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RECRUITING Not applicable ClinicalTrials.gov

Aerobic Exercise and Obsessive-Compulsive Disorder Symptoms

Sponsor: Yale University • ClinicalTrials.gov ID: NCT07103902

Registry updated: 2026-09-29
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Description

The purpose of this study is to examine the acute effects of exercise on cognitive flexibility and symptom reactivity. The main questions it aims to answer are: Does moderate intensity physical activity reduce subjective distress, compulsive urges, and intrusions- and increase cognitive flexibility- in adults with obsessive-compulsive disorder compared to low-intensity physical activity? Researchers will compare low- to moderate-intensity exercise to see if moderate physical activity increases cognitive flexibility and reduces symptom reactivity in adults with obsessive-compulsive disorder (OCD). Participants will: Complete self-report surveys, psychiatric interviews, and cognitive tasks. Be assigned to either a low- or moderate-intensity exercise condition and complete physical activity. Repeat cognitive and symptom measures following the exercise intervention.

Interventions

  • Moderate-Intensity Exercise (Behavioral)
    Participants will engage in 20 minutes of cycling at approximately 70% max heart rate with a 2.5 minute warm up and a 2.5 minute cool down.
  • Low-Intensity Exercise (Behavioral)
    Participants will engage in 20 minutes of cycling at approximately 40-50% max heart rate with a 2.5 minute warm up and a 2.5 minute cool down.

Eligibility criteria

Inclusion Criteria: * Adults, age 18 to 64 years * Meet diagnostic criteria for OCD (per the DIAMOND) * Stable psychiatric or medication treatment (if ≥4-weeks), or if no active treatment. Psychotropic medications will be reviewed with the study psychiatrist on a case by case basis. Exclusion Criteria: * Active or unmanaged psychotic disorders, pervasive developmental disorders, bipolar disorder, current substance use disorder (moderate-to-severe), or high risk for suicide (defined as attempt, plan, or intent within past 3 months) * Documented motor impairments and medical condition(s) that prohibit physical exercise * Those who are pregnant or trying to become pregnant

Conditions

Obsessive-Compulsive Disorder (OCD)

Locations

  • Temple Medical Center — New Haven, Connecticut, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record