdom