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RECRUITING Not applicable ClinicalTrials.gov

Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

Sponsor: Massachusetts General Hospital • ClinicalTrials.gov ID: NCT06910969

Registry updated: 2026-09-24
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Description

The goal of this study is to demonstrate the efficacy of a multidisciplinary group-based telehealth intervention (HORIZONS) compared to minimally enhanced usual care for improving self-management and quality of life for hematopoietic stem cell transplant (HSCT) survivors living with chronic graft-versus host disease, and to identify critical facilitators and barriers for HORIZONS implementation and adoption.

Interventions

  • HORIZONS Intervention (Behavioral)
    Therapist-delivered multidisciplinary group-based telehealth intervention comprised of 8 sessions
  • Minimally enhanced usual care (Behavioral)
    Receiving a standardized booklet with evidence-based information on chronic GHVD management and HST survivorship recommendations

Eligibility criteria

Inclusion Criteria: * Adult patients (≥ 18 years) who have undergone allogeneic HCT * Have moderate to severe cGVHD based on patient-report * Have ability to participate in English or Spanish language group telehealth intervention. Exclusion Criteria: * Patients with mild cGVHD based on their self-report. * Patients with a major untreated psychiatric or cognitive condition which the treating oncology clinicians believes interferes with the capacity to provide informed consent. * Patients with active relapsed disease requiring therapy.

Conditions

Bone Marrow Transplant Complications Graft-versus-Host Disease

Locations

  • University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
  • Massachusetts General Hospital — Boston, Massachusetts, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record