RECRUITING Phase 3 ClinicalTrials.gov

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Sponsor: Amgen • ClinicalTrials.gov ID: NCT07037459

Registry updated: 2026-09-16

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Description

This trial will examine if maridebart cafraglutide as an adjunct to standard of care will lead to a reduction in heart failure (HF) events such as HF hospitalizations and urgent HF visits, cardiovascular (CV) deaths and improvement in HF symptoms in participants with HF with preserved ejection fraction (HFpEF) and HF with mildly reduced ejection fraction (HFmrEF) who are obese. This is a phase 3, global, multicenter, 2-part trial with a double-blind period and an open-label extension (OLE). The trial is event-driven, and Part 1 will conclude when approximately 850 primary endpoint events have occurred.

Interventions

Maridebart cafraglutide (Drug)
Maridebart cafraglutide will be administered SC.
Placebo (Drug)
Placebo will be administered SC.

Eligibility criteria

Inclusion Criteria: * Age ≥ 18 years at the time of informed consent. * BMI ≥ 30.0 kg/m\^2 at randomization. * HF diagnosed for at least 30 days with New York Heart Association (NYHA) Class II-IV at the time of informed consent. * Managed with HF standard of care therapies. * Left ventricular ejection fraction (LVEF) of \> 40% within 12 months before randomization. Exclusion Criteria: * History of any of the following within 60 days prior to or during screening: Type I (spontaneous) MI, valvular replacement or repair, coronary revascularization, coronary artery bypass graft surgery or other major cardiovascular surgery, stroke. * HF due to: hypertrophic cardiomyopathy, infiltrative cardiomyopathy, active or chronic myocarditis, constrictive pericarditis, cardiac tamponade, arrhythmogenic right ventricular or left ventricular cardiomyopathy/dysplasia, uncorrected primary valvular heart disease, clinically significant congenital heart disease. * Hospitalized with acute decompensated HF at the time of or during the screening period. * Type 1 diabetes mellitus, or any type of diabetes with the exception of T2DM or history of gestational diabetes. * For participants with a prior diagnosis of T2DM (including those diagnosed during screening): 1. HbA1c \> 10.0% (86 mmol/mol) at screening 2. Uncontrolled diabetes requiring immediate therapy 3. History of diabetic ketoacidosis or hyperosmolar state/coma within 12 months before randomization 4. One or more episodes of severe hypoglycemia within 6 months before randomization and/or history of hypoglycemia unawareness 5. History or presence of either proliferative diabetic retinopathy, or diabetic maculopathy, or severe non-proliferative diabetic retinopathy; or currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema. * SBP ≥ 180 mmHg during the screening period, or on three or more blood pressure-lowering drugs with a SBP \> 160 mmHg during the screening period (including day 1 prior to randomization). * History of chronic pancreatitis or acute pancreatitis in the 180 days before screening or during the screening period. * Any personal lifetime history of, or family history(first-degree relative\[s\]) of medullary thyroid carcinoma or MEN-2. * eGFR \< 20 mL/min/1.73 m\^2 (CKD-EPI creatinine (Cr)-cystatin C equation) or receiving dialysis at screening. * Calcitonin ≥ 50 ng/L (pg/mL) at screening. * Acute or chronic hepatitis. * Any of the following psychiatric history: 1. History of unstable major depressive disorder or other severe psychiatric disorder within 2 years prior to screening or during the screening period 2. Lifetime history of suicide attempt 3. History of non-suicidal self-injury within 5 years prior to screening or during the screening period. * History of any other condition that, in the opinion of the investigator, may preclude the participant from following the protocol and completing the trial. * Use of any glucagon-like peptide 1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) agonists or antagonists, or amylin analogs within 90 days prior to or during the screening period or planned use during the conduct of the trial.

Conditions

Heart Failure With Preserved Ejection Fraction Heart Failure With Mildly Reduced Ejection Fraction Obesity

Locations

University of Alabama Saint Vincent's Birmingham — Birmingham, Alabama, United States
SEC Clinical Research — Dothan, Alabama, United States
Eastern Shore Research Institute — Fairhope, Alabama, United States
Heart Center Research LLC — Huntsville, Alabama, United States
HonorHealth — Phoenix, Arizona, United States
Medical Advancement Centers of Arizona — Phoenix, Arizona, United States
Pima Heart and Vascular Clinical Research — Tucson, Arizona, United States
Yuma Clinical Trials — Yuma, Arizona, United States
Arkansas Cardiology — Little Rock, Arkansas, United States
National Heart Institute — Beverly Hills, California, United States
Valley Clinical Trials, LLC dba Flourish Research — Covina, California, United States
National Institute of Clinical Research — Huntington Beach, California, United States
310 Clinical Research — Inglewood, California, United States
Radin Cardiovascular Medical Group — Newport Beach, California, United States
Valley Clinical Trials — Northridge, California, United States
University of California Irvine — Orange, California, United States
Empire Clinical Research — Pomona, California, United States
San Diego Cardiac Center — San Diego, California, United States
Kaiser Permanente — San Francisco, California, United States
NorthBay Clinical Research LLC — Santa Rosa, California, United States
Manshadi Heart Institute — Stockton, California, United States
Cardiology Associates of Fairfield County PC — Stamford, Connecticut, United States
Orlando Heart and Vascular Institute — Altamonte Springs, Florida, United States
D and H Tamarac Research Center — Aventura, Florida, United States
Excel Medical Clinical Trials — Boca Raton, Florida, United States
Cardiovascular and Vein Center of Florida — Bradenton, Florida, United States
Millennium Medical Research — Coral Gables, Florida, United States
Elite Cardiac Research Center LLC — Hialeah, Florida, United States
Encore Medical Research LLC — Hollywood, Florida, United States
Nature Coast Clinical Research — Inverness, Florida, United States
East Coast Institute for Research — Jacksonville, Florida, United States
First Coast Cardiovascular Institute PA — Jacksonville, Florida, United States
Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
Clearwater Cardiovascular Consultants — Largo, Florida, United States
Ocala Cardiovascular Research — Ocala, Florida, United States
AdventHealth Orlando — Orlando, Florida, United States
Orlando Health Heart Institute — Orlando, Florida, United States
Ormond Beach Clinical Research — Ormond Beach, Florida, United States
Broward Research Center — Pembroke Pines, Florida, United States
Ascension Sacred Heart — Pensacola, Florida, United States
Cardiovascular Center of Sarasota — Sarasota, Florida, United States
Cardiology Partners Clinical Research Institute — Wellington, Florida, United States
Guardian Research Organization LLC — Winter Park, Florida, United States
Piedmont Heart Institute — Atlanta, Georgia, United States
Privia Medical Group Georgia LLC — Peachtree City, Georgia, United States
High Desert Heart and Vascular — Meridian, Idaho, United States
Chicago Medical Research LLC — Hazel Crest, Illinois, United States
Midwest Cardiovascular Research And Education Foundation — Elkhart, Indiana, United States
Ascension Medical Group — Indianapolis, Indiana, United States
Cardiovascular Research of Northwest Indiana LLC — Munster, Indiana, United States
Reid Physician Associates — Richmond, Indiana, United States
University of Kansas Medical Center — Kansas City, Kansas, United States
Johnson County Clintrials — Lenexa, Kansas, United States
Kansas Nephrology Research Institute LLC — Wichita, Kansas, United States
The Research Group of Lexington LLC — Lexington, Kentucky, United States
Our Lady of the Lake Medical Center — Baton Rouge, Louisiana, United States
Louisiana Heart Center - Hammond — Covington, Louisiana, United States
Heart Clinic of Hammond — Hammond, Louisiana, United States
Northshore Heart and Vascular LLC — Mandeville, Louisiana, United States
Ascension Saint Agnes Heart Care — Baltimore, Maryland, United States
Johns Hopkins University — Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants LLC — Beltsville, Maryland, United States
Flourish Bowie — Bowie, Maryland, United States
University of Michigan Health System, Dominos Farms — Ann Arbor, Michigan, United States
Embassy Research Network — Bloomfield Township, Michigan, United States
Henry Ford Health System — Detroit, Michigan, United States
Healthy Heart Cardiology — Grand Rapids, Michigan, United States
Advanced Cardiology Associates — Rochester Hills, Michigan, United States
Revival Research Institute — Southfield, Michigan, United States
Mankato Clinic — Mankato, Minnesota, United States
Fairview Health Services M Health Fairview St Johns Hospital — Maplewood, Minnesota, United States
University of Minnesota — Minneapolis, Minnesota, United States
Saint Luke's Hospital of Kansas City — Kansas City, Missouri, United States
Kalispell Regional Medical Center — Kalispell, Montana, United States
Bryan Heart — Lincoln, Nebraska, United States
Methodist Physicians Clinic Heart Consultants — Omaha, Nebraska, United States
Advanced Heart Care LLC — Bridgewater, New Jersey, United States
Virtua Health Incorporated — Marlton, New Jersey, United States
Saint Michaels Medical Center — Newark, New Jersey, United States
CardioMetabolic Collaborative Clinic — Somerset, New Jersey, United States
Capital Cardiology Associates — Albany, New York, United States
Icahn School of Medicine at Mount Sinai — New York, New York, United States
Hudson Valley Cardiovascular Practice PC — Poughkeepsie, New York, United States
Richmond University Medical Center — Staten Island, New York, United States
Asheville Cardiology Associates — Asheville, North Carolina, United States
Duke University Health System — Durham, North Carolina, United States
Ima Clinical Research - Lenoir — Lenoir, North Carolina, United States
Accellacare of Piedmont Healthcare — Statesville, North Carolina, United States
Accellacare of Wilmington — Wilmington, North Carolina, United States
South Oklahoma Heart Research — Oklahoma City, Oklahoma, United States
Abington Medical Specialists — Horsham, Pennsylvania, United States
University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
Monument Health Clinical Research — Rapid City, South Dakota, United States
Apex Research Foundation, LLC — Jackson, Tennessee, United States
The Jackson Clinic PA — Jackson, Tennessee, United States
Parkway Cardiology Associates — Oak Ridge, Tennessee, United States
Cardiovascular Research of Knoxville North Knoxville Medical Center — Powell, Tennessee, United States
Tennessee Center for Clinical Trials — Tullahoma, Tennessee, United States
PharmaTex Research, LLC — Amarillo, Texas, United States
Austin Heart — Austin, Texas, United States
Javara Research — Conroe, Texas, United States
Cedar Health Research, LLC — Dallas, Texas, United States
Dallas Heart and Vascular Consultants — Duncanville, Texas, United States
David Turbay, MD — El Paso, Texas, United States
East Texas Cardiology PA — Houston, Texas, United States
Biopharma Informatic — Houston, Texas, United States
Orion Medical — Houston, Texas, United States
Biopharma Informatic, LLC — Houston, Texas, United States
Biopharma Informatic — Houston, Texas, United States
Vital Heart and Vein — Humble, Texas, United States
North Dallas Research Associates — McKinney, Texas, United States
Texas Institute of Cardiology — McKinney, Texas, United States
Sherman Clinical Research — Sherman, Texas, United States
Northwest Houston Clinical Research PLLC — Tomball, Texas, United States
Conquest Research, LLC — Arlington, Virginia, United States
Virginia Heart — Falls Church, Virginia, United States
Carient Heart and Vascular — Manassas, Virginia, United States
Roanoke Heart Institute PLC — Roanoke, Virginia, United States
Salem VA Medical Center — Salem, Virginia, United States
Pulse Heart Institute — Puyallup, Washington, United States
Advocate Aurora Saint Lukes Medical Center — Milwaukee, Wisconsin, United States
Imoba Investigaciones medicas — CABA, Buenos Aires, Argentina
Centro de Investigaciones Metabolicas Cinme — CABA, Buenos Aires, Argentina
Cemedic Centro de Especialidades Medicas — CABA, Buenos Aires, Argentina
Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada — CABA, Buenos Aires, Argentina
Fundacion Respirar - Consultorios Medicos Dr Doreski — CABA, Buenos Aires, Argentina
Cemic - Centro de Educacion Medica e Investigaciones Clinicas Norberto Quirno — CABA, Buenos Aires, Argentina
Cardiología Palermo — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciprec Centro de Investigacion y Prevencion Cardiovascular — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Mautalen Salud e Investigacion Expertia SA-Osteo — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciad - Consultorio Integral de Atencion al Diabetico — Morón, Buenos Aires, Argentina
Dim Clinica Privada — Ramos Meija, Buenos Aires, Argentina
Go Centro Medico San Nicolas — San Nicolás de los Arroyos, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas de San Nicolas — San Nicolás de los Arroyos, Buenos Aires, Argentina
Clinica Fusavim Privada SRL — Villa María, Córdoba Province, Argentina
Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta — Rosario, Santa Fe Province, Argentina
Instituto CAICI - Centro de Asistencia e Investigacion Clinica Integral — Rosario, Santa Fe Province, Argentina
Centro Modelo de Cardiologia — San Miguel de Tucumán, Tucumán Province, Argentina
Investigaciones Clinicas Tucuman — San Miguel de Tucumán, Tucumán Province, Argentina
Instituto Medico Damic — Córdoba, Argentina
INECO Neurociencias Oronio — Rosario, Argentina
Hospital Dr Jose Maria Cullen — Santa Fe, Argentina
Centro de Investigaciones Clinicas del Litoral — Santa Fe, Argentina
Instituto de Investigaciones Clinicas Zarate — Zárate, Argentina
Canberra Hospital — Garran, Australian Capital Territory, Australia
Sydney Cardiometabolic Centre — Liverpool, New South Wales, Australia
Royal North Shore Hospital — St Leonards, New South Wales, Australia
Advara HeartCare Wesley — Auchenflower, Queensland, Australia
Sunshine Coast University Hospital — Birtinya, Queensland, Australia
Royal Brisbane and Womens Hospital — Herston, Queensland, Australia
Core Research Group Pty Ltd — Milton, Queensland, Australia
Gold Coast Hospital and Health Service — Southport, Queensland, Australia
Dr Heart Pty Ltd — Woolloongabba, Queensland, Australia
Flinders Medical Centre — Bedford Park, South Australia, Australia
Advara HeartCare Leabrook — Leabrook, South Australia, Australia
Victorian Heart Hospital — Clayton, Victoria, Australia
The Alfred Hospital — Melbourne, Victoria, Australia
Advara HeartCare Mulgrave — Mulgrave, Victoria, Australia
Advara HeartCare Joondalup — Joondalup, Western Australia, Australia
Fiona Stanley Hospital — Murdoch, Western Australia, Australia
Krankenhaus Sankt Josef Braunau — Braunau am Inn, Austria
Pro Kompetenzzentrum fuer Gesundheit — Graz, Austria
Medizinische Universitaet Graz — Graz, Austria
Klinikum Klagenfurt am Woerthersee — Klagenfurt, Austria
Ordensklinikum Linz Elisabethinen — Linz, Austria
Landeskrankenhaus Salzburg — Salzburg, Austria
Imed Sankt Poelten — Sankt Pölten, Austria
Universitaetsklinikum Sankt Poelten — Sankt Pölten, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien — Vienna, Austria
Herz Zentrum Waehring — Vienna, Austria
Ordinationszentrum imedneunzehn privat — Vienna, Austria
Krankenhaus Nord - Klinik Floridsdorf — Vienna, Austria
Azorg Campus Aalst - Moorselbaan — Aalst, Belgium
Universitair Ziekenhuis Brussel — Brussels, Belgium
Algemeen Ziekenhuis Sint Blasius — Dendermonde, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan — Genk, Belgium
Algemeen Ziekenhuis Maria Middelares — Ghent, Belgium
Universitair Ziekenhuis Gent — Ghent, Belgium
Jessa Ziekenhuis - Campus Virga Jesse — Hasselt, Belgium
AZ Herentals — Herentals, Belgium
Algemeen Ziekenhuis Groeninge - Campus Kennedylaan — Kortrijk, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven, Belgium
Centre Hospitalier Regional de la Citadelle — Liège, Belgium
Clinique Centre Hospitalier Chrétien MontLégia — Liège, Belgium
AZ Delta Campus Rumbeke — Roeselare, Belgium
Algemeen Ziekenhuis Turnhout — Turnhout, Belgium
Universite Catholique de Louvain Cliniques Universitaires de Mont-Godinne — Yvoir, Belgium
Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo — Vitória, Espírito Santo, Brazil
Hospital das Clinicas da Universidade Federal de Goias — Goiânia, Goiás, Brazil
Ccih - Consultoria em Controle de Infecção Hospitalar — Belo Horizonte, Minas Gerais, Brazil
Cardresearch Cardiologia Assistencial de Pesquisa — Belo Horizonte, Minas Gerais, Brazil
Nucleo de Pesquisa Clinica — Curitiba, Paraná, Brazil
Hospital de Clinicas de Porto Alegre — Porto Alegre, Rio Grande do Sul, Brazil
Fz Pesquisa e Servicos em Cardiologia Clinica Ltda — Porto Alegre, Rio Grande do Sul, Brazil
jmf Clinica do Coracao ltda — Aracaju, Sergipe, Brazil
Instituto de Pesquisa Clinica de Campinas - Ipecc — Campinas, São Paulo, Brazil
Loema Instituto de Pesquisa Clinica e Consultores Ltda - Clinica Loema — Campinas, São Paulo, Brazil
Instituto do Coracao de Marilia — Marília, São Paulo, Brazil
Clinicor Clinica Cardiologica — Ribeirão Preto, São Paulo, Brazil
Pesquisare Saude Ltda — Santo André, São Paulo, Brazil
Praxis Pesquisa Medica — Santo André, São Paulo, Brazil
Hospital de Base de Sao Jose do Rio Preto — São José do Rio Preto, São Paulo, Brazil
Instituto Dante Pazzanese de Cardiologia — São Paulo, São Paulo, Brazil
Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo — São Paulo, São Paulo, Brazil
Instituto de Molestias Cardiovasculares de Tatui — Tatuí, São Paulo, Brazil
IBPClin Instituto Brasil de Pesquisa Clinica — Rio de Janeiro, Brazil
Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD — Burgas, Bulgaria
Multiprofile Hospital for Active Treatment - Haskovo AD — Haskovo, Bulgaria
University Multiprofile Hospital for Active Treatment Sveti Georgi EAD — Plovdiv, Bulgaria
Medical Center Futuremeds EOOD — Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment Knyaginya Klementina - Sofia EAD — Sofia, Bulgaria
National Multiprofile Transport Hospital Tzar Boris III — Sofia, Bulgaria
Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD — Sofia, Bulgaria
Diagnostic-Consultative Center Alexandrovska EOOD — Sofia, Bulgaria
Medical Center Hera EOOD — Sofia, Bulgaria
Diagnostic-Consultative Center XX-Sofia EOOD — Sofia, Bulgaria
Diagnostic-Consultative Center Convex OOD — Sofia, Bulgaria
Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD — Veliko Tarnovo, Bulgaria
Specialised Hospital for Active Cardiology Treatment EAD — Yambol, Bulgaria
University of Alberta Hospital — Edmonton, Alberta, Canada
St Boniface Hospital — Winnipeg, Manitoba, Canada
Cardio 1 — Winnipeg, Manitoba, Canada
Brampton Clinical Trials — Brampton, Ontario, Canada
Cambridge Cardiac Care Centre — Cambridge, Ontario, Canada
Saul Vizel Professional Medicine Corporation - Vizel Cardiac Research — Cambridge, Ontario, Canada
Partners in Advanced Cardiac Evaluation — Newmarket, Ontario, Canada
North York Diagnostic and Cardiac Centre — North York, Ontario, Canada
Kawartha Cardiology Clinical Trials — Peterborough, Ontario, Canada
CardioQuest Research Centre — Sarnia, Ontario, Canada
Heart Health Institute Research Incorporated — Scarborough Village, Ontario, Canada
KMH Cardiology Centres Incorporated Hamilton — Stoney Creek, Ontario, Canada
Curans Heart Center — Thunder Bay, Ontario, Canada
Womens College Hospital — Toronto, Ontario, Canada
Diabetes Heart Research Centre — Toronto, Ontario, Canada
CPS Research — Waterloo, Ontario, Canada
Winchester District Memorial Hospital — Winchester, Ontario, Canada
Ecogene-21 — Chicoutimi, Quebec, Canada
Montreal Heart Institute — Montreal, Quebec, Canada
Diex Recherche Sherbrooke Est — Sherbrooke, Quebec, Canada
Diex Recherche Trois Rivieres — Trois-Rivières, Quebec, Canada
Centro de Investigacion Clinica del Sur — Temuco, Cautín, Chile
Centro de Estudios Cardiologicos y Medicina Interna CECMI — Temuco, Cautín, Chile
Hospital Las Higueras — Talcahuano, Concepción, Chile
Fundacion Innovacion Cardiovascular Clinica Ensenada — Independencia, Santiago Metropolitan, Chile
Enroll SpA — Providencia, Santiago Metropolitan, Chile
Oncocentro Apys — Viña del Mar, Valparaiso, Chile
Cinvec Estudios Clinicos quinta region Limitada — Viña del Mar, Valparaiso, Chile
Biocinetic servicios medicos limitada — Santiago, Chile
Pontificia Universidad Catolica de Chile — Santiago, Chile
Clinical Research Chile SpA — Valdivia, Chile
The Second Hospital of Anhui Medical University — Hefei, Anhui, China
Beijing Hospital — Beijing, Beijing Municipality, China
Fuwai Hospital Chinese Academy of Medical Sciences — Beijing, Beijing Municipality, China
Beijing Friendship Hospital, Capital Medical University — Beijing, Beijing Municipality, China
Peking University Third Hospital — Beijing, Beijing Municipality, China
Guangdong Provincial Peoples Hospital — Guangzhou, Guangdong, China
The Affiliated Hospital of Inner Mongolia Medical University — Haikou, Hainan, China
First Hospital of Qinhuangdao — Qinhuangdao, Hebei, China
The Second Hospital of Hebei Medical University — Shijiazhuang, Hebei, China
The First Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China
Huaihe Hospital of Henan University — Kaifeng, Henan, China
Luoyang Third Peoples Hospital — Luoyang, Henan, China
Zhengzhou Central Hospital — Zhengzhou, Henan, China
The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China
The Third Peoples Hospital of Hubei Province — Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University — Changsha, Hunan, China
The Third Xiangya Hospital of Central South University — Changsha, Hunan, China
The Third Hospital of Changsha — Changsha, Hunan, China
Hebei Petro China Central Hospital — Hengyang, Hunan, China
First Affiliated Hospital of Baotou Hospital, Inner — Baotou, Inner Mongolia, China
Affiliated Hospital of Chifeng University — Chifeng, Inner Mongolia, China
The First Peoples Hospital of Changzhou — Changzhou, Jiangsu, China
The Second Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China
Zhongda Hospital Southeast University — Nanjing, Jiangsu, China
Wuxi Peoples Hospital — Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
Pingxiang Peoples Hospital — Pingxiang, Jiangxi, China
Jilin Province Peoples Hospital — Changchun, Jilin, China
The First Bethune Hospital of Jilin University — Changchun, Jilin, China
China Japan Union Hospital of Jilin University — Changchun, Jilin, China
The Second Hospital of Jilin University — Changchun, Jilin, China
Siping City Center Peoples Hospital — Siping, Jilin, China
Zhongshan Hospital Affiliated to Dalian University — Shenyang, Liaoning, China
The Peoples Hospital of Liaoning Province — Shenyang, Liaoning, China
Shaanxi Provincial Peoples Hospital — Xi'an, Shaanxi, China
The First Affiliated Hospital of Xi An Medical University — Xi'an, Shaanxi, China
Qilu Hospital of Shandong University — Jinan, Shandong, China
Jinan Central Hospital — Jinan, Shandong, China
Tai'an City Central Hospital — Tai’an, Shandong, China
Shanghai General Hospital — Shanghai, Shanghai Municipality, China
Shanghai East Hospital — Shanghai, Shanghai Municipality, China
First Hospital of Shanxi Medical University — Taiyuan, Shanxi, China
Shanxi Cardiovascular Hospital — Taiyuan, Shanxi, China
The First Affiliated Hospital of Xi An Jiao Tong University — Xi’an, Shanxi, China
Yuncheng Central hospital — Yuncheng, Shanxi, China
Chengdu Fifth Peoples Hospital — Chengdu, Sichuan, China
The Second Affiliated Hospital of Chongqing Medical University — Chongqing, Sichuan, China
Tianjin Peoples Hospital — Tianjin, Tianjin Municipality, China
Teda International Cardiovascular Hospital — Tianjin, Tianjin Municipality, China
The First Affiliated Hospital Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
Lishui Central Hospital — Lishui, Zhejiang, China
Clinica Cardio Vid — Medellín, Antioquia, Colombia
Instituicion Prestadora de Salud Centro Cientifico Asistencial SAS — Barranquilla, Atlántico, Colombia
Centro de Investigacion Clinica de la Costa SAS — Barranquilla, Atlántico, Colombia
Corazon Institucion prestadora de Salud sas — Barranquilla, Atlántico, Colombia
Instituicion Prestadora de Salud Medicos Internistas de Caldas SAS — Manizales, Caldas Department, Colombia
Solano y Terront Servicios Medicos SAS - Unidad Integral de Endocrinologia Uniendo — Bogota, Cundinamarca, Colombia
Fundacion cardiovascular de Colombia — Bucaramanga, Santander Department, Colombia
Instituto Neumologico De Oriente Sa — Floridablanca, Santander Department, Colombia
Centro de Investigaciones Clinicas SAS — Cali, Valle del Cauca Department, Colombia
Fundacion Valle del Lili — Cali, Valle del Cauca Department, Colombia
Medicus Services sro — Brandýs nad Labem, Czechia
MUDr Libor Nechvatal sro — Brno, Czechia
Univmed sro — Brno, Czechia
MUDr Karel Kamenik sro — Brno, Czechia
Kardiologicka ambulance Brno sro — Brno, Czechia
Fakultni nemocnice Brno — Brno, Czechia
Vojenska nemocnice Brno — Brno, Czechia
Edumed sro — Broumov, Czechia
CorMedico sro — Bruntál, Czechia
Kardio Chlumec sro — Chlumec nad Cidlinou, Czechia
Ordinace pro choroby srdce sro — Chomutov, Czechia
Dika centrum sro — Havirov - Mesto, Czechia
Kardio Holesov sro — Holešov, Czechia
Edumed sro — Hradec Králové, Czechia
Edumed sro — Jaroměř, Czechia
Kardiologie - Liberec sro — Liberec, Czechia
Cevni ambulance Melnik — Mělník, Czechia
Edumed sro — Náchod, Czechia
PreventaMed sro — Olomouc, Czechia
Ostin sro — Ostrava, Czechia
CCR Ostrava sro — Ostrava, Czechia
MUDr Miroslav Koliba sro — Ostrava, Czechia
Pratia Czech sro — Pardubice, Czechia
Nemocnice Pardubickeho kraje as — Pardubice, Czechia
Kardiologie a Angiologie Praha sro - Komplexni Centrum Vyzkumu, Prevence a Lecby Kardiov Nemoci — Prague, Czechia
Avicena - kardiologie, interna sro — Prague, Czechia
Kardiologie Vinohrady sro — Prague, Czechia
Kardiologie Vinohrady sro — Prague, Czechia
Pratia Czech sro — Prague, Czechia
Institut klinicke a experimentalni mediciny — Prague, Czechia
Kardiologicke centrum MUDr Janky Skrobakove sro — Praha 5 - Smichov, Czechia
MUDr Jarmila Otrubova — Prostějov, Czechia
Kardio Vaclavik sro — Přerov, Czechia
Nemocnice Slany — Slaný, Czechia
Kardiologicka ambulance MUDr Ferkl, sro — Trutnov, Czechia
Ansaldo sro — Uherské Hradiště, Czechia
Clinical Trials Service sro — Uherské Hradiště, Czechia
Kardiologicka Ambulance MUDr Michaela Cervinkova, sro — Ústí nad Labem, Czechia
Kardiologie - Usti nad Labem sro — Ústí nad Labem, Czechia
Aarhus Universitetshospital — Aarhus N, Denmark
Esbjerg sygehus Syddansk universitetshospital — Esbjerg, Denmark
Frederiksberg/Bispebjerg Hospitaler — Frederiksberg, Denmark
Herlev and Gentofte Hospital — Herlev, Denmark
Regionshospitalet Gødstrup — Herning, Denmark
Hvidovre Hospital — Hvidovre, Denmark
Sjaellands Universitetshospital, Roskilde — Roskilde, Denmark
Helsinki University Hospital — Helsinki, Finland
Terveystalo Kamppi — Helsinki, Finland
Terveystalo Jyvaskyla — Jyväskylä, Finland
Turku University Hospital Tyks — Turku, Finland
Centre Hospitalier Universitaire Amiens Picardie - Site Sud — Amiens, France
Centre Hospitalier de Beziers — Béziers, France
Hospices Civils de Lyon Groupement Hospitalier Est - Hopital Louis Pradel — Bron, France
Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand — Dijon, France
Hopital prive Le Bois — Lille, France
Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon — Lille, France
Centre Hospitalier Universitaire de Montpellier - Hopital Arnaud de Villeneuve — Montpellier, France
Hopital prive du Confluent — Nantes, France
Centre Hospitalier Universitaire de Nice - Hopital Pasteur — Nice, France
Hopital Saint Antoine — Paris, France
Hopital Pitie-Salpetriere — Paris, France
Hopital Bichat Claude Bernard — Paris, France
Centre Hospitalier Intercommunal Toulon-La Seyne-sur-Mer - Hopital Sainte Musse — Toulon, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil — Toulouse, France
Centre Hospitalier de Tourcoing - Hopital Guy Chatiliez — Tourcoing, France
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau — Tours, France
Zentralklinik Bad Berka GmbH — Bad Berka, Germany
Rhoehn Klinik Campus Bad Neustadt — Bad Neustadt an der Saale, Germany
Segeberger Kliniken GmbH — Bad Segeberg, Germany
policum Berlin Friedenau — Berlin, Germany
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin — Berlin, Germany
Charite - Universitaetsmedizin Berlin, Campus Virchow — Berlin, Germany
Universitaetsklinikum Bonn — Bonn, Germany
Klinikum Lippe — Detmold, Germany
Zentrum fuer klinische Pruefungen in der Facharztzentrum Dresden-Neustadt Betriebsgesellschaft — Dresden, Germany
Universitaetsklinikum Dresden — Dresden, Germany
Universitaetsklinikum Duesseldorf — Düsseldorf, Germany
ClinPhenomics CVC GmbH — Frankfurt am Main, Germany
Universitaetsklinikum Frankfurt — Frankfurt am Main, Germany
Medizinisches Versorgungszentrum im Altstadt-Carree Fulda — Fulda, Germany
Universitaetsklinikum Hamburg Eppendorf — Hamburg, Germany
Cardiologicum Hamburg GbR — Hamburg, Germany
Kardiologische Praxis — Haßloch, Germany
Universitaetsklinikum Heidelberg — Heidelberg, Germany
Universitaetsklinikum des Saarlandes — Homburg, Germany
Universitaetsklinikum Jena — Jena, Germany
Kardiopraxis Schirmer — Kaiserslautern, Germany
Universitaetsklinikum Leipzig — Leipzig, Germany
zero Praxen GbR — Mannheim, Germany
Johannes Wesling Klinikum Minden — Minden, Germany
Klinikum rechts der Isar der TUM — München, Germany
FutureMeds Offenbach — Offenbach, Germany
Kardiologische Gemeinschaftspraxis Papenburg — Papenburg, Germany
Universitaetsklinikum Regensburg — Regensburg, Germany
Herz- und Gefaesszentrum Praxis Dr Overhoff Dr Kraemer — Siegen, Germany
Cardiologicum Herzklinik Ulm — Ulm, Germany
Praxis Dr med Ayham Al-Zoebi Facharzt fuer Innere Medizin und Kardiologie — Wermsdorf, Germany
University Hospital of Alexandroupolis — Alexandroupoli, Greece
Athens Naval Hospital — Athens, Greece
General Hospital for Thoracic Diseases of Athens "Sotiria — Athens, Greece
General Hospital of Athens Georgios Gennimatas — Athens, Greece
General Hospital of Athens Ippokrateio — Athens, Greece
Alexandra Hospital — Athens, Greece
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara — Athens, Greece
General Hospital Asklipieio Voulas — Athens, Greece
General Hospital of Chios "Skilitsion" — Chios, Greece
University Hospital of Larissa — Larissa, Greece
Hygeia Hospital — Marousi, Greece
Athens Medical Center - Amarousion Branch — Marousi, Athens, Greece
General Hospital Of Nea Ionia Konstantopouleio Patision — Nea Ionia, Greece
Tzaneio General Hospital — Piraeus, Greece
Ahepa University Hospital — Thessaloniki, Greece
Queen Mary Hospital, The University of Hong Kong — Hong Kong, Hong Kong
Prince of Wales Hospital, Chinese University of Hong Kong — Shatin, New Territories, Hong Kong
Tagore Medical Center — Balatonfüred, Hungary
Budapesti Szent Ferenc Korhaz — Budapest, Hungary
Geomedical Orvosi Kft — Budapest, Hungary
Bajcsy-Zsilinszky Korhaz es Rendelointezet — Budapest, Hungary
Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika — Budapest, Hungary
Eszak-Pesti Centrum Korhaz - Honvedkorhaz — Budapest, Hungary
MedKontroll Egeszsegkozpont — Budapest, Hungary
Budapesti Uzsoki Utcai Korhaz — Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont — Debrecen, Hungary
CRU Hungary Kft — Encs, Hungary
Gyongyosi Bugat Pal Korhaz — Gyöngyös, Hungary
Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz — Győr, Hungary
Bacs-Kiskun Varmegyei Oktatokorhaz — Kecskemét, Hungary
Keszthelyi Korhaz — Keszthely, Hungary
Kistarcsai Flor Ferenc Korhaz — Kistarcsa, Hungary
Komaromi Selye Janos Korhaz — Komárom, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz — Nyíregyháza, Hungary
Oroshazi Dr Laszlo Elek Korhaz es Rendelointezet — Orosháza, Hungary
COROMED-SMO Kft — Pécs, Hungary
DaVinci Maganklinika — Pécs, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont — Szeged, Hungary
Tolna Varmegyei Balassa Janos Korhaz — Szekszárd, Hungary
Szegedi Tudomanyegyetem SZGYA Klinikai Kozpont Dr Bugyi Istvan Szentesi Multidiszciplinaris Centrum — Szentes, Hungary
Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz — Székesfehérvár, Hungary
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet — Szolnok, Hungary
Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz — Szombathely, Hungary
Zala Varmegyei Szent Rafael Korhaz — Zalaegerszeg, Hungary
Azienda Ospedaliero Universitaria Consorziale Policlinico — Bari, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii — Bergamo, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia — Brescia, Italy
Azienda Unita Sanitaria Locale Toscana sud est Ospedale S. Margherita — Cortona AR, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia — Foggia, Italy
Azienda Unita Sanitaria Locale Romagna — Forlì, Italy
IRCCS Ospedale San Raffaele — Milan, Italy
IRCCS Centro Cardiologico Monzino — Milan, Italy
Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi — Naples, Italy
Azienda Ospedaliera Universitaria Federico II — Naples, Italy
Azienda Ospedaliero Universitaria di Parma — Parma, Italy
Fondazione IRCCS Policlinico San Matteo — Pavia, Italy
Azienda Unita Sanitaria Locale Romagna — Rimini, Italy
ASL TO3 Ospedale di Rivoli — Rivoli, Italy
Fondazione Policlinico Universitario Campus Bio-Medico — Roma, Italy
Azienda Ospedaliero Universitaria di Sassari — Sassari, Italy
Fujita Health University Hospital — Toyoake-shi, Aichi-ken, Japan
Akaicho Clinic — Chiba, Chiba, Japan
Fukuoka University Hospital — Fukuoka, Fukuoka, Japan
Kokura Memorial Hospital — Kitakyushu-shi, Fukuoka, Japan
Miyanosawa Clinic of Internal Medicine and Cardiology — Sapporo, Hokkaido, Japan
Hyogo Prefectural Harima-Himeji General Medical Center — Himeji-shi, Hyōgo, Japan
Higashi Takarazuka Satoh Hospital — Takarazuka-shi, Hyōgo, Japan
Ishikawa Prefectural Central Hospital — Kanazawa, Ishikawa-ken, Japan
Takamatsu Red Cross Hospital — Takamatsu, Kagawa-ken, Japan
Tenyoukai Central Clinic — Kagoshima, Kagoshima-ken, Japan
Sagamihara Kyodo Hospital — Sagamihara-shi, Kanagawa, Japan
Kumamoto Kinoh Hospital — Kumamoto, Kumamoto, Japan
Rakuwakai Otowa Hospital — Kyoto, Kyoto, Japan
North Alps Medical Center Azumi Hospital — Kitaazumi-gun, Nagano, Japan
Niigata University Medical and Dental Hospital — Niigata, Niigata, Japan
Oita Red Cross Hospital — Ōita, Oita Prefecture, Japan
Osaka Saiseikai Suita Hospital — Suita-shi, Osaka, Japan
Fujinomiya City General Hospital — Fujinomiya-shi, Shizuoka, Japan
Japanese Red Cross Hamamatsu Hospital — Hamamatsu, Shizuoka, Japan
Medical Corporation Kenshinkai Minamino Cardiovascular Hospital — Hachioji-shi, Tokyo, Japan
Affiliated Central Clinic of Higashiyamato Hospital — Higashiyamato-shi, Tokyo, Japan
Tokyo Shinagawa Hospital Social Medical Corporation Association Tokyokyojuno-kai — Shinagawa-ku, Tokyo, Japan
NewHeart Watanabe Institute — Suginami-ku, Tokyo, Japan
Sanin Rosai Hospital — Yonago-shi, Tottori, Japan
Soluciones Terapeuticas Medico Quirurgicas — Mexico City, Mexico City, Mexico
Cardiolink Clin Trials — Monterrey, Nuevo León, Mexico
Health Pharma Queretaro Sa de Cv — Juriquilla, Querétaro, Mexico
Centro de Estudios Clinicos de Queretaro — Querétaro City, Querétaro, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC — Culiacán, Sinaloa, Mexico
Hospital Cardiologica Aguascalientes — Aguascalientes, Mexico
Amsterdam Universitair Medisch Centrum — Amsterdam, Netherlands
Rijnstate Ziekenhuis — Arnhem, Netherlands
Amphia ziekenhuis — Breda, Netherlands
Reinier de Graaf Gasthuis — Delft, Netherlands
Deventer Ziekenhuis — Deventer, Netherlands
Albert Schweitzer Ziekenhuis, Locatie Dordwijk — Dordrecht, Netherlands
Catharina Ziekenhuis — Eindhoven, Netherlands
Treant Zorggroep, locatie Scheper ziekenhuis Emmen — Emmen, Netherlands
Medisch Spectrum Twente — Enschede, Netherlands
Universitair Medisch Centrum Groningen — Groningen, Netherlands
Zuyderland Medisch Centrum — Heerlen, Netherlands
Frisius Medisch Centrum, locatie Leeuwarden — Leeuwarden, Netherlands
Ikazia Ziekenhuis — Rotterdam, Netherlands
D and A Research and Genetics — Sneek, Netherlands
Haga Ziekenhuis — The Hague, Netherlands
Zaans Medisch Centrum — Zaandam, Netherlands
Marek Dariusz Klimkiewicz Klimed Marek Klimkiewicz — Bialystok, Poland
Centrum medyczne intercore sp zoo — Bydgoszcz, Poland
American Heart of Poland Spolka Akcyjna — Chrzanów, Poland
Centrum Badan Klinicznych Agnieszka Mital — Elblag, Poland
Uniwersyteckie Centrum Kliniczne — Gdansk, Poland
Pawel Miekus, NZOZ Sopockie Centrum Badan Kardiologicznych ProCordis Pawel Miekus — Gdynia, Poland
Niepubliczny Zaklad Opieki Zdrowotnej Medica Jerzy Cygler — Giżycko, Poland
Pro Familia Altera Sp zoo — Katowice, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia — Krakow, Poland
SPZOZ Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi — Lodz, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia — Lodz, Poland
CenterMed Spzoo Centermed Lublin — Lublin, Poland
Szpital Swietej Anny w Miechowie — Miechów, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia — Olsztyn, Poland
Medicome Spolka z Ograniczona Odpowiedzialnoscia — Oświęcim, Poland
Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa — Rzeszów, Poland
Velocity Nova Sp zoo — Skierniewice, Poland
Praktyka Lekarska Lidia Pawlowicz — Torun, Poland
American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca — Tychy, Poland
Oha-Med Sp zoo — Warsaw, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji — Warsaw, Poland
Gabinet Lekarski Maciej Karcz — Warsaw, Poland
Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu — Wroclaw, Poland
Futuremeds spolka z ograniczona odpowiedzialnoscia — Wroclaw, Poland
Halina Serafin NZOZ Centrum Medyczne "Serafin-Med" — Żarów, Poland
Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de Orta — Almada, Portugal
Unidade Local de Saude de Coimbra, EPE — Coimbra, Portugal
Unidade Local de Saude do Alto Ave, EPE — Guimarães, Portugal
Unidade Local de Saude de Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier — Lisbon, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria — Lisbon, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano — Matosinhos Municipality, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao — Porto, Portugal
Unidade Local de Saude de Gaia-Espinho, EPE — Vila Nova de Gaia, Portugal
Cardioplus Center SRL — Baia Mare, Romania
cmi Cardiologie - Dr Pop Calin — Baia Mare, Romania
Thera Card SRL — Brasov, Romania
Centrul Medical de Diagnostic si Tratament Ambulator Neomed — Brasov, Romania
Spitalul Universitar de Urgenta Bucuresti — Bucharest, Romania
Matcord Biomedica Buzau — Buzău, Romania
Consultmed SRL — Iași, Romania
Sal Med SRL — Piteşti, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures — Târgu Mureş, Romania
Cabinet Medical Individual Dr Podoleanu Cristian — Târgu Mureş, Romania
Spitalul Clinic Municipal de Urgenta Timisoara — Timișoara, Romania
Alian, sro — Bardejov, Slovakia
HeartCare sro — Bardejov, Slovakia
Narodny ustav srdcovych a cievnych chorob, as — Bratislava, Slovakia
Novate sro — Bratislava, Slovakia
Kardiomedina sro — Dolný Kubín, Slovakia
Nemocnica Dr Vojtecha Alexandra v Kezmarku no — Kežmarok, Slovakia
Medical group Kosice sro — Košice, Slovakia
Cardio D and R, sro Kosice — Košice, Slovakia
KardioLEV sro — Levoča, Slovakia
Kardio 1 sro — Lučenec, Slovakia
Nemocnicna as — Malacky, Slovakia
Oralek, sro — Námestovo, Slovakia
Kardiomed NZ, sro — Nové Zámky, Slovakia
KaCH, sro — Nové Zámky, Slovakia
Nemocnica Poprad, as — Poprad, Slovakia
Intermedis sro — Prešov, Slovakia
Medispol, sro — Prešov, Slovakia
Interna SK, sro — Svidník, Slovakia
Pentes, sro — Žilina, Slovakia
Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea
Seoul National University Hospital — Seoul, South Korea
Severance Hospital Yonsei University Health System — Seoul, South Korea
Yonsei University Wonju Severance Christian Hospital — Wonju-si, Gangwon-do, South Korea
Hospital Universitario Reina Sofia — Córdoba, Andalusia, Spain
Hospital Clinico Universitario Virgen de la Victoria — Málaga, Andalusia, Spain
Hospital Universitario de Gran Canaria Doctor Negrin — Las Palmas de Gran Canaria, Canary Islands, Spain
Hospital Universitari Germans Trias i Pujol — Badalona, Catalonia, Spain
Hospital Universitari Vall d Hebron — Barcelona, Catalonia, Spain
Hospital Clinic i Provincial de Barcelona — Barcelona, Catalonia, Spain
Hospital Universitari de Bellvitge — L'Hospitalet de Llobregat, Catalonia, Spain
Hospital Universitario Arnau de Vilanova Lleida — Lleida, Catalonia, Spain
Complexo Hospitalario Universitario A Coruña — A Coruña, Galicia, Spain
Hospital Universitario Puerta de Hierro Majadahonda — Majadahonda, Madrid, Spain
Hospital Universitario Virgen de la Arrixaca — El Palmar, Murcia, Spain
Hospital Marina Salud de Denia — Denia, Valencia, Spain
Hospital Clinico Universitario de Valencia — Valencia, Valencia, Spain
Hospital Universitari i Politecnic La Fe — Valencia, Valencia, Spain
Hospital Vithas Valencia Turia — Valencia, Valencia, Spain
Hospital Clinico San Carlos — Madrid, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain
Hospital Universitario La Paz — Madrid, Spain
Hospital Clinico Universitario de Salamanca — Salamanca, Spain
Falu Lasarett — Falun, Sweden
Carlanderska sjukhuset — Gothenburg, Sweden
Helsingborgs Lasarett — Helsingborg, Sweden
Clemenstorgets Hjartmottagning — Lund, Sweden
Vrinnevisjukhuset i Norrkoeping — Norrköping, Sweden
Karolinska Universitetssjukhuset Solna — Solna, Sweden
Capio Saint Gorans Hospital — Stockholm, Sweden
Danderyds Sjukhus — Stockholm, Sweden
Universitaetsspital Basel — Basel, Switzerland
Inselspital Bern — Bern, Switzerland
Hopitaux Universitaires de Geneve — Geneva, Switzerland
Centre hospitalier universitaire vaudois — Lausanne, Switzerland
Luzerner Kantonsspital — Lucerne, Switzerland
Istituto Cardiocentro Ticino — Lugano, Switzerland
Kantonsspital Sankt Gallen — Sankt Gallen, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
China Medical University Hospital — Taichung, Taiwan
National Cheng Kung University Hospital — Tainan, Taiwan
National Taiwan University Hospital — Taipei, Taiwan
Taipei Medical University Hospital — Taipei, Taiwan
Taipei Veterans General Hospital — Taipei, Taiwan
Afyonkarahisar Saglik Bilimleri Universitesi Hastanesi — Afyonkarahisar, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi — Ankara, Turkey (Türkiye)
Hitit Universitesi Erol Olcok Egitim ve Arastirma Hastanesi — Çorum, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi — Istanbul, Turkey (Türkiye)
Bagcilar Medipol Mega Universite Hastanesi — Istanbul, Turkey (Türkiye)
Mehmet Akif Ersoy Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi — Istanbul, Turkey (Türkiye)
Dr Siyami Ersek Gogus Kalp ve Damar Cerrahisi Egitim ve Arastirma Hastanesi — Istanbul, Turkey (Türkiye)
Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi — Istanbul, Turkey (Türkiye)
Dokuz Eylul Universitesi Tip Fakultesi Hastanesi — Izmir, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Hastanesi — Kayseri, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi Hastanesi — Kocaeli, Turkey (Türkiye)
Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi — Konya, Turkey (Türkiye)
University Hospital Monklands — Airdrie, United Kingdom
North Tyneside General Hospital — Ashington, United Kingdom
Ormeau Clinical Trials Ltd — Belfast, United Kingdom
Royal Bournemouth Hospital — Bournemouth, United Kingdom
Princess of Wales Hospital — Bridgend, United Kingdom
Southmead Hospital — Bristol, United Kingdom
St Richards Hospital — Chichester, United Kingdom
Ninewells Hospital and Medicine School — Dundee, United Kingdom
Royal Devon and Exeter Hospital — Exeter, United Kingdom
Glasgow Royal Infirmary — Glasgow, United Kingdom
Wycombe Hospital — High Wycombe, United Kingdom
Highlands Clinical Research Facility, Raigmore Hospital — Inverness, United Kingdom
University Hospital Crosshouse — Kilmarnock, United Kingdom
Glenfield Hospital — Leicester, United Kingdom
University College London Hospital — London, United Kingdom
St Georges Hospital — London, United Kingdom
Manchester Royal Infirmary — Manchester, United Kingdom
Newcastle NIHR Commercial Research Delivery Centre — Newcastle upon Tyne, United Kingdom
Craigavon Area Hospital — Portadown, Craigavon, United Kingdom
University Hospital of North Tees — Stockton-on-Tees, United Kingdom
Breckland Alliance Research — Thetford, United Kingdom
Pinderfields Hospital — Wakefield, United Kingdom
Marine Lake & Estuary Medical Practice — West Kirby, United Kingdom

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