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RECRUITING Not applicable ClinicalTrials.gov

Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)

Sponsor: Assiut University • ClinicalTrials.gov ID: NCT06988111

Registry updated: 2026-09-22
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Description

Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.

Interventions

  • BIPAP (Device)
    The second arm (NIV group) will be managed by BIPAP device for post-operative respiratory failure
  • Vapotherm (Device)
    The first arm (HVNC group) will be managed by Vapotherm device for post-operative respiratory failure

Eligibility criteria

Inclusion criteria: * Age above 18 years * within 48 hours after major surgery * PAO2/FIO2 less than 200 * Signs of respiratory distress and respiratory rate (RR) more than 25 cycles/minute Exclusion Criteria: * Age below 18 years * Pregnant ladies * Orofacial trauma or burns * Active Gastrointestinal bleeding

Conditions

Respiratory Failure Without Hypercapnia Respiratory Failure With Hypercapnia Postoperative Respiratory Complication

Locations

  • Assuit Univeristy — Asyut, Assuit, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record