Visugromab in Cachexia International Trial

Description

A study of how well and safely a new drug called visugromab works in people with certain kinds of cancer (including lung and bowel cancer) and unintended weight loss known as cachexia. The main questions it aims to answer are: * Does visugromab help participants put weight back on and have a better appetite? * Does visugromab help participants move more and better? * What medical problems do participants have when taking visugromab? Researchers will compare visugromab to a placebo (a look-alike substance that contains no drug). Participants will visit the hospital or clinic once every 4 weeks to receive visugromab or placebo via a drip into a vein and to undergo checkups and tests.

Interventions

• Visugromab (CTL-002) (Drug)
  High dose
• Placebo (Drug)
  IV infusion
• Visugromab (CTL-002) (Drug)
  Medium dose
• Visugromab (CTL-002) (Drug)
  Low dose

Eligibility criteria

Conditions

Locations

• Eastern Connecticut Hematology & Oncology — Norwich, Connecticut, United States
• Clermont Oncology Center — Clermont, Florida, United States
• Mid Florida Hematology and Oncology Centers — Orange City, Florida, United States
• Cleveland Clinic Martin Health — Stuart, Florida, United States
• Augusta University Medical Center — Augusta, Georgia, United States
• Astera Cancer Care — East Brunswick, New Jersey, United States
• Cleveland Clinic Avon Hospital — Avon, Ohio, United States
• Cleveland Clinic (Main Campus) — Cleveland, Ohio, United States
• Cleveland Clinic Fairview Hospital — Fairview, Ohio, United States
• Cleveland Clinic Hillcrest Hospital — Mayfield Heights, Ohio, United States
• Specialized Hospital for Active Treatment in Oncology — Haskovo, Bulgaria
• Medical Centre Futuremeds Plovdiv — Plovdiv, Bulgaria
• University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna-ISUL — Sofia, Bulgaria
• Complex Oncology Center - Vratsa EOOD — Vratsa, Bulgaria
• Multiscan, s.r.o., Nemocnice Horovice — Hořovice, Czechia
• Fakultni nemocnice Hradec Kralove — Hradec Králové, Czechia
• Fakultni nemocnice Olomouc — Olomouc, Czechia
• Vseobecna fakultni nemocnice v Praze — Prague, Czechia
• Fakultni nemocnice v Motole — Prague, Czechia
• CHRU de Brest - Hopital Morvan — Brest, France
• AP-HP Hôpital Henri Mondor — Créteil, France
• Léon Bérard Center (Centre Léon Bérard) — Lyon, France
• HCL Centre Hospitalier Lyon Sud — Lyon, France
• Centre Paul Strauss — Strasbourg, France
• Johanniter Krankenhaus Bonn — Bonn, Germany
• University Hospital Carl Gustav Carus Dresden (Universitätsklinikum Carl Gustav Carus Dresden) — Dresden, Germany
• LungenClinic Grosshansdorf GmbH — Großhansdorf, Germany
• Muenchen Klinik Neuperlach — München, Germany
• Centro Riferimento Oncologico - Aviano — Aviano, Italy
• ASST degli Spedali Civili di Brescia — Brescia, Italy
• Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna — Ferrara, Italy
• IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST S.r.l. — Meldola, Italy
• Centro Ricerche Cliniche di Verona — Verona, Italy
• Haukeland University Hospital — Bergen, Norway
• Sorlandet sykehus HF - Kristiansand — Kristiansand, Norway
• Oslo University Hospital — Oslo, Norway
• Akershus University Hospital — Oslo, Norway
• St. Olavs hospital HF, Universitetssykehuset i Trondheim — Trondheim, Norway
• Pratia Onkologia Katowice — Katowice, Poland
• Jagiellońskie Centrum Innowacji Sp. z o.o. — Krakow, Poland
• Pratia MCM Kraków — Krakow, Poland
• FutureMeds Krakow — Krakow, Poland
• Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie — Krakow, Poland
• Futuremeds Łódź — Lodz, Poland
• Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi. — Lodz, Poland
• MS CLINSEARCH Specjalistyczny NZOZ Janusz Milanowski, Katarzyna Szmygin - Milanowska Sp. j. — Lublin, Poland
• FutureMeds Targówek — Warsaw, Poland
• Pratia Onkologia Wrocław — Wroclaw, Poland
• FutureMeds Sp.zo.o - FutureMeds Wrocław — Wroclaw, Poland
• Futuremeds Romania Brasov — Brasov, Romania
• Oncolab Craiova — Craiova, Romania
• St. Nectarie Oncology Center, Craiova — Craiova, Romania
• Futuremeds Romania Galati — Galati, Romania
• Spitalul Pelican Oradea — Oradea, Romania
• Ovidius Clinical Hospital — Ovidiu, Romania
• Gral Medical - Oncofort Hospital Pitesti — Piteşti, Romania
• Oncomed S.R.L. — Timișoara, Romania
• University Hospital of A Coruña (Hospital Universitario de A Coruña) — A Coruña, Spain
• Hospital Clinic Barcelona — Barcelona, Spain
• Futuremeds Hospital Viamed Santa Elena — Madrid, Spain
• Hospital Universitario Puerta de Hierro — Majadahonda, Spain
• Tumor Zentrum Aarau — Aarau, Switzerland
• Universitaetsspital Basel — Basel, Switzerland
• Istituto Oncologico della Svizzera Italiana — Bellinzona, Switzerland
• Gruppo Ospedaliero Moncucco - Clinica Moncucco — Lugano, Switzerland
• Cantonal Hospital St. Gallen (Kantonsspital St. Gallen) — Sankt Gallen, Switzerland
• University Hospital of Zurich (Universitätsspital Zürich) — Zurich, Switzerland
• Royal Sussex County Hospital — Brighton, United Kingdom
• Addenbrooke's Hospital — Cambridge, United Kingdom
• Ninewells Hospital — Dundee, United Kingdom
• Western General Hospital — Edinburgh, United Kingdom
• Royal Surrey County Hospital — Guildford, United Kingdom
• The Christie — Manchester, United Kingdom
• Freeman Hospital — Newcastle upon Tyne, United Kingdom