N
← Back to Search
Sponsored

Accelerate Your Clinical Trial Recruitment

Reach thousands of high-intent patients matching your specific inclusion criteria.

Start Campaign
RECRUITING Not applicable ClinicalTrials.gov

Perioperative Intravenous Nimodipine Trial

Sponsor: University of Ioannina • ClinicalTrials.gov ID: NCT07048522

Registry updated: 2026-09-14
Ad

Recruiting for Similar Conditions?

Sponsors are looking for patients like you. See if you qualify for compensated research studies.

Check Eligibility →

Description

The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.

Interventions

  • Nimodipine (Drug)
    A continuous dose of 2 mg/h (10 ml/h) of nimodipine solution will be administered continuously one (1) h prior to start of operation until 24 h after the end of the procedure.
  • Isotonic Saline (Drug)
    A continuous dose of 10 ml/h of normal saline solution will be administered continuously one (1) h prior to start of operation until 24 h after the end of the procedure.

Eligibility criteria

Inclusion Criteria: * Patients scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra Exclusion Criteria: * Age \< 18 years, \> 75 years * American Society of Anesthesiologists (ASA) physical status \> III * Allergy to nimodipine * Inability to provide informed consent * Known severe renal insufficiency * Known severe bradyarrhythmia * Daily opioid consumption the last 7 days before surgery * Pain intensity assessed using the Numerical Rating Scale (NRS; 0-10), with scores greater than 5 reported on more than half of the days during the past month.

Conditions

Colectomy Open Surgery Pain Pain, Postoperative Pain, Acute

Locations

  • St. Andrews General Hospital of Patras, GREECE — Pátrai, Achaea, Greece
Sponsored

Partner with Nurenyx

Showcase your study to thousands of motivated patients matching your criteria.

Learn More

Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record