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Transcranial Magnetic Stimulation in Misophonia

Sponsor: Icahn School of Medicine at Mount Sinai • ClinicalTrials.gov ID: NCT06960083

Registry updated: 2026-10-15

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Description

The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

Interventions

Transcranial Magnetic Stimulation (TMS) (Other)
Transcranial Magnetic Stimulation (TMS) is an FDA-approved non-invasive brain stimulation technology. It is currently used for treating depression. Applications to other disorders such as OCD and anxiety using TMS are currently under investigation. TMS will be administered for 25 minutes.

Eligibility criteria

Inclusion Criteria: * Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear. * Must be between the ages of 18 - 55. * Must be fluent in English since the study's instructions, surveys, and tasks will be in English. Exclusion Criteria: * Epilepsy or previous episode of convulsion or seizure. * Previous episode of fainting spell or syncope. * Head trauma. * Hearing problems. * Cochlear implant. * Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.). * Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS). * Presence of cardiac pacemaker or intracardiac lines. * Presence of medication infusion device. * Use of pro-convulsant or epileptogenic medications. * Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children. * Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children. * Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.

Conditions

Misophonia

Locations

Mount Sinai West — New York, New York, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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