N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Phase 2 ClinicalTrials.gov

A Study of MHB036C Combined With MHB039A in Patients With Advanced Breast Cancer or Other Advanced Malignant Solid Tumors

Sponsor: Minghui Pharmaceutical (Hangzhou) Ltd • ClinicalTrials.gov ID: NCT07130383

Registry updated: 2026-10-09
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

This is an open-label, multicenter Phase II study of MHB036C combined with MHB039A in patients with advanced Breast Cancer or other advanced malignant solid tumors. The study was designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of MHB036C and MHB039A combination therapy.

Interventions

  • MHB036C for Injection (Drug)
    Intravenous administration
  • MHB039A for Injection (Drug)
    Intravenous administration

Eligibility criteria

Inclusion Criteria: 1. Voluntarily agrees to participate in the study and signs the informed consent form. 2. Age ≥ 18 and ≤75 years, no restriction on gender. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. 4. Estimated life expectancy ≥ 3 months. 5. Histologically or cytologically confirmed locally advanced or metastatic advanced solid tumors. 6. At least one measurable lesion per RECIST v1.1 criteria. 7. Adequate bone marrow reserve and organ function. 8. Eligible participants of childbearing potential (males and females) must agree to take highly reliable contraceptive measures with their partners during the study and within at least 12 weeks after the last dose. \- Exclusion Criteria: 1. History of ≥2 primary malignancies within 5 years prior to informed consent. 2. Received anti-tumor treatment within 4 weeks or within the 5 half-lives of the previous treatment (whichever is shorter) before dosing. 3. Medication of other unmarketed investigational drugs or therapies within 4 weeks before dosing. 4. Undergone major organ surgery (excluding biopsy) or significant trauma within 4 weeks before dosing or requiring elective surgery during the study. 5. Vaccinated with attenuated live vaccines within 4 weeks before dosing. 6. Treated with with systemic corticosteroids within 14 days before dosing. 7. Central nervous system metastasis. 8. Uncontrolled third-space effusion. 9. Serious cardiovascular or cerebrovascular diseases. 10. Severe lung disease affecting pulmonary function. 11. Active infection requiring systemic therapy. 12. Known hypersensitivity or delayed allergic reaction to the investigational product or its components. 13. Drug abuse or other medical/psychiatric condition that may interfere with study participation or results. 14. Known alcohol or drug dependence. 15. Pregnant or breastfeeding women, or individuals planning to conceive.

Conditions

Advanced Breast Cancer Advanced Malignant Solid Tumor

Locations

  • Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record