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RECRUITING Not applicable ClinicalTrials.gov

Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged

Sponsor: University of Nebraska • ClinicalTrials.gov ID: NCT06943846

Registry updated: 2026-10-08
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Description

The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.

Interventions

  • Platelet-rich fibrin (PRF) (Procedure)
    Platelet-rich fibrin added to extraction socket

Eligibility criteria

Inclusion Criteria: * Patient at University of Nebraska Medical Center (UNMC) College of Dentistry * Requires extraction of posterior tooth * Able and willing to provide consent/assent Exclusion Criteria: * Systemic conditions that delay wound healing * Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy

Conditions

Edentulism

Locations

  • University of Nebraska Medical Center College of Dentistry — Lincoln, Nebraska, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record