A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

Description

The purpose of this study is to learn about the safety and effects of the study medicine PF-07248144 when given along with fulvestrant for the possible treatment of HR-positive, HER2-negative advanced or metastatic breast cancer. HR-positive breast cancer cells have proteins on their surface called receptors that bind to hormones like estrogen and progesterone (female sex hormones). These hormones can promote the growth of cancer cells. HER2-negative describes cells that have a small amount or none of a protein called HER2 on their surface. In normal cells, HER2 helps control cell growth. Cancer cells that are HER2-negative may grow more slowly and are less likely to recur (come back) or spread to other parts of the body than cancer cells that have a large amount of HER2 on their surface. Advanced cancer is a term that is often used to describe cancer that is unlikely to be cured. Metastatic cancer is the type where the cancer cells spread from one part of the body to another. This study is seeking for participants whose breast cancer has gotten worsen after receiving cyclin dependent kinase (CDK) 4/6 inhibitor-based therapy. Half of participants in this study will receive their usual study treatment, everolimus with endocrine therapy (either exemestane or fulvestrant) for HR-positive/HER2-negative advanced or metastatic breast cancer (A/mBC). The study doctor will discuss which hormone therapy is right for the participant before treatment begins. PF-07248144 is a tablet that will be taken by mouth at home every day in a 28-day cycle. Fulvestrant will be given as two injections (one injection in the buttock) at visits to the study clinic. Everolimus and exemestane are also tablets and will be taken by mouth at home every day in a 28-day cycle. The study will compare the experiences of people receiving PF-07248144 in combination with fulvestrant to those of the people who do not. This will help see if PF-07248144 in combination with fulvestrant is safe and effective.

Interventions

• PF-07248144 (Drug)
  KAT6 inhibitor
• Fulvestrant (Drug)
  Endocrine therapy
• Everolimus (Drug)
  mTOR inhibitor
• Exemestane (Drug)
  Endocrine therapy

Eligibility criteria

Conditions

Locations

• Alaska Oncology and Hematology, LLC — Anchorage, Alaska, United States
• Ironwood Cancer & Research Centers — Chandler, Arizona, United States
• Banner Gateway Medical Center — Gilbert, Arizona, United States
• Banner MD Anderson Cancer Center — Gilbert, Arizona, United States
• Ironwood Cancer & Research Centers — Gilbert, Arizona, United States
• Ironwood Cancer & Research Centers — Glendale, Arizona, United States
• Ironwood Cancer & Research Centers — Goodyear, Arizona, United States
• Ironwood Cancer & Research Centers — Mesa, Arizona, United States
• Ironwood Cancer & Research Centers — Mesa, Arizona, United States
• Ironwood Cancer & Research Centers — Phoenix, Arizona, United States
• Ironwood Cancer & Research Centers — Scottsdale, Arizona, United States
• Highlands Oncology Group, PA — Fayetteville, Arkansas, United States
• Highlands Oncology Group, PA — Rogers, Arkansas, United States
• Highlands Oncology Group, PA — Springdale, Arkansas, United States
• Oncura Health - Anaheim — Anaheim, California, United States
• Ventura County Hematology Oncology Specialists — Camarillo, California, United States
• Oncura Health - Fountain Valley — Fountain Valley, California, United States
• Oncura Health - Corporate (Central IDS & Regulatory Only) — Glendale, California, United States
• Oncura Health - Good Samaritan — Los Angeles, California, United States
• Dr. Karandeep Singh MD — Oxnard, California, United States
• Rolling Oaks Radiology - Oxnard — Oxnard, California, United States
• Ventura County Hematology Oncology Specialists — Oxnard, California, United States
• Rolling Oaks Radiology North Solar — Oxnard, California, United States
• Clinical and Translational Research Unit (CTRU) — Palo Alto, California, United States
• Stanford Cancer Center — Palo Alto, California, United States
• Stanford Women's Cancer Center — Palo Alto, California, United States
• Sansum Clinic — Santa Barbara, California, United States
• Sansum Clinic — Solvang, California, United States
• Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, California, United States
• Torrance Memorial Physician Network - Cancer Care — Torrance, California, United States
• Torrance Memorial Physician Network-Cancer Care — Torrance, California, United States
• Harbor-UCLA Medical Center — Torrance, California, United States
• Oncura Health - Valley Presbyterian — Van Nuys, California, United States
• Ventura County Hematology Oncology Specialists — Ventura, California, United States
• Rocky Mountain Cancer Centers LLP — Aurora, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Boulder, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Centennial, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Colorado Springs, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Colorado Springs, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Denver, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Englewood, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Lakewood, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Littleton, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Lone Tree, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Longmont, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Pueblo, Colorado, United States
• Rocky Mountain Cancer Centers LLP — Thornton, Colorado, United States
• Smilow Cancer Hospital - Derby — Derby, Connecticut, United States
• Smilow Cancer Hospital - Fairfield — Fairfield, Connecticut, United States
• Smilow Cancer Hospital - Glastonbury — Glastonbury, Connecticut, United States
• Smilow Cancer Hospital - Greenwich — Greenwich, Connecticut, United States
• Smilow Cancer Hospital - Guilford — Guilford, Connecticut, United States
• Smilow Cancer Hospital at Saint Francis — Hartford, Connecticut, United States
• Smilow Cancer Hospital - Yale New Haven Health — New Haven, Connecticut, United States
• Yale-New Haven Hospital — New Haven, Connecticut, United States
• Smilow Cancer Hospital - North Haven — North Haven, Connecticut, United States
• Smilow Cancer Hospital - Long Ridge — Stamford, Connecticut, United States
• Smilow Cancer Hospital - Torrington — Torrington, Connecticut, United States
• Smilow Cancer Hospital - Trumbull — Trumbull, Connecticut, United States
• Smilow Cancer Hospital - Waterbury — Waterbury, Connecticut, United States
• Smilow Cancer Hospital - Waterford — Waterford, Connecticut, United States
• MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
• Emory University Hospital Midtown — Atlanta, Georgia, United States
• Emory University Hospital — Atlanta, Georgia, United States
• Investigational Drug Service Emory University Clinic — Atlanta, Georgia, United States
• Winship Cancer Institute — Atlanta, Georgia, United States
• Emory Saint Joseph's Hospital — Atlanta, Georgia, United States
• Summit Cancer Care, PC — Savannah, Georgia, United States
• Summit Cancer Care — Savannah, Georgia, United States
• Endeavor Health Cancer Institute at Swedish Hospital, Nancy W. Knowles Cancer Center — Elmhurst, Illinois, United States
• Prime Saint Francis-Infusion Services Evanston — Evanston, Illinois, United States
• Hope and Healing Clinical Research LLC — Hinsdale, Illinois, United States
• Endeavor Health Cancer Institute at Swedish Hospital — Naperville, Illinois, United States
• Hope and Healing Clinical Research — New Lenox, Illinois, United States
• Advocate Christ Medical Center — Oak Lawn, Illinois, United States
• Advocate Medical Group-Park Ridge, Luther Lane-Oncology — Park Ridge, Illinois, United States
• Memorial Hospital. — Shiloh, Illinois, United States
• Siteman Cancer Center - Shiloh — Shiloh, Illinois, United States
• Orchard Healthcare Research Inc. — Skokie, Illinois, United States
• Prime Saint Francis-Infusion Services Skokie — Skokie, Illinois, United States
• University Medical Center, Inc. ; DBA UofL Health - UofL Hospital/Brown Cancer Center — Louisville, Kentucky, United States
• UofL Health Brown Cancer Center Medical Center Northeast — Louisville, Kentucky, United States
• University Medical Center New Orleans — New Orleans, Louisiana, United States
• Maryland Oncology Hematology P.A. — Annapolis, Maryland, United States
• Mercy Medical Center - Baltimore — Baltimore, Maryland, United States
• Mfsmc-Hjwci — Baltimore, Maryland, United States
• MedStar Franklin Square Cancer Center at Loch Raven — Baltimore, Maryland, United States
• Maryland Oncology Hematology P.A. — Bethesda, Maryland, United States
• Maryland Oncology Hematology P.A. — Brandywine, Maryland, United States
• Maryland Oncology Hematology P.A. — Columbia, Maryland, United States
• Maryland Oncology Hematology P.A. — Germantown, Maryland, United States
• Maryland Oncology Hematology P.A. — Largo, Maryland, United States
• Maryland Oncology Hematology P.A. — Rockville, Maryland, United States
• Maryland Oncology Hematology P.A. — Silver Spring, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Dana-Farber Cancer Institute - Chestnut Hill — Newton, Massachusetts, United States
• The Cancer & Hematology Centers — Big Rapids, Michigan, United States
• Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion) — Detroit, Michigan, United States
• The Cancer & Hematology Centers — Grand Rapids, Michigan, United States
• The Cancer & Hematology Centers — Grand Rapids, Michigan, United States
• The Cancer & Hematology Centers — Holland, Michigan, United States
• The Cancer & Hematology Centers — Norton Shores, Michigan, United States
• Minnesota Oncology Hematology, P.A. — Burnsville, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Coon Rapids, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Edina, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Maple Grove, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Maplewood, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Minneapolis, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Plymouth, Minnesota, United States
• Minnesota Oncology Hematology, P.A. — Woodbury, Minnesota, United States
• Siteman Cancer Center - St Peters — City of Saint Peters, Missouri, United States
• Missouri Cancer Associates — Columbia, Missouri, United States
• Siteman Cancer Center - West County — Creve Coeur, Missouri, United States
• Siteman Cancer Center - North County — Florissant, Missouri, United States
• Saint Luke's Cancer Institute — Kansas City, Missouri, United States
• Saint Luke's Hospital of Kansas City — Kansas City, Missouri, United States
• Siteman Cancer Center — St Louis, Missouri, United States
• Barnes-Jewish Hospital — St Louis, Missouri, United States
• Washington University School of Medicine - Siteman Cancer Center — St Louis, Missouri, United States
• Siteman Cancer Center - South County — St Louis, Missouri, United States
• David C. Pratt Cancer Center — St Louis, Missouri, United States
• Bozeman Health Deaconess Hospital — Bozeman, Montana, United States
• Comprehensive Cancer Centers of Nevada — Henderson, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Henderson, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Renown Health Medical Oncology — Reno, Nevada, United States
• Renown Office of Clinical Research — Reno, Nevada, United States
• Renown Regional Medical Center — Reno, Nevada, United States
• Renown Health Conrad Breast Center — Reno, Nevada, United States
• Renown Office of Clinical Research South Meadows — Reno, Nevada, United States
• Hackensack University Medical Center — Hackensack, New Jersey, United States
• John Theurer Cancer Center at Hackensack University Medical Center — Hackensack, New Jersey, United States
• University of Rochester Cancer Center Pharmacy — Rochester, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• Wake Forest Baptist Hematology and Oncology - Clemmons — Clemmons, North Carolina, United States
• Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina, United States
• Roper Hospital — Charleston, South Carolina, United States
• Bon Secours St. Francis Hospital — Charleston, South Carolina, United States
• Charleston Oncology, A Department of Bon Secours St. Francis Hospital — Charleston, South Carolina, United States
• Roper St. Francis Healthcare, Clinical Biotechnology Research Institute (CBRI) — Charleston, South Carolina, United States
• St. Francis Hospital Breast Care - Medical Plaza — Charleston, South Carolina, United States
• Roper St Francis Mount Pleasant Hospital — Mt. Pleasant, South Carolina, United States
• Charleston Oncology - A Department of Bon Secours St. Francis Hospital — North Charleston, South Carolina, United States
• Roper St. Francis Hospital - Berkeley — Summerville, South Carolina, United States
• The West Clinic, PLLC dba West Cancer Center — Germantown, Tennessee, United States
• Sarah Cannon Research Institute - Pharmacy — Nashville, Tennessee, United States
• SCRI Oncology Partners — Nashville, Tennessee, United States
• Vanderbilt Breast Center at One Hundred Oaks — Nashville, Tennessee, United States
• Henry-Joyce Cancer Clinic — Nashville, Tennessee, United States
• Texas Oncology-West Texas — Abilene, Texas, United States
• Texas Oncology-Northeast Texas — Allen, Texas, United States
• Texas Oncology-West Texas — Amarillo, Texas, United States
• Texas Oncology - Central/South Texas — Austin, Texas, United States
• Texas Oncology - Central South (Balcones Dr) — Austin, Texas, United States
• Texas Oncology - Central South (James Casey) — Austin, Texas, United States
• Texas Oncology - Central South (Renfert Way) — Austin, Texas, United States
• MD Anderson The Woodlands — Conroe, Texas, United States
• Texas Oncology-Northeast Texas — Denison, Texas, United States
• Texas Oncology-Northeast Texas — Denton, Texas, United States
• Texas Oncology-West Texas — El Paso, Texas, United States
• Texas Oncology-West Texas — El Paso, Texas, United States
• Texas Oncology-West Texas — El Paso, Texas, United States
• Texas Oncology-Northeast Texas — Flower Mound, Texas, United States
• Texas Oncology - San Antonio — Fredericksburg, Texas, United States
• Texas Oncology - Central South (Pease) — Harlingen, Texas, United States
• The University of Texas M. D. Anderson Cancer Center — Houston, Texas, United States
• University of Texas MD Anderson Cancer Center — Houston, Texas, United States
• MD Anderson West Houston — Houston, Texas, United States
• US Oncology Investigation Products Center(IPC) — Irving, Texas, United States
• US Oncology Investigational Product Center (IPC) — Irving, Texas, United States
• US Oncology Investigational Products Center — Irving, Texas, United States
• MD Anderson League City — League City, Texas, United States
• Texas Oncology-Northeast Texas — Lewisville, Texas, United States
• Texas Oncology-Northeast Texas — Longview, Texas, United States
• Texas Oncology - Central South (South 2nd) — McAllen, Texas, United States
• Texas Oncology-Northeast Texas — McKinney, Texas, United States
• Texas Oncology-West Texas — Midland, Texas, United States
• Texas Oncology - San Antonio — New Braunfels, Texas, United States
• Texas Oncology-West Texas — Odessa, Texas, United States
• Texas Oncology-Northeast Texas — Palestine, Texas, United States
• Texas Oncology-Northeast Texas — Paris, Texas, United States
• Texas Oncology - San Antonio — San Antonio, Texas, United States
• Texas Oncology - San Antonio — San Antonio, Texas, United States
• Texas Oncology - San Antonio — San Antonio, Texas, United States
• MD Anderson in Sugar Land — Sugar Land, Texas, United States
• Texas Oncology-Northeast Texas — Tyler, Texas, United States
• Texas Oncology - Central South (Horizon Cir) — Waco, Texas, United States
• Texas Oncology - Central South — Waco, Texas, United States
• Texas Oncology - Central South (E 6th St) — Weslaco, Texas, United States
• Texas Oncology-West Texas — Wichita Falls, Texas, United States
• Huntsman Cancer Institute — Salt Lake City, Utah, United States
• Virginia Cancer Specialists, PC — Arlington, Virginia, United States
• Virginia Oncology Associates — Chesapeake, Virginia, United States
• Virginia Cancer Specialists — Fairfax, Virginia, United States
• Virginia Cancer Specialists — Manassas, Virginia, United States
• Bon Secours Cancer Institute at Memorial Regional Medical Center — Mechanicsville, Virginia, United States
• Bon Secours St. Francis Medical Center — Midlothian, Virginia, United States
• Virginia Oncology Associates — Norfolk, Virginia, United States
• Virginia Cancer Specialists, PC — Reston, Virginia, United States
• Bon Secours Cancer Institute at St. Mary's Hospital — Richmond, Virginia, United States
• Virginia Oncology Associates — Virginia Beach, Virginia, United States
• Virginia Oncology Associates — Williamsburg, Virginia, United States
• Providence Regional Cancer System - Aberdeen — Aberdeen, Washington, United States
• Providence Regional Cancer System - Centralia — Centralia, Washington, United States
• Providence Regional Cancer System - Lacey — Lacey, Washington, United States
• Harborview Medical Center — Seattle, Washington, United States
• Fred Hutchinson Cancer Center — Seattle, Washington, United States
• University of Washington Medical Center — Seattle, Washington, United States
• Aurora BayCare Medical Center — Green Bay, Wisconsin, United States
• Aurora St Luke's Medical Center — Milwaukee, Wisconsin, United States
• Fundación Respirar — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
• IADT - Instituto Argentino de diagnóstico y Tratamiento — Buenos Aires, Buenos Aires F.D., Argentina
• Organizacion Medica de Investigacion — CABA, Buenos Aires F.D., Argentina
• Centro Medico Fleischer — Buenos Aires, Argentina
• Fundación CORI para la Investigación y Prevención del Cáncer — La Rioja, Argentina
• Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
• Cancer Research SA Pty Ltd — Adelaide, South Australia, Australia
• ICON Cancer Centre - Kurralta Park — Kurralta Park, South Australia, Australia
• Peter MacCallum Cancer Centre — Melbourne, Victoria, Australia
• Western Health-Sunshine & Footscray Hospitals — St Albans, Victoria, Australia
• Algemeen Ziekenhuis klina — Brasschaat, Antwerpen, Belgium
• Clinique Saint Pierre — Ottignies-Louvain-la-Neuve, Brabant Wallon, Belgium
• Institut Jules Bordet — Anderlecht, Bruxelles-capitale, Région de, Belgium
• Cliniques universitaires Saint-Luc — Brussels, Bruxelles-capitale, Région de, Belgium
• Grand Hôpital de Charleroi — Charleroi, Hainaut, Belgium
• Jessa Ziekenhuis — Hasselt, Limburg, Belgium
• UZ Leuven — Leuven, Vlaams-brabant, Belgium
• AZ Groeninge Campus Kennedylaan — Kortrijk, West-vlaanderen, Belgium
• Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman — Liège, Belgium
• Afecc Associacao Feminina Educacao Combate Cancer — Vitória, Espírito Santo, Brazil
• Hospital de Cancer de Londrina — Londrina, Paraná, Brazil
• ONCOSITE - Centro de Pesquisa Clinica em Oncologia — Ijuí, Rio Grande do Sul, Brazil
• Hospital Moinhos de Vento — Porto Alegre, Rio Grande do Sul, Brazil
• Hospital São Lucas da PUCRS — Porto Alegre, Rio Grande do Sul, Brazil
• ANIMI - Unidade de Tratamento Oncologico — Lages, Santa Catarina, Brazil
• Centro de Oncologia - CEON+ - Unidade São Caetano do Sul — São Caetano do Sul, São Paulo, Brazil
• Icesp - Instituto Do Câncer Do Estado de São Paulo — São Paulo, Brazil
• IBCC - Núcleo de Pesquisa e Ensino — São Paulo, Brazil
• Multiprofile Hospital for Active Treatment Serdikamed EOOD — Sofia, Sofia (stolitsa), Bulgaria
• Complex Oncology Center - Burgas — Burgas, Bulgaria
• Specialized Hospital for Active Treatment of Oncology - Haskovo — Haskovo, Bulgaria
• Complex Oncology Center - Plovdiv EOOD — Plovdiv, Bulgaria
• Complex Oncology Center - Shumen — Shumen, Bulgaria
• MHAT for Women's Health Nadezhda — Sofia, Bulgaria
• "University Specialized Hospital for Active Treatment of Oncology Prof. Ivan Chernozemski" EAD — Sofia, Bulgaria
• Cross Cancer Institute — Edmonton, Alberta, Canada
• The Ottawa Hospital Cancer Centre — Ottawa, Ontario, Canada
• Sunnybrook Research Institute — Toronto, Ontario, Canada
• Centre Hospitalier de l'Université de Montréal — Montreal, Quebec, Canada
• Jewish General Hospital — Montreal, Quebec, Canada
• McGill University Health Centre — Montreal, Quebec, Canada
• CHU de Québec-Université Laval, Hôpital du Saint-Sacrement — Québec, Quebec, Canada
• CHU de Québec-Université Laval — Québec, Canada
• Anhui Provincial Cancer Hospital — Hefei, Anhui, China
• Beijing Cancer hospital — Beijing, Beijing Municipality, China
• Fujian Medical University Union Hospital — Fuzhou, Fujian, China
• Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China
• Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
• Southern Medical University Nanfang Hospital — Guangzhou, Guangdong, China
• Guangxi Medical University Affiliated Tumor Hospital — Nanning, Guangxi, China
• Affiliated Hospital of Hebei University — Baoding, Hebei, China
• Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China
• Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology — Wuhan, Hubei, China
• Hubei Cancer Hospital — Wuhan, Hubei, China
• Hunan Cancer Hospital — Changsha, Hunan, China
• Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School — Nanjing, Jiangsu, China
• Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School — Nanjing, Jiangsu, China
• Nanchang People's Hospital — Nanchang, Jiangxi, China
• The First Hospital of Jilin University — Changchun, Jilin, China
• The 2nd Affiliated Hospital of Dalian Medical University — Dalian, Liaoning, China
• The Second Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China
• Shandong Cancer Hospital — Jinan, Shandong, China
• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China
• Sir Run Run Shaw Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
• The Second Affiliated hospital of Zhejiang University school of medicine — Hangzhou, Zhejiang, China
• Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China
• The First Affiliated Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China
• Fakultni Thomayerova nemocnice — Prague, Praha 4, Czechia
• Fakultni nemocnice Bulovka — Prague, Praha 8, Czechia
• Nemocnice AGEL Novy Jicin a.s. — Nový Jičín, Czechia
• Fakultni nemocnice Kralovske Vinohrady — Prague, Czechia
• Vseobecna fakultni nemocnice v Praze — Prague, Czechia
• Fakultni nemocnice Motol a Homolka — Prague, Czechia
• Kuopion Yliopistollinen Sairaala — Kuopio, Northern Savonia, Finland
• Tampereen yliopistollinen sairaala — Tampere, Pirkanmaa, Finland
• Vaasan Keskussairaala — Vaasa, Pohjanmaa, Finland
• Docrates Syöpäsairaala — Helsinki, Uusimaa, Finland
• Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer — Rennes, Brittany Region, France
• CHU de Brest - Hôpital de la Cavale Blanch — Brest, Finistère, France
• Institut Curie - site Saint-Cloud — Saint-Cloud, Hauts-de-seine, France
• Institut Régional du Cancer Montpellier — Montpellier, Hérault, France
• Institut de Cancérologie de Lorraine Alexis Vautrin — Vandœuvre-lès-Nancy, Lorraine, France
• Hôpital Femme Mère Enfant — Bron, Rhône, France
• Hôpital de la Croix-Rousse — Lyon, Rhône, France
• Centre Hospitalier Lyon Sud — Pierre-Bénite, Rhône, France
• CHU Besançon — Besançon, France
• Institut Bergonié — Bordeaux, France
• Centre François Baclesse — Caen, France
• Institut Paoli-Calmettes — Marseille, France
• Institut Gustave Roussy — Villejuif, France
• MVZ für Hämatologie und Onkologie Ravensburg GmbH - Studienzentrum — Ravensburg, Baden-Wurttemberg, Germany
• Universitätsklinik Ulm — Ulm, Baden-Wurttemberg, Germany
• Hämatologie-onkologie im Zentrum MVZ GmbH — Augsburg, Bavaria, Germany
• Universitaetsklinikum Erlangen — Erlangen, Bavaria, Germany
• Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung — Essen, North Rhine-Westphalia, Germany
• Otto-von-Guericke-Universität, Medizinische Fakultät Universitätsklinikum Magdeburg A.ö.R. — Magdeburg, Saxony-Anhalt, Germany
• Charité Universitaetsmedizin Berlin - Campus Mitte — Berlin, Germany
• Praxisklinik Krebsheilkunde fur Frauen — Berlin, Germany
• Praxisklinik Krebsheilkunde fur Frauen — Berlin, Germany
• Mammazentrum HH am Krankenhaus Jerusalem — Hamburg, Germany
• IASO General Clinic — Athens, Attica, Greece
• Hygeia Hospital — Marousi, Attikí, Greece
• University General Hospital of Alexandroupoli — Alexandroupoli, East Macedonia and Thrace, Greece
• University General Hospital of Heraklion — Heraklion, Irakleío, Greece
• European Interbalkan Medical Center — Thessaloniki, Thessaloníki, Greece
• University General Hospital of Larissa — Larissa, Thessalía, Greece
• Aretaieio Hospital — Athens, Greece
• Semmelweis Egyetem — Budapest, Hungary
• Országos Onkológiai Intézet Mellkasi es Hasuregi Daganatok es Klinikai Farmakologiai Osztaly — Budapest, Hungary
• Debreceni Egyetem Klinikai Kozpont — Debrecen, Hungary
• Nirmal Hospital Pvt Ltd. — Surat, Gujarat, India
• Artemis hospital — Gurugram, Haryana, India
• Spandana Oncology Centre (SOC) — Bengaluru, Karnataka, India
• Tata Memorial Hospital — Mumbai, Maharashtra, India
• HCG Manavata Cancer Centre — Nashik, Maharashtra, India
• Apex Wellness Hospital — Nashik, Maharashtra, India
• Sahyadri Super Speciality Hospital — Pune, Maharashtra, India
• Bhakti Vedanta Hospital and Research Institute — Thane, Maharashtra, India
• Institute of Medical Sciences and Sum Hospital — Bhubaneswar, Odisha, India
• Sawai Man Singh Medical College Hospital (SMS Hospital) — Jaipur, Rajasthan, India
• Rabin Medical Center — Petah Tikva, Central District, Israel
• Sheba Medical Center — Ramat Gan, Central District, Israel
• Shaare Zedek Medical Center — Jerusalem, Jerusalem, Israel
• Hadassah Medical Center — Jerusalem, Jerusalem, Israel
• Rambam Health Care Campus — Haifa, Northern District, Israel
• Sourasky Medical Center — Tel Aviv, TELL ABĪB, Israel
• IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola — Bologna, Emilia-Romagna, Italy
• IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" — Meldola, Emilia-Romagna, Italy
• Fondazione IRCCS San Gerardo dei Tintori — Monza, Lombardy, Italy
• Istituto Nazionale dei Tumori IRCCS Fondazione G Pascale — Naples, Naples, Italy
• Istituto Nazionale Tumori Regina Elena — Rome, ROMA, Italy
• Azienda USL Toscana Nord Ovest_Ospedale Civile di Livorno — Livorno, Tuscany, Italy
• Ospedale San Raffaele — Milan, Italy
• Istituto Europeo di Oncologia IRCCS — Milan, Italy
• Azienda Ospedaliero-Universitaria Policlinico di Modena — Modena, Italy
• Chiba cancer center — Chiba, Chiba, Japan
• National Cancer Center Hospital East — Kashiwa, Chiba, Japan
• National Hospital Organization Shikoku Cancer Center — Matsuyama, Ehime, Japan
• Gunma Prefectural Cancer Center — Otashi, Gunma, Japan
• Tokai University Hospital — Isehara, Kanagawa, Japan
• Kanagawa cancer center — Yokohama, Kanagawa, Japan
• The University of Osaka Hospital — Suita, Osaka, Japan
• Juntendo University Hospital — Bunkyo-ku, Tokyo, Japan
• National Cancer Center Hospital — Chuo-ku, Tokyo, Japan
• St. Luke's International Hospital — Chuo-ku, Tokyo, Japan
• The Cancer Institute Hospital of JFCR — Koto, Tokyo, Japan
• Japan Institute for Health Security National Center for Global Health and Medicine — Shinjuku-ku, Tokyo, Japan
• National Hospital Organization Kyushu Cancer Center — Fukuoka, Japan
• Hiroshima City Hospital — Hiroshima, Japan
• Okayama University Hospital — Okayama, Japan
• Showa Medical University Hospital — Tokyo, Japan
• COI/ CENTRO ONCOLOGICO INTERNACIONAL SAPI de CV — Tlajomulco de Zuñiga, Jalisco, Mexico
• Centro de Investigacion Clinica de Oaxaca — Oaxaca City, Oaxaca, Mexico
• Sitio Clínico UIS Chihuahua — Chihuahua City, Mexico
• COI Centro Oncologico Internacional S.A.P.I. de C.V. — Mexico City, Mexico
• Fundación Santos y de la Garza Evia I.B.P — San Pedro Garza García, Mexico
• Tergooi MC — Hilversum, North Holland, Netherlands
• Franciscus Vlietland Ziekenhuis — Schiedam, South Holland, Netherlands
• Christchurch Hospital — Christchurch, Canterbury, New Zealand
• Auckland City Hospital — Auckland, New Zealand
• Capital, Coast and Hutt Valley District - Wellington Regional Hospital — Wellington, New Zealand
• Centrum Onkologii im. Prof. Franciszka Lukaszczyka — Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland
• Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o. — Krakow, Lesser Poland Voivodeship, Poland
• Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii — Wroclaw, Lower Silesian Voivodeship, Poland
• Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy — Warsaw, Masovian Voivodeship, Poland
• SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu — Opole, Poland
• Ad-Vance Medical Research — Ponce, Puerto Rico
• Onkologicky Ustav sv. Alzbety — Bratislava, Bratislava Region, Slovakia
• Vychodoslovensky Onkologicky ustav a.s. — Košice, Košice Region, Slovakia
• Nemocnica s poliklinikou Stefana Kukuru Michalovce a.s. — Michalovce, Košice Region, Slovakia
• Nemocnica AGEL Komarno — Komárno, Nitra Region, Slovakia
• Narodny onkologicky ustav — Bratislava, Slovakia
• Fakultna nemocnica s poliklinikou Nove Zamky — Nové Zámky, Slovakia
• Fakultna nemocnica Trnava — Trnava, Slovakia
• The Medical Oncology Centre of Rosebank — Johannesburg, Gauteng, South Africa
• The Oncology Centre — Durban, KwaZulu-Natal, South Africa
• National Cancer Center — Goyang-si, Kyǒnggi-do, South Korea
• Seoul National University Bundang Hospital — Seongnam-si, Kyǒnggi-do, South Korea
• Gangnam Severance Hospital, Yonsei University Health System — Gangnam-gu, Seoul-teukbyeolsi [seoul], South Korea
• Korea University Anam Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Seoul National University Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Severance Hospital, Yonsei University Health System — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Asan Medical Center — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Samsung Medical Center — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• The Catholic Univ. of Korea Seoul St. Mary's Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Korea University Guro Hospital — Seoul, Seoul-teukbyeolsi [seoul], South Korea
• Kyungpook National University Chilgok Hospital — Deagu, Taegu-kwangyǒkshi, South Korea
• CHUAC-Complejo Hospitalario Universitario A Coruña — A Coruña, A Coruña [LA Coruña], Spain
• Hospital Universitari Vall d'Hebron — Barcelona, Barcelona [barcelona], Spain
• Osi Bilbao-Basurto — Bilbao, Basque Country, Spain
• Hospital Clínic de Barcelona — Barcelona, Catalunya [cataluña], Spain
• Hospital Universitario Virgen de la Victoria — Málaga, Málaga, Spain
• Hospital Universitario San Cecilio — Granada, Spain
• Hospital Universitario de Jaen — Jaén, Spain
• Hospital Universitario HM Sanchinarro — Madrid, Spain
• Hospital Universitario Miguel Servet — Zaragoza, Spain
• Södersjukhuset — Stockholm, Stockholms LÄN [se-01], Sweden
• Sahlgrenska Universitetssjukhuset — Gothenburg, Sweden
• Chi Mei Medical Center — Tainan, Tainan, Taiwan
• National Cheng Kung University Hospital — Tainan, Taiwan
• National Taiwan University Hospital — Taipei, Taiwan
• Mackay Memorial Hospital — Taipei, Taiwan
• Koo Foundation Sun Yat-Sen Cancer Center — Taipei, Taiwan
• Taipei Veterans General Hospital — Taipei, Taiwan
• Chang Gung Medical Foundation-Linkou Branch — Taoyuan, Taiwan
• Medipol Mega Universite Hastanesi — Istanbul, İ̇stanbul, Turkey (Türkiye)
• İ.A.Ü VM Medical Park Florya Hastanesi — Küçükçekmece, İ̇stanbul, Turkey (Türkiye)
• Hacettepe Universite Hastaneleri — Ankara, Turkey (Türkiye)
• Memorial Ankara Hastanesi — Ankara, Turkey (Türkiye)
• Ankara Bilkent Şehir Hastanesi — Ankara, Turkey (Türkiye)
• Dicle Üniversitesi — Diyarbakır, Turkey (Türkiye)
• Samsun Medical Park Hastanesi — Samsun, Turkey (Türkiye)
• Maidstone & Tunbridge Wells NHS Trust — Maidstone, KENT, United Kingdom
• Musgrove Park Hospital — Taunton, Somerset, United Kingdom
• The Royal Marsden NHS Foundation Trust — Sutton, Surrey, United Kingdom
• University Hospital Coventry & Warwickshire — Coventry, Warwickshire, United Kingdom
• The Royal Marsden NHS Foundation Trust — London, United Kingdom
• Peterborough City Hospital — Peterborough, United Kingdom