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RECRUITING Not applicable ClinicalTrials.gov

Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

Sponsor: University of California, San Francisco • ClinicalTrials.gov ID: NCT06960421

Registry updated: 2026-10-16
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Description

The goal of XFIT study is to measure the safety of an 8-week telehealth-delivered exercise and behavioral training program to treat frailty in lung transplant candidates in their own home. The main questions XFIT aims to answer are: * Is XFIT safe? * Is XFIT feasible and acceptable by participants? * Is XFIT effective in improving frailty and physical function as reflected in patient-reported outcomes. Participants will: \- Participate in the 8-week XFIT program or enhanced standard of care

Interventions

  • XFIT (Behavioral)
    XFIT is an 8-week telehealth-delivered, home-based exercise/behavior modification intervention. It integrates theoretical frameworks of behavior change to engage frail lung transplant candidates in program of pre-habilitation.

Eligibility criteria

Group 1 Inclusion Criteria: * Age 18 - 65 years * Lung Transplant Candidates * Speaks English or Spanish * ≤ 8LPM O2 on 6MWT * SPPB score ≤ 10 Exclusion Criteria: * Lives Alone * BMI \< 18.0 kg/m2 * Engaged in clinical pulmonary rehabilitation program * Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE * Deemed unsafe by site PI Group 2 Inclusion Criteria: * Age 18 - 75 years * Speaks English or Spanish * ≤ 15LPM O2 on 6MWT * SPPB score ≤ 10 Exclusion Criteria: * Lives Alone * BMI \< 18.0 kg/m2 * Engaged in clinical pulmonary rehabilitation program * Severely reduced RV systolic function on TTE * Deemed unsafe by site PI

Conditions

Frailty Lung Tranplant Candidate

Locations

  • University of California,San Francisco — San Francisco, California, United States
  • Columbia University — New York, New York, United States
  • University of North Carolina — Chapel Hill, North Carolina, United States
  • University of Pennsylvania — Philadelphia, Pennsylvania, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record