RECRUITING Phase 3 ClinicalTrials.gov

A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN)

Sponsor: Biogen • ClinicalTrials.gov ID: NCT06935357

Registry updated: 2026-10-14

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Description

In this study, researchers will learn more about the use of felzartamab in participants with immunoglobulin A nephropathy (IgAN). IgAN is a kidney disease caused by the buildup of an antibody called IgA in the kidneys over time. In people with IgAN, abnormal IgA and other antibodies form clusters that build up in the small filters of the kidneys, which leads to inflammation and damage. Felzartamab is designed to target certain immune cells that produce these abnormal antibodies. This study will focus on participants who have protein in their urine (proteinuria) as a result of damaged kidneys. The main goal of the study is to learn about the effect felzartamab has on proteinuria. The main question that researchers want to answer is: • How much does the amount of protein in the urine change from the start of the study to Week 36? Researchers will learn about the effect felzartamab has on the kidneys' ability to filter blood. They will also learn more about the safety of felzartamab and how it is processed by the body. The study will be done as follows: * Participants will be screened to check if they can join the study. * Participants will be randomized to receive either felzartamab or a placebo. A placebo looks like the study drug but contains no real medicine. * Neither the researchers nor the participants will know what the participants will receive. * Participants will receive felzartamab or placebo as intravenous (IV) infusions. The treatment period will last 24 weeks. * Afterwards, participants will enter a follow-up period which will last 80 weeks. * In total, participants will have 17 study visits. Participants will stay in the study for about 2 years.

Interventions

Felzartamab (Drug)
Administered IV
Placebo (Drug)
Administered IV

Eligibility criteria

Key Inclusion Criteria: * Biopsy-confirmed diagnosis of IgAN within the past 10 years prior to signature of the informed consent form (ICF). For participants with diabetes mellitus type 2, an IgAN diagnostic biopsy within the past 24 months prior to signing the ICF. * An eGFR ≥ 30 mL/min/1.73 m\^2 at Screening as calculated using the 2021 chronic kidney disease epidemiology (CKD-EPI) creatinine formula. An eGFR of ≥ 20 and \< 30 mL/min/1.73 m\^2 is acceptable for the cohorts 3 and 4. * Proteinuria of ≥ 1.0 gram per day (g/day) or UPCR ≥0.8 gram per gram (g/g) as assessed by an adequate 24-hour urine collection. * Clinically stable on a maximally tolerated dose or maximally approved dose of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) for at least 12 weeks prior to Screening. Participants may also be using sodium-glucose cotransporter-2 inhibitors (SGLT2is); endothelin receptor antagonists (ERAs) or dual endothelin angiotensin receptor antagonist (DEARAs) approved for the treatment of IgAN; and/or mineralocorticoid receptor antagonists (MRAs) as long as the dose is stable for at least 12 weeks prior to Screening. Participants should remain on stable doses of these background medications for the duration of the study. Once the ICF is signed and thereafter, the doses cannot be changed during the study nor the drugs discontinued except if deemed related to an AE. Participants using a DEARA (e.g., sparsentan) will not be permitted to use simultaneous ACEI or ARB medication. Key Exclusion Criteria: * Any history of secondary forms of IgAN, indicated by the presence of any other systemic disease potentially leading to IgA deposits as determined by the Investigator. * History of rapidly progressive variant of IgAN, defined as eGFR loss by \> 50% per 3 months and not explained by changes in renin-angiotensin system (RAS) blockade or other factors. * IgAN-(MCD) variant. * Concomitant other progressive glomerulonephritis or non-immunologic glomerular disease such as diabetic nephropathy. * Type 2 diabetes mellitus with Hemoglobin A1c (HbA1c) \> 8% at Screening, or evidence of diabetic nephropathy on biopsy, history of diabetic microvascular or macrovascular disease (eg, diabetic retinopathy, peripheral neuropathy). * Any diagnosed or suspected immunosuppressed or immunodeficient state such as asplenia, human immunodeficiency virus (HIV), primary immunodeficiencies, organ or bone marrow transplantation, with the exception of corneal transplants. * Previously treated with immunosuppressive or other immunomodulatory agents such as but not limited to cyclophosphamide, rituximab, infliximab, eculizumab, canakinumab, mycophenolate mofetil (MMF) or mycophenolate sodium (MPS), cyclosporine, tacrolimus, sirolimus, everolimus, or systemic glucocorticoid exposure (\> 7.5 milligrams per day \[mg/d\] prednisone-equivalent for indications other than IgAN or any dose if given for the treatment of IgAN) within 4 months prior to Screening. Use of hydroxychloroquine in Mainland China is allowed if the candidate has been on this for at least 6 months prior to Screening with a stable dose for at least 12 weeks prior to Screening. If a potential participant requires systemic glucocorticoids at any dose for IgAN during Screening, this will result in a screen fail. If a potential participant requires systemic glucocorticoids \> 7.5 mg/day prednisone-equivalent for indications other than IgAN during Screening, this will result in a screen fail. * Participants currently treated with oral budesonide. Participants who have stopped this therapy ≥ 4 months prior to Screening may be eligible. * Active clinically significant infections, known history of recurrent clinically significant infection, or Screening laboratory evidence consistent with an active infection, or non-prophylactic treatment with IV anti-infectives (antibacterials, antiviral or antifungals). Participants with a history of opportunistic infections are excluded. * Hypogammaglobulinemia: serum Immunoglobin G (IgG) \< 6.0 gram per litre (g/L), at Screening. Note: Other protocol-defined Inclusion/Exclusion criteria may apply.

Conditions

Immunoglobulin A Nephropathy (IgAN)

Locations

Applied Research Center of Arkansas — Little Rock, Arkansas, United States
Kidney & Hypertension Center - Apple Valley — Apple Valley, California, United States
Scripps Green Hospital — Carlsbad, California, United States
National Institute of clinical Research Administration Office — Garden Grove, California, United States
UCLA Health David Geffen School of Medicine — Los Angeles, California, United States
FOMAT Medical Research - FOMAT - PPDS — Oxnard, California, United States
North America Research Institute-San Dimas — San Dimas, California, United States
Nova Clinical Research, LLC — Bradenton, Florida, United States
University of Florida - Gainesville - 1600 SW Archer Rd — Gainesville, Florida, United States
Royal Research, Corp. — Hollywood, Florida, United States
Central Florida Kidney Specialists — Orlando, Florida, United States
CDC Research Institute, LLC — Port Saint Lucie, Florida, United States
American Clinical Trials LLC — Acworth, Georgia, United States
The Vasculitis and Glomerulonephritis Center at Massachusetts General Hospital — Boston, Massachusetts, United States
Brigham and Women's Hospital — Boston, Massachusetts, United States
UMass Memorial Medical Center — Worcester, Massachusetts, United States
Henry Ford Hospital — Detroit, Michigan, United States
Elixia Health - Michigan Kidney Consultants, LLC - Elixia - PPDS — Pontiac, Michigan, United States
Anointed Nephrology and HTN - SKYCRNG - PPDS — Brookhaven, Mississippi, United States
Midwest Nephrology Associates,Inc. — City of Saint Peters, Missouri, United States
Icahn School of Medicine at Mount Sinai — New York, New York, United States
James J Peters Veterans Administration Medical Center - NAVREF - PPDS — The Bronx, New York, United States
Penn Renal Electrolyte and Hypertension Perelman — Philadelphia, Pennsylvania, United States
Lifespan at Rhode Island Hospital — Providence, Rhode Island, United States
Knoxville Kidney Center, PLLC — Knoxville, Tennessee, United States
Texas Kidney Institute - Dallas — Dallas, Texas, United States
Provecta Research Network — Houston, Texas, United States
R & H Clinical Research — Katy, Texas, United States
Medical College of Wisconsin, Inc. — Milwaukee, Wisconsin, United States
Hospital General de Agudos Dr. Cosme Argerich — La Boca, Buenos Aires F.D., Argentina
Hospital Italiano de Buenos Aires — Almagro, Ciudad Autónoma de BuenosAires, Argentina
INECO Neurociencias Oroño — Rosario, Santa Fe Province, Argentina
CIMER-Centro Integral de Medicina Respiratoria — San Miguel de Tucumán, Tucumán Province, Argentina
Consultorios Médicos Dr. Doreski - Fundacion Respirar - PPDS — Buenos Aires, Argentina
DOM Centro de Reumatología — Buenos Aires, Argentina
Maffei Centro Médico — Buenos Aires, Argentina
Clínica de Nefrología Urología Y Enfermedades Cardiovasculares — Santa Fe, Argentina
John Hunter Hospital — New Lambton, New South Wales, Australia
Concord Repatriation General Hospital — New South Wales, New South Wales, Australia
Royal North Shore Hospital-Reserve Road — St Leonards, New South Wales, Australia
Westmead Hospital — Westmead, New South Wales, Australia
Townsville Hospital — Douglas, Queensland, Australia
Royal Brisbane & Women's Hospital — Herston, Queensland, Australia
Gold Coast University Hospital — Southport, Queensland, Australia
Griffith University — Southport, Queensland, Australia
Princess Alexandra Hospital — Woolloongabba, Queensland, Australia
Sunshine Hospital - Australia — St Albans, Victoria, Australia
Hôpital Erasme - PPDS — Anderlecht, Brussels Capital, Belgium
ZOL Genk - campus Sint-Jan — Genk, Limburg, Belgium
UZ Leuven - PPDS — Leuven, Vlaams Brabant, Belgium
Jan Yperman — Ieper, West-Vlaanderen, Belgium
AZ Groeninge — Kortrijk, West-Vlaanderen, Belgium
Cliniques Universitaires Saint-Luc — Brussels, Belgium
Freire Pesquisa Clínica — Belo Horizonte, Minas Gerais, Brazil
Irmandade da Santa Casa de Misericórdia de Belo Horizonte - PPDS — Belo Horizonte, Minas Gerais, Brazil
Centro Mineiro de Pesquisa - CMiP — Juiz de Fora, Minas Gerais, Brazil
Fundação Universidade de Caxias do Sul - Instituto de Pesquisas em Saúde — Caxias do Sul, Rio Grande do Sul, Brazil
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS — Porto Alegre, Rio Grande do Sul, Brazil
Hospital Alemao Oswaldo Cruz- HAOC — São Paulo, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo — São Paulo, Brazil
Medical Center Medconsult Pleven - Lovech Branch — Lovech, Bulgaria
Medical Center Hera EOOD, Montana - Hera Clinics - PPDS — Montana, Bulgaria
Medical Center Medconsult Pleven OOD — Pleven, Bulgaria
University Multiprofile Hospital for Active Treatment Sv Ivan Rilski EAD-15 Acad. Ivan Geshov Blvd — Sofia, Bulgaria
St Paul's Hospital — Vancouver, British Columbia, Canada
McGill University Health Centre (MUHC) — Montreal, Quebec, Canada
Fu Yang People's Hospital - South Campus — Fuyang, Anhui, China
The First Affiliated Hospital of Anhui Medical University - Jixilu Campus — Hefei, Anhui, China
Peking University First Hospital - Changqiao Campus — Beijing, Beijing Municipality, China
Beijing Tsinghua Changgung Hospital — Beijing, Beijing Municipality, China
Fujian Medical University Union Hospital — Fuzhou, Fujian, China
Zhongshan Hospital Xiamen University — Xiamen, Fujian, China
Gansu Provincial Hospital — Lanzhou, Gansu, China
Sun Yat-sen Memorial Hospital, Sun Yat-sen University - North Campus — Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University - Yanjiang Campus — Guangzhou, Guangdong, China
Shenzhen Hospital of Southern Medical University — Shenzhen, Guangdong, China
Peking University Shenzhen Hospital — Shenzhen, Guangdong, China
Zhongshan Hospital of Traditional Chinese Medicine — Zhongshan, Guangdong, China
The First Affiliated Hospital of Guangxi Medical University — Nanning, Guangxi, China
The People's Hospital of Guangxi Zhuang Autonomous Region — Nanning, Guangxi, China
Guizhou Provincial People's Hospital — Guiyang, Guiyang, China
The Affiliated Hospital of Guizhou Medical University — Guiyang, Guizhou, China
Cangzhou Central Hospital — Cangzhou, Hebei, China
The Second Hospital of Hebei Medical University - Main — Shijiazhuang, Hebei, China
The Third Hospital of Hebei Medical University — Shijiazhuang, Hebei, China
Daqing Oilfield General Hospital — Daqing, Heilongjiang, China
The First Affiliated Hospital of Henan Science and Technology University - Jinghua Campus — Luoyang, Henan, China
Prince of Wales Hospital - Hong Kong — Hong Kong, Hong Kong, China
Queen Mary Hospital PPDS — Hong Kong, Hong Kong, China
Tung Wah Hospital — Hong Kong, Hong Kong, China
Renmin Hospital of Wuhan University - Main Campus — Wuhan, Hubei, China
Yichang Central People's Hospital - Wujiagang Campus — Yichang, Hubei, China
The Second Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China
Affiliated Hospital of Nantong University — Nantong, Jiangsu, China
Wuxi Peoples Hospital — Wuxi, Jiangsu, China
Shengjing Hospital of China Medical University - Huaxiang Campus — Shenyang, Liaoning, China
Qilu Hospital of Shandong University — Jinan, Shandong, China
The Second Hospital of Shandong University — Jinan, Shandong, China
Yantai Yuhuangding Hospital — Yantai, Shandong, China
Zhongshan Hospital Fudan University — Shanghai, Shanghai Municipality, China
Huashan Hospital Fudan University - PPDS — Shanghai, Shanghai Municipality, China
Shanghai General Hospital - North Campus — Shanghai, Shanghai Municipality, China
Jiading Central Hospital — Shanghai, Shanghai Municipality, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital — Chengdu, Sichuan, China
Jinhua Municipal Central Hospital — Jinhua, Zhejiang, China
Taizhou Hospital of Zhejiang Province - Main — Taizhou, Zhejiang, China
Clinica de la Costa S.A.S. - PPDS — Barranquilla, Atlántico, Colombia
Fundacion Santa Fe de Bogota - Calle 119 A No. 7 - 49 — Bogotá, Bogota D.C., Colombia
Hospital Universitario San Ignacio — Bogotá, Cundinamarca, Colombia
Healthy Medical Center S.A.S. — Zipaquirá, Cundinamarca, Colombia
Fundacion Valle Del Lili — Cali, Valle del Cauca Department, Colombia
Klinicki bolnicki centar Sestre Milosrdnice - Vinogradska cesta 29 — Zagreb, City of Zagreb, Croatia
Polyclinic Bonifarm — Zagreb, City of Zagreb, Croatia
Clinical Hospital Center Rijeka — Rijeka, Croatia
Special Hospital Medico — Rijeka, Croatia
Vseobecna Fakultni Nemocnice V Praze — Prague, Prague, Czechia
Institut klinicke a experimentalni mediciny — Prague, Praha, Hlavní Mesto, Czechia
CHU de Strasbourg - Nouvel Hôpital Civil — Strasbourg, Bas-Rhin, France
CHU de Besançon — Besançon, Dobus, France
CHU de Bordeaux - Hôpital Pellegrin — Bordeaux, Gironde, France
CHU de Reims - Hôpital Maison Blanche — Reims, Grand Est, France
GHRMSA - Hôpital Emile Muller — Mulhouse, Haut-Rhin, France
Hopital Foch — Suresnes, Hauts-de-Seine, France
CHRU d'Orleans- Hôpital de La Source — Orléans, Loiret, France
CHU de Nîmes - Hopital Universitaire Caremeau — Nîmes Cédex 9, Occitanie, France
AP-HP - Hôpital Henri Mondor — Créteil, Val-de-Marne, France
Centre Hospitalier Departemental de Vendee — La Roche-sur-Yon, Vendée, France
CHU Amiens Picardie - Site Sud — Dreuil-lès-Amiens, France
AP-HP - Hôpital Saint-Louis — Paris, France
AP-HP - Hopital Tenon — Paris, France
Universitätsklinikum Heidelberg — Heidelberg, Baden-Wurttemberg, Germany
Robert Bosch Krankenhaus — Stuttgart, Baden-Wurttemberg, Germany
Nephrologisches Zentrum Villingen-Schwenningen — Villingen-Schwenningen, Baden-Wurttemberg, Germany
Universitätsklinikum Frankfurt, Apotheke Haus 19 — Frankfurt am Main, Hesse, Germany
Städtisches Klinikum Braunschweig - Salzdahlumer Straße 90 — Braunschweig, Lower Saxony, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz — Mainz, Rhineland-Palatinate, Germany
Universitätsklinikum Carl Gustav Carus an der TU Dresden — Dresden, Saxony, Germany
Universitätsklinikum Leipzig — Leipzig, Saxony, Germany
Charité - Universitätsmedizin Berlin — Berlin, Germany
Universitätsklinikum Hamburg Eppendorf — Hamburg, Germany
University General Hospital of Patras — Pátrai, Achaïa, Greece
General Hospital of Athens ''G. Gennimatas'' — Athens, Attica, Greece
General Hospital of Athens ''Hippokratio'' — Athens, Attica, Greece
Laiko General Hospital of Athens — Athens, Attica, Greece
University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA — Chaïdári, Attica, Greece
General Hospital of Heraklion Venizeleio — Heraklion, Irakleio, Greece
PAGNI-University General Hospital of Heraklion — Heraklion, Irakleio, Greece
University General Hospital of Ioannina — Ioannina, Greece
AHEPA University General Hospital of Thessaloniki — Thessaloniki, Greece
General Hospital of Thessaloniki ''G. Papanikolaou'' — Thessaloniki, Greece
Osmania General Hospital — Hyderabad, Andhra Pradesh, India
Nizams Institute of Medical Sciences — Hyderabad, Andhra Pradesh, India
All India Institute of Medical Sciences ( AIIMS ) - Raipur — Raipur, Chhattisgarh, India
Zydus Hospital — Ahmedabad, Gujarat, India
Muljibhai Patel Society for Research in Nephro-Urology — Nadiād, Gujarat, India
Manipal Hospital Bangalore — Bangalore, Karnataka, India
M.S. Ramaiah Medical College and Hospital — Bangalore, Karnataka, India
Government Medical College, Kozhikode — Kozhikode, Kerala, India
Trivandrum Medical College Hospital — Trivandrum, Kerala, India
Seth G S Medical College and K E M Hospital — Mumbai, Maharashtra, India
Noble Hospital — Pune, Maharashtra, India
Max Super Speciality Hospital - Saket — New Delhi, National Capital Territory of Delhi, India
Sir Ganga Ram Hospital — New Delhi, National Capital Territory of Delhi, India
King George Medical University — Lucknow, Uttar Pradesh, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences — Lucknow, Uttar Pradesh, India
Nil Ratan Sircar Medical College and Hospital — Kolkata, West Bengal, India
Postgraduate Institute of Medical Education & Research (PGIMER) — Chandigarh, India
Azienda Ospedaliero Universitaria Consorziale Policlinico — Bari, Apulia, Italy
Azienda Ospedaliero Universitaria di Parma — Fontevivo, Emilia-Romagna, Italy
Azienda Ospedaliero-Universitaria di Modena - Policlinico di Modena — Modena, Emilia-Romagna, Italy
AUSL Piacenza - Ospedale Guglielmo da Saliceto — Piacenza, Emilia-Romagna, Italy
Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) - Ospedale di Cattinara — Trieste, Friuli Venezia Giulia, Italy
IRCCS Azienda Ospedaliera Metropolitana - Ospedale Policlinico San Martino — Genoa, Liguria, Italy
ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia — Brescia, Lombardy, Italy
Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò — Ranica, Lombardy, Italy
IRCCS Istituto Clinico Humanitas — Rozzano, Lombardy, Italy
Azienda Ospedaliero Universitaria Maggiore della Carità — Novara, Piedmont, Italy
ASL Città di Torino - Ospedale San Giovanni Bosco — Turin, Piedmont, Italy
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda — Florence, Tuscany, Italy
Fujita Health University Hospital — Toyoake-shi, Aiti, Japan
Hirosaki University Hospital — Hirosaki-shi, Aomori, Japan
National Hospital Organization Chiba Medical Center Chibahigashi National Hospital — Chiba, Chiba, Japan
Juntendo University Urayasu Hospital — Urayasu-Shi, Chiba, Japan
Hokkaido University Hospital — Sapporo, Hokkaido, Japan
Hospital of the University of Occupational and Environmental Health, Japan — Kitakyushu-shi, Hukuoka, Japan
Fukushima Medical University Hospital — Fukushima, Hukusima, Japan
Toranomon Hospital Kajigaya — Kawasaki-shi, Kanagawa, Japan
Kitasato University Hospital — Sagamihara-shi, Kanagawa, Japan
Yokohama City University Hospital — Yokohama, Kanagawa, Japan
University Hospital, Kyoto Prefectural University of Medicine — Kyoto, Kyôto, Japan
Tohoku Medical and Pharmaceutical University Hospital — Sendai, Miyagi, Japan
Nara Medical University Hospital — Kashihara, Nara, Japan
Kawasaki Medical School Hospital — Kurashiki, Okayama-ken, Japan
Hamamatsu University Hospital — Hamamatsu, Sizouka, Japan
Tokushima University Hospital — Tokushima, Tokushima, Japan
The Jikei University West Medical Center — Ashikaga-Shi, Tokyo, Japan
Juntendo University Hospital — Bunkyo-Ku, Tokyo, Japan
Jikei University Hospital — Minato-ku, Tokyo, Japan
Showa Medical University Hospital — Shinagawa-ku, Tokyo, Japan
Ikeda Municipal Hospital — Ikeda-shi, Ôsaka, Japan
Osaka University Hospital — Suita-shi, Ôsaka, Japan
Hospital Tengku Ampuan Afzan — Kuantan, Pahang, Malaysia
Hospital Raja Permaisuri Bainun — Perak, Pahang, Malaysia
University Malaya Medical Centre — Lembah Pantai, WilayahPersekutuan KualaLumpur, Malaysia
Auckland City Hospital — Auckland, New Zealand
Aotearoa Clinical Trials Trust- Middlemore Hospital — Auckland, New Zealand
Wellington Hospital — Wellington, New Zealand
Norzel Medical and Diagnostic Clinic Foundation Corp. — Cebu City, Cebu, Philippines
The Medical City - Ortigas Ave - PPDS — Pasig, Metropolitan Manila, Philippines
MCM Krakow - PRATIA - PPDS — Krakow, Lesser Poland Voivodeship, Poland
SCM Clinic - Prywatny Szpital Specjalistyczny — Krakow, Lesser Poland Voivodeship, Poland
SPZOZ Centralny Szpital Kliniczny UM w Lodzi - ul. Pomorska 251 — Lodz, Lódzkie, Poland
Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7 — Gdansk, Pomeranian Voivodeship, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne — Szczecin, West Pomeranian Voivodeship, Poland
Uniwersytecki Szpital Kliniczny Nr 2 PUM w Szczecinie — Szczecin, Poland
ULS de Lisboa Ocidental, EPE - Hospital Santa Cruz — Carnaxide, Lisbon District, Portugal
ULS de Gaia/Espinho, EPE - Unidade I — Vila Nova de Gaia, Lisbon District, Portugal
ULS da Região de Aveiro, EPE - Hospital Infante D. Pedro — Aveiro, Portugal
Centro Clínico Académico, Braga - Hospital de Braga — Braga, Portugal
ULS de Coimbra, EPE - Hospitais da Universidade de Coimbra — Coimbra, Portugal
ULS da Região de Leiria, EPE - Hospital de Santo André — Leiria, Portugal
ULS da Arrábida, EPE - Hospital de São Bernardo — Setúbal, Portugal
FDI Clinical Research — San Juan, Puerto Rico
Pusan National University Hospital — Busan, Gwangyeogsi, South Korea
Hallym University Sacred Heart Hospital — Anyang-si, Gyeonggido, South Korea
Seoul National University Bundang Hospital — Seongnam-si, Gyeonggido, South Korea
Ajou University Hospital — Suwon, Gyeonggido, South Korea
Severance Hospital Yonsei University Health System — Seoul, Seoul Teugbyeolsi, South Korea
Hanyang University Seoul Hospital — Seoul, Seoul Teugbyeolsi, South Korea
Inje University Haeundae Paik Hospital — Busan, South Korea
Seoul National University Hospital — Seoul, South Korea
Samsung Medical Center — Seoul, South Korea
Fundacio Puigvert — Viladecans, Barcelona, Spain
Hospital del Mar — Barcelona, Catalonia, Spain
Hospital Universitario A Coruña — A Coruña, Galicia, Spain
Hospital Universitario Fundacion Alcorcon — Alcorcón, Madrid, Spain
Hospital Universitario de Getafe — Getafe, Madrid, Spain
Hospital Universitario Vall d'Hebron - PPDS — Barcelona, Spain
Hospital General San Pedro de Alcantara — Cáceres, Spain
Hospital Universitari de Girona Dr Josep Trueta — Girona, Spain
Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
Hospital Universitario 12 de Octubre — Madrid, Spain
Hospital Universitario Virgen Macarena — Seville, Spain
Hospital Universitario Miguel Servet — Zaragoza, Spain
National Cheng Kung University Hospital — Dawan, Taiwan, Province of China, Taiwan
Far Eastern Memorial Hospital — New Taipei City, Taiwan, Province of China, Taiwan
China Medical University Hospital - PPDS — Taichung, Taiwan, Province of China, Taiwan
Mackay Memorial Hospital-Taipei branch — Taipei, Taiwan, Province of China, Taiwan
Taipei Municipal Wanfang Hospital — Taipei, Taiwan, Province of China, Taiwan
Chang Gung Memorial Hospital, Linkou — Taoyuan, Taiwan, Province of China, Taiwan
Kaohsiung Medical University - Chung-Ho Memorial Hospital — Kaohsiung City, Taiwan
Taipei Medical University Shuang Ho Hospital — New Taipei City, Taiwan
Kocaeli Universitesi Arastirma ve Uygulama Hastanesi — İzmit, Kocaeli, Turkey (Türkiye)
Ankara Bilkent Sehir Hastanesi — Ankara, Turkey, Turkey (Türkiye)
Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi — Istanbul, Turkey, Turkey (Türkiye)
Mehmet Akif Inan Egitim ve Arastirma Hastanesi — Sanliurfa, Turkey, Turkey (Türkiye)
Akdeniz University Medical Faculty — Antalya, Turkey (Türkiye)
Istanbul Universitesi - Cerrahpasa Cerrahpasa Tip Fakultesi Hastanesi — Istanbul, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Gevher Nesibe Hastanesi — Kayseri, Turkey (Türkiye)
Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi — Konya, Turkey (Türkiye)
St Pancras Clinical Research — London, Greater London, United Kingdom
Royal Preston Hospital - NWCRN- PPDS — Preston, Lancashire, United Kingdom
Leicester General Hospital — Leicester, Leicestershire, United Kingdom
Northern General Hospital — Sheffield, South Yorkshire, United Kingdom
Royal Stoke University Hospital — Stoke-on-Trent, Staffordshire, United Kingdom

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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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