RECRUITING Phase 3 ClinicalTrials.gov

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

Sponsor: Amgen • ClinicalTrials.gov ID: NCT07136012

Registry updated: 2026-08-21

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Description

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Interventions

Olpasiran (Drug)
Olpasiran will be administered via SC injection.
Placebo (Drug)
Placebo will be administered via SC injection.

Eligibility criteria

Inclusion Criteria: * Age ≥50 years * Lp(a)≥ 200 nmol/L during screening * Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis Exclusion Criteria: * Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia) * Prior or planned arterial revascularization * History of major bleeding disorder

Conditions

Cardiovascular Disease

Locations

Advanced Cardiovascular LLC — Alexander City, Alabama, United States
University of Alabama Birmingham Saint Vincents Birmingham — Birmingham, Alabama, United States
Birmingham Clinical Research — Birmingham, Alabama, United States
Alliance For Multispecialty Research - Daphne — Daphne, Alabama, United States
Eastern Shore Research Institute — Fairhope, Alabama, United States
Heart Center Research LLC — Huntsville, Alabama, United States
CB Flock Research Corporation — Mobile, Alabama, United States
Phoenix Clinical — Phoenix, Arizona, United States
Elite Clinical Studies LLC — Phoenix, Arizona, United States
Hero Clinical Research — Phoenix, Arizona, United States
HonorHealth Research Institute — Scottsdale, Arizona, United States
Eclipse Clinical Research — Tucson, Arizona, United States
Lynn Institute of the Ozarks — Little Rock, Arkansas, United States
National Heart Institute — Beverly Hills, California, United States
310 Clinical Research — Inglewood, California, United States
University of California San Diego — La Jolla, California, United States
InvivoCure — Los Angeles, California, United States
Valley Clinical Trials — Northridge, California, United States
Clinical Trials Research - Sacramento — Roseville, California, United States
Alliance Clinical Research — San Diego, California, United States
Encompass Clinical Research — Spring Valley, California, United States
Stanford Health Care — Stanford, California, United States
Manshadi Heart Institute — Stockton, California, United States
Blue Coast Cardiology — Vista, California, United States
Diablo Clinical Research — Walnut Creek, California, United States
Focus Clinical Research — West Hills, California, United States
Interventional Cardiology Medical Group — West Hills, California, United States
UCHealth Memorial Central — Colorado Springs, Colorado, United States
South Denver Cardiology Associates — Littleton, Colorado, United States
Gandelman Cardiology, PC — Greenwich, Connecticut, United States
ClinTrial Hamden — Hamden, Connecticut, United States
Chase Medical Research LLC — Waterbury, Connecticut, United States
Excel Medical Clinical Trials — Boca Raton, Florida, United States
Clearwater Cardiovascular Consultants — Clearwater, Florida, United States
Proactive Clinical Research — Fort Lauderdale, Florida, United States
Elite Cardiac Research Center LLC — Hialeah, Florida, United States
Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
East Coast Institute for Research, LLC — Lake City, Florida, United States
Columbus Clinical Services LLC — Miami, Florida, United States
Kendall South Medical Center — Miami, Florida, United States
Inpatient Research Clinic, LLC — Miami Lakes, Florida, United States
Panax Clinical Research — Miami Lakes, Florida, United States
Indago Research and Health Center — Miami Lakes, Florida, United States
Eminat, LLC — Miramar, Florida, United States
Suncoast Clinical Research Inc — New Port Richey, Florida, United States
Ocala Cardiovascular Research — Ocala, Florida, United States
Ocala Research Institute, Inc — Ocala, Florida, United States
Ormond Beach Clinical Research — Ormond Beach, Florida, United States
Baptist Health Care — Pensacola, Florida, United States
Denali Health Plant City — Plant City, Florida, United States
FWD Clinical Research — Tamarac, Florida, United States
Clinical Site Partners Orlando dba Flourish Research — Winter Park, Florida, United States
Guardian Research Organization LLC — Winter Park, Florida, United States
Emory University Hospital — Atlanta, Georgia, United States
East Coast Institute for Research — Canton, Georgia, United States
Northeast Georgia Medical Center Wisteria Building — Cumming, Georgia, United States
Nsc Research — Johns Creek, Georgia, United States
Georgia Clinical Research — Lawrenceville, Georgia, United States
North Georgia Clinical Research — Woodstock, Georgia, United States
St Lukes Idaho — Meridian, Idaho, United States
Solaris Clinical Research — Meridian, Idaho, United States
Endeavor Health-Northwest Community Healthcare — Arlington Heights, Illinois, United States
Christie Clinic — Champaign, Illinois, United States
Advocate Lutheran General Hospital — Park Ridge, Illinois, United States
Alliance for Multispecialty Research LLC - Park Ridge — Park Ridge, Illinois, United States
MediSphere Medical Research Center LLC — Evansville, Indiana, United States
Parkview Research Center — Fort Wayne, Indiana, United States
Franciscan Health Indianapolis — Indianapolis, Indiana, United States
Ascension Saint Vincent Heart Center — Indianapolis, Indiana, United States
Cardiovascular Research of Northwest Indiana LLC — Munster, Indiana, United States
Reid Physician Associates — Richmond, Indiana, United States
MercyOne Iowa Heart Center — West Des Moines, Iowa, United States
Hutchinson Clinic PA — Hutchinson, Kansas, United States
University of Kansas Medical Center — Kansas City, Kansas, United States
Midwest Heart and Vascular Specialists — Overland Park, Kansas, United States
Graves Gilbert Clinic — Bowling Green, Kentucky, United States
Baptist Health Lexington — Lexington, Kentucky, United States
The Research Group of Lexington LLC — Lexington, Kentucky, United States
Heart Clinic of Hammond — Covington, Louisiana, United States
IMA Clinical Research — Monroe, Louisiana, United States
Louisiana Heart Center — Slidell, Louisiana, United States
Monroe Research LLC — West Monroe, Louisiana, United States
Ascension Saint Agnes Heart Care — Baltimore, Maryland, United States
Johns Hopkins Hospital — Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC — Beltsville, Maryland, United States
Suburban Hospital — Bethesda, Maryland, United States
Flourish Research — Bowie, Maryland, United States
Johns Hopkins University — Columbia, Maryland, United States
Centennial Medical Group — Columbia, Maryland, United States
Capitol Cardiology Associates — Lanham, Maryland, United States
MedStar Health Research Institute — Olney, Maryland, United States
Brigham and Womens Hospital — Boston, Massachusetts, United States
Henry Ford Health System — Detroit, Michigan, United States
Healthy Heart Cardiology — Grand Rapids, Michigan, United States
MyMichigan Medical Center Midland - Clinical Research Department — Midland, Michigan, United States
Advanced Cardiology Associates — Rochester Hills, Michigan, United States
Revival Research Institute — Southfield, Michigan, United States
Saint Marys Medical Center — Duluth, Minnesota, United States
Health East Cancer Care — Maplewood, Minnesota, United States
University of Minnesota — Minneapolis, Minnesota, United States
Mayo Clinic — Rochester, Minnesota, United States
Methodist Hospital — Saint Louis Park, Minnesota, United States
Jackson Heart Clinic — Jackson, Mississippi, United States
Cardiology Associates Research LLC — Tupelo, Mississippi, United States
Sisters of Saint Mary Health Heart and Vascular Care — Bridgeton, Missouri, United States
Kansas City Veterans Affairs Medical Center — Kansas City, Missouri, United States
Washington University — St Louis, Missouri, United States
Bryan Heart — Lincoln, Nebraska, United States
Physician Research Collaboration, LLC — Lincoln, Nebraska, United States
Excel Clinical Research — Las Vegas, Nevada, United States
American Institute of Medical Research — Las Vegas, Nevada, United States
Las Vegas Clinical Trials — North Las Vegas, Nevada, United States
Renown Institute for Heart and Vascular Health — Reno, Nevada, United States
Advanced Heart Care LLC — Bridgewater, New Jersey, United States
Advanced Heart and Vascular Institute of Hunterdon — Flemington, New Jersey, United States
Clinical Reseach Philadelphia Pennington — Hamilton, New Jersey, United States
Med Clinical Research Partners - Irvington — Irvington, New Jersey, United States
New Jersey Medcare / New Jersey Heart — Linden, New Jersey, United States
Saint Michaels Medical Center — Newark, New Jersey, United States
Circuit Clinical / Optum Medical Care of New Jersey — Secaucus, New Jersey, United States
The Heart House - Washington Township — Sewell, New Jersey, United States
CardioMetabolic Collaborative Clinic — Somerset, New Jersey, United States
Ima Clinical Research - Warren — Warren Township, New Jersey, United States
Albany Medical College — Albany, New York, United States
Basil Clinical — Inwood, New York, United States
Rasai Research — Jackson Heights, New York, United States
Crystal Run Healthcare — Monroe, New York, United States
Icahn School of Medicine at Mount Sinai — New York, New York, United States
Mount Sinai Queens — New York, New York, United States
Ima Clinical Research Manhattan — New York, New York, United States
Niagara Falls Memorial Medical Center — Niagara Falls, New York, United States
Circuit Clinical Orchard Park Family Practice — Orchard Park, New York, United States
Hudson Valley Cardiovascular Physicians PC — Poughkeepsie, New York, United States
Saratoga Clinical Research, LLC — Saratoga Springs, New York, United States
Duke University Health System — Durham, North Carolina, United States
Moses H Cone Memorial Hospital — Greensboro, North Carolina, United States
Medication Management LLC — Greensboro, North Carolina, United States
Triad Clinical Trials, LLC — Greensboro, North Carolina, United States
ClinCept, LLC — Kinston, North Carolina, United States
Monroe Biomedical Research — Monroe, North Carolina, United States
Piedmont Healthcare — Statesville, North Carolina, United States
Accellacare Research of Wilmington — Wilmington, North Carolina, United States
Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
Lillestol Research LLC — Fargo, North Dakota, United States
Aultman Cardiology Clinical Trials — Canton, Ohio, United States
The Christ Hospital — Cincinnati, Ohio, United States
Velocity Clinical Research - Cincinnati — Cincinnati, Ohio, United States
Nexgen Research — Lima, Ohio, United States
K and R Research — Marion, Ohio, United States
Alliance for Multispecialty Research — Norman, Oklahoma, United States
University of Pennsylvania — Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians, Inc — Pittsburgh, Pennsylvania, United States
Pottstown Medical Specialists Inc — Pottstown, Pennsylvania, United States
Miriam Hospital — East Greenwich, Rhode Island, United States
Pharmacorp Clinical Trials Inc — Charleston, South Carolina, United States
Medical University of South Carolina — Charleston, South Carolina, United States
Prisma Health Carolina Cardiology - Greenville — Gantt, South Carolina, United States
Walker Family Care — Little River, South Carolina, United States
Accellacare Charleston — Mt. Pleasant, South Carolina, United States
Tribe Clinical Research - Spartanburg — Spartanburg, South Carolina, United States
Monument Health Clinical Research — Rapid City, South Dakota, United States
Erlanger Health, Inc. — Chattanooga, Tennessee, United States
Apex Research Foundation, LLC — Jackson, Tennessee, United States
Alliance for Multispecialty Research Knoxville — Knoxville, Tennessee, United States
Ascension Saint Thomas — Nashville, Tennessee, United States
Parkway Cardiology Associates — Oak Ridge, Tennessee, United States
Tennessee Center for Clinical Trials — Tullahoma, Tennessee, United States
PharmaTex Research, LLC — Amarillo, Texas, United States
Texas Diabetes and Endocrinology — Austin, Texas, United States
Ima Clinical Research — Austin, Texas, United States
Pioneer Medical Associates — Carrollton, Texas, United States
Baylor Scott and White Heart and Vascular Hospital-Dallas — Dallas, Texas, United States
Zenos Clinical Research — Dallas, Texas, United States
The Heartbeat Clinic — Dallas, Texas, United States
Cedar Health Research, LLC — Dallas, Texas, United States
Cedar Health Research, LLC — Euless, Texas, United States
East Texas Cardiology PA — Houston, Texas, United States
Baylor College of Medicine — Houston, Texas, United States
Cardiovascular Specialists of Willowbrook — Houston, Texas, United States
Vital Heart and Vein — Humble, Texas, United States
Tcr Institute Llc — Kingwood, Texas, United States
Epic Clinical Research — Lewisville, Texas, United States
Texas Tech University Health Sciences Center — Lubbock, Texas, United States
North Dallas Research Associates — McKinney, Texas, United States
Revival Research Institute — McKinney, Texas, United States
Texas Institute of Cardiology — McKinney, Texas, United States
Southern Endocrinology Associates PA — Mesquite, Texas, United States
Orion Medical — Pasadena, Texas, United States
Valley Institute of Research Plano — Plano, Texas, United States
Ima Clinical Research San Antonio — San Antonio, Texas, United States
St Davids Heart & Vascular PLLC dba Austin Heart — San Marcos, Texas, United States
Tyler Cardiovascular Consultants — Tyler, Texas, United States
Alpine Research Organization — Layton, Utah, United States
Inova Cardiology - Fairfax — Fairfax, Virginia, United States
Virginia Heart — Falls Church, Virginia, United States
Virginia Heart - Loudoun — Leesburg, Virginia, United States
Carient Heart and Vascular — Manassas, Virginia, United States
Bon Secours Cardiology — Midlothian, Virginia, United States
Tidewater Physicians Multispecialty Group Clinical Research — Newport News, Virginia, United States
Alliance for Multispecialty Research Norfolk — Norfolk, Virginia, United States
Centricity Research — Suffolk, Virginia, United States
Selma Medical Associates — Winchester, Virginia, United States
Winchester Medical Center — Winchester, Virginia, United States
Western Washington Medical Group — Everett, Washington, United States
Rainier Clinical Research Center — Renton, Washington, United States
Canberra Hospital — Garran, Australian Capital Territory, Australia
Royal Prince Alfred Hospital — Camperdown, New South Wales, Australia
Novatrials — Charlestown, New South Wales, Australia
Concord Repatriation General Hospital — Concord, New South Wales, Australia
Aim Research — Merewether, New South Wales, Australia
Orange Health Service — Orange, New South Wales, Australia
Wollongong Hospital — Wollongong, New South Wales, Australia
Advara HeartCare Wesley — Auchenflower, Queensland, Australia
Core Research Group Pty Ltd — Milton, Queensland, Australia
University of The Sunshine Coast Clinical Trials, Sippy Downs — Sippy Downs, Queensland, Australia
Dr Heart Pty Ltd — Woolloongabba, Queensland, Australia
Flinders Medical Centre — Bedford Park, South Australia, Australia
Advara HeartCare Leabrook — Leabrook, South Australia, Australia
Fusion Clinical Research — Norwood, South Australia, Australia
Victorian Heart Hospital — Clayton, Victoria, Australia
The Alfred Hospital — Melbourne, Victoria, Australia
Momentum Clinical Research - Sunshine — Melbourne, Victoria, Australia
Clinitrials - Mandurah — Greenfields, Western Australia, Australia
Advara HeartCare Joondalup — Joondalup, Western Australia, Australia
Hollywood Private Hospital — Nedlands, Western Australia, Australia
Linear Clinical Research Limited — Nedlands, Western Australia, Australia
Clinitrials - West Perth — Perth, Western Australia, Australia
Centricity Research Calgary — Calgary, Alberta, Canada
Edmonton Cardiology Consultants — Edmonton, Alberta, Canada
Fraser Clinical Trials — New Westminster, British Columbia, Canada
SMH Cardiology Clinical Trials Incorporated — Surrey, British Columbia, Canada
ARC Biosystems Incorporated — Vancouver, British Columbia, Canada
Victoria Heart Institute Foundation — Victoria, British Columbia, Canada
Discovery Clinical Services Ltd — Victoria, British Columbia, Canada
Centricity Research Brampton — Brampton, Ontario, Canada
Circulate Cardiac & Vascular Centre — Burlington, Ontario, Canada
Cambridge Cardiac Care Centre — Cambridge, Ontario, Canada
Hamilton Health Sciences Hamilton General Hospital — Hamilton, Ontario, Canada
Premier Clinical Trial Network — Hamilton, Ontario, Canada
St Josephs Hospital — London, Ontario, Canada
Elevate Clinical Research KMH Missisauga — Mississauga, Ontario, Canada
Partners in Advanced Cardiac Evaluation — Newmarket, Ontario, Canada
North York Diagnostic and Cardiac Centre — North York, Ontario, Canada
Oakville Cardiovascular Research — Oakville, Ontario, Canada
Heart Health Institute Research Incorporated — Scarborough Village, Ontario, Canada
Womens College Hospital — Toronto, Ontario, Canada
Ecogene-21 — Chicoutimi, Quebec, Canada
Montreal Heart Institute — Montreal, Quebec, Canada
Institut de recherches cliniques de Montreal — Montreal, Quebec, Canada
Centre de Recherche du Centre Hospitalier de l Universite de Montreal — Montreal, Quebec, Canada
Research Institute of McGill University Health Center - Glen Site — Montreal, Quebec, Canada
CIUSSS de l Estrie CHUS Hopital Fleurimont — Sherbrooke, Quebec, Canada

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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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