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RECRUITING Not applicable ClinicalTrials.gov

Correlation of STN-DBS Induced Visuospatial Changes and Freezing of Gait

Sponsor: Medical University of South Carolina • ClinicalTrials.gov ID: NCT06994728

Registry updated: 2026-08-24
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Description

The purpose of this research is to determine how deep brain stimulation (DBS) for Parkinson's disease affects attention and visuospatial function. Additionally, this study will evaluate how deficits in visual attention are associated with freezing of gait (FOG) in Parkinson's disease. There is currently no reliable treatment for FOG and little is understood about the underlying reason this occurs. Some recent research has found that stimulating the right side of the brain seems to improve FOG. The right side of the brain is also paramount for visual attention, which is why investigators are conducting this study.

Interventions

  • Left STN-DBS on, right STN-DBS off first (Device)
    There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.
  • Right STN-DBS on, left STN-DBS off first (Device)
    There will not be any change to baseline DBS stimulation settings, only each side will be sequentially turned off during cognitive and freezing of gait assessments.

Eligibility criteria

Inclusion Criteria: * Subjects above 18 years of age * Subjects with freezing of gait * Subjects with bilateral STN-DBS surgery as part of their clinical care for Parkinson's disease Exclusion Criteria: * Uncorrected visual or hearing impairments, as indicated by self-report * Individuals who are pregnant or expect to become pregnant during the course of the study * Individuals with dementia or relevant brain lesions impacting cognition or gait

Conditions

Parkinson Disease Gait Disorders, Neurologic Visuospatial/Perceptual Abilities

Locations

  • Medical University of South Carolina — Charleston, South Carolina, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record