RECRUITING Phase 3 ClinicalTrials.gov

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

Sponsor: Mirati Therapeutics Inc. • ClinicalTrials.gov ID: NCT06875310

Registry updated: 2026-10-13

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Description

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation

Interventions

Adagrasib (Drug)
Specified dose on specified days
Pembrolizumab (Drug)
Specified dose on specified days
Carboplatin (Drug)
Specified dose on specified days
Pemetrexed (Drug)
Specified dose on specified days
Placebo (Drug)
Specified dose on specified days
Cisplatin (Drug)
Specified dose on specified days

Eligibility criteria

Inclusion Criteria: * Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor sample and/or circulating tumor deoxyribonucleic acid (ctDNA). * Locally advanced or metastatic disease. * Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion. * No prior systemic anti-cancer therapy given for advanced or metastatic disease. * Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection). * Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter. * Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx. Exclusion Criteria: * Participants with an active autoimmune or inflammatory disease requiring systemic treatment within 2 years. * Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment that are ongoing or with risk of recurrence. * Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities. * Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry. * Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting. * Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration. * Other protocol-defined Inclusion/Exclusion criteria apply.

Conditions

Carcinoma, Non-Small-Cell Lung

Locations

University of Alabama at Birmingham — Birmingham, Alabama, United States
Highlands Oncology Group - Springdale — Springdale, Arkansas, United States
Providence Medical Foundation — Fullerton, California, United States
Local Institution - 0682 — Loma Linda, California, United States
Helios Clinical Research — Long Beach, California, United States
National Jewish Health Medical Center — Denver, Colorado, United States
Medical Oncology Hematology Consultants, PA — Newark, Delaware, United States
Morton Plant Hospital - BayCare Health System — Clearwater, Florida, United States
Cancer Specialists of North Florida — Jacksonville, Florida, United States
Local Institution - 0696 — Miami, Florida, United States
Ocala Oncology Center PL DBA Florida Cancer Affiliates - Ocala — Ocala, Florida, United States
Mid Florida Hematology and Oncology Center — Orange City, Florida, United States
Cancer Care Centers of Brevard, Inc. — Palm Bay, Florida, United States
Florida Clinical Trials Group. — Plantation, Florida, United States
St. Anthony's Hospital — St. Petersburg, Florida, United States
Florida Clinical Trials Group. — Tamarac, Florida, United States
H. Lee Moffitt Cancer Center & Research Institute — Tampa, Florida, United States
Local Institution - 0647 — Tampa, Florida, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital — Marietta, Georgia, United States
Illinois Cancer Specialists — Arlington Heights, Illinois, United States
University of Illinois at Chicago — Chicago, Illinois, United States
Springfield Clinic Main Campus — Springfield, Illinois, United States
Northwest Cancer Centers, P.C. — Dyer, Indiana, United States
Parkview Research Center at Parkview Regional Medical Center — Fort Wayne, Indiana, United States
Local Institution - 0423 — Munster, Indiana, United States
Mercy Medical Center — Cedar Rapids, Iowa, United States
Saint Elizabeth Medical Center Edgewood — Edgewood, Kentucky, United States
The University of Louisville, James Graham Brown Cancer Center — Louisville, Kentucky, United States
Owensboro Medical Health System — Owensboro, Kentucky, United States
Mercy Health-Paducah Medical Oncology and Hematology — Paducah, Kentucky, United States
Louisiana State University Health Sciences Shreveport — Shreveport, Louisiana, United States
Velocity Clinical Research, Annapolis — Annapolis, Maryland, United States
Maryland Oncology Hematology - Columbia — Columbia, Maryland, United States
Dana-Farber Cancer Institute — Boston, Massachusetts, United States
Karmanos Cancer Institute — Detroit, Michigan, United States
SSM Health Cancer Care - Fenton — Fenton, Missouri, United States
Local Institution - 0678 — Cooperstown, New York, United States
Ellis Hospital — Schenectady, New York, United States
White Plains Hospital — White Plains, New York, United States
Local Institution - 0624 — Asheville, North Carolina, United States
Local Institution - 0688 — Easton, Pennsylvania, United States
Local Institution - 0376 — Hershey, Pennsylvania, United States
WellSpan Oncology Research — York, Pennsylvania, United States
Local Institution - 0681 — Greenville, South Carolina, United States
St Francis Cancer Center — Greenville, South Carolina, United States
SCRI Oncology Partners — Nashville, Tennessee, United States
Local Institution - 0697 — Nashville, Tennessee, United States
Texas Oncology Sammons Cancer Center — Dallas, Texas, United States
University Of Texas Medical Branch At Galveston — Galveston, Texas, United States
Oncology & Hematology of South Texas — Laredo, Texas, United States
Texas Oncology - San Antonio — San Antonio, Texas, United States
Texas Oncology - Northeast Texas — Tyler, Texas, United States
Instituto Alexander Fleming — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
IDIM - Instituto de Investigaciones Metabólicas — Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital Universitario Austral — Pilar, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires — ABB, Buenos Aires F.D., Argentina
Local Institution - 0571 — Buenos Aires, Buenos Aires F.D., Argentina
Clinica Adventista Belgrano — CABA, Buenos Aires F.D., Argentina
Sanatorio Plaza — Rosario, Santa Fe Province, Argentina
Canberra Hospital — Canberra, Australian Capital Territory, Australia
Tamworth Hospital — North Tamworth, New South Wales, Australia
Orange Hospital — Orange, New South Wales, Australia
Princess Alexandra Hospital — Brisbane, Queensland, Australia
Lyell McEwin Hospital — Elizabeth Vale, South Australia, Australia
Frankston Hospital — Frankston, Victoria, Australia
Northern Hospital — Melbourne, Victoria, Australia
Latrobe Regional Health — Traralgon, Victoria, Australia
Joondalup Health Campus — Joondalup, Western Australia, Australia
Medizinische Universität Graz — Graz, Styria, Austria
Klinikum Wels-Grieskirchen GmbH — Wels, Upper Austria, Austria
Kepler Universitätsklinikum — Linz, Austria
Medizinische Universität Wien — Vienna, Austria
Klinik Floridsdorf — Vienna, Austria
UZ Brussel — Brussels, Bruxelles-Capitale, Région de, Belgium
Cliniques universitaires Saint-Luc — Brussels, Bruxelles-Capitale, Région de, Belgium
Jessa Ziekenhuis — Hasselt, Limburg, Belgium
AZ Maria Middelares — Ghent, Oost-Vlaanderen, Belgium
UZ Leuven — Leuven, Vlaams-Brabant, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman — Liège, Belgium
CEDOES — Vitória, Espírito Santo, Brazil
Nucleo de Oncologia da Bahia — Salvador, Estado de Bahia, Brazil
Cetus Oncologia - Unidade Belo Horizonte — Belo Horizonte, Minas Gerais, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia — Ijuí, Rio Grande do Sul, Brazil
Hospital São Lucas da PUCRS — Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Oncologia Saint Gallen — Santa Cruz do Sul, Rio Grande do Sul, Brazil
Hospital de Amor Amazônia — Porto Velho, Rondônia, Brazil
Clínica de Oncologia Reichow — Blumenau, Santa Catarina, Brazil
Clínica de Neoplasias Litoral — Itajaí, Santa Catarina, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos — Barretos, São Paulo, Brazil
Advanze Pesquisa — São Carlos, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto — São José do Rio Preto, São Paulo, Brazil
A. C. Camargo Cancer Center — São Paulo, São Paulo, Brazil
Instituto Nacional de Câncer - INCA — Rio de Janeiro, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo — São Paulo, Brazil
MBAL Uni Hospital — Panagyurishte, Pazardzhik, Bulgaria
Multiprofile Hospital for Active Treatment Serdika EOOD — Sofia, Sofia (stolitsa), Bulgaria
Complex Oncology Center - Ruse EOOD — Rousse, Bulgaria
Trakia Hospital — Stara Zagora, Bulgaria
Local Institution - 0074 — Halifax, Nova Scotia, Canada
St. Marys Hospital Center — Montreal, Quebec, Canada
Bradfordhill — Recoleta, Santiago Metropolitan, Chile
FALP — Santiago, Santiago Metropolitan, Chile
The First Afflilated Hospital of Bengbu Medical College — Bengbu, Anhui, China
Anhui Provincial Hospital — Hefei, Anhui, China
Beijing Cancer hospital — Beijing, Beijing Municipality, China
Beijing Peking Union Medical College Hospital — Beijing, Beijing Municipality, China
Beijing Chest Hospital,Capital Medical University — Beijing, Beijing Municipality, China
Chongqing University Cancer Hospital — Chongqing, Chongqing Municipality, China
Fujian Medical University Union Hospital — Fuzhou Fujian, Fujian, China
The First Affiliated hospital of Xiamen University — Xiamen, Fujian, China
The First Affiliated Hospital, Sun Yat-sen University — Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College — Shantou, Guangdong, China
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center — Shenzhen, Guangdong, China
ShenZhen People's Hospital — Shenzhen, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital — Nanning, Guangxi, China
Fourth Hospital of Hebei Medical University — Shijiazhuang, Hebei, China
Harbin Medical University Cancer Hospital — Harbin, Heilongjiang, China
Nanyang City Center Hospital — Nanyang, Henan, China
The First Affiliated Hospital of Henan Medical University — Xinxiang, Henan, China
Tongji Hospital Tongji Medical,Science & Technology — Wuhan, Hubei, China
Hunan Cancer Hospital — Changsha, Hunan, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School — Nanjing, Jiangsu, China
The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China
Northern Jiangsu People's Hospital — Yangzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
The First Hospital of Jilin University — Changchun, Jilin, China
The First Hospital of China Medical University — Shenyang, Liaoning, China
Shengjing Hospital of China Medical University — Shenyang, Liaoning, China
Liaoning Cancer Hospital — Shenyang, Liaoning, China
Shandong Cancer Hospital — Jinan, Shandong, China
LinYi Cancer Hospital — Linyi, Shandong, China
Shanghai Chest Hospital — Shanghai, Shanghai Municipality, China
Local Institution - 0381 — Shanghai, Shanghai Municipality, China
Shanghai East Hospital — Shanghai, Shanghai Municipality, China
Shanxi Cancer Hospital — Taiyuan, Shanxi, China
Sichuan Cancer hospital — Chengdu, Sichuan, China
West China Hospital, Sichuan University — Chengdu, Sichuan, China
Tianjin Medical University General Hospital — Tianjin, Tianjin Municipality, China
The first Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province — Taizhou, Zhejiang, China
Clinica Somer — Rionegro, Antioquia, Colombia
Local Institution - 0191 — Puerto Colombia, Atlántico, Colombia
Local Institution - 0189 — Bogotá, Bogota D.C., Colombia
Sociedad De Oncología y Hematología Del Cesar SAS — Valledupar, Cesar Department, Colombia
Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S — Montería, COR, Colombia
Local Institution - 0671 — Bogota, Cundinamarca, Colombia
Fundación Cardiovascular de Colombia — Floridablanca, Santander Department, Colombia
Fundación Valle del Lili — Cali, Valle del Cauca Department, Colombia
Clinica Medellin S.A — Medellín, Colombia
Opća bolnica Dubrovnik — Dubrovnik, Dubrovnik-Neretva County, Croatia
Poliklinika MEDICO - Rijeka — Rijeka, Primorje-Gorski Kotar County, Croatia
Klinički Bolnički Centar Split — Split, Split-Dalmatia County, Croatia
Klinički bolnički centar Osijek — Osijek, Croatia
Clinic for lung diseases — Zagreb, Croatia
Local Institution - 0159 — Mulhouse, Alsace, France
Centre François Baclesse — Caen, Calvados, France
Centre Georges François Leclerc — Dijon, Côte-d'Or, France
CHRU de Brest — Brest, Finistère, France
Institut Régional du Cancer Montpellier — Montpellier, Hérault, France
Chu Grenoble Alpes — La Tronche, Isère, France
Centre Hospitalier Universitaire d'Angers — Angers, Maine-et-Loire, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois — Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France
Institut Paoli-Calmettes — Marseille, Provence-Alpes-Côte d'Azur Region, France
CHU d'Amiens-Picardie - Hôpital Sud — Amiens, Somme, France
Gustave Roussy — Villejuif, Val-de-Marne, France
Hôpital Ambroise Paré — Boulogne-Billancourt, France
Chu Gabriel Montpied — Clermont-Ferrand, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren — Limoges, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord — Marseille, France
Local Institution - 0133 — Paris, France
Hopitaux Universitaires Paris Centre-Hopital Cochin — Paris, France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes — Saint-Herblain, France
Klinikum Esslingen — Esslingen am Neckar, Baden-Wurttemberg, Germany
Bundeswehrkrankenhaus Ulm — Ulm, Baden-Wurttemberg, Germany
Klinikum der Ludwig-Maximilians-Universitaet Muenchen — München, Bavaria, Germany
Centrum für Hämatologie und Onkologie Bethanien — Frankfurt am Main, Hesse, Germany
UKGM Gießen/Marburg — Giessen, Hesse, Germany
Praxis Onkologie am Raschplatz — Hanover, Lower Saxony, Germany
Pius Hospital Oldenburg — Oldenburg, Lower Saxony, Germany
Klinikum Köln-Merheim — Cologne, North Rhine-Westphalia, Germany
Evangelisches Krankenhaus Herne - Eickel — Herne, North Rhine-Westphalia, Germany
Universitätsklinikum Halle — Halle, Saxony-Anhalt, Germany
Malteser Krankenhaus St. Franziskus-Hospital — Flensburg, Schleswig-Holstein, Germany
SRH Wald-Klinikum Gera GmbH — Gera, Thuringia, Germany
Universitätsklinikum Jena — Jena, Thuringia, Germany
Vivantes Klinikum Neukölln — Berlin, Germany
Evangelische Lungenklinik Berlin — Berlin, Germany
Local Institution - 0675 — Halle, Germany
Lungenklinik Hemer — Hemer, Germany
Klinikum Stuttgart - Katharinenhospital — Stuttgart, Germany
Universitaetsklinikum Wuerzburg — Würzburg, Germany
Errikos Dunant Hospital Center — Athens, Attikí, Greece
Thoracic General Hospital of Athens "I Sotiria" — Athens, Attikí, Greece
University General Hospital of Larissa — Larissa, Thessalía, Greece
Queen Mary Hospital — Hksar, Hong Kong
Queen Mary Hospital — Hksar, Hong Kong
Mátrai Gyógyintézet — Gyöngyös - Mátraháza, Heves County, Hungary
Local Institution - 0157 — Tatabánya, Komárom-Esztergom, Hungary
Farkasgyepui Tudogyogyintezet — Farkasgyepű, Veszprém megye, Hungary
Semmelweis Egyetem — Budapest, Hungary
Országos Korányi Pulmonológiai Intézet — Budapest, Hungary
Petz Aladar Egyetemi Oktato Korhaz — Győr, Hungary
Apollo Hospitals - Visakhapatnam - Health City — Visakhapatnam, Andhra Pradesh, India
Hemato Oncology Clinic — Ahmedabad, Gujarat, India
Marengo CIMS Hospital — Ahmedabad, Gujarat, India
Local Institution - 0155 — Thiruvananthapuram, Kerala, India
Local Institution - 0154 — Mumbai, Maharashtra, India
All India Institute of Medical Sciences — New Delhi, National Capital Territory of Delhi, India
Vardhman Mahavir Medical College and Safdarjung Hospital — New Delhi, National Capital Territory of Delhi, India
Rajiv Gandhi Cancer Institute And Research Centre — New Delhi, National Capital Territory of Delhi, India
Institute of Medical Sciences and Sum Hospital — Bhubaneswar, Odisha, India
Meenakshi Mission Hospital and Research Centre — Madurai, Tamil Nadu, India
Yashoda Hospitals - Hitech City — Hyderabad, Telangana, India
Mahamana Pandit Madan Mohan Malviya Cancer Centre — Varanasi, Uttar Pradesh, India
Narayana Superspecialty Hospital — Howrah, West Bengal, India
Netaji Subhas Chandra Bose Cancer Hospital — Kolkata, West Bengal, India
Basavatarakam Indo American Cancer Hospital & Research Institute — Hyderabad, India
Cork University Hospital — Cork, Ireland
Mater Private Hospital - Dublin — Dublin, Ireland
St. James's Hospital — Dublin, Ireland
UCD School of Medicine Beacon Hospital — Dublin, Ireland
Beaumont Hospital, Dublin — Dublin, Ireland
Rabin Medical Center — Petah Tikva, Central District, Israel
Sheba Medical Center — Ramat Gan, Central District, Israel
Yitzhak Shamir Medical Center — Ẕerifin, Central District, Israel
Hadassah Medical Center — Jerusalem, Jerusalem, Israel
Carmel Hospital — Haifa, Ḥeifā, Israel
Instituto Tumori Giovanni Paolo II — Bari, Apulia, Italy
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" — Meldola, Emilia-Romagna, Italy
Local Institution - 0066 — Naples, Napoli, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga — Orbassano, Piedmont, Italy
Istituto Nazionale Tumori Regina Elena — Rome, Roma, Italy
Azienda Ospedaliera Universitaria Careggi — Florence, Tuscany, Italy
IRCCS AOM Azienda Ospedaliera Metropolitana — Genova, Italy
Istituto Oncologico Veneto IRCCS — Padova, Italy
Azienda Ospedaliero Universitaria di Parma — Parma, Italy
Fondazione IRCCS Policlinico San Matteo — Pavia, Italy
Ospedale di Circolo e Fondazione Macchi Varese — Varese, Italy
Local Institution - 0607 — Nagoya, Aichi-ken, Japan
National Hospital Organization Nagoya Medical Center — Nagoya, Aichi-ken, Japan
Hokkaido University Hospital — Sapporo, Hokkaido, Japan
Local Institution - 0304 — Kanazawa, Ishikawa-ken, Japan
Kitasato University Hospital — Sagamihara, Kanagawa, Japan
Local Institution - 0369 — Yokohama, Kanagawa, Japan
Sendai Kousei Hospital — Sendai, Miyagi, Japan
Local Institution - 0306 — Kashihara, Nara, Japan
Local Institution - 0368 — Kurashiki, Okayama-ken, Japan
Kansai Medical University Hospital — Hirakata, Osaka, Japan
Saitama Medical University International Medical Center — Hidaka, Saitama, Japan
Local Institution - 0300 — Ina-machi, Saitama, Japan
Hamamatsu University Hospital — Hamamatsu, Shizuoka, Japan
Local Institution - 0299 — Shimotsuga, Tochigi, Japan
Tokyo Metropolitan Komagome Hospital — Bunkyo Ku, Tokyo, Japan
Toyama University Hospital — Toyoma, Toyama, Japan
Local Institution - 0542 — Iwakuni, Yamaguchi, Japan
Local Institution - 0307 — Akashi, Japan
Aomori Prefectural Central Hospital — Aomori, Japan
Kyushu University Hospital — Fukuoka, Japan
Local Institution - 0367 — Fukushima, Japan
Local Institution - 0308 — Kumamoto, Japan
Nagasaki University Hospital — Nagasaki, Japan
Osaka City General Hospital — Osaka, Japan
Osaka International Cancer Institute — Osaka, Japan
Centro de Infusion E Investigacion Oncologia de Saltillo S.C. — Saltillo, Coahuila, Mexico
Gefarma (Atrys) — Mexico City, DIF, Mexico
Grupo Ollin Care — Pachuca, Hidalgo, Mexico
Hospital Civil Fray Antonio Alcalde — Guadalajara, Jalisco, Mexico
Axis Heilsa S. de R.L. de C.V. — Monterrey, Nuevo León, Mexico
Local Institution - 0175 — Chihuahua City, Mexico
Unidad Médica Onco-hematológica — Puebla City, Mexico
Local Institution - 0638 — Puebla City, Mexico
FAICIC S. de R.L. de C.V. — Veracruz, Mexico
Maastricht UMC+ — Maastricht, Limburg, Netherlands
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL) — Amsterdam, North Holland, Netherlands
Med-Polonia Sp. z o. o. — Poznan, Greater Poland Voivodeship, Poland
Local Institution - 0206 — Gorlice, Lesser Poland Voivodeship, Poland
Local Institution - 0079 — Krakow, Lesser Poland Voivodeship, Poland
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii — Wroclaw, Lower Silesian Voivodeship, Poland
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie — Lublin, Lublin Voivodeship, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka — Bydgoszcz, Poland
Pratia Onkologia Katowice — Katowice, Poland
Szpital Specjalistyczny w Prabutach Spolka z o.o. — Prabuty, Poland
Instituto Português de Oncologia de Lisboa Francisco Gentil — Lisbon, Lisbon District, Portugal
Instituto Portugês de Oncologia de Coimbra Francisco Gentil — Coimbra, Portugal
Centro Hospitalar do Porto - Hospital de Santo António — Porto, Portugal
SC Memorial Healthcare International SRL — Bucharest, Bucharest, Romania
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu" — Bucharest, Bucharest, Romania
Cardiomed SRL Cluj-Napoca — Cluj-Napoca, Cluj, Romania
SC Radiotherapy Center Cluj SRL — Florești, Cluj, Romania
Ovidius Clinical Hospital OCH — Ovidiu, Constanța County, Romania
Centrul de Oncologie "Sfântul Nectarie" — Craiova, Dolj, Romania
Oncohelp Medical Center — Timișoara, Timiș County, Romania
Institutul Oncologic Cluj — Cluj-Napoca, Romania
Institutul Oncologic Cluj — Cluj-Napoca, Romania
Affidea Constanța — Constanța, Romania
S.C. Centrul de Oncologie Euroclinic S.R.L. — Iași, Romania
Institutul Regional de Oncologie — Iași, Romania
Spitalul Municipal Schuller Ploiești — Ploieşti, Romania
King Faisal Specialist Hospital — Jeddah, Makkah Al Mukarramah, Saudi Arabia
King Abdulaziz Medical City - National Guard Hospital — Riyadh, Saudi Arabia
King Faisal Specialist Hospital and Research Center — Riyadh, Saudi Arabia
Chungbuk National University Hospital — Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea
Gachon University Gil Medical Center — Namdong-gu, Incheon-gwangyeoksi [Incheon], South Korea
Pusan National University Yangsan Hospital — Yangsan, Kyǒngsangnam-do, South Korea
Pusan National University Hospital — Busan, Pusan-Kwangyǒkshi, South Korea
Severance Hospital, Yonsei University Health System — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Konkuk University Medical Center — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Local Institution - 0248 — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Korea University Guro Hospital — Seoul, Seoul-teukbyeolsi [Seoul], South Korea
CHUAC-Hospital Teresa Herrera — A Coruña, A Coruña [La Coruña], Spain
CHUS - Hospital Clinico Universitario — Santiago de Compostela, A Coruña [La Coruña], Spain
Hospital Universitari Vall d'Hebron — Barcelona, Barcelona [Barcelona], Spain
Local Institution - 0497 — Hospitalet, Barcelona [Barcelona], Spain
Local Institution - 0505 — Barcelona, Catalunya [Cataluña], Spain
Hospital Son Llàtzer — Palma, Illes Balears [Islas Baleares], Spain
Hospital General Universitario Gregorio Marañon — Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Ramón y Cajal — Madrid, Madrid, Comunidad de, Spain
Hospital Universitario 12 de Octubre — Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Puerta de Hierro Majadahonda — Majadahonda, Madrid, Comunidad de, Spain
CHUVI- Hospital Alvaro Cunqueiro — Pontevedra, Pontevedra [Pontevedra], Spain
Hospital Arnau de Vilanova — Valencia, València, Spain
Hospital Clinico San Carlos — Madrid, Spain
H.R.U Málaga - Hospital General — Málaga, Spain
Hospital Universitario Virgen Del Rocio — Seville, Spain
Local Institution - 0495 — Valencia, Spain
Kantonsspital Münsterlingen - Spital Thurgau AG — Münsterlingen, Switzerland
Chi Mei Hospital - Liouying Branch — Tainan, Tainan, Taiwan
Tri-Service General Hospital — Taipei City, Taipei, Taiwan
Taipei Medical University Shuang Ho Hospital — New Taipei City, Taiwan
National Cheng Kung University Hospital — Tainan, Taiwan
National Taiwan University Hospital — Taipei, Taiwan
Chulalongkorn University — Bangkok, Bangkok, Thailand
Faculty of Medicine - Khon Kaen University — Muang, Changwat Khon Kaen, Thailand
Songklanagarind hospital — Hat Yai, Changwat Songkhla, Thailand
I.E.U. Medical Point Hastanesi — Izmir, Karsiyaka, İzmir, Turkey (Türkiye)
Baskent University Dr. Turgut Noyan Research and Training Center — Adana, Turkey (Türkiye)
Hacettepe Universite Hastaneleri — Ankara, Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals — Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi — Ankara, Turkey (Türkiye)
Local Institution - 0550 — Istanbul, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi — Istanbul, Turkey (Türkiye)
Ege Universitesi Hastanesi — Izmir, Turkey (Türkiye)
University College London Hospital — London, London, City of, United Kingdom
Guy's & St Thomas' NHS Foundation Trust — London, London, City of, United Kingdom
Heartlands Hospital — Birmingham, United Kingdom
Local Institution - 0545 — Guildford, United Kingdom
The Royal Surrey County Hospital — Guildford, United Kingdom
Local Institution - 0093 — Manchester, United Kingdom

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