RECRUITING Phase 3 ClinicalTrials.gov

Short-term Low-dose Low-molecular-weight Heparin to Prevent Postpartum Thrombosis

Sponsor: Marc Blondon • ClinicalTrials.gov ID: NCT07140211

Registry updated: 2026-10-06

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Description

The goal of this clinical trial is to evaluate the risk-benefit of a short-term treatment with a low-dose low-molecular-weight heparin (LMWH), in the postpartum period (after delivery). The main questions it aims to answer are: * compared to no treatment, does short-term postpartum LMWH modify the risk of venous thromboembolism within 90 days of delivery? * compared to no treatment, does short-term postpartum LMWH modify the risks of bleeding and wound complications? Participants will take low-dose LMWH for 7-10 days or no treatment, and will be followed for 90 days post-delivery.

Interventions

Low-dose low-molecular-weight heparin (Drug)
Low-molecular-weight heparin given for 7-10 days after delivery: * enoxaparin 4000-6000IU o.d. * nadroparin 3800-5700IU o.d. * dalteparin 5000-7500IU o.d. * tinzaparin 4500-7000IU o.d.

Eligibility criteria

Inclusion Criteria: postpartum women after delivery AND ≥1 major risk factor / ≥2 minor risk factors: * Major risk factors: Emergency cesarean section ; Pre-pregnancy BMI ≥35kg/m2 ; Known low-risk thrombophilia (heterozygous factor V Leiden; heterozygous G20210 prothrombin mutation) ; Pre-eclampsia ; Pre-term delivery ; Peripartum systemic infection ; Intra-uterine growth restriction ; Pregnancy loss * Minor risk factors: Age ≥35 years ; Pre-pregnancy BMI 30.0-34.9kg/m2 ; Current smoking ; Elective cesarean section ; Postpartum hemorrhage ; Antenatal immobility Exclusion Criteria: * ≥2 doses of postpartum LMWH * Any indication for therapeutic anticoagulation * A high-risk of postpartum VTE * An increased bleeding risk * A contra-indication to heparin

Conditions

Venous Thromboembolism (VTE) Postpartum

Locations

Kantonsspital Baden — Baden, Switzerland
Universitätsspital Basel — Basel, Switzerland
Lindenhofspital — Bern, Switzerland
Geneva University Hospitals — Geneva, Switzerland
Centre Hospitalier Universitaire Vaudois — Lausanne, Switzerland
Luzerner Kantonspital — Lucerne, Switzerland
Ente Ospedaliero Cantonale — Lugano, Switzerland
Réseau Hospitalier Neuchâtelois — Neuchâtel, Switzerland
Hôpital du Valais — Sion, Switzerland

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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