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Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts

Sponsor: Saglik Bilimleri Universitesi • ClinicalTrials.gov ID: NCT07146776

Registry updated: 2026-09-11

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Description

The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.

Interventions

open flap debridement with I-prf and xenogeneic graft (Procedure)
During the surgical phase of treatment, patients will undergo open flap debridement surgery. Infiltrative local anesthesia will first be administered to the involved teeth. The gingiva will be incised within the gingival sulcus using a scalpel, and a full-thickness flap will be carefully elevated with a periosteal elevator. Granulation tissue and dental calculus will be completely removed using Gracey curettes (American Eagle, USA) and an ultrasonic scaler. Subsequently, a xenogeneic bone graft mixed with injectable platelet-rich fibrin (i-PRF) will be applied. The flap will then be sutured using 4-0 polypropylene sutures.
open flap debridement with saline and xenogenic graft (Procedure)
During the surgical phase of treatment, patients will undergo open flap debridement surgery. Infiltrative local anesthesia will first be administered to the involved teeth. The gingiva will be incised within the gingival sulcus using a scalpel, and a full-thickness flap will be carefully elevated with a periosteal elevator. Granulation tissue and dental calculus will be thoroughly removed using Gracey curettes (American Eagle, USA) and an ultrasonic scaler. A xenogeneic bone graft mixed with physiological saline will then be applied. Finally, the flap will be sutured using 4-0 polypropylene sutures.

Eligibility criteria

Inclusion Criteria: * Male and female patients aged 18-65 years * Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification * PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment) * Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm * Non-smokers (those who smoke up to 10 per day may be included) Exclusion Criteria: * Patients under 18 years of age or older than 65 years of age * Patients unable to consent * Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes * Single-walled intrabony defects * Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study * Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year * Smoking more than 10 cigarettes per day * Pregnancy or breastfeeding * Those taking medications that affect the gums (e.g., calcium channel blockers, phenytoin or cyclosporine) * Teeth with furcation defects * Those undergoing active orthodontic treatment * Those who are allergic to the biomaterials used in the study or prescribed medications

Conditions

Periodontitis Intrabony Periodontal Defect Periodontal Diseases Periodontal Defect Periodontal Bone Loss

Locations

Sağlık Bilimleri Üniversitesi — Istanbul, Üsküdar, Turkey (Türkiye)

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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