A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Description

The purpose of this study is to evaluate the efficacy and safety of tacabrutideg alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).

Interventions

• Tacabrutideg (Drug)
  Tacabrutideg will be administered orally
• Pirtobrutinib (Drug)
  Pirtobrutinib will be administered orally

Eligibility criteria

Conditions

Locations

• University of Alabama At Birmingham Hospital — Birmingham, Alabama, United States
• Mayo Clinic Phoenix — Phoenix, Arizona, United States
• Kaiser Permanente Southern California — Irvine, California, United States
• University of California San Diego (Ucsd) Moores Cancer Center — La Jolla, California, United States
• Cancer and Blood Specialty Clinic — Los Alamitos, California, United States
• UCLA Department of Medicine Hematologyoncology — Los Angeles, California, United States
• Kaiser Permanente Oakland Medical Center — Oakland, California, United States
• Stanford Cancer Institute — Palo Alto, California, United States
• Kaiser Permanente Roseville Medical Center — Roseville, California, United States
• Kaiser Permanente San Francisco Medical Center Oncology — San Francisco, California, United States
• Kaiser Permanente Santa Clara Medical Center Oncologyhematology — Santa Clara, California, United States
• Kaiser Permanente Northern California — Vallejo, California, United States
• Kaiser Permanente Walnut Creek Medical Center — Walnut Creek, California, United States
• Christiana Care — Newark, Delaware, United States
• Medstar Georgetown University Hospital — Washington D.C., District of Columbia, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• Cancer Specialists of North Florida — Jacksonville, Florida, United States
• Mount Sinai Medical Center Braman Comprehensive Cancer Center — Miami, Florida, United States
• University of Chicago Medical Center — Chicago, Illinois, United States
• Mission Cancer and Blood — Waukee, Iowa, United States
• The University of Kansas Cancer Center — Westwood, Kansas, United States
• Our Lady of the Lake Hospital — Baton Rouge, Louisiana, United States
• Mary Bird Perkins Cancer Center — Baton Rouge, Louisiana, United States
• Ochsner Clinic Foundation — New Orleans, Louisiana, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Karmanos Cancer Institute — Detroit, Michigan, United States
• Mayo Clinic Rochester — Rochester, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Titan Health Partners Llc Dba Astera Cancer Care — East Brunswick, New Jersey, United States
• John Theurer Cancer Center Hackensack University Medical Center — Hackensack, New Jersey, United States
• Columbia University Medical Center — New York, New York, United States
• Weill Cornell Medical College Newyork Presbyterian Hospital — New York, New York, United States
• Memorial Sloan Kettering Cancer Center Mskcc — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• University of North Carolina At Chapel Hill — Chapel Hill, North Carolina, United States
• Atrium Health Levine Cancer Institute (Lci) — Charlotte, North Carolina, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina, United States
• Dayton Physician Network — Dayton, Ohio, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Tennessee Oncology, Pllc Nashville — Nashville, Tennessee, United States
• Md Anderson Cancer Center — Houston, Texas, United States
• Texas Oncology Palestine Cancer Center — Palestine, Texas, United States
• Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia) — Roanake, Virginia, United States
• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
• Summit Cancer Centers — Spokane, Washington, United States
• Northwest Medical Specialties — Tacoma, Washington, United States
• Gunderson Health System — La Crosse, Wisconsin, United States
• FUNDALEU — Caba, Argentina
• Sanatorio Allende — Córdoba, Argentina
• Centro Oncologico de Integracion Regional (Coir) — Mendoza, Argentina
• Hospital Privado de Rosario — Rosario, Argentina
• Concord Repatriation General Hospital — Concord, New South Wales, Australia
• St George Private Hospital — Kogarah, New South Wales, Australia
• Westmead Private Hospital — Westmead, New South Wales, Australia
• Pindara Private Hospital — Benowa, Queensland, Australia
• Sunshine Coast Hospital and Health Service — Birtinya, Queensland, Australia
• John Flynn Private Hospital — Tugun, Queensland, Australia
• Flinders Medical Centre — Bedford PK, South Australia, Australia
• St Vincents Hospital Melbourne — Fitzroy, Victoria, Australia
• Peninsula Private Hospital — Frankston, Victoria, Australia
• Austin Health — Heidelberg, Victoria, Australia
• Cabrini Hospital Malvern — Malvern, Victoria, Australia
• Peter Maccallum Cancer Centre — Melbourne, Victoria, Australia
• The Alfred Hospital — Melbourne, Victoria, Australia
• Linear Clinical Research — Nedlands, Western Australia, Australia
• Medical University Graz — Graz, Austria
• Medizinische Universitatsklinik Innsbruck — Innsbruck, Austria
• Ordensklinikum Linz Gmbh Elisabethinen — Linz, Austria
• Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg — Salzburg, Austria
• Uk St Poelten — Sankt Pölten, Austria
• Institut Jules Bordet — Anderlecht, Belgium
• UZ GENT — Ghent, Belgium
• Az Groeninge Campus Loofstraat — Kortrijk, Belgium
• Chc Montlegia — Liège, Belgium
• Chu de Liege — Liège, Belgium
• Az Sint Maarten — Mechelen, Belgium
• Chu Ucl Namur — Yvoir, Belgium
• Centro de Pesquisa Clinica Dom Bosco Ltda — Araçatuba, Brazil
• Hospital Felicio Rocho — Belo Horizonte, Brazil
• Ictr Instituto Do Cancer E Transplante de Curitiba — Curitiba, Brazil
• Hospital de Clinicas de Goiania Ufg — Goiânia, Brazil
• Inca Instituto Nacional de Cancer — Rio de Janeiro, Brazil
• Ensino E Terapia de Inovacao Clinica Amo Etica — Salvador, Brazil
• Hospital Nove de Julho Dasa — São Paulo, Brazil
• Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo — São Paulo, Brazil
• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China
• Fujian Medical University Union Hospital — Fuzhou, Fujian, China
• The First Hospital of Lanzhou University — Lanzhou, Gansu, China
• Sun Yat Sen University Cancer Center — Guangzhou, Guangdong, China
• Jiangmen Central Hospital — Jiangmen, Guangdong, China
• The First Affiliated Hospital of Guangxi Medical University — Nanning, Guangxi, China
• Guizhou Provincial Peoples Hospital — Guiyang, Guizhou, China
• The Fourth Hospital of Hebei Medical University East Branch — Shijiazhuang, Hebei, China
• The First Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China
• Xuchang Central Hospitalluminghu Branch — Xuchang, Henan, China
• Henan Cancer Hospital — Zhengzhou, Henan, China
• Union Hospital, Tongji Medical College, Huazhong University of Science and Technologychegu Branch — Wuhan, Hubei, China
• Hunan Cancer Hospital — Changsha, Hunan, China
• Affiliated Hospital of Nantong University — Nantong, Jiangsu, China
• The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China
• Wuxi Peoples Hospital — Wuxi, Jiangsu, China
• The Affiliated Hospital of Xuzhou Medical University — Xuzhou, Jiangsu, China
• The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
• The First Hospital of Jilin University — Changchun, Jilin, China
• The Second Hospital of Dalian Medical University — Dalian, Liaoning, China
• Shengjing Hospital of China Medical University — Shenyang, Liaoning, China
• Qinghai University Affiliated Hospital — Xining, Qinghai, China
• The Second Affiliated Hospital of Xian Jiaotong University — Xi'an, Shaanxi, China
• Binzhou Medical University Hospital — Binzhou, Shandong, China
• Taian City Central Hospital — Taian, Shandong, China
• Renji Hospital Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China
• Shanxi Bethune Hospital — Taiyuan, Shanxi, China
• Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital — Chengdu, Sichuan, China
• Dazhou Central Hospital — Dazhou, Sichuan, China
• The Affiliated Hospital of Southwest Medical University — Luzhou, Sichuan, China
• Institute of Hematology and Hospital of Blood Disease — Tianjin, Tianjin Municipality, China
• First Affiliated Hospital of Kunming Medical University — Kunming, Yunnan, China
• The First Affiliated Hospital of Ningbo University — Ningbo, Zhejiang, China
• The First Affiliated Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China
• Centre de Lutte Contre Le Cancer Institut Bergonie — Bordeaux, France
• Hopital Estaing — ClermontFerrand, France
• Centre Hospitalier Universitaire Nantes Hotel Dieu — Nantes, France
• Hopital Saint Louis — Paris, France
• Centre Henri Becquerel — Rouen, France
• Iuc Toulouse Oncopole — Toulouse, France
• Chu Tours Hopital Bretonneau — Tours, France
• Chu Nancy Hopital Brabois — VandoeuvrelesNancy, France
• St Josef Hospital Klinikum Der Ruhr Universitat Bochum — Bochum, Germany
• Universitatsklinikum Bonn — Bonn, Germany
• Uniklinik Koeln (Aoer) — Cologne, Germany
• Gemeinschaftspraxis Fur Hamatologie Und Onkologie Dortmund — Dortmund, Germany
• Stadtisches Klinikum Karlsruhe — Karlsruhe, Germany
• Mvz Fur Hamatologie Und Onkologie Lubeckgmbh — Lübeck, Germany
• Robert Bosch Krankenhaus, Abteilung Hamatologie, Onkologie Und Palliativmedizin — Stuttgart, Germany
• Universitaetsklinikum Ulm — Ulm, Germany
• Gemeinschaftspraxis Fuer Haematologie Und Onkologie Westerstede — Westerstede, Germany
• Bnai Zion Medical Center — Haifa, Israel
• Shaare Zedek Medical Center — Jerusalem, Israel
• Hadassah University Hospital Ein Kerem — Jerusalem, Israel
• Meir Medical Center — KfarSava, Israel
• Rabin Medical Center — Petah Tikva, Israel
• Sheba Medical Center — Ramat Gan, Israel
• Sourasky Tel Aviv Medical Center — Tel Aviv, Israel
• Policlinico Sorsola Malpighi, Aou Di Bologna — Bologna, Italy
• Ospedale San Raffaele — Milan, Italy
• Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda — Milan, Italy
• Azienda Ospedaliera Di Padova — Padova, Italy
• Aichi Cancer Center Hospital Clinical Oncology — Nagoya, Aichi-ken, Japan
• Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital — Nakamuraku, Aichi-ken, Japan
• Matsuyama Red Cross Hospital — Matsuyama, Ehime, Japan
• Fukushima Medical University Hospital — Fukushima, Fukushima, Japan
• Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital — Hiroshima, Hiroshima, Japan
• Aiiku Hospital — Sapporo, Hokkaido, Japan
• Kochi Medical School Hospital — Nankoku, Kochi, Japan
• Kumamoto University Hospital — Kumamoto, Kumamoto, Japan
• Japanese Red Cross Kyoto Daini Hospital — Kyotoshi, Kyoto, Japan
• Oita Prefectural Hospital — Ōita, Oita Prefecture, Japan
• Okayama University Hospital — Okayama, Okayama-ken, Japan
• Osaka Metropolitan University Hospital — Osaka, Osaka, Japan
• Kindai University Hospital — Sakai, Osaka, Japan
• Dokkyo Medical University Saitama Medical Center — Koshigaya, Saitama, Japan
• Tokyo Metropolitan Komagome Hospital — Bunkyoku, Tokyo, Japan
• Cancer Institute Hospital of Jfcr — Kotoku, Tokyo, Japan
• National Hospital Organization (Nho) Disaster Medical Center — Tachikawashi, Tokyo, Japan
• Yamagata University Hospital — Yamagata, Yamagata, Japan
• Centro de Investigacion Clinica Gramel — México, Mexico
• Christus Latam Hub Center of Excellence and Innovation Sc — Monterrey, Mexico
• Centro de Investigacion Clinica de Oaxaca — Oaxaca City, Mexico
• Centro Hemato Oncologico Privado de Toluca — Toluca, Mexico
• Albert Schweitzer Ziekenhuis — Dordrecht, Netherlands
• Catharina Hospital — EJ Eindhoven, Netherlands
• Groene Hart Hospital — Gouda, Netherlands
• University of Medical Center Groningen (Umcg) — Groningen, Netherlands
• Canisius Wilhelmina Ziekenhuis — Nijmegen, Netherlands
• Universitair Medisch Centrum Utrecht — Utrecht, Netherlands
• North Shore Hospital — Auckland, New Zealand
• Tauranga Hospital — Tauranga, New Zealand
• Wellington Regional Hospital (Ccdhb) — Wellington, New Zealand
• Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii — Gdansk, Poland
• Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach — Kielce, Poland
• Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi — Lodz, Poland
• Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie — Lublin, Poland
• Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii — Olsztyn, Poland
• Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu — Torun, Poland
• Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie — Warsaw, Poland
• Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu — Wroclaw, Poland
• Auxilio Mutuo Cancer Center — San Juan, Puerto Rico
• Coltea Clinical Hospital — Bucharest, Romania
• Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca — ClujNapoca, Romania
• Institutul Regional de Oncologie Iasi — Iași, Romania
• Singapore General Hospital — Singapore, Singapore
• Tan Tock Seng Hospital Haematology — Singapore, Singapore
• Pusan National University Hospital — Seogu, Busan Gwang'Yeogsi, South Korea
• Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea
• Gyeongsang National University Hospital — Jinju, Gyeongsangnam-do, South Korea
• The Catholic University of Korea, Seoul St Marys Hospital — SeochoGu, Seoul Teugbyeolsi, South Korea
• Severance Hospital Yonsei University Health System — SeodaemunGu, Seoul Teugbyeolsi, South Korea
• Seoul National University Hospital — Seoul, Seoul Teugbyeolsi, South Korea
• Ico Badalona — Badalona, Spain
• Hospital Universitario de Burgos — Burgos, Spain
• Hospital Universitario de Gran Canaria Dr Negrin — Las Palmas de Gran Canaria, Spain
• Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
• Hospital Universitario Puerta de Hierro Majadahonda — Majadahonda, Spain
• Hospital Universitari Son Espases — Palma de Mallorca, Spain
• Hospital Universitario Virgen Del Rocio — Seville, Spain
• Sahlgrenska Universitetssjukhuset — Gothenburg, Sweden
• Karolinska Universitetssjukhuset Solna — Stockholm, Sweden
• Inselspital Bern (Inselspital, Universitatsspital Bern) — Bern, Switzerland
• Universitatsspital Zurich — Zurich, Switzerland
• University Hospitals Sussex Nhs Foundation Trust — Brighton, United Kingdom
• Kent and Canterbury Hospital — Canterbury, United Kingdom
• Norfolk and Norwich University Hospitals Nhs Foundation Trust — Norwich, United Kingdom
• Oxford University Hospitals Nhs Foundation Trust — Oxford, United Kingdom
• Spire Leeds Healthcare Spire Leeds Hospital — Roundhay, United Kingdom
• Salisbury Foundation Trust — Salisbury, United Kingdom