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Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation

Sponsor: University Hospital, Strasbourg, France • ClinicalTrials.gov ID: NCT07067736

Registry updated: 2026-08-20

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Description

The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections. The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.

Interventions

Cefazolin antibiotic prophylaxis (Other)
Determination of cerebrospinal fluid concentration

Eligibility criteria

Inclusion Criteria: Age \>18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg. Exclusion Criteria: * Age \<18 years old * Pregnant women * Infected patients * Known cefazolin allergy * Other molecule used for the antibiotic prophylaxis * Guardianship or conservatorship * Patients under curative antibiotherapy * Non sterile pre operative CSF * Refusal to participate

Conditions

Hydrocephaly CSF Shunts Antibiotic Prophylaxis

Locations

Hôpitaux Universitaires de Strasbourg — Strasbourg, France

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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