RECRUITING Phase 3 ClinicalTrials.gov

A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Sponsor: Boehringer Ingelheim • ClinicalTrials.gov ID: NCT06935370

Registry updated: 2026-10-14

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Description

This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before they start on the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure. In this study, participants are put into 2 groups randomly. Participants have an equal chance of being in either group. One group takes vicadrostat/empagliflozin tablets, and the other group takes placebo/empagliflozin tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants take the study medicines as tablets once a day for between about 6 months and about 3.5 years. During this time, they can continue their regular treatment for heart failure. Participants can stay in the study as long as they benefit from treatment and can tolerate it, for a maximum of about 3.5 years. During this time, they visit the study site regularly. The exact number of visits is different for each participant, depending on how long they stay in the study. The study staff may also contact the participants by phone for some visits. Participants also regularly answer questions about their well-being. The doctors document when participants experience worsening of their heart failure symptoms, go to hospital due to heart failure or die during the study. The time until these events are observed is compared between the two treatment groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.

Interventions

vicadrostat (Drug)
vicadrostat
empagliflozin (Drug)
empagliflozin
Placebo (Drug)
Placebo matching vicadrostat

Eligibility criteria

Inclusion criteria: 1. At least 18 years old and at least at the legal age of consent in countries where it is greater than 18 years 2. Signed and dated written informed consent in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial 3. Male or female participants. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the protocol. 4. Chronic heart failure (HF) diagnosed at least 3 months before Visit 1, and in New York Heart Association (NYHA) classes II to IV at Visit 1, with left ventricular ejection fraction (LVEF) \< 40% per local reading (obtained by echocardiography, radionuclide ventriculography, invasive angiography, magnetic resonance imaging (MRI), or computed tomography (CT)). 5. Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) at Visit 1, analysed at the central laboratory 6. Treated according to best possible standard of care (SOC) (disregarding sodium-dependent glucose co-transporter 2 inhibitor (SGLT2i) and mineralocorticoid receptor antagonist (MRA)) in accordance with applicable heart failure (HF) local/international guidelines and judgement of the investigator. Additional inclusion criteria apply. Exclusion criteria: 1. Treatment with an MRA (e.g. spironolactone, eplerenone, finerenone) within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. Treatment with an MRA should not be discontinued with the intention of study enrolment. 2. Treatment with amiloride or other potassium-sparing diuretic within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. 3. Receiving the following treatments: * A direct renin inhibitor (e.g. aliskiren) at Visit 2 * More than one angiotensin-converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNi) used simultaneously at Visit 2 * Other aldosterone synthase inhibitors, e.g. baxdrostat at Visit 2 or planned during the trial * Systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) at Visit 2 * In case of acute decompensated HF: * i.v. inotrope, i.v. vasodilating drug (e.g. nitrate, nitroprusside), or i.v. natriuretic peptide (e.g. nesiritide, carperitide), or mechanical support (e.g. intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, any ventricular assist device) within 24 hours prior to randomisation * i.v. diuretic with a dose that has been increased/intensified within 6 hours prior to randomisation (a stable dose of an i.v. diuretic is not exclusionary) 4. Myocardial infarction (MI), transient ischemic attack (TIA), stroke, coronary artery bypass graft surgery (CABG), heart valve surgery/intervention or any other major surgery (major according to the investigator's assessment) within 90 days prior to Visit 2, or scheduled for major elective surgery (e.g. hip replacement, CABG) 5. Percutaneous coronary intervention (PCI) or any angiography using iodinated contrast agents in the 7 days prior to Visit 2 6. Heart transplant recipient, awaiting heart transplant, or currently implanted left ventricular assist device (LVAD) 7. Known cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic obstructive cardiomyopathy or known pericardial constriction, or cardiomyopathy with potentially reversible cause such as stress or peripartum cardiomyopathy or cardiomyopathy induced by chemotherapy within 12 months prior to Visit 1 and until Visit 2 8. Acute inflammatory heart disease, such as acute myocarditis, within 90 days preceding prior to Visit 1 and until Visit 2 Further exclusion criteria apply.

Conditions

Heart Failure

Locations

Cure Clinical Research — Beverly Hills, California, United States
Valley Clinical Trials, Inc. — Covina, California, United States
North Coast Cardiology — Encinitas, California, United States
Merced Vein and Vascular Center — Merced, California, United States
Radin Cardiovascular Medical Group — Newport Beach, California, United States
Amicis Research Center - Nordhoff — Northridge, California, United States
University of California San Diego — San Diego, California, United States
Paradigm Clinical Research - San Diego — San Diego, California, United States
Amicis Research Corporate — Santa Clarita, California, United States
Care Access Research — Thousand Oaks, California, United States
Bay Area Cardiology — Brandon, Florida, United States
Cardiology Associates Research Co. — Daytona Beach, Florida, United States
Suncoast Research Associates, LLC — Doral, Florida, United States
Malcom Randall VA Medical Center — Gainesville, Florida, United States
Velocity Clinical Research-Hallandale Beach-67888 — Hallandale, Florida, United States
University of Florida — Jacksonville, Florida, United States
East Coast Institute For Research, LLC — Jacksonville, Florida, United States
Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
University of Miami - Miller School of Medicine — Miami, Florida, United States
Infinite Clinical Research Inc — Miami, Florida, United States
Inpatient Research Clinic, LLC — Miami Lakes, Florida, United States
Innovation Medical Research Center — Palmetto Bay, Florida, United States
Peace River Cardiovascular Center — Port Charlotte, Florida, United States
St. Johns Center for Clinical Research — Saint Augustine, Florida, United States
University of South Florida — Tampa, Florida, United States
Cardiology Partners Clinical Research Institute — Wellington, Florida, United States
Cozy Research LLC — Wesley Chapel, Florida, United States
Flourish Research — Winter Park, Florida, United States
Atlanta Clinical Research Centers — Atlanta, Georgia, United States
NSC Research Inc — Johns Creek, Georgia, United States
Northwest Heart Clinical Research, LLC — Arlington Heights, Illinois, United States
Chicago Medical Research — Hazel Crest, Illinois, United States
Clinical Investigation Specialists, Inc. — Libertyville, Illinois, United States
AMR Park Ridge — Park Ridge, Illinois, United States
Springfield Clinic — Springfield, Illinois, United States
Midwest Cardiovascular Research and Education Foundation — Elkhart, Indiana, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc — Indianapolis, Indiana, United States
Indiana Medical Research Institute — Merrillville, Indiana, United States
Cardiovascular Research of Northwest Indiana, LLC — Munster, Indiana, United States
Reid Hospital — Richmond, Indiana, United States
The Iowa Clinic, PC — West Des Moines, Iowa, United States
University of Kansas Medical Center — Kansas City, Kansas, United States
Kansas Nephrology Research Institute, LLC — Wichita, Kansas, United States
Robert J Dole Veterans Affairs Medical Center — Wichita, Kansas, United States
West Houston Area Clinical Trial Consultants, LLC - Wichita — Wichita, Kansas, United States
Heart Clinic of Hammond — Hammond, Louisiana, United States
Grace Research, LLC-Shreveport-64616 — Shreveport, Louisiana, United States
Ascension Saint Agnes Heart Care — Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants — Beltsville, Maryland, United States
Capitol Cardiology Associates — Lanham, Maryland, United States
Cardiology and Vascular Associates - CAVA — Bloomfield Hills, Michigan, United States
Michigan Healthcare Professionals Pulse Cardiology — Farmington Hills, Michigan, United States
Henry Ford Providence Hospital — Southfield, Michigan, United States
Michigan Heart, PC — Ypsilanti, Michigan, United States
Minneapolis VA Health Care System — Minneapolis, Minnesota, United States
Mayo Clinic, Rochester — Rochester, Minnesota, United States
Regions Hospital — Saint Paul, Minnesota, United States
Kansas City VA Medical Center — Kansas City, Missouri, United States
St. Louis Heart and Vascular, P.C. — St Louis, Missouri, United States
Be Well Clinical Studies — Omaha, Nebraska, United States
Advanced Heart Care, LLC — Bridgewater, New Jersey, United States
Mount Sinai Hospital-New York-52529 — New York, New York, United States
Icahn School of Medicine at Mount Sinai — New York, New York, United States
IMA Clinical Research Lenoir — Lenoir, North Carolina, United States
Pinehurst Medical Clinic, Inc. - East — Pinehurst, North Carolina, United States
Piedmont Healthcare, Inc. — Statesville, North Carolina, United States
Wilmington Health — Wilmington, North Carolina, United States
VA Northeast Ohio Healthcare System — Cleveland, Ohio, United States
K and R Research LLC — Marion, Ohio, United States
Cardiology Consultants of Philadelphia — Yardley, Pennsylvania, United States
Bon Secours Medical Group Greenville Specialty Care, LLC — Greenville, South Carolina, United States
Pharmatex Research — Amarillo, Texas, United States
Amarillo Heart Clinical Research Institute, Incorporated — Amarillo, Texas, United States
NextStage Clinical Research — Beaumont, Texas, United States
Clinical Research Solution, LLC — Cypress, Texas, United States
Texas Health Research and Education Institute — Dallas, Texas, United States
Southwest Family Medicine Associates — Dallas, Texas, United States
Helios CR Inc - Fort Worth — Fort Worth, Texas, United States
The Methodist Hospital Research Institute — Houston, Texas, United States
DM Clinical Research — Irving, Texas, United States
DCOL Center for Clinical Research — Longview, Texas, United States
North Texas Research Associates — McKinney, Texas, United States
Revival Research Institute, LLC - McKinney — McKinney, Texas, United States
Texas Institute Of Cardiology — McKinney, Texas, United States
Accurate Clinical Research, Inc. — Richmond, Texas, United States
Northwest Heart Center — Tomball, Texas, United States
NextStage Clinical Research — Waco, Texas, United States
Carient Heart and Vascular — Manassas, Virginia, United States
Carilion Clinic — Roanoke, Virginia, United States
Inst de Inv Clinicas-Bahia Blanca — Bahía Blanca, Argentina
Hospital Regional de Bahia Blanca — Bahía Blanca, Argentina
Centro de Investigaciones Metabolicas (CINME) — Buenos Aires, Argentina
CIPREC — Buenos Aires, Argentina
Hospital Italiano de Buenos Aires — Ciudad Autonoma Buenos Aires, Argentina
Fundacion Favaloro — Ciudad Autonoma Buenos Aires, Argentina
Mautalen- Salud e Investigacion — Ciudad Autonoma Buenos Aires, Argentina
Centro Medico Dra Laura Maffei — Ciudad Autonoma Buenos Aires, Argentina
Glenny Corp. S.A. Bioclinica Argentina — Ciudad Autonoma Buenos Aires, Argentina
Clinica Coronel Suarez — Coronel Suárez, Argentina
Sanatorio Allende — Córdoba, Argentina
Sanatorio Privado Duarte Quiros De Clinica Colombo SA — Córdoba, Argentina
Well Medica — Córdoba, Argentina
Instituto Medico DAMIC S.R.L. — Córdoba, Argentina
Centro Medico Luquez — Córdoba, Argentina
Centro de Investigaciones Clinicas Baigorria — Granadero Baigorria, Argentina
Centro de Investigaciones Medicas Mar del Plata — Mar del Plata, Argentina
Hospital Universitario Austral — Pilar, Argentina
Instituto Medico CER — Quilmes, Argentina
Instituto de Investigaciones Clinicas de Quilmes — Quilmes, Argentina
DIM Clinica Privada — Ramos Mejía, Argentina
INECO Neurociencias Oroño — Rosario, Argentina
Instituto de Investigaciones Clinicas de Rosario — Rosario, Argentina
Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica — Rosario, Argentina
Sanatorio Parque S.A. — Rosario, Argentina
Instituto CAICI — Rosario, Argentina
Investigaciones Clinicas Salta (ICSAL) — Salta, Argentina
Centro Cardiovascular Salta — Salta, Argentina
Corporacion Medica de Gral. San Martin S.A. — San Martin, Argentina
Investigaciones en Patologias Respiratorias — San Miguel de Tucumán, Argentina
Investigaciones Clinicas Tucuman — San Miguel de Tucumán, Argentina
Centro Integral de Arritmias Tucuman — San Miguel de Tucumán, Argentina
Centro Modelo de Cardiologia — San Miguel de Tucumán, Argentina
Clinica Mayo — San Miguel de Tucumán, Argentina
Instituto de Investigaciones Clinicas San Nicolas — San Nicolás, Argentina
Hospital Dr. Jose Maria Cullen — Santa Fe, Argentina
Centro de Investigaciones Clinicas del Litoral — Santa Fe, Argentina
CEMEDIC - Centro de Especialidades Medicas — Villa Luro, Argentina
Ziekenhuis Oost-Limburg — Genk, Belgium
AZ Sint-Lucas — Ghent, Belgium
Grand Hôpital de Charleroi — Gilly, Belgium
C.H.U. de Tivoli — La Louvière, Belgium
CHR de la Citadelle — Liège, Belgium
Hospital Sirio Libanes — Bela Vista, Brazil
Hospital Felicio Rocho — Belo Horizonte, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda — Belo Horizonte, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda. — Brasília, Brazil
Hospital DF Star — Brasília, Brazil
CECAP - Centro de Cardiologia Clínica — Brasília, Brazil
Hospital Angelina Caron — Campina Grande do Sul, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas — Campinas, Brazil
I9 Pesquisas Clinicas - Loema Instituto de Pesquisa Clínica e Consultores SS Ltda — Campinas, Brazil
Hospital do Rocio — Campo Largo, Brazil
Fundacao Universidade de Caxias do Sul — Caxias do Sul, Brazil
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR — Curitiba, Brazil
Via Medica — Goiânia, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás — Goiânia, Brazil
ICM - Instituto do Coracao de Marilia — Marília, Brazil
Hospital Vera Cruz — Minas Gerais, Brazil
Instituto Atena de Pesquisa Clinica — Natal, Brazil
Instituto Mederi de Pesquisa e Saude — Passo Fundo, Brazil
Hospital de Clinicas de Porto Alegre — Porto Alegre, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre — Porto Alegre, Brazil
Nucleo de Pesquisa Clinica do Rio Grande do Sul (NPCRS) — Porto Alegre, Brazil
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Sociedade Simples — Porto Alegre, Brazil
Hospital Esperança Recife — Recife, Brazil
Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CAPED — Ribeirão Preto, Brazil
Instituto Brasil de Pesquisa Clinica (IBPClin) — Rio de Janeiro, Brazil
Ruschel Medicina e Pesquisa Clínica — Rio de Janeiro, Brazil
Instituto D'Or Pesquisa e Ensino - Rio de Janeiro — Rio de Janeiro, Brazil
Hospital Cardio Pulmonar — Salvador, Brazil
Pesquisare — Santo André, Brazil
Praxis Pesquisa Medica — Santo André, Brazil
Instituto Domingo Braile — São José do Rio Preto, Brazil
Fundaçao Faculdade Regional de Medicina de Sao Jose do Rio Preto — São José do Rio Preto, Brazil
CIPES - Centro Internacional de Pesquisa Clínica — São José dos Campos, Brazil
Cpquali Pesquisa Clinica Ltda — São Paulo, Brazil
CPCLIN - Centro de Pesquisas Clínicas Ltda. — São Paulo, Brazil
CEPIC - Centro Paulista de Investigacao Clinica e Servicos — São Paulo, Brazil
Eurolatino Pesquisas Médicas Ltda. — Uberlândia, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória — Vitória, Brazil
Medical center 4LIFE Ltd. — Burgas, Bulgaria
MHAT Heart and brain — Burgas, Bulgaria
Medical Center Doktor Staykov Ltd. — Burgas, Bulgaria
Diamedical Medical Center 2013 — Dimitrovgrad, Bulgaria
MHAT "Sveta Ekaterina-Dimitrovgrad", EOOD — Dimitrovgrad, Bulgaria
Medical Center New Polyclinic Gabrovo Ltd. — Gabrovo, Bulgaria
MHAT Ivan Skenderov EOOD — Gotse Delchev, Bulgaria
Medical Center Rodopimed EOOD — Kardzhali, Bulgaria
Medical Center Hera - Kyustendil EOOD — Kyustendil, Bulgaria
Tonus 2013 Ltd. — Pazardzhik, Bulgaria
Ambulatory Individual Practice for Cardiology Specialized Medical Care — Pernik, Bulgaria
Medical Center Medconsult Pleven OOD — Pleven, Bulgaria
MHAT Heart and brain — Pleven, Bulgaria
UMHAT "Sv. Georgi", EAD — Plovdiv, Bulgaria
MBAL Sveta Karidad EAD — Plovdiv, Bulgaria
Medical Center Rusemed EOOD — Rousse, Bulgaria
National Multiprofile Transport Hospital "Tzar Boris III" — Sofia, Bulgaria
Medical Center For Specialized Medical Help In Cardiovascular Diseases OOD — Sofia, Bulgaria
University Hospital Lozenetz — Sofia, Bulgaria
Alexandrovska University Hospital — Sofia, Bulgaria
Diagnostic Consultative Center Alexandrovska — Sofia, Bulgaria
University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD — Sofia, Bulgaria
Medical Center Hera EOOD — Sofia, Bulgaria
UMHAT "Tsaritsa Yoanna-ISUL" EAD — Sofia, Bulgaria
ASOMHIDC - Individual practice "Cardio Tonus" EOOD — Sofia, Bulgaria
Multiprofile Hospital MHATEM 'Pirogov', Sofia — Sofia, Bulgaria
Diagnostic Consultation Center XX-Sofia EOOD — Sofia, Bulgaria
MHAT "St. Sofia" — Sofia, Bulgaria
Kalimat Medical Center Ltd. — Sofia, Bulgaria
Medical Center Intermedica Ltd. — Sofia, Bulgaria
Medical Center Medicabilis Ltd. — Sofia, Bulgaria
Medical center DEA Medicals Ltd. — Sofia, Bulgaria
Medical Center Zara-Med EOOD — Stara Zagora, Bulgaria
UMHAT Prof. Dr. Stoyan Kirkovich AD — Stara Zagora, Bulgaria
MDHAT 'Dr. Stefan Cherkezov', AD — Veliko Tarnovo, Bulgaria
Medical Center Medica Plus Ltd. — Veliko Tarnovo, Bulgaria
Medical Centre Nevromedics EOOD — Veliko Tarnovo, Bulgaria
MHAT St Panteleimon — Yambol, Bulgaria
Saul Vizel Medicine Professional Corporation — Cambridge, Ontario, Canada
Health Sciences North — Greater Sudbury, Ontario, Canada
Premier Clinical Trial Network — Hamilton, Ontario, Canada
Elevate Clinical Research - KMH Hamilton — Kitchener, Ontario, Canada
KMH Cardiology Centres (Mississauga) — Mississauga, Ontario, Canada
Oakville Trafalgar Memorial Hospital — Oakville, Ontario, Canada
James Cha, MD — Oshawa, Ontario, Canada
Kawartha Cardiology Clinical Trials — Peterborough, Ontario, Canada
CardioQuest Research Centre — Sarnia, Ontario, Canada
Fadia El Boreky Medicine Professional Corporation — Waterloo, Ontario, Canada
ViaCar Recherches Cliniques Inc. (Brossard) — Brossard, Quebec, Canada
Diex Recherche (Sherbrooke) — Sherbrooke, Quebec, Canada
Diex Recherche (Trois-Rivieres) — Trois-Rivières, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Quebec (IUCPQ) — Québec, Canada
CIUSSS du Saguenay - Lac-Saint-Jean — Québec, Canada
Enroll Spa — Santiago, Chile
CeCim - Centro de Estudios Clinicos e Investigacion Medica — Santiago, Chile
Centro de Investigacion del Maule — Talca, Chile
Hospital Las Higueras — Talcahuano, Chile
CECMI Ltda — Temuco, Chile
CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar — Viña del Mar, Chile
Beijing AnZhen Hospital, Capital Medical University — Beijing, China
Cardiovascular Institute and Fu Wai Hospital — Beijing, China
Jilin Province People's Hospital — Changchun, China
The First Hospital of Jilin University — Changchun, China
China-Japan Union Hospital of Jilin University — Changchun, China
Changde Second People's Hospital — Changde, China
Hunan Provincial People's Hospital — Changsha, China
The Second Xiangya Hospital Of Central South University — Changsha, China
The Third Hospital of Changsha — Changsha, China
Sichuan Provincial People's Hospital — Chengdu, China
Chenzhou No.1 people's Hospital — Chenzhou, China
Second Affiliated Hospital Chongqing Medical University — Chongqing, China
Chongqing Three Gorges Central Hospital — Chongqing, China
Affiliated Zhongshan Hospital of Dalian University — Dalian, China
Daqingshi People's Hospital — Daqing, China
The First People's Hospital of Foshan — Foshan, China
The First Affiliated Hospital of Fujian Medical University — Fuzhou, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine — Guangzhou, China
Guangdong Provincial People's Hospital — Guangzhou, China
Third Affiliated Hospital of Guangzhou Medical University — Guangzhou, China
The Affiliated Panyu Central Hospital of Guangzhou Medical University — Guangzhou, China
Guizhou Provincial People's Hospital — Guiyang, China
Hainan General Hospital — Haikou, China
The First Affiliated Hospital of Harbin Medical University — Harbin, China
Jiangmen Central Hospital — Jiangmen, China
Center Hospital of Jinan — Jinan, China
Lanzhou University Second Hospital — Lanzhou, China
Linfen Central Hospital — Linfen, China
Luoyang First People's Hospital — Luoyang, China
The First Affiliated Hospital of Henan University of Science and Technology — Luoyang, China
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital — Nanchang, China
The First Affiliated Hospital of Nanchang University — Nanchang, China
Zhongda Hospital Southeast University — Nanjing, China
Nanjing Jiangning Hospital — Nanjing, China
The First Affiliated Hospital of Guangxi Medical University — Nanning, China
Nanyang First People's Hospital — Nanyang, China
Nanyang Second General Hospital — Nanyang, China
Ningbo Second Hospital — Ningbo, China
The First Affiliated Hospital of Ningbo University — Ningbo, China
Pingxiang People's Hospital — Pingxiang, China
Zhongshan Hospital Affiliated to Fudan University — Shanghai, China
Tongren hospital, Shanghai Jiaotong University School of Medicine — Shanghai, China
Shanghai General Hospital — Shanghai, China
Shengjing Hospital of China Medical University — Shenyang, China
People's Hospital of Liaoning Province — Shenyang, China
Shenzhen People's Hospital — Shenzhen, China
The Second Hospital of Hebei Medical University — Shijiazhuang, China
Shanxi Bethune Hospital — Taiyuan, China
Shanxi Cardiovascular Hospital — Taiyuan, China
Taian City Central Hospital — Tai’an, China
Tianjin Union Medical Center Nankai University Affiliated Hospital — Tianjin, China
The 2nd Hospital of Tianjin Medical University — Tianjin, China
Hubei Province Zhongshan Hospital — Wuhan, China
Renmin Hospital of Wuhan University — Wuhan, China
Shaanxi Provincial People's Hospital — Xi'an, China
Xinxiang Central Hospital — Xinxiang, China
The People's Hospital Of Xuancheng City — Xuancheng, China
The General Hospital of XZCMG (The Second Affiliated Hospital of Xuzhou Medical University) — Xuzhou, China
The first People's Hosptal of Yinchuan — Yinchuan, China
Yueyang Central Hospital — Yueyang, China
Yuncheng Central Hospital — Yuncheng, China
The First Affiliated Hospital of Hebei North University — Zhangjiakou, China
The First Affiliated Hospital of Zhengzhou University — Zhengzhou, China
Affiliated Hospital of Jiangsu University — Zhenjiang, China
Cardiomet CEQUIN S.A.S — Armenia, Colombia
Centro de Investigacion Medico Asistencial S.A.S — Barranquilla, Colombia
Corazon IPS S.A.S. — Barranquilla, Colombia
Fundacion Santa Fe de Bogota — Bogotá, Colombia
Administradora Country S.A.S. — Bogotá, Colombia
Fundacion Hospital Infantil Universitario de San Jose — Bogotá, Colombia
IPS Centro Medico Julian Coronel S.A. — Cali, Colombia
Centro de Diagnostico Cardiologico S.A.S. — Cartagena, Colombia
Asociacion IPS medicos internistas de Caldas S.A.S. — Manizales, Colombia
T Y C Inversiones S.A.S Grupsalud — Santa Marta, Colombia
MUDr. Hana Burianova — Bílovec, Czechia
Medicus Services s.r.o. — Brandýs nad Labem, Czechia
Fakultni nemocnice u sv. Anny v Brne — Brno, Czechia
MUDr. Jan Hubac s.r.o. — Chrudim, Czechia
EDUMED s.r.o. — Jaroměř, Czechia
MUDr Petra Maskova PhD — Litovel, Czechia
KardioBusak s.r.o. — Louny, Czechia
InterKardioML s.r.o. — Mariánské Lázně, Czechia
MUDr. Zdenek Vomacka kardiologie a interna s.r.o. — Olomouc, Czechia
MUDr. Jan Kvasnicka CSc — Prague, Czechia
Kardiologie Vinohrady s r o — Prague, Czechia
Institute for Clinical and Experimental Medicine — Prague, Czechia
University Thomayer´s Hospital — Praha 4-Krc, Czechia
Nemocnice Slany — Slaný, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o. — Trutnov, Czechia
Clinical Trials Services s.r.o — Uherské Hradiště, Czechia
Sygehus Sønderjylland Åbenrå — Aabenraa, Denmark
Rigshospitalet Copenhagen — Copenhagen, Denmark
Bispebjerg og Frederiksberg Hospital — Copenhagen NV, Denmark
Amager-Hvidovre Hospital — Copenhagen S, Denmark
Herlev and Gentofte Hospital — Herlev, Denmark
Holbæk Sygehus — Holbæk, Denmark
Hvidovre Hospital — Hvidovre, Denmark
Sjællands Universitetshospital — Roskilde, Denmark
Slagelse Sygehus — Slagelse, Denmark
Klinikum am Plattenwald — Bad Friedrichshall, Germany
CIMS Studienzentrum Bamberg GmbH — Bamberg, Germany
Vivantes Netzwerk für Gesundheit GmbH — Berlin, Germany
Kardiologie im Spreebogen — Berlin, Germany
Velocity Clinical Research Germany GmbH, Berlin — Berlin, Germany
KARDIA - Dr. Hashemi — Berlin, Germany
Vivantes Humboldt-Klinikum — Berlin, Germany
GFO Kliniken Bonn, Betriebsstaette St. Marien — Bonn, Germany
Universitätsklinikum Bonn AöR — Bonn, Germany
Internistische Gemeinschaftspraxis in Bünde — Bünde, Germany
SANA Kliniken Oberfranken Coburg GmbH — Coburg, Germany
Klinische Forschung Dresden GmbH — Dresden, Germany
Facharztzentrum Dresden-Neustadt Betriebsgesellschaft mbH — Dresden, Germany
Helios Klinikum Erfurt — Erfurt, Germany
Elisabeth-Krankenhaus Essen GmbH — Essen, Germany
Asklepios Klinik St Georg — Hamburg, Germany
Klinische Forschung Hannover-Mitte GmbH — Hanover, Germany
Medizinische Hochschule Hannover — Hanover, Germany
Kardiopraxis Schirmer — Kaiserslautern, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel — Kiel, Germany
Asklepios Klinik Langen-Seligenstadt GmbH — Langen, Germany
Velocity Clinical Research Germany GmbH, Leipzig — Leipzig, Germany
Klinikum der Stadt Ludwigshafen am Rhein GmbH — Ludwigshafen, Germany
Praxis Oedeme — Lüneburg, Germany
ze:ro Praxen MVZ fuer Nierenerkrankungen und Bluthochdruck GmbH Mannheim — Mannheim, Germany
Kardiologische Gemeinschaftspraxis Dres. med. Reiff, Linse, Haj-Yehia und Specking — Moers, Germany
Marienhaus Klinikum St. Elisabeth — Neuwied, Germany
Kardiologische Praxis Papenburg — Papenburg, Germany
Universitätsklinikum Regensburg — Regensburg, Germany
Kardiologische Praxis im Steiner Thor — Straubing, Germany
Gemeinschaftspraxis Dr. Josef Grosskopf und Dr. Wilma Grosskopf — Wallerfing, Germany
Nephrologische Gemeinschaftspraxis — Walsrode, Germany
Cardiologicum Hamburg GbR — Wandsbek, Germany
Kardiologische Praxis, Wermsdorf — Wermsdorf, Germany
Velocity Clinical Research Germany GmbH, Wiesbaden — Wiesbaden, Germany
Klinikum Worms gGmbH — Worms, Germany
Belgyogyaszati es Kardiologiai Maganrendelo — Békéscsaba, Hungary
Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz — Budapest, Hungary
Obudai Egeszegugyi Centrum — Budapest, Hungary
Belvaros-Lipotvaros Egeszsegugyi Szolgalat — Budapest, Hungary
Gottsegen National Cardiovascular Center — Budapest, Hungary
Semmelweis University — Budapest, Hungary
Privat Doktor Egeszseguegyi Szolgaltato Zrt. — Budapest, Hungary
Kardio Innova Kft. — Budapest, Hungary
BKS Research Ltd — Hatvan, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz — Miskolc, Hungary
IPR Hungary Kft. — Miskolc, Hungary
TaNa Med Kft. — Mosonmagyaróvár, Hungary
Coromed-Smo Kft. — Pécs, Hungary
Tolna Varmegyei Balassa Janos Korhaz — Szekszárd, Hungary
Belvarosi Egeszseghaz Kft. — Zalaegerszeg, Hungary
Kamal Nayan Bajaj Hospital — Aurangabad, India
Narayana Institute of Cardiac Sciences — Bangalore, India
S.P. Medical College & Associated Group of Hospitals — Bikaner, India
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH — Chennai, India
Apollo Hospital - Chennai — Chennai, India
Lisie Hospital — Kochi, India
IPGMER and SSKM Hospital — Kolkata, India
Supe Heart & Diabetes Hospital & Research Centre — Nashik, India
Chopda Medicare and Research Centre Pvt Ltd — Nashik, India
Max Super Speciality Hospital — New Delhi, India
Indira Gandhi Institute of Medical Sciences — Patna, India
Nirmal Hospital — Surat, India
Unicare Heart Institute — Surat, India
King George Hospital — Visakhapatnam, India
Humanitas Gavazzeni — Bergamo, Italy
ASST Papa Giovanni XXIII — Bergamo, Italy
Azienda Ospedaliera Universitaria "Federico II" — Naples, Italy
Fondazione IRCCS Policlinico S. Matteo — Pavia, Italy
Azienda Ospedaliera Universitaria Pisana — Pisa, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza — Roma, Italy
Istituto Clinico Humanitas — Rozzano, Italy
Hyogo Prefectural Amagasaki General Medical Center — Amagasaki-shi, Japan
Asahi General Hospital — Asahi-shi, Japan
Shonan Fujisawa Tokushukai Hospital — Fujisawa-shi, Japan
Kyushu University Hospital — Fukuoka, Japan
Fukuokaken Saiseikai Futsukaichi Hospital — Fukuoka, Chikushino, Japan
Gunma University Hospital — Gunma, Maebashi, Japan
Minamino Cardiovascular Hospital — Hachioji-shi, Japan
National Hospital Organization Hamada Medical Center — Hamada-shi, Japan
JA-Shizuoka Enshu Hospital — Hamamatsu, Japan
Hyogo Prefectural Harima-Himeji General Medical Center — Himeji-shi, Japan
Hiratsuka Kyosai Hospital — Hiratsuka-shi, Japan
Hitachi Ltd. Hitachinaka General Hospital — Hitachi-Naka, Japan
National Hospital Organization Kanazawa Medical Center — Ishikawa, Kanazawa, Japan
National Hospital Organization Iwakuni Clinical Center — Iwakuni-shi, Japan
Tokushukai Shonan Kamakura General Hospital — Kamakura-shi, Japan
Tokushukai Hayama Heart Center — Kanagawa, Miura-gun, Japan
Mitoyo General Hospital — Kanonji-shi, Japan
Ibaraki Prefectural Central Hospital — Kasama-shi, Japan
Kasugai Municipal Hospital — Kasugai-shi, Japan
Saiseikai Kawaguchi Hospital — Kawaguchi-shi, Japan
St. Marianna University Hospital — Kawasaki-shi, Japan
Tokushukai Kishiwada Tokushukai Hospital — Kishiwada-shi, Japan
National Hospital Organization Kobe Medical Center — Kobe, Japan
Kumamoto University Hospital — Kumamoto, Japan
Japanese Red Cross Kumamoto Hospital — Kumamoto, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center — Kure, Japan
Chibanishi General Hospital — Matsudo-shi, Japan
Shinshu University Hospital — Matsumoto-shi, Japan
Ehime Prefectural Central Hospital — Matsuyama, Japan
Matsuyama Shimin Hospital — Matsuyama, Japan
National Hospital Organization Tokyo Medical Center — Meguro-ku, Japan
Mito Saiseikai General Hospital — Mito, Japan
Sendai Cardiovascular Center — Miyagi, Sendai, Japan
Nagasaki Harbor Medical Center — Nagasaki, Nagasaki, Japan
Nagoya Kyoritsu Hospital — Nagoya, Japan
Nagoya City University Hospital — Nagoya, Japan
Hokushin General Hospital — Nakano-shi, Japan
Nara Medical University Hospital — Nara, Kashihara, Japan
Juzenkai The Sakakibara Heart Institute of Okayama — Okayama, Okayama, Japan
Ome Municipal General Hospital — Ome-shi, Japan
Nagasaki Medical Center — Omura-shi, Japan
Osaka Metropolitan University Hospital — Osaka, Japan
Osaka General Medical Center — Osaka, Japan
Kosekai Iwatsuki-minami Hospital — Saitama, Saitama, Japan
Osaka Rosai Hospital — Sakaishi, Japan
Teine Keijinkai Hospital — Sapporo, Japan
Tohoku University Hospital — Sendai, Japan
NHO Sendai Medical Center — Sendai, Japan
NHO Kanmon Medical Center — Shimonoseki-shi, Japan
National Cerebral and Cardiovascular Center — Suita-shi, Japan
The University of Osaka Hospital — Suita-shi, Japan
Tachikawa Hospital — Tachikawa-shi, Japan
National Hospital Organization Takasaki General Medical Center — Takasaki-shi, Japan
NHO Minami Wakayama Medical Center — Tanabe-shi, Japan
Tokushima Prefectural Central Hospital — Tokushima, Japan
Tomakomai City Hospital — Tomakomai-shi, Japan
Toyota Memorial Hospital — Toyota-shi, Japan
NHO Shinshu Ueda Medical Center — Ueda-shi, Japan
Hospital Cardiologica Aguascalientes — Aguascalientes, Mexico
Centro Especializado de Investigación Medical Group Culiacan — Culiacán, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C. — Culiacán, Mexico
Cardiologia Clinica e Intervencionista — Guadalajara, Mexico
Proactive CR Mexico S.A. de C.V. — Irapuato, Mexico
Clinstile S.A. de C.V. — México, Mexico
Cardiolink Clin Trials S.C. — Monterrey, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez — Monterrey, Mexico
Centro de Estudios Clinicos de Queretaro S.C — Querétaro, Mexico
Centro de Investigacion Cardiovascular y Metabolica — Tijuana, Mexico
CIMAB S.A. de C.V. — Torreón, Mexico
Universitair Medisch Centrum Groningen — Groningen, Netherlands
Maastricht University Medisch Centrum — Maastricht, Netherlands
St. Antonius Ziekenhuis — Nieuwegein, Netherlands
Isala Klinieken Stichting — Zwolle, Netherlands
Polsko-Amerykanskie Kliniki Serca — Bielsko-Biala, Poland
Centrum Medyczne Intercor Sp. z o.o. — Bydgoszcz, Poland
Pratia Bydgoszcz Clinical Research Site — Bydgoszcz, Poland
NZOZ Medical Center KERmed — Bydgoszcz, Poland
Centrum Medyczne Pratia Gdynia — Gdynia, Poland
Specjalistyczna Praktyka Lekarska Ewa Mirek-Bryniarska — Krakow, Poland
Pratia MCM Krakow — Krakow, Poland
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j. — Legnica, Poland
Santa SP. z o.o — Lodz, Poland
Velocity Nova Sp. z o.o. — Lublin, Poland
Zanamed Medical Clinic Sp. z o.o. — Lublin, Poland
Nzoz Heureka — Piaseczno, Poland
CBK Med Clinic SP Z O O — Płock, Poland
Centrum Medyczne Medyk — Rzeszów, Poland
Lukmed Lukasz Wozniak — Siedlce, Poland
Velocity Skierniewice Sp. z o.o — Skierniewice, Poland
Centrum Medyczne Pratia Poznan — Skórzewo, Poland
Velocity Staszow — Staszów, Poland
Sedimed Sp. z o.o. — Szczecin, Poland
Balsammedica Sp. z o. o. — Warsaw, Poland
MTZ Clinical Research Powered by Pratia — Warsaw, Poland
ETG Warszawa — Warsaw, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ — Wroclaw, Poland
Sedimed Sp. z o.o. — Wroclaw, Poland
Velocity Nova Sp. z o.o. — Zamość, Poland
Centrum Medyczne Serafin med — Żarów, Poland
Spitalul Judetean De Urgenta Dr. Constantin Opris Baia Mare — Baia Mare, Romania
Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu — Baloteşti, Romania
S.C.Centrul Medical Unirea S.R.L. — Brasov, Romania
Spitalul Clinic Judetean de Urgenta Brasov — Brasov, Romania
Emergency University Hospital — Bucharest, Romania
Clinica Medicala Data Plus SRL — Bucharest, Romania
Spitalul Angiocare SRL — Cluj-Napoca, Romania
Emergency County Hospital Craiova — Craiova, Romania
Spitalul Clinic Judetean de Urgenta Bihor — Oradea, Romania
Sal Med Srl — Piteşti, Romania
U 2 Serv Com S.R.L. — Suceava, Romania
Country Clinical Emergency Hospital, Targu-Mures — Târgu Mureş, Romania
Podoleanu G. Cristian-Gheorghe-Calin — Târgu Mureş, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures — Târgu Mureş, Romania
S.C Medicali's S.R.L — Timișoara, Romania
Timisoara Municipal Emergency Clinical Hospital — Timișoara, Romania
King AbdulAziz University Hospital — Al Ahsa, Saudi Arabia
King Fahad Specialist Hospital - Research Center — Dammam, Saudi Arabia
Imam Abdulrahman bin Faisal University — Dammam, Saudi Arabia
King Faisal Specialist Hospital and Research Center — Riyadh, Saudi Arabia
Clinical Center " Dr Dragisa Misovic Dedinje" — Belgrade, Serbia
University Clinical Center of Serbia — Belgrade, Serbia
Institute of Cardiovascular Diseases of Vojvodine — Kamenitz, Serbia
University Clinical Center of Kragujevac — Kragujevac, Serbia
University Clinical Center Nis — Niš, Serbia
Institute for Treatment and Rehabilitation, Niska Banja — Niška Banja, Serbia
General Hospital Pancevo — Pančevo, Serbia
General Hospital Sveti Luka — Smederevo, Serbia
Health Centre Zajecar — Zaječar, Serbia
Stredoslovensky Ustav Srdcovych A Cievnych Chorob A S — Banská Bystrica, Slovakia
Alian s.r.o. — Bardejov, Slovakia
Cliniq s.r.o. — Bratislava, Slovakia
Premedix Clinic — Bratislava, Slovakia
Nemocnica S Poliklinikou Brezno N.O. — Brezno, Slovakia
Medical Group Kosice s.r.o — Košice, Slovakia
KARDIO R s r o — Košice, Slovakia
Cardio D&R s.r.o. Kosice — Košice, Slovakia
KARDIO 1 s.r.o. — Lučenec, Slovakia
Kardiomed s.r.o. — Lučenec, Slovakia
KVC Kardiovaskularne Centrum s.r.o. — Martin, Slovakia
Cardioamb s.r.o — Nové Zámky, Slovakia
Nemocnica AGEL Zvolen a.s. — Zvolen, Slovakia
Inje University Busan Paik Hospital — Busan, South Korea
Dong-A University Hospital — Busan, South Korea
Pusan National University Yangsan Hospital — Busan, South Korea
Chonnam National University Hospital — Gwangju, South Korea
Gachon University Gil Medical Center — Incheon, South Korea
Seoul National University Bundang Hospital — Seongnam, South Korea
Severance Hospital — Seoul, South Korea
Samsung Medical Center — Seoul, South Korea
Korea University Guro Hospital — Seoul, South Korea
Korea University Anam Hospital — Seoul, South Korea
Yonsei University Wonju Severance Christian Hospital — Wŏnju, South Korea
Hospital Clínic de Barcelona — Barcelona, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain
Hospital Universitario La Paz — Madrid, Spain
Hospital Virgen del Camino — Sanlúcar de Barrameda, Spain
Complexo Hospitalario Universitario De Santiago — Santiago de Compostela, Spain
Hospital Universitario De Torrejon — Torrejón de Ardoz, Spain
Hospital Clinico Universitario de Valencia — Valencia, Spain
Hospital General Universitario de Valencia — Valencia, Spain
Hospital Universitari i Politècnic La Fe — Valencia, Spain
Hospital Virgen de las Montañas — Villamartín, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
E-Da Hospital — Kaohsiung City, Taiwan
China Medical University Hospital — Taichung, Taiwan
Taichung Veterans General Hospital — Taichung, Taiwan
Taipei Medical University Hospital — Taipei, Taiwan
Taipei Veterans General Hospital — Taipei, Taiwan
Tri-Service General Hospital — Taipei, Taiwan
Changhua Christian Hospital — Taipei, Taiwan
Cukurova Universitesi Tip Fakultesi Gog. Hast. Anabilim Dali — Adana, Turkey (Türkiye)
Ataturk Universitesi Tip Fakultesi — Erzurum, Turkey (Türkiye)
Osmangazi Uni Medical Faculty — Eskişehir, Turkey (Türkiye)
Gaziantep University Medical Faculty Sahinbey Educational Research Hospital — Gaziantep, Turkey (Türkiye)
Siyami Ersek Heart Hospital — Istanbul, Turkey (Türkiye)
Kutahya Health Science University — Kütahya, Turkey (Türkiye)
Inonu Uni. Med. Fac., Battalgazi — Malatya, Turkey (Türkiye)
Mersin University Medical Faculty — Mersin, Turkey (Türkiye)
Southmead Hospital — Bristol, United Kingdom
Golden Jubilee National Hospital — Clydebank, United Kingdom
Royal Devon and Exeter Hospital, Wonford — Exeter, United Kingdom
Calderdale Royal Hospital — Halifax, United Kingdom
Northwick Park Hospital — Harrow, United Kingdom
St Bartholomew's Hospital — London, United Kingdom
Bach Mai hospital — Hanoi, Vietnam
Tam Anh General Hospital — Hanoi, Vietnam
Hanoi Heart Hospital — Hà Nội, Vietnam
Military Hospital 175 — Ho Chi Minh City, Vietnam
Nguyen Tri Phuong Hospital — Ho Chi Minh City, Vietnam
Tam Anh HCMC — Ho Chi Minh City, Vietnam
Thong Nhat Hospital HCMC — Ho Chi Minh City, Vietnam
Cho Ray Hospital — Ho Chi Minh City, Vietnam
University Medical Center HCMC — Ho Chi Minh City, Vietnam
Trung Vuong Hospital — Ho Chi Minh City, Vietnam

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