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RECRUITING Phase 3 ClinicalTrials.gov

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Sponsor: National Cancer Institute (NCI) • ClinicalTrials.gov ID: NCT07061977

Registry updated: 2026-10-22
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Description

This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.

Interventions

  • Biospecimen Collection (Procedure)
    Undergo blood sample collection
  • Brachytherapy (Radiation)
    Undergo brachytherapy
  • Carboplatin (Drug)
    Given IV
  • Chest Radiography (Procedure)
    Undergo chest x-ray
  • Cisplatin (Drug)
    Given IV
  • Computed Tomography (Procedure)
    Undergo CT scan
  • External Beam Radiation Therapy (Radiation)
    Undergo EBRT
  • Intensity-Modulated Radiation Therapy (Radiation)
    Undergo IMRT
  • Magnetic Resonance Imaging (Procedure)
    Undergo MRI
  • Paclitaxel (Drug)
    Given IV
  • Pembrolizumab (Biological)
    Given IV
  • Positron Emission Tomography (Procedure)
    Undergo PET scan

Eligibility criteria

Inclusion Criteria: * Patients must have pathologically confirmed newly diagnosed cervical cancer. Eligible pathologic types: squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma * Patients must have locally advanced cervical cancer (LACC) with T3 or T4 disease with or without lymph node involvement: * IIIA (T3aN0M0) * IIIB (T3bN0M0) * IIIC1(T3aN1M0, T3bN1M0) * IIIC2 (T3aN2M0, T3bN2M0) * IVA (T4aN0M0, T4aN1M0, T4aN2M0) No prior hysterectomy defined as removal of the entire uterus. * NOTE: prior partial/subtotal hysterectomy for reasons other than cervical cancer are eligible to participate in the study. No plan to perform a hysterectomy as part of initial cervical cancer therapy. No paraaortic lymph node (PALN) metastases above the T12/L1 interspace. * Note: Nodal status can be confirmed by imaging (CT, MRI, or PET/CT), fine needle aspirate/core biopsy, extra peritoneal biopsy, laparoscopic biopsy, or lymphadenectomy. Radiologic definition of lymph node staging: * N1: * One or more pelvic lymph nodes with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or * One or more pelvic lymph nodes with short axis diameter of ≥ 10 mm and standardized uptake value maximum (SUVmax) ≥ 2.5 by fludeoxyglucose (FDG)-PET * N2: * One or more para-aortic lymph node with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or * One or more para-aortic lymph node with short axis diameter of ≥ 10 mm and SUVmax ≥ 2.5 by FDG-PET * No prior definitive surgical, radiation, or systemic therapy for cervical cancer * No prior immunotherapy * No prior pelvic radiation therapy for any disease * Age ≥ 18 * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2 * Not pregnant and not nursing * Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3 * Platelets ≥ 100,000 cells/mm\^3 * Hemoglobin ≥ 8 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobulin \[Hgb\] ≥ 8 g/dl is acceptable) * Creatinine clearance (CrCL) of ≥ 50 mL/min by the Cockcroft-Gault formula * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * No active infection requiring parenteral antibiotics * No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacille Calmette Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines are live attenuated vaccines and are not allowed * No diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior registration * No active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * No history of (non-infectious) pneumonitis that required steroids, or current pneumonitis * No history of allergic reaction to the study agent(s) or compounds of similar chemical or biologic composition to the study agent(s) (or any of its excipients)

Conditions

Locally Advanced Cervical Adenocarcinoma Locally Advanced Cervical Adenosquamous Carcinoma Locally Advanced Cervical Squamous Cell Carcinoma Stage IIIA Cervical Cancer FIGO 2018 Stage IIIB Cervical Cancer FIGO 2018 Stage IIIC1 Cervical Cancer FIGO 2018 Stage IIIC2 Cervical Cancer FIGO 2018 Stage IVA Cervical Cancer FIGO 2018

Locations

  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama, United States
  • Highlands Oncology Group - Fayetteville — Fayetteville, Arkansas, United States
  • University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
  • Highlands Oncology Group - Rogers — Rogers, Arkansas, United States
  • Highlands Oncology Group — Springdale, Arkansas, United States
  • Kaiser Permanente-Bellflower — Bellflower, California, United States
  • City of Hope Corona — Corona, California, United States
  • City of Hope Comprehensive Cancer Center — Duarte, California, United States
  • Kaiser Permanente South Bay — Harbor City, California, United States
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California, United States
  • City of Hope at Irvine Lennar — Irvine, California, United States
  • Kaiser Permanente-Irvine — Irvine, California, United States
  • UC San Diego Moores Cancer Center — La Jolla, California, United States
  • City of Hope Antelope Valley — Lancaster, California, United States
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States
  • Kaiser Permanente West Los Angeles — Los Angeles, California, United States
  • Cedars-Sinai Medical Center — Los Angeles, California, United States
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California, United States
  • Kaiser Permanente - Panorama City — Panorama City, California, United States
  • Sutter Medical Center Sacramento — Sacramento, California, United States
  • Salinas Valley Memorial — Salinas, California, United States
  • Kaiser Permanente-San Diego Zion — San Diego, California, United States
  • Kaiser Permanente-San Marcos — San Marcos, California, United States
  • City of Hope South Pasadena — South Pasadena, California, United States
  • City of Hope Upland — Upland, California, United States
  • Kaiser Permanente-Woodland Hills — Woodland Hills, California, United States
  • UCHealth University of Colorado Hospital — Aurora, Colorado, United States
  • UCHealth Highlands Ranch Hospital — Highlands Ranch, Colorado, United States
  • Danbury Hospital — Danbury, Connecticut, United States
  • Norwalk Hospital — Norwalk, Connecticut, United States
  • Beebe South Coastal Health Campus — Millville, Delaware, United States
  • Helen F Graham Cancer Center — Newark, Delaware, United States
  • Medical Oncology Hematology Consultants PA — Newark, Delaware, United States
  • Beebe Health Campus — Rehoboth Beach, Delaware, United States
  • UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Coral Springs — Coral Springs, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Doral — Doral, Florida, United States
  • Broward Health Medical Center — Fort Lauderdale, Florida, United States
  • Memorial Regional Hospital/Joe DiMaggio Children's Hospital — Hollywood, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Hollywood — Hollywood, Florida, United States
  • University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida, United States
  • Miami Cancer Institute — Miami, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Kendall — Miami, Florida, United States
  • Mount Sinai Medical Center — Miami Beach, Florida, United States
  • Sarasota Memorial Hospital-Venice — N. Venice, Florida, United States
  • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia — North Miami, Florida, United States
  • Health Central — Ocoee, Florida, United States
  • Orlando Health Cancer Institute — Orlando, Florida, United States
  • Memorial Hospital West — Pembroke Pines, Florida, United States
  • UM Sylvester Comprehensive Cancer Center at Plantation — Plantation, Florida, United States
  • Moffitt Cancer Center at SouthShore — Ruskin, Florida, United States
  • Florida Cancer Specialists - Sarasota Downtown — Sarasota, Florida, United States
  • FPG - Surgical Oncology Clinics Gynecologic Oncology Surgery — Sarasota, Florida, United States
  • Sarasota Memorial Hospital — Sarasota, Florida, United States
  • Sarasota Memorial Health Care Center at University Parkway — Sarasota, Florida, United States
  • Moffitt Cancer Center-International Plaza — Tampa, Florida, United States
  • Moffitt Cancer Center - McKinley Campus — Tampa, Florida, United States
  • Moffitt Cancer Center — Tampa, Florida, United States
  • Florida Cancer Specialists - Venice Pinebrook — Venice, Florida, United States
  • Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida, United States
  • Emory University Hospital Midtown — Atlanta, Georgia, United States
  • Piedmont Hospital — Atlanta, Georgia, United States
  • Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia, United States
  • Emory Decatur Hospital — Decatur, Georgia, United States
  • CTCA at Southeastern Regional Medical Center — Newnan, Georgia, United States
  • Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho, United States
  • Saint Luke's Cancer Institute - Boise — Boise, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho, United States
  • Kootenai Health - Coeur d'Alene — Coeur d'Alene, Idaho, United States
  • Saint Luke's Cancer Institute - Fruitland — Fruitland, Idaho, United States
  • Saint Luke's Cancer Institute - Meridian — Meridian, Idaho, United States
  • Saint Alphonsus Cancer Care Center-Nampa — Nampa, Idaho, United States
  • Saint Luke's Cancer Institute - Nampa — Nampa, Idaho, United States
  • Kootenai Clinic Cancer Services - Post Falls — Post Falls, Idaho, United States
  • Northwestern University — Chicago, Illinois, United States
  • Rush MD Anderson Cancer Center — Chicago, Illinois, United States
  • University of Illinois — Chicago, Illinois, United States
  • Carle at The Riverfront — Danville, Illinois, United States
  • Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois, United States
  • Decatur Memorial Hospital — Decatur, Illinois, United States
  • Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois, United States
  • Carle Physician Group-Effingham — Effingham, Illinois, United States
  • Crossroads Cancer Center — Effingham, Illinois, United States
  • NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois, United States
  • Northwestern Medicine Cancer Center Delnor — Geneva, Illinois, United States
  • NorthShore University HealthSystem-Glenbrook Hospital — Glenview, Illinois, United States
  • Carle Physician Group-Mattoon/Charleston — Mattoon, Illinois, United States
  • Loyola University Medical Center — Maywood, Illinois, United States
  • Northwestern Medicine Oak Brook — Oak Brook, Illinois, United States
  • Northwestern Medicine Orland Park — Orland Park, Illinois, United States
  • OSF Saint Francis Radiation Oncology at Peoria Cancer Center — Peoria, Illinois, United States
  • OSF Saint Francis Medical Center — Peoria, Illinois, United States
  • UW Health Carbone Cancer Center Rockford — Rockford, Illinois, United States
  • Southern Illinois University School of Medicine — Springfield, Illinois, United States
  • Springfield Clinic — Springfield, Illinois, United States
  • Springfield Memorial Hospital — Springfield, Illinois, United States
  • Carle Cancer Center — Urbana, Illinois, United States
  • Northwestern Medicine Cancer Center Warrenville — Warrenville, Illinois, United States
  • Midwestern Regional Medical Center — Zion, Illinois, United States
  • IU Health North Hospital — Carmel, Indiana, United States
  • Northwest Cancer Center - Crown Point — Crown Point, Indiana, United States
  • Northwest Oncology LLC — Dyer, Indiana, United States
  • Parkview Regional Medical Center — Fort Wayne, Indiana, United States
  • Northwest Cancer Center - Hobart — Hobart, Indiana, United States
  • Saint Mary Medical Center — Hobart, Indiana, United States
  • Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
  • Sidney and Lois Eskenazi Hospital — Indianapolis, Indiana, United States
  • The Community Hospital — Munster, Indiana, United States
  • Women's Diagnostic Center - Munster — Munster, Indiana, United States
  • Northwest Cancer Center - Valparaiso — Valparaiso, Indiana, United States
  • UI Health Care Mission Cancer and Blood - Ankeny Clinic — Ankeny, Iowa, United States
  • Mercy Hospital — Cedar Rapids, Iowa, United States
  • Oncology Associates at Mercy Medical Center — Cedar Rapids, Iowa, United States
  • UI Health Care Mission Cancer and Blood - West Des Moines Clinic — Clive, Iowa, United States
  • Iowa Methodist Medical Center — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Des Moines Clinic — Des Moines, Iowa, United States
  • Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Laurel Clinic — Des Moines, Iowa, United States
  • University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
  • UI Health Care Mission Cancer and Blood - Waukee Clinic — Waukee, Iowa, United States
  • University of Kansas Cancer Center — Kansas City, Kansas, United States
  • University of Kansas Cancer Center-Overland Park — Overland Park, Kansas, United States
  • University of Kansas Hospital-Indian Creek Campus — Overland Park, Kansas, United States
  • University of Kansas Hospital-Westwood Cancer Center — Westwood, Kansas, United States
  • University of Kentucky/Markey Cancer Center — Lexington, Kentucky, United States
  • West Jefferson Medical Center — Marrero, Louisiana, United States
  • East Jefferson General Hospital — Metairie, Louisiana, United States
  • LSU Healthcare Network / Metairie Multi-Specialty Clinic — Metairie, Louisiana, United States
  • University Medical Center New Orleans — New Orleans, Louisiana, United States
  • Ochsner Baptist Medical Center — New Orleans, Louisiana, United States
  • Ochsner Medical Center Jefferson — New Orleans, Louisiana, United States
  • MaineHealth Coastal Cancer Treatment Center — Bath, Maine, United States
  • MaineHealth Maine Medical Center - Portland — Portland, Maine, United States
  • MaineHealth Cancer Care Center of York County — Sanford, Maine, United States
  • MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine, United States
  • University of Maryland/Greenebaum Cancer Center — Baltimore, Maryland, United States
  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland, United States
  • UM Upper Chesapeake Medical Center — Bel Air, Maryland, United States
  • Central Maryland Radiation Oncology in Howard County — Columbia, Maryland, United States
  • University of Maryland Shore Medical Center at Easton — Easton, Maryland, United States
  • UM Baltimore Washington Medical Center/Tate Cancer Center — Glen Burnie, Maryland, United States
  • UM Capital Region Medical Center — Largo, Maryland, United States
  • UM Saint Joseph Medical Center — Towson, Maryland, United States
  • Tufts Medical Center — Boston, Massachusetts, United States
  • Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor — Ann Arbor, Michigan, United States
  • University of Michigan Rogel Cancer Center — Ann Arbor, Michigan, United States
  • Trinity Health Medical Center - Brighton — Brighton, Michigan, United States
  • University of Michigan - Brighton Center for Specialty Care — Brighton, Michigan, United States
  • Trinity Health Medical Center - Canton — Canton, Michigan, United States
  • Chelsea Hospital — Chelsea, Michigan, United States
  • Corewell Health Dearborn Hospital — Dearborn, Michigan, United States
  • Bronson Methodist Hospital — Kalamazoo, Michigan, United States
  • West Michigan Cancer Center — Kalamazoo, Michigan, United States
  • University of Michigan Health - Sparrow Lansing — Lansing, Michigan, United States
  • Trinity Health Saint Mary Mercy Livonia Hospital — Livonia, Michigan, United States
  • Trinity Health Saint Joseph Mercy Oakland Hospital — Pontiac, Michigan, United States
  • Corewell Health William Beaumont University Hospital — Royal Oak, Michigan, United States
  • Corewell Health Beaumont Troy Hospital — Troy, Michigan, United States
  • Essentia Health Saint Joseph's Medical Center — Brainerd, Minnesota, United States
  • Essentia Health - Deer River Clinic — Deer River, Minnesota, United States
  • Essentia Health Cancer Center — Duluth, Minnesota, United States
  • Miller-Dwan Hospital — Duluth, Minnesota, United States
  • Essentia Health Hibbing Clinic — Hibbing, Minnesota, United States
  • Mayo Clinic in Rochester — Rochester, Minnesota, United States
  • Regions Hospital — Saint Paul, Minnesota, United States
  • Essentia Health Sandstone — Sandstone, Minnesota, United States
  • Essentia Health Virginia Clinic — Virginia, Minnesota, United States
  • Freeman Health System — Joplin, Missouri, United States
  • University of Kansas Cancer Center - Briarcliff — Kansas City, Missouri, United States
  • University of Kansas Cancer Center - North — Kansas City, Missouri, United States
  • University of Kansas Cancer Center - Lee's Summit — Lee's Summit, Missouri, United States
  • Phelps Health Delbert Day Cancer Institute — Rolla, Missouri, United States
  • Mercy Hospital Springfield — Springfield, Missouri, United States
  • Mercy Hospital Saint Louis — St Louis, Missouri, United States
  • Billings Clinic Cancer Center — Billings, Montana, United States
  • Community Medical Center — Missoula, Montana, United States
  • Nebraska Medicine-Bellevue — Bellevue, Nebraska, United States
  • Nebraska Methodist Hospital — Omaha, Nebraska, United States
  • Nebraska Medicine-Village Pointe — Omaha, Nebraska, United States
  • University of Nebraska Medical Center — Omaha, Nebraska, United States
  • Women's Cancer Center of Nevada — Las Vegas, Nevada, United States
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center — Lebanon, New Hampshire, United States
  • Memorial Sloan Kettering Basking Ridge — Basking Ridge, New Jersey, United States
  • Cooper Hospital University Medical Center — Camden, New Jersey, United States
  • Jersey City Medical Center — Jersey City, New Jersey, United States
  • Cooperman Barnabas Medical Center — Livingston, New Jersey, United States
  • Monmouth Medical Center — Long Branch, New Jersey, United States
  • Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States
  • Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States
  • Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
  • Rutgers New Jersey Medical School — Newark, New Jersey, United States
  • Capital Health Medical Center-Hopewell — Pennington, New Jersey, United States
  • Community Medical Center — Toms River, New Jersey, United States
  • University of New Mexico Cancer Center — Albuquerque, New Mexico, United States
  • Northwell Health Imbert Cancer Center — Bay Shore, New York, United States
  • Roswell Park Cancer Institute — Buffalo, New York, United States
  • Memorial Sloan Kettering Commack — Commack, New York, United States
  • Northwell Health Physician Partners at Flushing — Flushing, New York, United States
  • Northwell Health Physicians Partners Radiation Medicine at Queens — Forest Hills, New York, United States
  • Northwell Health Cancer Institute at Huntington — Greenlawn, New York, United States
  • Memorial Sloan Kettering Westchester — Harrison, New York, United States
  • Northwell Health/Center for Advanced Medicine — Lake Success, New York, United States
  • NYU Langone Hospital - Long Island — Mineola, New York, United States
  • Northern Westchester Hospital — Mount Kisco, New York, United States
  • Mount Sinai Chelsea — New York, New York, United States
  • Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York, New York, United States
  • Mount Sinai West — New York, New York, United States
  • Mount Sinai Hospital — New York, New York, United States
  • Manhattan Eye Ear and Throat Hospital — New York, New York, United States
  • Memorial Sloan Kettering Cancer Center — New York, New York, United States
  • Lenox Hill Hospital — New York, New York, United States
  • Upstate Cancer Center Radiation Oncology at Oswego — Oswego, New York, United States
  • Queens Cancer Center — Rego Park, New York, United States
  • Phelps Memorial Hospital Center — Sleepy Hollow, New York, United States
  • Staten Island University Hospital — Staten Island, New York, United States
  • Stony Brook University Medical Center — Stony Brook, New York, United States
  • State University of New York Upstate Medical University — Syracuse, New York, United States
  • Upstate Cancer Center at Hill Radiation Oncology — Syracuse, New York, United States
  • Montefiore Medical Center-Einstein Campus — The Bronx, New York, United States
  • Montefiore Medical Center-Weiler Hospital — The Bronx, New York, United States
  • Montefiore Medical Center - Moses Campus — The Bronx, New York, United States
  • Memorial Sloan Kettering Nassau — Uniondale, New York, United States
  • Upstate Cancer Center at Verona — Verona, New York, United States
  • UNC Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina, United States
  • Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina, United States
  • Novant Health Presbyterian Medical Center — Charlotte, North Carolina, United States
  • Atrium Health Cabarrus/LCI-Concord — Concord, North Carolina, United States
  • Duke University Medical Center — Durham, North Carolina, United States
  • Levine Cancer Institute-Gaston — Gastonia, North Carolina, United States
  • Hayworth Cancer Center — High Point, North Carolina, United States
  • Novant Health Cancer Institute - Huntersville — Huntersville, North Carolina, United States
  • Novant Health Cancer Institute - Kernersville — Kernersville, North Carolina, United States
  • Matthews Radiation Oncology Center — Matthews, North Carolina, United States
  • Duke Women's Cancer Care Raleigh — Raleigh, North Carolina, United States
  • Novant Cancer Institute Radiation Oncology - Supply — Supply, North Carolina, United States
  • Novant Health Cancer Institute Radiation Oncology - Wilmington — Wilmington, North Carolina, United States
  • Novant Health New Hanover Regional Medical Center — Wilmington, North Carolina, United States
  • Novant Health Forsyth Medical Center — Winston-Salem, North Carolina, United States
  • Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States
  • UHHS-Chagrin Highlands Medical Center — Beachwood, Ohio, United States
  • Aultman Health Foundation — Canton, Ohio, United States
  • Miami Valley Hospital South — Centerville, Ohio, United States
  • Geauga Hospital — Chardon, Ohio, United States
  • University of Cincinnati Cancer Center-UC Medical Center — Cincinnati, Ohio, United States
  • Case Western Reserve University — Cleveland, Ohio, United States
  • Cleveland Clinic Foundation — Cleveland, Ohio, United States
  • Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
  • Miami Valley Hospital — Dayton, Ohio, United States
  • Miami Valley Hospital North — Dayton, Ohio, United States
  • Atrium Medical Center-Middletown Regional Hospital — Franklin, Ohio, United States
  • Miami Valley Cancer Care and Infusion — Greenville, Ohio, United States
  • Hillcrest Hospital Cancer Center — Mayfield Heights, Ohio, United States
  • UH Seidman Cancer Center at Lake Health Mentor Campus — Mentor, Ohio, United States
  • University Hospitals Parma Medical Center — Parma, Ohio, United States
  • ProMedica Flower Hospital — Sylvania, Ohio, United States
  • Upper Valley Medical Center — Troy, Ohio, United States
  • University of Cincinnati Cancer Center-West Chester — West Chester, Ohio, United States
  • UH Seidman Cancer Center at Saint John Medical Center — Westlake, Ohio, United States
  • University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States
  • Oklahoma Cancer Specialists and Research Institute-Tulsa — Tulsa, Oklahoma, United States
  • Clackamas Radiation Oncology Center — Clackamas, Oregon, United States
  • Providence Newberg Medical Center — Newberg, Oregon, United States
  • Providence Willamette Falls Medical Center — Oregon City, Oregon, United States
  • Legacy Good Samaritan Hospital and Medical Center — Portland, Oregon, United States
  • Providence Portland Medical Center — Portland, Oregon, United States
  • Providence Saint Vincent Medical Center — Portland, Oregon, United States
  • Kaiser Permanente Northwest — Portland, Oregon, United States
  • Oregon Health and Science University — Portland, Oregon, United States
  • Legacy Meridian Park Hospital — Tualatin, Oregon, United States
  • Lehigh Valley Hospital-Cedar Crest — Allentown, Pennsylvania, United States
  • Saint Luke's Cancer Center - Allentown — Allentown, Pennsylvania, United States
  • Saint Luke's University Hospital-Bethlehem Campus — Bethlehem, Pennsylvania, United States
  • Lehigh Valley Hospital - Muhlenberg — Bethlehem, Pennsylvania, United States
  • Geisinger Medical Center — Danville, Pennsylvania, United States
  • Geisinger Cancer Center Dickson City — Dickson City, Pennsylvania, United States
  • Pocono Medical Center — East Stroudsburg, Pennsylvania, United States
  • Saint Luke's Hospital-Anderson Campus — Easton, Pennsylvania, United States
  • UPMC Hillman Cancer Center Erie — Erie, Pennsylvania, United States
  • UPMC Cancer Centers - Arnold Palmer Pavilion — Greensburg, Pennsylvania, United States
  • UPMC Pinnacle Cancer Center/Community Osteopathic Campus — Harrisburg, Pennsylvania, United States
  • Penn State Milton S Hershey Medical Center — Hershey, Pennsylvania, United States
  • IRMC Cancer Center — Indiana, Pennsylvania, United States
  • Jefferson Hospital — Jefferson Hills, Pennsylvania, United States
  • UPMC-Johnstown/John P. Murtha Regional Cancer Center — Johnstown, Pennsylvania, United States
  • Geisinger Medical Oncology-Lewisburg — Lewisburg, Pennsylvania, United States
  • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion — Mechanicsburg, Pennsylvania, United States
  • Forbes Hospital — Monroeville, Pennsylvania, United States
  • Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States
  • Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
  • Temple University Hospital — Philadelphia, Pennsylvania, United States
  • Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Magee Womens Hospital — Pittsburgh, Pennsylvania, United States
  • West Penn Hospital — Pittsburgh, Pennsylvania, United States
  • UPMC-Passavant Hospital — Pittsburgh, Pennsylvania, United States
  • Saint Luke's Hospital - Upper Bucks Campus — Quakertown, Pennsylvania, United States
  • UPMC Cancer Center at UPMC Northwest — Seneca, Pennsylvania, United States
  • Saint Luke's Hospital - Monroe Campus — Stroudsburg, Pennsylvania, United States
  • Wexford Health and Wellness Pavilion — Wexford, Pennsylvania, United States
  • Geisinger Wyoming Valley/Henry Cancer Center — Wilkes-Barre, Pennsylvania, United States
  • Asplundh Cancer Pavilion — Willow Grove, Pennsylvania, United States
  • Women and Infants Hospital — Providence, Rhode Island, United States
  • Medical University of South Carolina — Charleston, South Carolina, United States
  • Gibbs Cancer Center-Gaffney — Gaffney, South Carolina, United States
  • Gibbs Cancer Center-Pelham — Greer, South Carolina, United States
  • Spartanburg Medical Center — Spartanburg, South Carolina, United States
  • Avera Cancer Institute — Sioux Falls, South Dakota, United States
  • Parkland Memorial Hospital — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas, Texas, United States
  • UT Southwestern/Simmons Cancer Center-Fort Worth — Fort Worth, Texas, United States
  • UT Southwestern Clinical Center at Richardson/Plano — Richardson, Texas, United States
  • Farmington Health Center — Farmington, Utah, United States
  • University of Utah Sugarhouse Health Center — Salt Lake City, Utah, United States
  • Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah, United States
  • University of Vermont Medical Center — Burlington, Vermont, United States
  • University of Vermont and State Agricultural College — Burlington, Vermont, United States
  • Inova Alexandria Hospital — Alexandria, Virginia, United States
  • University of Virginia Cancer Center — Charlottesville, Virginia, United States
  • Inova Schar Cancer Institute — Fairfax, Virginia, United States
  • Inova Fair Oaks Hospital — Fairfax, Virginia, United States
  • Inova Fairfax Hospital — Falls Church, Virginia, United States
  • Inova Loudoun Hospital — Leesburg, Virginia, United States
  • VCU Massey Comprehensive Cancer Center — Richmond, Virginia, United States
  • Carilion Roanoke Memorial Hospital — Roanoke, Virginia, United States
  • Fred Hutchinson Cancer Center — Seattle, Washington, United States
  • Legacy Salmon Creek Hospital — Vancouver, Washington, United States
  • United Hospital Center — Bridgeport, West Virginia, United States
  • Vandalia Health/CAMC Institute for Academic Medicine — Charleston, West Virginia, United States
  • West Virginia University Healthcare — Morgantown, West Virginia, United States
  • Camden Clark Medical Center — Parkersburg, West Virginia, United States
  • Duluth Clinic Ashland — Ashland, Wisconsin, United States
  • Northwest Wisconsin Cancer Center — Ashland, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center — Madison, Wisconsin, United States
  • University of Wisconsin Carbone Cancer Center - University Hospital — Madison, Wisconsin, United States
  • Medical College of Wisconsin — Milwaukee, Wisconsin, United States
  • ProHealth D N Greenwald Center — Mukwonago, Wisconsin, United States
  • Cancer Center of Western Wisconsin — New Richmond, Wisconsin, United States
  • ProHealth Oconomowoc Memorial Hospital — Oconomowoc, Wisconsin, United States
  • Essentia Health Saint Mary's Hospital - Superior — Superior, Wisconsin, United States
  • UW Cancer Center at ProHealth Care — Waukesha, Wisconsin, United States
  • Memorial Hospital of Laramie County — Cheyenne, Wyoming, United States
  • Doctors Cancer Center — Manati, Puerto Rico
  • Centro Comprensivo de Cancer de UPR — San Juan, Puerto Rico
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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